Interferant removal from amphetamine immunoassay专利检索-氢氧化铵酸，碱，盐，酸酐和碱专利检索查询-专利查询网

Interferant removal from amphetamine immunoassay

阅读：982发布：2023-12-19

专利汇可以提供Interferant removal from amphetamine immunoassay专利检索，专利查询，专利分析的服务。并且A method for removing Beta -hydroxyamine compounds as an interferant from immunoassays, where like compounds, such as amphetamine, methamphetamine, and the like are to be determined. The sample, for example, urine is treated with aqueous periodate at a mildly basic pH for a time sufficient to remove the Beta hydroxyamine as an interferant, the pH being maintained by an ammonium hydroxide. The sample may then be used in assays for the determination of amphetamine or like compounds without interference from the Beta -hydroxyamine compound.，下面是Interferant removal from amphetamine immunoassay专利的具体信息内容。

权利要求

1. IN AN ASSAY METHOD FOR DETERMINING ARALKYL AMINES, WHEREIN 1-ARALKYL B-HYDROXYAMINES INTERFERE, THE IMPROVEMENT WHICH COMPRISES: TREATING THE SAMPLE TO BE ASSAYED AT A PH GREATER THAN ABOUT 8 WITH AN AMOUNT OF AQUEOUS PERIODATE SOLUTION SUFFICIENT TO REMOVE THE HYDROXYAMINE INTERFERANT WHEREIN SAID PH IS MAINTAINED BY THE PRESENCE OF AN AMMONIUM HYDROXIDE.

2. A method according to claim 1, wherein the concentration of said periodate is in the range of about 10 3 to 10 7 moles/ml.

3. A method according to claim 1, wherein said periodate is at a concentration in the range of about 10 4 to 10 6 moles/ml.

4. A method according to claim 1, wherein the concentration of said ammonium hydroxide is in an amount of from 2 to 20 times the concentration of periodate and said ammonium hydroxide is tetraalkyl ammonium hydroxide.

5. In a method for carrying out immunoassays to detect amphetamine or methamphetamine, the improvement which comprises: treating the sample to be assayed with aqueous periodate solution at a concentration in the range of about 10 4 to 10 6 moles/ml in the presence of an ammonium hydroxide in an amount sufficient to provide a pH in the range of about 8 to 9.

6. A method according to claim 5, wherein said ammonium hydroxide is tetramethyl ammonium hydroxide.

7. A method according to claim 5, wherein said ammonium hydroxide is NH4OH.

8. A method according to claim 5, wherein said treating is carried out at a temperature in the range of about 10* to 40* C and for a time in the range of about 1 to 10 minutes.

9. An aqueous solution which is 0.05 to 0.5 M in periodate and 0.5 to 2 M in tetraalkylammonium hydroxide of from four to eight carbon atoms.

10. A solution according to claim 9, wherein said tetraalkylammonium hydroxide is tetramethylammonium hydroxide and said periodate ranges from 0.05 to 0.3 M in concentration.

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Interferant removal from amphetamine immunoassay

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