COMPUTER ASSISTED ANTIBODY RE-EPITOPING |
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| 申请号 | US15531308 | 申请日 | 2015-11-25 | 公开(公告)号 | US20180068055A1 | 公开(公告)日 | 2018-03-08 |
| 申请人 | Biolojic Design Ltd.; | 发明人 | Yanay OFRAN; Guy NIMROD; Sharon FISCHMAN; Asael HERMAN; | ||||
| 摘要 | The present invention is directed to a method for generating a library of antigen binding molecules for screening for binding to an epitope of interest, said method comprising: a. selecting a template antigen-binding molecule from a set of possible template antigen binding molecules wherein said selected template does not specifically bind the epitope of interest but is known to specifically bind another epitope; b. selecting at least one residue position in said template antigen-binding molecule for mutation; and c. selecting at least one variant residue to substitute at the at least one residue position selected in b; such that a library containing a plurality of variants of said template is generated. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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