| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 261 | COMPOSITIONS AND METHODS INCLUDING EXPRESSION AND BIOACTIVITY OF BOVINE FOLLICLE STIMULATING HORMONE | US12028155 | 2008-02-08 | US20080312151A1 | 2008-12-18 | Mark A. COLGIN; Richard G. Donnelly; Brad Stroud |
| The present invention provides methods of producing biologically active recombinant bFSH and methods of increasing reproduction in mammals, particularly bovine, using recombinant bFSH. Also provided are methods of producing single chain recombinant bFSH. The recombinant bFSH of the present invention increases superovulation, embryo development, and reproductive efficiency in cattle and other ungulates. | ||||||
| 262 | UNGULATE EMBRYONIC STEM-LIKE CELLS, MAKING AND USING THE CELLS TO PRODUCE A TRANSGENIC UNGULATE | PCT/IB1996000016 | 1996-01-09 | WO1997025413A1 | 1997-07-17 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; ANDERSON, Gary, B.; SHIM, Hosup |
| Primordial germ cells are extracted from post blastocyst embryos of an ungulate such as extracting primordial germ cells from the gonadal ridges of 25-day porcine embryos or 34-40 day bovine embryos. The primordial germ cells are cultured in long term culture (over 30 days) resulting in cells which resemble embryonic stem cells in morphology and with respect to maintaining pluripotency. The cells obtained can be maintained for several months in culture and can be genetically manipulated using homologous recombination technology in order to insert desired genetic material into the genetic compliment of the cell at a desired location. The genetically manipulated cell can be inserted into a blastocyst obtained from the same species of animal as the cell was derived in order to produce a chimeric ungulate which ungulate may, via its genetic engineering, produce desired pharmaceutical products. | ||||||
| 263 | COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES OF THE FOOT OF AN ANIMAL | PCT/US2008081341 | 2008-10-27 | WO2009055799A3 | 2009-09-17 | KENNEKE ELI L |
| The present invention is directed to an activator composition comprising copper sulfate, zinc sulfate, sodium chloride, and ammonium sulfate, for the activation of an anti-microbial composition. The resulting activated anti-microbial composition is used for the treatment of an infectious disease of a foot of an animal, particularly for the use of ungulates. Benefits of using the activator composition, either alone or in conjunction with other anti-microbial compositions, include the reduction of copper deposited into the environment from anti-microbial treatments, extended use of an anti-microbial composition, and maintenance of low levels of infectious diseases of the feet of animals. | ||||||
| 264 | TRANSGENIC UNGULATES EXPRESSING CTLA4-IG AND USES THEREOF | PCT/US2006030842 | 2006-08-09 | WO2007035213A3 | 2007-10-11 | AYARES DAVID LEE; COOPER DAVID K C |
| The present invention provides ungulates, including pigs, expressing CTLA4-Ig, as well as tissue, organs, cells and cell lines derived from such animals. Such animals, tissues, organs and cells can be used in research and medical therapy, including xenotransplanation. In addition, methods are provided to prepare organs, tissues and cells expressing the CTLA4-Ig for use in xenotransplantation, and nucleic acid constructs and vectors useful therein. | ||||||
| 265 | TRANSGENIC UNGULATES EXPRESSING CTLA4-IG AND USES THEREOF | PCT/US2006/030842 | 2006-08-09 | WO2007035213A2 | 2007-03-29 | AYARES, David, Lee; COOPER, David, K., C. |
The present invention provides ungulates, including pigs, expressing CTLA4-Ig, as well as tissue, organs, cells and cell lines derived from such animals. Such animals, tissues, organs and cells can be used in research and medical therapy, including xenotransplanation. In addition, methods are provided to prepare organs, tissues and cells expressing the CTLA4-Ig for use in xenotransplantation, and nucleic acid constructs and vectors useful therein. |
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| 266 | COMPOSITIONS AND METHODS FOR ACCURATE EARLY PREGNANCY DIAGNOSIS IN UNGULATES | PCT/US2004011456 | 2004-04-14 | WO2004095033A2 | 2004-11-04 | MATHIALAGAN NAGAPPAN |
| This invention provides improved methods for early detection of ungulate (e.g., bovine) pregnancy, and novel antibodies useful in such assays. The antibodies are generated by using specific amino acid sequences within ubiquitin cross-reactive protein (UCRP) as immunogens. Elevated levels of UCRP proteins, when detected in a sample (e.g., bodily fluid) of the animal from days 15-30, and especially days 15-28 after insemination, indicate that the animal is pregnant. The invention can be employed to increase efficiency of commercial farm animal breeding programs. | ||||||
| 267 | COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES OF THE FOOT OF AN ANIMAL | PCT/US2008/081341 | 2008-10-27 | WO2009055799A2 | 2009-04-30 | KENNEKE, Eli, L. |
The present invention is directed to an activator composition comprising copper sulfate, zinc sulfate, sodium chloride, and ammonium sulfate, for the activation of an anti-microbial composition. The resulting activated anti-microbial composition is used for the treatment of an infectious disease of a foot of an animal, particularly for the use of ungulates. Benefits of using the activator composition, either alone or in conjunction with other anti-microbial compositions, include the reduction of copper deposited into the environment from anti-microbial treatments, extended use of an anti-microbial composition, and maintenance of low levels of infectious diseases of the feet of animals. |
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| 268 | BOVINE PREGNANCY TEST | PCT/US0230459 | 2002-09-24 | WO03028582A3 | 2003-06-19 | ROTH J W; COLGIN MARK; HURST ROGER; NEWMAN DIANE; LANDMANN CATHY |
| This invention provides bovine pregnancy test methods and devices. The test is also suitable for other ruminant and/or ungulate animals. Antigens from Group A (early pregnancy antigens), and/or Group B (mid-pregnancy antigens), and Group C (early, mid- and late pregnancy antigens) are detected in a fluid from the animal, and pregnancy is reliably determined. The pregnancy assays of this invention are preferably carried out using immunoassay devices which provide immediate results in the field. | ||||||
| 269 | BOVINE PREGNANCY TEST | PCT/US2002/030459 | 2002-09-24 | WO2003028582A2 | 2003-04-10 | ROTH, J., W.; COLGIN, Mark; HURST, Roger; NEWMAN, Diane; LANDMANN, Cathy |
This invention provides bovine pregnancy test methods and devices. The test is also suitable for other ruminant and/or ungulate animals. Antigens from Group A (early pregnancy antigens), and/or Group B (mid-pregnancy antigens), and Group C (early, mid- and late pregnancy antigens) are detected in a fluid from the animal, and pregnancy is reliably determined. The pregnancy assays of this invention are preferably carried out using immunoassay devices which provide immediate results in the field. |
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| 270 | Production of ungulates, preferably bovines that produce human immunoglobulins | US12151181 | 2008-05-05 | US07820878B2 | 2010-10-26 | Richard A. Goldsby; James M. Robl; Barbara A. Osborne; Yoshimi Kuroiwa |
| The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B- or T-lymphocytes, and therefore will not develop native B- or T-cells. Because they are unable to produce B- and T-lymphocytes, these IgM, rag-1, or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B- and T-lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1, and/or rag-2 deficient ungulates, in utero or shortly after birth, human B- and T-lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans. | ||||||
| 271 | Production of ungulates, preferably bovines that produce human immunoglobulins | US12151181 | 2008-05-05 | US20090276866A1 | 2009-11-05 | Richard A. Goldsby; James M. Robl; Barbara A. Osborne; Yoshimi Kuroiwa |
| The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B- or T-lymphocytes, and therefore will not develop native B- or T-cells. Because they are unable to produce B- and T-lymphocytes, these IgM, rag-1, or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B- and T-lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1, and/or rag-2 deficient ungulates, in utero or shortly after birth, human B- and T-lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans. | ||||||
| 272 | Gene expression profiles that identify genetically elite cattle | US10857294 | 2004-05-27 | US07638275B2 | 2009-12-29 | Harris A. Lewin; Zonglin Liu; Sandra Rodriguez-Zas; Robin E. Everts |
| Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals. | ||||||
| 273 | Leg sock for horses | US12317655 | 2008-12-24 | US20100154366A1 | 2010-06-24 | Raymond Petterson |
| The present invention comprises a sock for use on the leg of a horse or ungulate, such as a cow, donkey or other hoofed animal. In the preferred embodiment the sock is tubular in shape having an upper opening and a lower opening. The sock is generally comprised of an upper cuff, main body and lower cuff. The upper cuff is configured to frictionally engage the leg of the horse such that the sock will not easily slip down on the leg of the horse. The main body is hollow and is configured to bunch together to hold the horse's body heat close to the leg of the horse. The lower cuff is configured to expand over said hoof of said ungulate and when over the hoof conform to or hug the small pastern. | ||||||
| 274 | Embryonic germ cells, method for making same, and using the cells to produce a chimeric porcine | US09627919 | 2000-07-28 | US06545199B1 | 2003-04-08 | Gary B. Anderson; Hosup Shim |
| Primordial germ cells are extracted from post blastocyst embryos of an ungulate such as extracting primordial germ cells from the gonadal ridges of 25-day porcine embryos or 34-40 day bovine embryos. The primordial germ cells are cultured in long term culture (over 30 days) resulting in cells which resemble embryonic stem cells in morphology and with respect to maintaining pluripotency. The cells obtained can be maintained for several months in culture and can be genetically manipulated using homologous recombination technology in order to insert desired genetic material into the genetic compliment of the cell at a desired location. The genetically manipulated cell can be inserted into a blastocyst obtained from the same species of animal as the cell was derived in order to produce a chimeric ungulate which ungulate may, via its genetic engineering, produce desired pharmaceutical products. | ||||||
| 275 | Leg Socks for Horses | US12980715 | 2010-12-29 | US20110154787A1 | 2011-06-30 | Raymond Petterson |
| The present invention comprises a sock for use on the leg of a horse or ungulate, such as a cow, donkey or other hoofed animal. In the preferred embodiment the sock is tubular in shape having an upper opening and a lower opening. The sock is generally comprised of an upper cuff, main body and lower cuff. The upper cuff and main body are configured to frictionally engage creating a circumferential force on the leg of the horse such that the sock will not easily slip down on the leg of the horse. Expanded knit around the knee joint and fetlock joints allow for the free motion of those joints thus alleviating contrary forces that would normally and otherwise cause the sock to be pulled down by that motion. The lower cuff is configured to expand over said hoof of said ungulate and when over the hoof conform to or hug the small pastern. | ||||||
| 276 | Method of producing antibody-fortified dry whey | US259735 | 1988-10-19 | US5017372A | 1991-05-21 | Donald H. Hastings |
| A method of producing a dry whey protein powder fortified with naturally occurring polyclonal antibody IgG to preselected infectious intestinal disease antigens, primarily diarrhea-causing enterotoxigenic Escherichia coli bacteria bearing colonization factor antigens (CFA) I or II and heat labile toxins. The product is made by first immunizing a pregnant ungulate, such as a cow, by administration of antigens of the preselected disease. After parturition the milk from the ungulate is collected and maintained in its natural state. The milk is subjected to a standard cheese-making process which produces coagulated casein and whey. The antibody IgG is carried into the whey, which is concentrated and dried. The resulting dried protein powder contains the antibody. The product may be administered orally to living beings, both humans and other animals, to prevent contraction of the preselected disease and to treat bodies exposed to the disease. | ||||||
| 277 | A SYSTEM AND METHOD FOR MEASURING RELATIVE LEG POSITIONS OF AN UNGULATE | PCT/AU2011/001248 | 2011-09-29 | WO2012040782A1 | 2012-04-05 | DOYLE, John Conan |
A system (20) for measuring relative front (12, 13) and hind leg (16, 17) positions of a standing ungulate, the system including a sensing area within which an ungulate to be measured stands and which comprises a plurality of discrete linear sensor regions (30) spaced a known distance apart within the sensing area, each sensing region having a sensor operatively associated therewith, which sensor is responsive to the presence of the lower part of a leg within a sensing region and; a processor for receiving data from each sensor, identifying those sensor regions within which a lower part of a leg is present and based upon the distance between the identified sensor regions, determining the relative front and hind leg positions. |
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| 278 | Methods of prescreening cells for nuclear transfer procedures | US11081945 | 2005-03-16 | US20060123500A1 | 2006-06-08 | Yann Echelard; Li-How Chen |
| The present invention provides for the production of transgenic animals through pre-screening methods designed to improve the efficiency of nuclear transfer and consequentially the production characteristics of transgenic mammals relative to proteins of interest. The invention is thus useful in the production of transgenic ungulate animals capable of producing desired biopharmaceuticals in their milk at higher yield than a comparable heterzygote or producing animals with better physiological attributes. | ||||||
| 279 | COMPOSITIONS AND METHODS FOR TREATING HOOF DISEASES | EP09760439.1 | 2009-11-25 | EP2349231B1 | 2017-08-23 | DEMARCO, John P.; DEMARCO, Robert J. |
| 280 | Leg Socks for Horses | US14922702 | 2015-10-26 | US20160286759A1 | 2016-10-06 | Raymond Petterson |
| The present invention comprises a sock for use on the leg of a horse or ungulate, such as a cow, donkey or other hoofed animal. In the preferred embodiment the sock is tubular in shape having an upper opening and a lower opening. The sock is generally comprised of an upper cuff, main body and lower cuff. The upper cuff and main body are configured to frictionally engage creating a circumferential force on the leg of the horse such that the sock will not easily slip down on the leg of the horse. Expanded knit around the knee joint and fetlock joints allow for the free motion of those joints thus alleviating contrary forces that would normally and otherwise cause the sock to be pulled down by that motion. The lower cuff is configured to expand over said hoof of said ungulate and when over the hoof conform to or hug the small pastern. | ||||||
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