SYSTEMS AND METHODS OF DELIVERY OF BIOACTIVE AGENTS USING BACTERIAL TOXIN-DERIVED TRANSPORT SEQUENCES |
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| 申请号 | EP11825567 | 申请日 | 2011-09-15 | 公开(公告)号 | EP2616045A4 | 公开(公告)日 | 2014-12-24 |
| 申请人 | MRSNY RANDALL J; MAHMOOD TAHIR; | 发明人 | MRSNY RANDALL J; MAHMOOD TAHIR; | ||||
| 摘要 | The field of the present invention relates, in part, to a strategy for novel pharmaceutical applications. More specifically, the present invention relates to a genetically detoxified form of Vibrio cholera exotoxin (cholix) and the use of cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active therapeutics. Importantly, the systems and methods described herein provide for the following: the ability to deliver macromolecule doses without injections; the ability to deliver cargo, such as (but not limited to) siRNA or antisense molecules into intracellular compartments where their activity is required; and the delivery of nanoparticles and dendrimer-based carriers across biological membranes, which otherwise would have been impeded due to the barrier properties of most such membranes. | ||||||
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