首页 / 专利库 / 酸,碱,盐,酸酐和碱 / 过酸 / 17{60 -alkanoyloxy-11{62 -methyl-19-norpregna-4,6-diene-3,20-diones and the 6{60 -chloro-19-norpregn-4-ene-3,20-diones corresponding

17{60 -alkanoyloxy-11{62 -methyl-19-norpregna-4,6-diene-3,20-diones and the 6{60 -chloro-19-norpregn-4-ene-3,20-diones corresponding

阅读:865发布:2022-07-22

专利汇可以提供17{60 -alkanoyloxy-11{62 -methyl-19-norpregna-4,6-diene-3,20-diones and the 6{60 -chloro-19-norpregn-4-ene-3,20-diones corresponding专利检索,专利查询,专利分析的服务。并且17 Alpha -Alkanoyloxy-11 Beta -methyl-19-norpregn-4-ene-3,20diones are converted to the corresponding enol ethers by standard methods and the latter derivatives are, alternatively, oxidized to yield the corresponding 4,6-diene-3,20-diones or are contacted first with an N-chloroamide or N-chloroimide, e.g., Nchlorosuccinimide, then with a strong mineral acid to yield the 6 Alpha -chloro compounds. Reaction of the aforementioned 4,6diene-3,20-diones with a peracid results in the corresponding 6 Alpha ,7 Alpha -epoxy-3-keto- Delta 4 compounds, which are contacted with a hydrogen halide, and the resulting 6 Beta chloro-7 Alpha -hydroxy compounds are dehydrated by conversion first to the 7-methanesulfonate followed by heating with a suitable base to provide the desired 6-chloro-3-keto- Delta 4,6 derivatives. The compounds of this invention are unusually potent progestational and estrogen-inhibitory agents.,下面是17{60 -alkanoyloxy-11{62 -methyl-19-norpregna-4,6-diene-3,20-diones and the 6{60 -chloro-19-norpregn-4-ene-3,20-diones corresponding专利的具体信息内容。

  • 2. A compound of the formula
  • 3. A compound of the formula
  • 4. A compound of the formula
  • 5. The compound according to claim 1 which is 17 Alpha -acetoxy-11 Beta -methyl-19-norpregna-4,6-diene-3,20-dione.
  • 6. The compound according to claim 1 which is 17 Alpha -acetoxy-6 Alpha -chloro-11 Beta -methyl-19-norpregn-4-ene-3,20-dione.
  • 7. The compound according to claim 1 which is 17 Alpha -acetoxy-6-chloro-11 Beta -methyl-19-norpregna-4,6-diene-3,20-dione.
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