Lyophilized biological products专利检索-生物活性成分生物防治专利检索查询-专利查询网

Lyophilized biological products

阅读：669发布：2023-04-26

专利汇可以提供Lyophilized biological products专利检索，专利查询，专利分析的服务。并且Disclosed herein is a homogeneous, lyophilized particulate product of a substance containing at least one biologically active component and a process for its preparation which involves forming a solution or colloidal suspension of the substance, spraying the solution or colloidal suspension into a moving bath of fluorocarbon refrigerant and lyophilizing the resultant frozen droplets. The porous product has a spherical shape, free-flowing properties, and rapid dissolution times.，下面是Lyophilized biological products专利的具体信息内容。

权利要求

1. A LYOPHILIZED PRODUCT CONTAINING AT LEAST ONE BIOLOGICALLY ACTIVE COMPONENT SAID PRODUCT COMPRISING A PLURALITY OF UNIFORM SIZED POROUS SPHERES, SAID PRODUCT BEING FORMED ACCORDING TO A PROCESS COMPRISING THE STEPS OF: A. FORMING A SOLUTION OR COLLOIDAL SUSPENSION OF A SUBSTANCE CONTAINING AT LEAST ONE BIOLOGICALLY ACTIVE MATERIAL IN A LIQUID WHICH WILL FREEZE AND WHICH WILL ALSO VAPORIZE AT A TEMPERATURE WHICH WILL NOT DESTROY THE BIOLOGICAL ACTIVITY OF SAID MATERIAL; B. SPRAYING SAID SOLUTION OR COLLOIDAL SUSPENSION ONTO THE SURFACE OF A MOVING BATH OF BOILING FLUOROCARBON RERIGERANT HAVING A BOILING TEMPERATURE OF BELOW ABOUT -20*C. FROM A SUFFICIENT HEIGHT ABOVE THE SURFACE OF THE MOVING BATH TO ALLOW DROPLET FORMATION BEFORE THE SOLUTION STRIKES THE SURFACE OF THE MOVING BATH, WHEREBY SAID DROPLETS ARE FROZEN; AND C. LYOPHILIZING SAID DROPLETS TO FORM A PLURALITY OF UNIFORMED SIZED POROUS SPHERES IN WHICH THE VOLUME OF THE SPHERE THAT IS NOT OCCUPIED BY PORES CONTAINS A UNIFORM DISTRIBUTION OF SAID SUBSTANCE CONTAINING AT LEAST ONE BIOLOGICALLY ACTIVE MATERIAL.

2. The product of claim 1 wherein the pores constitute at least about 90 percent of the volume of said spheres.

3. The product of claim 1 wherein said substance comprises a pharmaceutical.

4. The product of claim 1 wherein said substance comprises a pharmaceutical selected from the group consisting of vitamins, hormones, tranquilizers and antibiotics.

5. The product of claim 1 wherein said substance comprises a protein.

6. The product of claim 1 wherein said substance comprises an enzyme.

7. The product of claim 1 wherein said substance comprises a gelatin.

8. The product of claim 1 wherein said substaNce is selected from the group consisting of serum or plasma.

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Lyophilized biological products

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