Oleanolic acid methyl ester derivatives |
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| 申请号 | US15815587 | 申请日 | 2017-11-16 | 公开(公告)号 | US09969768B1 | 公开(公告)日 | 2018-05-15 |
| 申请人 | KING SAUD UNIVERSITY; | 发明人 | Ahmed M. Naglah; Abd El-Galil E. Amr; Mohamed A. Al-Omar; | ||||
| 摘要 | Oleanolic acid methyl ester derivatives demonstrate potent anti-diabetic activities. In in vitro anti-diabetic testing, the derivatives showed more potency regarding dipeptidyl peptidase-4 (DPP-IV) inhibitor activity, peroxisome proliferator-activated receptors (PPARs) agonist activity, and α-Glucosidase inhibitors activity, as compared to reference standards oleanolic acid and acarbose. In in vivo oral hypoglycemic testing, both acute and sub-acute studies demonstrated that the derivatives had high potency and long duration of action compared to the reference standards pioglitazone, acarbose and oleanolic acid. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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