Methods and compositions for repair of cartilage using an in vivo bioreactor |
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| 申请号 | US15371994 | 申请日 | 2016-12-07 | 公开(公告)号 | US10052410B2 | 公开(公告)日 | 2018-08-21 |
| 申请人 | SpinalCyte, LLC; | 发明人 | Lionel C. Sevrain; Sylvie Y. Verdier-Sevrain; | ||||
| 摘要 | Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain. | ||||||
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