SYSTEMS AND METHODS FOR BIOMIMETIC FLUID PROCESSING |
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| 申请号 | US15300070 | 申请日 | 2015-03-30 | 公开(公告)号 | US20170183616A1 | 公开(公告)日 | 2017-06-29 |
| 申请人 | BRIGHAM AND WOMEN'S HOSPITAL, INC.; | 发明人 | Jonathan N. Thon; Joseph E. Italiano; Linas Mazutis; David A. Weitz; | ||||
| 摘要 | Systems and methods generating physiologic models that can produce functional biological substances are provided. In some aspects, a system includes a substrate and a first and second channel formed therein. The channels extend longitudinally and are substantially parallel to each other. A series of apertures extend between the first channel and second channel to create a fluid communication path passing through columns separating the channels that extends further along the longitudinal dimension than other dimensions. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates within a predetermined range in the channels. | ||||||
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