Methods for inducing the differentiation of blood monocytes into functional dendritic cells |
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| 申请号 | US15072732 | 申请日 | 2016-03-17 | 公开(公告)号 | US10087418B2 | 公开(公告)日 | 2018-10-02 |
| 申请人 | Yale University; | 发明人 | Richard Leslie Edelson; | ||||
| 摘要 | Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood and produce a leukocyte concentrate comprising monocytes and plasma containing proteins. The leukocyte concentrate comprising monocytes and plasma containing proteins is pumped through a plastic treatment device, such as a photopheresis device. The resulting treated cells may be incubated for a sufficient period of time to allow the monocytes to form dendritic cells, or the treated cells may be reinfused directly to the subject. | ||||||
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| 说明书全文 | |||||||
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