Engineered Clostridium Botulinum Toxin Adapted To Deliver Molecules Into Selected Cells专利检索- .戊糖基转移酶专利检索查询-专利查询网

Engineered Clostridium Botulinum Toxin Adapted To Deliver Molecules Into Selected Cells
申请号	US15574151	申请日	2016-05-14	公开(公告)号	US20180127734A1	公开(公告)日	2018-05-10
申请人	Benjamin J. Pavlik; Paul Blum; Kevin Van Cott;			发明人	Benjamin J. Pavlik; Paul Blum; Kevin Van Cott;
摘要	An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.
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