E1 ENZYME MUTANTS AND USES THEREOF专利检索- .细胞色素作为受体专利检索查询-专利查询网

E1 ENZYME MUTANTS AND USES THEREOF
申请号	PCT/US2012058983	申请日	2012-10-05	公开(公告)号	WO2013052814A8	公开(公告)日	2014-01-16
申请人	MILLENNIUM PHARM INC;			发明人	AMIDON BENJAMIN STONE; BROWNELL JAMES; GAVIN JAMES M; KOENIG ERIK M; SINTCHAK MICHAEL D; SMITH PETER G;
摘要	The invention provides isolated nucleic acids molecules, designated UBA3, UAE, or UBA6, or other E1 enzyme variant nucleic acid molecules, which encode novel E1 enzyme variant proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing UBA3, UAE, or UBA6, or other E1 enzyme variant nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a UBA3, UAE, or UBA6, or other E1 enzyme variant gene has been introduced or disrupted. The invention still further provides isolated UBA3, UAE, or UBA6, or other E1 enzyme variant proteins, fusion proteins, antigenic peptides and anti- UBA3, UAE, or UBA6, or other E1 enzyme variant antibodies. The invention provides methods to identify agents that inhibit UBA3, UAE, or UBA6, or other E1 enzyme variant expression or activity. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
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