| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 | JP2012157157 | 2012-07-13 | JP5642736B2 | 2014-12-17 | マンニオン，リチャード，オーウェン; オドンネル，エドワード，パトリック; マクケナ，ウィリアム、ヘンリー; フアン，ハイヨン，ハフ |
| 42 | Tamper resistant oral pharmaceutical dosage form comprising opioid analgesic | JP2012157157 | 2012-07-13 | JP2012236835A | 2012-12-06 | MANNION RICHARD OWEN; O'DONNELL EDWARD PATRICK; MCKENNA WILLIAM HENRY; HUANG HAIYONG HUGH |
| PROBLEM TO BE SOLVED: To provide a pharmaceutical dosage, for example a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment.SOLUTION: The process of preparing a solid oral extended release pharmaceutical dosage form, comprising at least the steps of: (a) combining (1) at least one polyethylene oxide having, based on rheological measurements, an approximate molecular weight of at least 1,000,000, and (2) at least one active agent, to form a composition; (b) shaping the composition to form an extended release matrix formulation; and (c) curing the extended release matrix formulation including at least a curing step of subjecting the extended release matrix formulation to a temperature which is at least the softening temperature of the polyethylene oxide for a time period of at least about 1 minute. | ||||||
| 43 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 | JP2016146843 | 2016-07-27 | JP6286491B2 | 2018-02-28 | マンニオン,リチャード,オーウェン; オドンネル,エドワード,パトリック; マクケナ,ウィリアム、ヘンリー; フアン,ハイヨン,ハフ |
| 44 | Tamper-resistant oral pharmaceutical dosage form comprising an opioid analgesic | JP2012045261 | 2012-03-01 | JP5373133B2 | 2013-12-18 | マンニオン，リチャード，オーウェン; オドンネル，エドワード，パトリック; マクケナ，ウィリアム、ヘンリー; フアン，ハイヨン，ハフ |
| The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. | ||||||
| 45 | Tamper-resistant oral pharmaceutical dosage form comprising opioid analgesic | JP2012157159 | 2012-07-13 | JP2012229250A | 2012-11-22 | MANNION RICHARD OWEN; O'DONNELL EDWARD PATRICK; MCKENNA WILLIAM HENRY; HUANG HAIYONG HUGH |
| PROBLEM TO BE SOLVED: To provide a tamper-resistant dosage form comprising an opioid analgesic, to provide a method for producing the same, and to provide a method for use and treatment thereof.SOLUTION: There is provided a controlled release solid oral pharmaceutical dosage form comprising a controlled release matrix formulation in the form of a tablet or multi-particulates as the object. The tablet or individual multi-particulates can be at least flattened without breaking, characterized by a thickness of the tablet or of the individual multi-particulates after flattening which corresponds to about ≤60% of the thickness of the tablet or of the individual multi-particulates before flattening. In the dosage form, the flattened tablet or flattened multi-particulates provide an in vitro dissolution rate, when measured in a USP Apparatus 1 (basket) at 100 rpm in 900 mL simulated gastric fluid without enzymes (SGF) at 37°C, characterized by the percent amount of an active agent released at 0.5 h of the dissolution that deviates no more than about 20% points from the corresponding in vitro dissolution rate of a non-flattened reference tablet or non-flattened reference multi-particulates. | ||||||
| 46 | Tamper-resistant oral pharmaceutical dosage form comprising opioid analgesic | JP2012157158 | 2012-07-13 | JP2012229249A | 2012-11-22 | MANNION RICHARD OWEN; O'DONNELL EDWARD PATRICK; MCKENNA WILLIAM HENRY; HUANG HAIYONG HUGH |
| PROBLEM TO BE SOLVED: To provide a controlled release oral pharmaceutical dosage form comprising an active agent which is tamper resistant, and to provide a method for preparing the same.SOLUTION: There is provided a method for preparing a controlled release solid oral pharmaceutical dosage form including at least the steps of: (a) a step of combining at least one polyethylene oxide having, based on (1) rheological measurements, an approximate molecular weight of at least 1,000,000, and (2) at least one active agent, to form a composition; (b) a step of shaping the composition, to form a controlled release matrix formulation; and (c) a curing step of subjecting the controlled release matrix formulation to a temperature which is at least the softening temperature of the polyethylene oxide for a time period of at least about 1 min; and comprising at least a step of curing the controlled release matrix formulation. Furthermore, there is provided the extended release oral pharmaceutical dosage form. The active agent is preferably an opioid analgesic, especially oxycodone hydrochloride. | ||||||
| 47 | Tamper-resistant oral pharmaceutical dosage form comprising an opioid analgesic | JP2009525126 | 2007-08-24 | JP5069300B2 | 2012-11-07 | オドンネル，エドワード，パトリック; フアン，ハイヨン，ハフ; マクケナ，ウィリアム、ヘンリー; マンニオン，リチャード，オーウェン |
| The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. | ||||||
| 48 | Tamper resistant oral pharmaceutical dosage form comprising opioid analgesic | JP2012096011 | 2012-04-19 | JP2012167102A | 2012-09-06 | MANNION RICHARD OWEN; O'DONNELL EDWARD PATRICK; MCKENNA WILLIAM HENRY; HUANG HAIYONG HUGH |
| PROBLEM TO BE SOLVED: To provide pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.SOLUTION: The pharmaceutical dosage form includes an extended release matrix formulation comprising a composition comprising at least: (1) at least one polyethylene oxide having, based on rheological measurements, an approximate molecular weight of at least 1,000,000, and (2) at least one active agent; and wherein the composition comprises at least about 80 wt.% polyethylene oxide. | ||||||
| 49 | Tamper-resistant oral pharmaceutical dosage form comprising opioid analgesic | JP2012045261 | 2012-03-01 | JP2012136543A | 2012-07-19 | MANNION RICHARD OWEN; O'DONNELL EDWARD PATRICK; MCKENNA WILLIAM HENRY; HUANG HAIYONG HUGH |
| PROBLEM TO BE SOLVED: To provide a tamper-resistant dosage form of an opioid analgesic, etc., and production methods, uses, and treatment methods thereof.SOLUTION: The present invention is directed to a solid oral extended release pharmaceutical dosage form comprising an extended release matrix formulation in the form of a tablet or multi-particulates, wherein the tablet or the individual multi-particulates can at least be flattened without breaking, characterized by a thickness of the tablet or the individual multi-particulate after the flattening which corresponds to no more than about 60% of the thickness of the tablet or the individual multi-particulate before flattening, and wherein the flattened tablet or the flattened multi-particulates provide an in-vitro dissolution rate, when measured in a USP (United States Pharmacopeia) apparatus 1 (basket) at 100 rpm in 900 mL simulated gastric fluid (SGF) without enzymes at 37°C characterized by the percent amount of active agent released at 0.5 hours of dissolution that deviates no more than a limit of about 20% from the corresponding in-vitro dissolution rate of a non flattened reference tablet or non flattened reference multi-particulates. | ||||||
| 50 | Tamper-resistant oral pharmaceutical dosage form comprising an opioid analgesic | JP2009525126 | 2007-08-24 | JP2010501543A | 2010-01-21 | オドンネル，エドワード，パトリック; フアン，ハイヨン，ハフ; マクケナ，ウィリアム、ヘンリー; マンニオン，リチャード，オーウェン |
| 本発明は、医薬剤形、例えばオピオイド鎮痛薬を含む不正改変抵抗性剤形、ならびにその製造方法、使用、および治療方法に関する。 | ||||||
| 51 | Pharmaceutical dosage forms | EP11157013.1 | 2007-08-24 | EP2399580B1 | 2013-04-03 | Mannion, Richard Owen; Huang, Haiyong Hugh; McKenna, William Henry; O'Donnell, Edward, P. |
| The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. | ||||||
| 52 | Tamper resistant oral pharmaceutical dosage forms comprising an opioid analgesic | EP10192641.8 | 2007-08-24 | EP2292229B1 | 2012-05-23 | Mannion, Richard Owen; Huang, Haiyong Hugh; McKenna, William Henry; O'Donnell, Edward, P. |
| The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. | ||||||
| 53 | Pharmaceutical dosage forms | EP11157003.2 | 2007-08-24 | EP2384754A1 | 2011-11-09 | Mannion, Richard Owen; Huang, Haiyong Hugh; McKenna, William Henry; O'Donnell, Edward, P. |
The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. |
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| 54 | Pharmaceutical dosage forms | EP11156997.6 | 2007-08-24 | EP2343071A1 | 2011-07-13 | Mannion, Richard Owen; Huang, Haiyong Hugh; McKenna, William Henry; O'Donnell, Edward, P. |
The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. |
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| 55 | Tamper resistant oral pharmaceutical dosage forms comprising an opioid analgesic | EP09156843.6 | 2007-08-24 | EP2082742A1 | 2009-07-29 | McKenna, William Henry; Mannion, Richard Owen; O'Donnell, Edward Patrick; Huang, Haiyong Hugh |
The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. |
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| 56 | Tamper resistant oral pharmaceutical dosage forms comprising an opioid analgesic | EP09156838.6 | 2007-08-24 | EP2080514A1 | 2009-07-22 | McKenna, William Henry; Mannion, Richard Owen; O'Donnell, Edward Patrick; Huang, Haiyong Hugh |
The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. |
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| 57 | AUFBEREITUNG EINER NOVOLAK-FORMMASSE FÜR KOLLEKTOREN | EP94915506.0 | 1994-05-25 | EP0703944A1 | 1996-04-03 | BAUN, Werner; GLATZ, Ursula; LUDWIG, Frank; MOSER, Thomas |
| Described are asbestos-free moulding compounds based on phenol-formaldehyde resins, also known as phenolic resins, which are prepared in a turbo mixer with the addition of water. The moulding compounds include up to 30 % by wt. of a novolak resin plus short glass fibres and long glass fibres, the total glass-fibre content being about 30 % by wt. The glass fibres are preferably mixed in the ratio, by weight, of short fibres to long fibres of 2:1. The mineral fillers preferred for the moulding compounds are chalk and clays, together making up about 30 % by wt. Other components are cross-linking agents, mould-release agents, accelerators and, optionally, colorants, in most cases in quantities less than 3 % by wt. The moulding compounds are obtained as granular products with a low dust content. They can be plasticized and further processed using automatic production machinery. The moulding compounds thus obtained have properties which make them suitable for use in the manufacture of commutators for electric motors. | ||||||
| 58 | METHOD AND COMPOSITION INCLUDING THERMOPLASTIC PARTICLES AND HOLLOW MICROSPHERES AND ARTICLES MADE FROM THEM | EP15759579.4 | 2015-08-14 | EP3183104A1 | 2017-06-28 | YALCIN, Baris; GUNES, Ibrahim S.; THUNHORST, Kristin L. |
| A method of making a molded article. The method includes introducing into a mold a composition including thermoplastic particles with hollow microspheres attached to their outer surfaces, rotating the mold, and heating the mold at a temperature at which the thermoplastic particles melt. The hollow microspheres are included in the molded article. Molded articles are also disclosed. A powder composition that includes thermoplastic powder particles and hollow ceramic microspheres attached to outer surfaces of at least some of the thermoplastic powder particles is also disclosed. The hollow ceramic microspheres are either adhered to the outer surfaces of at least some of the thermoplastic powder particles with a liquid or embedded in the outer surfaces of at least some of the thermoplastic powder particles. | ||||||
| 59 | STABILISATORMISCHUNGEN FÜR HALOGENHALTIGE KUNSTSTOFFE DURCH UNTERWASSERGRANULIERUNG | EP11702459.6 | 2011-02-08 | EP2545116B1 | 2014-07-16 | REITH, Walter |
| 60 | Pharmaceutical dosage forms | EP11157006.5 | 2007-08-24 | EP2399579B1 | 2013-04-03 | Mannion, Richard Owen; Huang, Haiyong Hugh; McKenna, William Henry; O'Donnell, Edward, P. |
| The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. | ||||||
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