Methods and compositions for inhibition of Ras |
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| 申请号 | US15508387 | 申请日 | 2015-09-25 | 公开(公告)号 | US10011600B2 | 公开(公告)日 | 2018-07-03 |
| 申请人 | ARAXES PHARMA LLC; | 发明人 | Liansheng Li; Jun Feng; Yun Oliver Long; Pingda Ren; Yi Liu; | ||||
| 摘要 | Inhibitors of Ras protein, methods to modulate the activity of Ras protein, and methods of treatment of disorders mediated by Ras protein are provided. A method for regulating activity of a K-Ras, H-Ras or N-Ras mutant protein with a compound is described. Disorders that can be treated include cancer, such as hematological cancer, pancreatic cancer, MYH associated polyposis, colorectal cancer, or lung cancer. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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