首页 / 专利库 / 溶剂类 / 有机溶剂 / N-甲基吗啉-N-氧化物 / Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid

Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid

阅读:503发布:2022-04-18

专利汇可以提供Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid专利检索,专利查询,专利分析的服务。并且PURPOSE: To prepare the titled compound useful as an analgesic and antiphlogistic agent, in high yield, by the hydrolysis and decarbonation of a novel compound.
CONSTITUTION: 1-Methylpyrrole of formula II is made to react with a compound of formula III (R
3 and R
4 are lower alkyl or together with the adjacent N atom form a heterocyclic group such as morpholino, piperidino, etc.) in the presence of a condensation agent such as phosphorus oxychloride in a solvent to obtain 1-methyl- 5-(p-toluoyl)pyrrole of formula IV, which is made to react with a compound of formula V (R
1 and R
2 are lower alkyl) in the presence of a catalyst such as rhodium acetate, in the absence of solvent or in a solvent. The novel intermediate of formula I thus obtained, e.g. [1-methyl-5-(p-toluoyl)pyrrole-2]-malonic acid dimethyl ester, is hydrolyzed and decarbonated by heating and refluxing in a solvent such as a lower alcohol in the presence of a base such as an alkali hydroxide at 50W 120°C, for 1W10hr to afford the objective compound.
COPYRIGHT: (C)1982,JPO&Japio,下面是Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid专利的具体信息内容。

高效检索全球专利

专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台,是提供专利分析,专利查询,专利检索等数据服务功能的知识产权数据服务商。

我们的产品包含105个国家的1.26亿组数据,免费查、免费专利分析。

申请试用

分析报告

专利汇分析报告产品可以对行业情报数据进行梳理分析,涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度,系统通过AI智能系统对图表进行解读,只需1分钟,一键生成行业专利分析报告。

申请试用

QQ群二维码
意见反馈