Production of Glycosylated Nootkatol in Recombinant Hosts |
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| 申请号 | US15774134 | 申请日 | 2016-11-14 | 公开(公告)号 | US20180327723A1 | 公开(公告)日 | 2018-11-15 |
| 申请人 | Evolva SA; | 发明人 | Dayal Saran; Jorgen Hansen; Philippe Prochasson; Patrick Roussel; Laura Occhipinti; Alexei Ouspenski; Sumire Honda Malca; | ||||
| 摘要 | The invention relates to methods for producing glycosylated nootkatol. In particular, a recombinant host comprising a gene encoding a UDP-glycosyltransferase polypeptide capable of glycosylating nootkatol is disclosed. Glycosylation of nootkatol detoxifies nootkatol, allowing for greater production of (glycosylated-)nootkatol, a precursor of nootkatone, and therefore greater production of nootkatone. The invention also relates to methods of converting non-toxic, glycosylated nootkatol produced by a recombinant host to nootkatol, wherein the nootkatol can subsequently be converted to large quantities of nootkatone to be used in flavorings, perfumes, and/or insect repellents. | ||||||
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| 说明书全文 | |||||||
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