| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | 수술 현미경과 광학 영상 장치를 이용하여 OCT 이미징을 수행하는 방법 및 이를 수행하기 위한 장치들 | KR20160089763 | 2016-07-15 | KR20180008026A | 2018-01-24 | OH WANG YUHL; PARK JAE CHAN; YOO HONG KI; SHIN IN HO; KIM CHANG SOO |
| 수술현미경과광학영상장치를이용하여 OCT 이미징을수행하는방법및 이를수행하기위한장치들이개시된다. 일실시예에따른 OCT 이미징수행방법은수술현미경의광학계를이용하여상기수술현미경으로관찰하는샘플의관찰영역으로빛을출력하는단계와, 상기관찰영역으로부터산란되는빛에기초하여간섭신호를검출하는단계를포함한다. | ||||||
| 162 | Heads up displays for optical coherence tomography integrated surgical microscopes | US14471600 | 2014-08-28 | US09402539B2 | 2016-08-02 | Eric L. Buckland |
| Surgical microscope systems are provided including an optical coherence tomography (OCT) system; an objective lens; oculars for direct viewing of a subject distal to the objective lens; a heads up display module configured to direct an optical image through the oculars to be visible to a user of at least one ocular; and a coupling element connected to the surgical microscope coupling the OCT system, the heads up display module and the objective lens. The coupling element has first and second faces, the first face positioned toward the oculars of the surgical microscope and the second face positioned toward the subject. The coupling element is configured to receive a heads up optical display signal at the first face of the coupling element and reflect the signal in a wavelength band of the heads up display module; and receive a signal on the second face of the coupling element and reflect the signal in a wavelength band of the OCT system. | ||||||
| 163 | NOVEL PHOTOACTIVABLE FLUORESCENT DYES FOR OPTICAL MICROSCOPY AND IMAGING TECHNIQUES | US13395323 | 2009-09-10 | US20120202216A1 | 2012-08-09 | Stefan W. Hell; Vladimir N. Belov; Vadim P. Boyarskiy; Christian A. Wurm; Stefan Jakobs; Claudia Geisler |
| The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1=O, A2=N, A3=C; G2: A1=S, A2=N, A3=C; G3: A1=O, A2=O, A3=N; G4: A1=S, A2=O, A3=N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420 nm) generate fluorescent rhodamine or carbopyronine derivatives and small non-toxic fragments such as N2 or N2O. The invention also relates to methods for preparing such compounds and to the use of these compounds for optical microscopy and imaging techniques. | ||||||
| 164 | Systems and Methods for Surgical Microscope and Optical Coherence Tomography (OCT) Imaging | US13010497 | 2011-01-20 | US20120092615A1 | 2012-04-19 | Joseph A. Izatt; Yuankai K. Tao; Cynthia A. Toth |
| A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter. The beam forming unit is configured to form the illumination beam of the OCT unit so as to generally correspond to a size of the microscope main objective. | ||||||
| 165 | Heads Up Displays for Optical Coherence Tomography Integrated Surgical Microscopes | US14471600 | 2014-08-28 | US20150062531A1 | 2015-03-05 | Eric L. Buckland |
| Surgical microscope systems are provided including an optical coherence tomography (OCT) system; an objective lens; oculars for direct viewing of a subject distal to the objective lens; a heads up display module configured to direct an optical image through the oculars to be visible to a user of at least one ocular; and a coupling element connected to the surgical microscope coupling the OCT system, the heads up display module and the objective lens. The coupling element has first and second faces, the first face positioned toward the oculars of the surgical microscope and the second face positioned toward the subject. The coupling element is configured to receive a heads up optical display signal at the first face of the coupling element and reflect the signal in a wavelength band of the heads up display module; and receive a signal on the second face of the coupling element and reflect the signal in a wavelength band of the OCT system. | ||||||
| 166 | OPTOFLUIDIC MICRODEVICE FOR IN-VITRO LASER SURGERY AND TRANSFECTION INVOLVING CELLS AND MICROORGANISMS | US14256853 | 2014-04-18 | US20140329325A1 | 2014-11-06 | David Fozdar |
| A device for use in laser optical transfection of biological targets including an optofluidic microdevice and a piece of optical glass. The optofluidic microdevice has a central vertical outlet and a microchannel network that includes a plurality of entrapping channels with narrowings. The microchannel network is fused with the optical glass. In one aspect the device is used with a petri dish having an optical window. In another aspect the device is used with a well plate having a plurality of wells and associated optical windows. In a third aspect the device is used with a barrier. Each of the aspects forms a peripheral space around the optofluidic microdevice capable of retaining a live culture of biological targets and material that is desired to be injected into those biological targets. Polymer tubing is inserted into the central vertical outlet which connects the device to an external pump. The external pump provides an inward suction force which draws the biological targets from the peripheral space into the microchannel network. The biological targets are then captured at the openings or within the narrowings in the entrapping channels of the microchannel network where they can be transfected by laser light emitting from a laser through the optical glass. | ||||||
| 167 | Surgical Microscopes Using Optical Coherence Tomography and Related Systems and Methods | US13836576 | 2013-03-15 | US20130265545A1 | 2013-10-10 | Eric L. Buckland; Nestor O. Farmiga; Robert H. Hart; Andrew Murnan; Christopher Saxer |
| Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam. | ||||||
| 168 | Methods and systems for analyzing a specimen using atomic force microscopy profiling in combination with an optical technique | US10934786 | 2004-09-03 | US07430898B1 | 2008-10-07 | Michael Weber-Grabau; Christopher F. Bevis; Michael Faeyrman; Ofir Zamir |
| A system that includes an optical subsystem and an atomic force microscope probe is provided. The optical subsystem is configured to generate positional information about a location on a surface of the specimen. The system is configured to position the probe proximate the location based on the positional information. One method includes generating positional information about a location on a surface of a specimen with an optical subsystem. The method also includes positioning an atomic force microscopy probe proximate the location based on the positional information. Another system includes an optical subsystem configured to measure overlay of a wafer using scatterometry. The system also includes an atomic force microscope configured to measure a characteristic of a feature on the wafer. An additional method includes measuring overlay of a wafer using scatterometry. The method also includes measuring a characteristic of a feature on the wafer using atomic force microscopy. | ||||||
| 169 | Light-emitting diode illumination system for an optical observation device, in particular a stereomicroscope or stereo surgical microscope | US10926695 | 2004-08-26 | US07229202B2 | 2007-06-12 | Ulrich Sander |
| The invention concerns an illumination apparatus for an optical observation device (10), in particular a stereomicroscope or a stereo surgical microscope. A multi-armed light guide with coupler (2) mixes colored light emitted by light-emitting diodes (1a–c) to yield white mixed light (15). | ||||||
| 170 | STRUCTURED ILLUMINATION MICROSCOPY OPTICAL ARRANGEMENT INCLUDING PROJECTION ARTIFACT SUPRESSION ELEMENT | US14081885 | 2013-11-15 | US20150136949A1 | 2015-05-21 | Frans De Nooij; Paul Gerard Gladnick |
| A structured illumination microscopy optical arrangement includes a projection path and an imaging path. The imaging path includes an imaging sensor and imaging optical elements. The projection path includes a light generator, a pattern generating element such as a spatial light modulator (SLM), and projection optical elements including an output lens and a projector artifact suppression element (PASE) located in the projection path between the SLM and the output lens. The PASE may include birefringent material which splits respective light rays of the structured illumination pattern source light to provide at least one replication of the structured illumination pattern with an offset transverse to the projection path. The offset replication of the structured illumination pattern increases the accuracy of the system by reducing spatial harmonic errors and spurious intensity variations due to projector pixel gap artifacts which may otherwise produce errors in resulting Z-height measurements. | ||||||
| 171 | Systems and methods for surgical microscope and optical coherence tomography (OCT) imaging | US13010497 | 2011-01-20 | US08366271B2 | 2013-02-05 | Joseph A. Izatt; Yuankai K. Tao; Cynthia A. Toth |
| A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter. The beam forming unit is configured to form the illumination beam of the OCT unit so as to generally correspond to a size of the microscope main objective. | ||||||
| 172 | Techniques for automated diagnosis of cell-borne anomalies with digital optical microscope | US10477648 | 2003-11-13 | US20040241677A1 | 2004-12-02 | Jeffrey S Lin; Andrew B Feldman; Plamen A Demirev; Peter F Scholl; Sean P Murphy |
| Techniques for automatically analyzing a biological sample with a microscope include obtaining a first digital image of a first field of view of the biological sample. Cell data and anomalous data are automatically determined. Cell data indicates an area co-located in the first digital image with a cell set of one or more cells of a particular type. Anomalous data indicates an area co-located in the first digital image with an anomalous set of zero or more particular objects that are anomalous to normal cells of the particular type. The cell data and the anomalous data are automatically combined to determine the particular objects inside the cell set in the first digital image. An analytical result for the biological sample is generated based on the particular objects inside the cell set. These techniques allow the automated classification and quantification of malaria in microscope views of blood smears, among other diseases. | ||||||
| 173 | Light-emitting diode illumination system for an optical observation device, in particular a stereomicroscope or stereo surgical microscope | US10926695 | 2004-08-26 | US20050047172A1 | 2005-03-03 | Ulrich Sander |
| The invention concerns an illumination apparatus for an optical observation device (10), in particular a stereomicroscope or a stereo surgical microscope. A multi-armed light guide with coupler (2) mixes colored light emitted by light-emitting diodes (1a-c) to yield white mixed light (15). | ||||||
| 174 | OPTICAL MICROSCOPE DEVICE, MICROSCOPY METHOD, AND COMPUTER PROGRAM FOR MICROSCOPY USING SINGLE-LIGHT-EMITTING-PARTICLE DETECTION TECHNOLOGY | EP14832322.3 | 2014-06-23 | EP3029505A1 | 2016-06-08 | YAMAGUCHI, Mitsushiro; TANABE, Tetsuya |
There is provided a microscopic observation technique capable of detecting a light-emitting object or a light-emitting particle whose position varies dynamically in a thick sample by using the way of the scanning molecule counting method. In the optical microscopic observation technique according to the present invention, a light-emitting particle is detected by detecting the light from the light-emitting particle moving in a liquid with the optical system of a confocal microscope or a multiphoton microscope. In processing operations, the light from the light detection region is detected while moving the position of the light detection region in each observed subregion obtained by dividing a region to be observed of the microscope into plural regions; the signal of the light from a light-emitting particle is individually detected; and the position of the light-emitting particle corresponding to the detected signal is determined in the region to be observed. The moving of the position of the light detection region in each observed subregion is performed continuously in at least two directions or and/or continuously multiple times in each observed subregion. |
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| 175 | OPTICAL MICROSCOPE DEVICE, MICROSCOPY METHOD, AND COMPUTER PROGRAM FOR MICROSCOPY USING SINGLE-LIGHT-EMITTING-PARTICLE DETECTION TECHNOLOGY | EP14832322 | 2014-06-23 | EP3029505A4 | 2017-03-15 | YAMAGUCHI MITSUSHIRO; TANABE TETSUYA |
| 176 | Electrically tunable fabry-perot interferometer produced by surface micromechanical techniques for use in optical material analysis | EP95300799.4 | 1995-02-09 | EP0668490B1 | 1999-09-08 | Blomberg, Martti; Lehto, Ari; Orpana, Markku |
| 177 | 物鏡,特別是半導體顯微平版印刷術投影曝射機器用物鏡,以及由晶體材料所製成以作為物鏡之最後光學元件之薄光學元件之製造方法 | TW089110357 | 2000-05-29 | TW460709B | 2001-10-21 | 舒斯特 卡爾海因茨 |
| 一種物鏡lO，特別是半導體顯微平版印刷術投影曝射機器用物鏡，其具有複數個光學元件支承於托座中，在光束方向之最後光學元件１被以一種免安裝及可更換的形式直接連接至倒數第二光學元件２。連接可藉由緊貼一作為最後光學元件１之薄等距板而達成。 | ||||||
| 178 | 利用差動光學切片干涉顯微術測量透明薄膜特性之方法及系統 METHOD AND SYSTEM FOR CHARACTERIZING TRANSPARENT THIN-FILMS USING DIFFERENTIAL OPTICAL SECTIONING INTERFERENCE MICROSCOPY | TW096119721 | 2007-06-01 | TWI328676B | 2010-08-11 | 李超煌; 王俊杰 |
| 一種用以量測透明薄膜之折射率及厚度之影像、差動光切片干涉顯微術(DOSIM)系統與方法。折射率及厚度係由透明薄膜樣本的兩干涉影像計算出，此兩干涉影像乃是該透明薄膜樣本在光切片顯微術縱向反應曲線之線性區內垂直移動(vertical offset)一段距離前後分別取得。在此，該影像由一顯微物鏡在垂直於薄膜表面的方向取得，故該透明薄膜影像之橫向解析度可以基於雷利準則(Rayleigh criterion)，即0.61λ/數值孔徑估算出(0.61λ/NA)。 | ||||||
| 179 | 利用差動光學切片干涉顯微術測量透明薄膜特性之方法 METHOD FOR CHARACTERIZING TRANSPARENT THIN-FILMS USING DIFFERENTIAL OPTICAL SECTIONING INTERFERENCE MICROSCOPY | TW096119721 | 2007-06-01 | TW200842319A | 2008-11-01 | 李超煌 LEE, CHAU HWANG; 王俊杰 WANG, CHUN CHIEH |
| 一種用以量測透明薄膜之折射率及厚度之影像、差動光切片干涉顯微術(DOSIM)系統與方法。折射率及厚度係由透明薄膜樣本的兩干涉影像計算出,此兩干涉影像乃是該透明薄膜樣本在光切片顯微術縱向反應曲線之線性區內垂直移動(vertical offset)一段距離前後分別取得。在此,該影像由一顯微物鏡在垂直於薄膜表面的方向取得,故該透明薄膜影像之橫向解析度可以基於雷利準則(Rayleigh criterion),即0.61���/數値孔徑估算出(0.61���/NA)。 | ||||||
| 180 | Operative microscope having diffuse optical imaging system with tomographic image reconstruction and superposition in field of view | US13586558 | 2012-08-15 | US09254103B2 | 2016-02-09 | Venkataramanan Krishnaswamy; Brian William Pogue |
| An imaging system has a microscope having an objective lens and a projection device configured to project spatially modulated light in one of several preselected predetermined pattern through the objective lens and onto tissue. The system camera configured to record an image of the tissue through the microscope and objective lens as illuminated by the spatially modulated light, and an image processor having a memory with a routine for performing spatial Fourier analysis on the image of the tissue to recover spatial frequencies. The image processor also constructs a three dimensional model of the tissue, and performs fitting of at least absorbance and scattering parameters of voxels of the model to match the recovered spatial frequencies. The processor then displays tomographic slices of the three dimensional model. | ||||||
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