METHOD FOR PRODUCING OPTICALLY ACTIVE 2-(2-FLUOROBIPHENYL-4-YL) PROPANOIC ACID |
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| 申请号 | US15764598 | 申请日 | 2016-09-29 | 公开(公告)号 | US20180282252A1 | 公开(公告)日 | 2018-10-04 |
| 申请人 | TAISHO PHARMACEUTICAL CO., LTD.; | 发明人 | Norikazu OTAKE; Daisuke MATSUDA; Rie SHIMONO; Hideaki TABUSE; Minoru MORIYA; Yohei KOBASHI; Yohei MATSUDA; Tomokazu TAMAOKI; | ||||
| 摘要 | A novel process for producing optically active 2-(2-fluorobiphenyl-4-yl)propanoic acid is disclosed. This production process is characterized in that a compound of formula [1] is reacted with magnesium and so forth to prepare an organometallic reagent, which is reacted with a compound of formula [2] in the presence of a catalytic amount of a nickel compound and a catalytic amount of an optically active compound of formula [3] to obtain a compound represented by formula [4] which is subsequently converted to a compound represented by formula [5] or a pharmaceutically acceptable salt thereof. | ||||||
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| 说明书全文 | |||||||
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