PEPTIDE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE |
|||||||
| 申请号 | US15710696 | 申请日 | 2017-09-20 | 公开(公告)号 | US20180080926A1 | 公开(公告)日 | 2018-03-22 |
| 申请人 | The Board of Trustees of the Leland Stanford Junior University; Washington University; | 发明人 | Daria Mochly-Rosen; Gerald W. Dorn, II; | ||||
| 摘要 | Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
QQ群二维码
意见反馈
意见反馈