METHOD FOR MODULATING THE EVOLUTION OF A POLYPEPTIDE ENCODED BY A NUCLEIC ACID SEQUENCE |
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| 申请号 | PCT/IB2005003317 | 申请日 | 2005-09-19 | 公开(公告)号 | WO2006046132A3 | 公开(公告)日 | 2006-08-17 |
| 申请人 | PASTEUR INSTITUT; MAZEL DIDIER; CAMBRAY GUILLAUME; | 发明人 | MAZEL DIDIER; CAMBRAY GUILLAUME; | ||||
| 摘要 | A method for modulating the ability of a gene to mutate by analyzing codon usage within the gene and selecting a synonymous nucleotide sequence with a higher, lower or different capacity to mutate. The method permits widening and optimization of the evolutionary landscape of a protein. A computer-implemented method for analyzing and selecting nucleotide sequences with an altered ability to mutate. | ||||||
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| 说明书全文 | |||||||
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