| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | OCT/OCM 기술을 이용한 3차원 조직 검사방법 | KR1020150119931 | 2015-08-26 | KR1020170024666A | 2017-03-08 | 정웅규; 안드레이바빌; 민은정; 이준원; 정선우 |
| 본발명은, 검사하고자하는조직을깊이방향으로설정두께만큼씩연속적으로자르고, 이렇게생긴복수의슬라이스들을각각촬영하여적층한후 얼라인하여하나의 3차원영상으로합하기때문에, OCT 장비나 OCM 장비가촬영할수 있는깊이의한계점을해결할수 있으며, 상기조직의크기에제한없이 3차원정보를얻을수 있다. 또한, 상기 OCT 장비나 OCM 장비는, 기존의 CT, MRI, PET 등의장비보다해상도가높기때문에, 보다정밀한검사가가능하다. | ||||||
| 122 | TECHNIQUES FOR GESTURE RECOGNITION USING PHOTOPLETHYSMOGRAPHIC (PPMG) SENSOR AND LOW-POWER WEARABLE GESTURE RECOGNITION DEVICE USING THE SAME | PCT/US2016/047206 | 2016-08-16 | WO2017048439A1 | 2017-03-23 | CAMACHO PEREZ, Jose R.; MONCADA GONZALEZ, Hector Raul; CORDOURIER MARURI, Hector A.; ZAMORA ESQUIVEL, Julio C.; LOPEZ MEYER, Paulo; IBARRA VON BORSTEL, Alejandro |
A wearable gesture recognition device is disclosed that provides gesture recognition for gestures that may include a hold or steady-state component, and may account and adapt for real-time fit-level changes. The wearable gesture recognition device may integrate a photoplethysmographic (PPMG) and a piezoelectric (PZE) sensor such that respective sensor signals may be used individually, or in concert for gesture recognition. Thus the wearable gesture recognition device generally disclosed herein may advantageously perform gesture recognition through the fusion of PPMG and PZE signals. To support continuous gesture recognition, the wearable gesture recognition device may use a low-power activity detection scheme that analyzes a PZE signal prior to higher-power gesture classification. Moreover, the wearable gesture recognition device may provide power management by controlling a duty-cycle of the PPMG sensor without necessarily reducing recognition performance. The PPMG sensor and the PZE sensor may be co-located and housed within a same sensor package. |
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| 123 | FLUORESCENT DYES WITH PHOSPHORYLATED HYDROXYMETHYL GROUPS AND THEIR USE IN LIGHT MICROSCOPY AND IMAGING TECHNIQUES | PCT/EP2011/005231 | 2011-10-18 | WO2013056720A1 | 2013-04-25 | HELL, Stefan, W.; NIZAMOV, Shamil; DONNERT, Gerald; KOLMAKOV, Kirill; SCHILL, Heiko; KASTRUP, Lars; WURM, Christian, A.; BELOV, Vladimir, N.; BUECKERS, Johanna; WILLIG, Katrin |
The invention relates to novel fluorescent dyes with phosphorylated hydroxymethyl groups, a method for preparing the same as well as to their use in imaging techniques. Said fluorescent dyes are coumarin, rhodamine or BODIPY dyes having of one of the following general formulae (I-III) wherein W = OP(0)Y1Y2 or P(0)Υ1Υ2, where Y1 and Y2 independently denote any of the following residues: OH, O(-), ORa and ORb, NHRa and NHRb, NRaRb and NRcRd, ORa and NHRb, ORa and NRbRc, NHRa and NRbRc; and any salt thereof. |
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| 124 | OPTICAL COHERENCE TOMOGRAPHY SURGICAL MICROSCOPE | EP13716661.7 | 2013-03-29 | EP2833779B1 | 2017-09-20 | BUCKLAND, Eric L.; FARMIGA, Nestor O.; HART, Robert H.; MURNAN, Andrew; SAXER, Christopher |
| Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam. | ||||||
| 125 | Optical force sensing element and microsurgical instrument | EP12171195.6 | 2012-06-07 | EP2626680A1 | 2013-08-14 | Bertholds, Axel; Llosas, Pere; Henein, Simon |
The present invention related to an optical force sensing element for microsurgical instruments (22), for measuring force F in three orthogonal directions x, y, z, comprising a monolithic cylinder structure (1), a cylindrical surface (4) and a top surface (5) suitable to absorb and transmit the force F to be measured. The structure featuring three punch-like notches (6), all being parallel to the y-direction, spaced apart along the z-axis and forming exactly two blades (7) between the first and the second notch (6) as well as between the second and the third notch (6). The structure further comprises three channels (8) parallel to the z-axis, extending from the bottom surface (3) to the top surface (5) and crossing the first notch (6) while bypassing the other two notches (6) in the structure (2). The force sensing element further comprises three optical fibres (9), each fixed in one of the three channels (8), all entering the structure (2) from the bottom surface (3), crossing the first notch and ending at or near the top surface (5) while being interrupted in the first notch (6) building two surfaces (10, 12) of each fibre by defining Fabry-Perot interferometric cavities (13). The invention further relates to a microsurgical instrument comprising such an element and to a method for manufacturing such an element.
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| 126 | 光コヒーレンス断層法機構を有する外科用顕微鏡システム | JP2009068567 | 2009-03-19 | JP5756253B2 | 2015-07-29 | クリストフ・ホーガー; マルクス・シーズセルバーグ; ケイス・オハラ; ユイ・キウ; シン・ウェイ; ヨッヒェン・エム・ホーン; ペーター・ライマー |
| 127 | Surgical microscopy system having optical coherence tomography facility | JP2009068567 | 2009-03-19 | JP2009230141A | 2009-10-08 | HAUGER CHRISTOPH; SEESSELBERG MARKUS; O'HARA KEITH; QIU YUE; WEI XIN; HORN JOCHEN M; REIMER PETER |
| <P>PROBLEM TO BE SOLVED: To provide a surgical microscopy system wherein an optical coherence tomography facility is integrated into a microscopy system. <P>SOLUTION: A beam of measuring light formed by collimating optics of an OCT system is deflected by a beam scanner, traverses imaging optics, and is reflected by a reflector so that the beam of measuring light traverses an objective lens of microscopy optics and is directed to an object region of the microscopy optics. A position of the beam of measuring light incident on the reflector is substantially independent on a direction into which the beam of measuring light is deflected by the beam scanner. When traveling through the beam scanner, the beam of measuring light is composed of a bundle of substantially parallel light rays. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 128 | 共焦点顕微鏡又は多光子顕微鏡の光学系を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム | JP2014528026 | 2013-05-16 | JPWO2014020967A1 | 2016-07-21 | 山口 光城; 光城 山口 |
| 走査分子計数法、FCS、FIDA、PCH等の光分析技術のための共焦点顕微鏡又は多光子顕微鏡の光学系を用いた光分析技術に於いて、光強度の計測前に光学系に於いて予定される状態が実現されているか否かの判定を可能にする技術が提供される。本発明による試料溶液中に配置された光検出領域からの光強度を計測し光強度の分析を行う光分析技術に於いては、試料容器に対する光検出領域の位置を移動させながら光検出器により出力された信号強度の大きさに基づいて、光検出領域が試料溶液中に配置され且つ光検出領域からの光強度の計測が実行可能であるか否か及び/又は光強度の計測が実行可能である試料容器に対する前記光検出領域の位置又はその範囲を判定する判定処理が実行される。 | ||||||
| 129 | 単一発光粒子検出技術を用いた光学顕微鏡装置、顕微鏡観察法及び顕微鏡観察のためのコンピュータプログラム | JP2015529456 | 2014-06-23 | JPWO2015015951A1 | 2017-03-02 | 光城 山口; 哲也 田邊 |
| 走査分子計数法の手法を利用して、厚みのある試料中に於いて動的に位置が変化する発光体又は発光粒子の検出が可能な顕微鏡観察技術が提供される。本発明による光学顕微鏡観察技術に於いては、共焦点顕微鏡又は多光子顕微鏡の光学系を用いて液体中にて運動する発光粒子(LP)からの光を検出し発光粒子(LP)を検出する。処理操作に於いて、顕微鏡の観察対象領域(ObR)を複数に分割して得られる観察小領域(OsR)毎に光検出領域(CV)の位置を移動させながら、前記光検出領域(CV)からの光を検出して、前記発光粒子(LP)からの光の信号を個別に検出し、検出信号に対応する発光粒子(LP)の観察対象領域(ObR)内に於ける位置を決定する。また、前記観察小領域(OsR)の各々に於ける前記光検出領域(CV)の位置の移動は、前記観察小領域(OsR)毎に少なくとも二つの方向に連続して及び/又は同一方向に連続して複数回実行されてよい。 | ||||||
| 130 | 整合米洛(Mirau)光學干涉顯微術之光學切層裝置 | TW106137526 | 2017-10-31 | TWI674089B | 2019-10-11 | 許光裕; HSU, KUANG-YU; 蔡建中; TSAI, CHIEN-CHUNG |
| An optical layering device integrating Mirau optical interference microscopy and fluorescent microscopy, which includes: a broadband light source device for generating a broadband light beam; an optical circulator having a first side A second side and a third side, the first side is facing the broadband light source device to divide an incident light beam into a transmitted light beam and a reflected light beam passing through the second side edge; A short-wave light source device for generating a short-wave light beam; a first two-color beam splitter having a first side, a second side, and a third side, the first side facing the short wave Light source device, the first dichroic beam splitter is used to make a light beam with a wavelength shorter than a preset wavelength impenetrable, and the wavelength of the short-wave beam is smaller than the preset wavelength; a Milo interference objective lens having a parallel light side And a condensing side, the parallel light side is facing the second side of the first two-color beam splitter; the same carrying unit is facing the condensing side of the Milo interference objective lens and is used to carry a Sample stained with fluorescer; a projection lens with a light incident side and a light exit side The light incident side faces the third side of the optical circulator; and a sensing unit faces the light exit side of the projection lens. | ||||||
| 131 | 整合米洛(Mirau)光學干涉顯微術之光學切層裝置 | TW106137526 | 2017-10-31 | TW201918230A | 2019-05-16 | 許光裕; HSU, KUANG-YU; 蔡建中; TSAI, CHIEN-CHUNG |
| 一種整合米洛(Mirau)光學干涉顯微術與螢光顯微術之光學切層裝置，其具有：一寬頻光源裝置，用以產生一寬頻光束；一光環行器，具有一第一側邊、一第二側邊及一第三側邊，所述第一側邊係面對該寬頻光源裝置以將一入射光束分成一透射光束及由所述第二側邊穿出之一反射光束；一短波光源裝置，用以產生一短波光束；一第一二色分光器，具有一第一側邊、一第二側邊及一第三側邊，所述第一側邊係面對該短波光源裝置，該第一二色分光器係用以使波長短於一預設波長之光束無法穿透，且該短波光束之波長小於該預設波長；一米洛干涉物鏡，具有一平行光側及一聚光側，該平行光側係面對該第一二色分光器之所述第二側邊；一樣本承載單元，面對該米洛干涉物鏡之聚光側且係用以承載一染有螢光劑之樣本；一投影透鏡，具有一入光側及一出光側，該入光側係面對該光環行器之所述第三側邊；以及一感測單元，係面對該投影透鏡之所述出光側。 | ||||||
| 132 | SURGICAL MICROSCOPE HAVING OPTICAL INTERFACES | US15050311 | 2016-02-22 | US20160170194A1 | 2016-06-16 | Andre Mueller; Daniel Kolster; Christian Luecke; Peter Reimer |
| An input coupling module selectively couples a beam path into a first or second stereoscopic component beam in a surgical microscope having an optical interface for guiding a beam path to be coupled-in. The input coupling module has a first beam splitter arranged in the first component beam and a second beam splitter arranged in the second component beam. The input coupling module contains an adjustable optics assembly, which selectively guides a beam path provided at the optical interface for coupling into the first or second component beam to the first beam splitter or the second beam splitter. The adjustable optics assembly includes an optical element displaceable by a linear movement from a first position to a second, position, and vice versa, for switching the beam path. The displaceable optical element is arranged in the beam path to be coupled-in in the first position and/or the second position. | ||||||
| 133 | 엘이디 광원을 이용한 혈관 이미지 장치와 이를 포함하는 레이저 혈관 수술 장치 | KR1020110004187 | 2011-01-14 | KR101245190B1 | 2013-03-20 | 정세채; 시두메라싱; 우숙이; 이흥순; 이현규 |
| 본 발명은 엘이디 광원을 이용한 혈관 이미지 장치와 이를 포함하는 레이저 혈관 수술 장치 및 방법에 관한 것으로, 더욱 상세하게는 백색광 LED(light emitting diode)로부터 발생한 빛의 파장 분포를 제어하여 망막 조직에 있는 혈관 내 혈액에 의한 광흡수가 최대화 되도록 함으로써 혈관이미지가 최대의 대조를 갖게 되는 혈관 이미지 장치에 관한 것이다.
또한, 주변 혈관과 혈관 이외의 조직과의 구별을 최적화함으로써 망막의 손상을 최소화 하면서 목표 부위의 선택적 제거능력이 탁월한 레이저 혈관 수술 장치에 관한 것이다. |
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| 134 | Surgical microscopy system having an optical coherence tomography facility | EP09003905.8 | 2009-03-18 | EP2103249B1 | 2016-06-08 | Hauger, Christoph, Dr.; Seesselberg, Markus; O'Hara, Keith; Qiu, Yue; Wei, Xing; Horn, Jochen M.; Reimer, Peter |
| 135 | OCT-assisted surgical microscope with multi-coordinate manipulator | EP97109168.1 | 1997-06-06 | EP0815801A3 | 1999-11-24 | Hellmuth, Thomas, Prof.Dr.; Kaschke,Michael,Dr.; Unold, Gerhard; Moore, John C. |
Embodiments of the present invention provide method and apparatus for use during a neurosurgical procedure to enable a multi-coordinate manipulator ( |
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| 136 | Zwei optisch-mechanisch gekoppelte Operationsmikroskope mit koaxialer Beleuchtung | EP89118124.0 | 1989-09-29 | EP0363762B1 | 1996-01-03 | Sander, Ulrich, Dr.; Lemke, Ulrich; Vogel, Albrecht |
| 137 | Surgical microscopy system having an optical coherence tomography facility | EP09003905.8 | 2009-03-18 | EP2103249B9 | 2016-10-19 | Hauger, Christoph, Dr.; Seesselberg, Markus; O'Hara, Keith; Qiu, Yue; Wei, Xing; Horn, Jochen M.; Reimer, Peter |
| 138 | OCT-assisted surgical microscope with multi-coordinate manipulator | EP97109168.1 | 1997-06-06 | EP0815801B1 | 2003-08-20 | Hellmuth, Thomas, Prof.Dr.; Kaschke,Michael,Dr.; Unold, Gerhard; Moore, John C. |
| 139 | Nonlinear optical device, multiphoton microscope, and endoscope | EP12001806.4 | 2012-03-16 | EP2500714A3 | 2015-05-27 | Fujiwara, Masato; Taira, Kenji |
Provided is a nonlinear optical device capable of alleviating, without the need for a complicated compensation mechanism, temporal broadening and the waveform distortion resulting from a group-velocity dispersion slope, to thereby irradiate an object with short optical pulses having high peak power. The nonlinear optical device includes a short optical pulse source (10) for generating short optical pulses and a short optical pulse delivery system (20) for delivering the short optical pulses generated from the short optical pulse source to an object, in which there is generated substantially no nonlinear optical effect and there is substantially no amount of group-velocity dispersion, the short optical pulse source generates short optical pulses, and the short optical pulses have a spectral width (full width at half maximum) λFWHM satisfying λ1<λFWHM<λ2.
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| 140 | 光學顯微術中的控制脈衝 CONTROLLING PULSES IN OPTICAL MICROSCOPY | TW095142542 | 2006-11-17 | TW200819731A | 2008-05-01 | 孔慶昌 KUNG, ANDY; 黃子倫 WEE, TSE LUEN; 黃書偉 HUANG, SHU WEI |
| 一種樣本成像方法描述如下。該樣本的特徵為經過一段特定的時間來限制樣本吸收入射光學能量至一限度。該方法包括:提供至少一輸入光波,該輸入光波包含複數個脈衝,每一脈衝具有大於100皮秒半高全寬的時寬及足夠大的脈衝能量,令使藉由樣本吸收足夠數目的連續脈衝而超過該限度。該方法亦包括引導輸入光波以聚焦在該樣本的第一部分上;偵測由輸出光波產生的能量,該能量由具有該輸入光波之樣本的第一部分中的非線性光學相互作用而產生;及根據由輸出光波的偵測能量產生該樣本的第一部分的代表値。 | ||||||
