| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 221 | THERAPEUTIC AGENT | PCT/GB2006/050085 | 2006-04-24 | WO2006111776A2 | 2006-10-26 | MCINTOSH, Deirdre |
Pharmaceutical compositions comprising serum obtained from non-immunised mammals, particularly ungulates, and more particularly goats, are described, together with methods for their preparation. The compositions are particularly useful for the treatment of multiple sclerosis, optic neuritis, rheumatoid arthritis, and HIV, but have applicability to a wide range of conditions. |
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| 222 | AKUSTISCHE ERMITTLUNG DER GANGART EINES HUFTIERES | PCT/DE2013/000184 | 2013-04-10 | WO2013152754A1 | 2013-10-17 | SCHÖN, Peter-Christian; WENDLAND, Kurt |
Die Gangart von Huftieren, insbesondere landwirtschaftlichen Nutztieren, wird akustisch ermittelt, so dass beispielsweise Huferkrankungen im Frühstadium erkannt werden können. Eine gegebene Gangart von Huftieren, speziell landwirtschaftlichen Nutztieren wird bestimmt, um unnatürliche Weisen einer Gangart zu erkennen. Dazu werden die Auftrittgeräusche eines Nutztieres/Huftieres (1) durch (einen) Schallsensor/en (5) in einem Frequenzbereich von mindestens 20 Hz bis 5 kHz erfasst. Die analogen Ausgangssignale werden dann an eine Signalaufbereitungseinheit (7) weitergeleitet und von dieser digitalisiert. Von der Signalaufbereitungseinheit (7) werden mindestens die spezifischen Parameter Zeitablauf und Verlauf der Auftritte, Frequenzspektrum und deren Verlauf, sowie das Schallpegelspektrum in mindestens einen Parametervektor konvertiert. Dieser/diese wird an eine Auswertungseinheit (8) weitergeleitet und dort klassifiziert und der Grad der Ähnlichkeit mit zuvor aufgenommenen Parametervektoren bestimmt. |
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| 223 | METHOD OF HOOF TRIMMING OF UNGULATES BY A LIQUID JET AND A VETERINARY TRIMMING ASSEMBLY | PCT/SK2014/050024 | 2014-12-08 | WO2015088454A1 | 2015-06-18 | KRAJNÝ, Zdenko, Ing. |
A method of hoof trimming of ungulates by a liquid jet, characterised in a sequence of steps: • stabilizing of the ungulate's hoof in a clamping device and/or a cage; • cleaning the ungulate's hoof and claw by a pressure liquid; • and preferably also in physical diagnostics of the hoof and the claw with locating of the borderline between the hoof and claw, • outlining of the cutting plane in the borderline area between the hoof and the claw; • separating the claw from the hoof by means of a liquid jet of a veterinary trimming assembly in an air or liquid environment along the cutting plane by the action of the pressure liquid jet with the operating pressure of 1 20 to 250 MPa and the pressure liquid flow rate of 4 to 15 l/min with the pressure liquid jet feed rate of 10 to 220 mm/min, wherein the thickness of the pressure liquid jet is 0.5 to 1.0 mm. The pressure liquid is water, or possibly water with an added abrasive and/or a disinfectant and/or a medicinal agent. |
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| 224 | GENE EXPRESSION PROFILES THAT IDENTIFY GENETICALLY ELITE UNGULATE MAMMALS | PCT/US2004016852 | 2004-05-27 | WO2005001132A3 | 2005-05-12 | LEWIN HARRIS A; LIU ZONGLING LEWIS; RODRIGUEZ-ZAS SANDRA; EVERTS ROBIN E |
| Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals. | ||||||
| 225 | Reducing ungulate pressure on post-burn areas in mosaic burns | US11126376 | 2003-07-25 | US20050193955A1 | 2005-09-08 | Mark Robbins |
| The present invention, in one embodiment, is a method of reducing ungulate pressure on burned sub-areas within a mosaic burn area. The method comprises identifying an unburned sub-area within the mosaic burn area and providing at least one highly palatable, portable, self-limiting, animal feed supplement in the first unburned sub-area. The highly palatable, portable, self-limiting, animal feed supplement attracts the ungulates to the first unburned sub-area and increases the length of the ungulates' stay in the first unburned sub-area. The ungulates are attracted to the first unburned sub-area by the supplement in preference to the burned sub-area with new growth. | ||||||
| 226 | 機能的α1,3ガラクトシルトランスフェラーゼを欠く動物に由来する組織生成物 | JP2016048606 | 2016-03-11 | JP2016105861A | 2016-06-16 | デイビッド アヤレス; ポール ローリクト |
| 【課題】機能的α1,3ガラクトシルトランスフェラーゼを欠く動物に由来する組織生成物の提供。 【解決手段】本発明は、機能的α1,3ガラクトシルトランスフェラーゼ(α−1,3.GT)のいずれの発現も欠く、動物に由来する組織を提供する。そのような組織は、整形外科再構築および修復、皮膚修復および内部組織修復のような異種移植の分野において、または医療機器として用いることができる。上記動物はウシ、ブタまたはヒツジのような反芻動物または有蹄動物であり得る。α−1,3−GT遺伝子のいずれの機能的発現も欠く動物からの組織は、ブタ、ウシまたはヒツジのような出生前、新生、または未成熟または十分に成熟した動物から得ることができる。 【選択図】なし |
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| 227 | TISSUE PRODUCT DERIVED FROM ANIMAL LACKING FUNCTIONAL α 1,3 GALACTOSYLTRANSFERASE | JP2013147567 | 2013-07-16 | JP2013215615A | 2013-10-24 | AYARES DAVID; ROHRICHT PAUL |
| PROBLEM TO BE SOLVED: To provide tissue products derived from animals lacking functional α 1,3 galactosyltransferase.SOLUTION: The present invention provides tissues derived from animals, which lack any expression of functional α 1,3 galactosyltransferase (α-1,3.GT). Such tissue can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repair and internal tissue repair or as medical devices. The animal can be a ruminant or an ungulate, such as a bovine, porcine, or ovine. The tissues from animals lacking any functional expression of the α-1,3-GT gene can be obtained from a prenatal, neonatal, immature, or mature animal, such as a porcine, bovine or ovine. | ||||||
| 228 | TRANSGENIC NON-HUMAN MAMMALS WITH KAPPA LIGHT CHAIN OF XENOGENOUS IMMUNOGLOBULIN | PCT/US2009/001501 | 2009-03-09 | WO2009111086A1 | 2009-09-11 | KUROIWA, Yoshimi; TOMIZUKA, Kazuma; ROBL, James, M. |
Genetically modified non-human mammals (e.g., bovines, porcines, and other ungulates) and cells containing a nucleic acid encoding all or part of a xenogenous kappa immunoglobulin gene capable of undergoing rearrangement and expressing a xenogenous kappa immunoglobulin are described. Antibodies produced from these non-human mammals and cells are described. Methods of making these mammals and cells are presented. In addition, methods of producing xenogenous (e.g., human) antibodies from the genetically modified non-human mammals and cells are described. |
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| 229 | TEXAS GAME DRAW | US11365312 | 2006-08-28 | US20080050411A1 | 2008-02-28 | Jonathan David Rudd |
| The present invention is a game attractant comprised of a mixture of rice bran, wheat bran and dried molasses to attract the attention of ungulates and avian fauna. By the incorporation of these three ingredients, the nutritional and vitamin value is elevated above the natural diet of the fauna. Therefore once expelled in pyramid form upon the intended-sight, the animals are attracted to the richness of this mix. | ||||||
| 230 | Chimeric virus-like particle or chimeric capsomers from BPV | US09913204 | 2000-02-10 | US06953579B1 | 2005-10-11 | Lutz Gissman; Martin Müller; Hermann Müller |
| The present invention relates to chimeric virus-like particles (cVLPs) or chimeric capsomers (cCs) from BPV, fusion proteins and DNAs coding for said proteins and to the use of cVLPs or cCs for the immunization of ungulates, especially horses. | ||||||
| 231 | PRION-FREE TRANSGENIC UNGULATES | PCT/US2001/009572 | 2001-03-26 | WO01073107A1 | 2001-10-04 | |
| Transgenic and cloned ungulates and particularly cloned cattle are disclosed, wherein such cattle contain a deletion or disruption of the prion gene locus and do not express functional prion protein, and are not susceptible to prion-related diseases such as bovine spongiform encephalopy or Mad Cow Disease. | ||||||
| 232 | Equine dental tool | US10165829 | 2002-06-06 | US20030228552A1 | 2003-12-11 | John J. Dipietro |
| An equine dental tool utilizing a sheath which encloses a rotatable shaft. The shaft terminates in an abrading element which is employed to grind the teeth of a horse or other ungulate. A rotating cable powered by a motor connects to the one end of the rotatable shaft. | ||||||
| 233 | Horse shoe cassette system | US54278 | 1998-04-02 | US5983611A | 1999-11-16 | Ingvar Alrik Smahl; Ronnie Smahl |
| A horse shoe cassette system for an animal's hoof. The cassette system comprises a plurality of hollow holders that are screwed into the hoof. Each holder has a threaded outside surface and a threaded inside opening defined therein. A flexible covering, of a general hollow ungulate shape to fit an ungulate's hoof, has a bottom plate that includes a first opening defined therein. A horse shoe is attached to the bottom plate of the flexible covering and the horse shoe has a second opening. A threaded screw member extends through the first and second openings and is screwed into the threaded inside opening of the holder disposed in the hoof. | ||||||
| 234 | COMPOSITIONS AND METHODS FOR TREATING HOOF DISEASES | EP09760439.1 | 2009-11-25 | EP2349231B1 | 2017-08-23 | DEMARCO, John P.; DEMARCO, Robert J. |
| 235 | COMPOSITIONS AND METHODS FOR TREATING HOOF DISEASES | EP09760439.1 | 2009-11-25 | EP2349231A1 | 2011-08-03 | DEMARCO, John P.; DEMARCO, Robert J. |
| The present invention is generally directed to compositions and methods for the treatment of an infectious disease of the foot of an animal. One aspect of the invention is directed to a method for preventing and/or treating one or more infectious diseases of the hoof in animals, comprising: preparing a copper-free and zinc-free composition comprising at least one cross- linking agent, wherein the cross-linking agent is not formaldehyde; and administering the composition to a lower leg and hoof area of said animal to prevent and/or treat said one or more infectious diseases. Another aspect of the invention is directed to a copper-free and zinc-free composition for the treatment and/or prevention of one or more infectious diseases of the hoof in animals, comprising at least one cross-linking agent, wherein said cross-linking agent is not formaldehyde. The present invention is also directed to a method for treating and / or preventing papillomatous digital dermatitis in an ungulate, comprising: preparing a copper-free and zinc- free composition comprising at least one cross-linking agent and at least one quaternary ammonium compound; and spraying or applying in a foam a therapeutically effective amount of said composition to a lower leg and hoof area of said ungulate in order to treat and / or prevent said papillomatous digitial dermatitis. | ||||||
| 236 | COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES | PCT/IE2015000014 | 2015-10-14 | WO2016059624A3 | 2016-10-06 | PRENDERGAST PATRICK T |
| A method for treating or preventing laminitis is provided comprising administering to an ungulate a therapeutically or prophylactically effective amount of a camelid protease inhibitor. Typically the ungulate is a horse and the camelid protease inhibitor is an inhibitor of equine metalloproteinases and equine serine proteases. The inhibitor may be isolated from blood from healthy camelid or may be generated by inoculating camelid with purified equine metalloproteinase enzymes and serine proteases or with snake venom metalloproteinases, such as those obtained from Bothrops jararaca. The inhibitor may a homodimer antibody or an antigen binding fragment of same. Also provided are compositions comprising such camelid protease inhibitors. | ||||||
| 237 | PRODUCTION OF UNGULATES, PREFERABLY BOVINES THAT PRODUCE HUMAN IMMUNOGLOBULINS | PCT/US2000/031737 | 2000-11-17 | WO01035735A1 | 2001-05-25 | |
| The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B or T lymphocytes, and therefor will not develop native B or T cells. Because they are unable to produce B and T lymphocytes, these IgM, rag-1 or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B and T lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1 and/or rag-2 deficient ungulates, in utero or shortly after birth, human B and T lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans. | ||||||
| 238 | UNGULATE EMBRYONIC STEM-LIKE CELLS, METHODS OF MAKING AND USING THE CELLS TO PRODUCE TRANSGENIC UNGULATES | PCT/US1997000041 | 1997-01-08 | WO1997025412A1 | 1997-07-17 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
| Primordial germ cells are extracted from post blastocyst embryos of an ungulate such as extracting primordial germ cells from the gonadal ridges of 25-day porcine embryos or 34-40 day bovine embryos. The primordial germ cells are cultured in long term culture (over 30 days) resulting in cells which resemble embryonic stem cells in morphology and with respect to maintaining pluripotency. The cells obtained can be maintained for several months in culture and can be genetically manipulated using homologous recombination technology in order to insert desired genetic material into the genetic compliment of the cell at a desired location. The genetically manipulated cell can be inserted into a blastocyst obtained from the same species of animal as the cell was derived in order to produce a chimeric ungulate which ungulate may, via its genetic engineering, produce desired pharmaceutical products. | ||||||
| 239 | GENE EXPRESSION PROFILES THAT IDENTIFY GENETICALLY ELITE UNGULATE MAMMALS | PCT/US2004/016852 | 2004-05-27 | WO2005001132A2 | 2005-01-06 | LEWIN, Harris, A.; LIU, Zongling, Lewis; RODRIGUEZ-ZAS, Sandra; EVERTS, Robin, E. |
Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals. |
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| 240 | METHODS OF PRESCREENING CELLS FOR NUCLEAR TRANSFER PROCEDURES | PCT/US2004/040816 | 2004-12-07 | WO2006062507A1 | 2006-06-15 | ECHELARD, Yann; CHEN, Li, HoW |
The present invention provides for the production of transgenic animals through pre-screening methods designed to improve the efficiency of nuclear transfer and consequentially the production characteristics of transgenic mammals relative to proteins of interest. The invention is thus useful in the production of transgenic ungulate animals capable of producing desired biopharmaceuticals in their milk at higher yield than a comparable heterzygote or producing animals with better physiological attributes. |
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