序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
81 PLATELET RICH PLASMA AND BONE MARROW ASPIRATE CELL SEPARATION AND REMOVAL METHODS AND DEVICES US15545601 2016-01-22 US20180296748A1 2018-10-18 Jane F. Emerson
Compositions and methods for separating a sample of whole blood or bone marrow aspirate into a fraction rich in at least one of platelets and pluripotent cells are provided. A sample of whole blood can be centrifuged in a collection tube comprising a separator substance formulated to settle between the PRP fraction and the at least one other fraction. Preferably, centrifugation is completed without substantial activation of platelets. Optionally, the separator substance could be hardened to form a solid barrier that allows removal of all or substantially all of the platelets in the PRP fraction without remixing of the PRP fraction with the at least one other fraction. Transfer devices and methods are also provided in which a sterile sample can be transferred from a separation/preparation container (e.g., vacutainer) to a consumer or other container (e.g., dropper) while maintaining sterility of the sample.
82 LIQUID PATTERNING DEVICE AND METHOD US15306523 2016-08-01 US20180029070A1 2018-02-01 Ho Young YUN; Myeong Woo Kang; Noo Li JEON
Disclosed is a liquid patterning device and liquid patterning method. The liquid patterning device includes: a substrate having a flat bottom and a surface; at least one microstructure formed to vertically protrude from the surface of the substrate and including a plurality of unit microposts so as to have a desired shape; and a liquid mover for moving a liquid to be patterned on the surface of the substrate in another direction from one direction of the microstructure.
83 Method for processing a fluid and fluid processing device US14295689 2014-06-04 US09849453B2 2017-12-26 Andreas Schaefer; Thomas Voit; Markus Zbinden; Andreas Schmiede
The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.
84 System and method for charging fluids US15048812 2016-02-19 US09789484B2 2017-10-17 Brian Chawke; Kieran Curran; David McGuire; Michael Sayers; Noel Sirr
Devices, systems, and methods for charging fluids are disclosed. The charging of fluids improves the mixing of fluids in microfluidic systems. The charging is performed by producing an ion field between an ionizing electrode and an opposed ground electrode. A fluid-containing vessel is positioned between the opposed electrodes and the ion field charges the fluid in the vessel.
85 Apparatus for and methods of processing liquids or liquid-based substances US14003606 2012-03-08 US09771553B2 2017-09-26 Paul Vulto; Sebastiaan Johannes Trietsch; Heiko Jan van der Linden; Thomas Hankemeier
Apparatus for processing liquids or liquid-based substances includes a plurality of volumes at least two of which are defined at least in part by one or more phaseguides inside the volume and/or in a conduit connected thereto for controlling aliquoting of one or more liquids or liquid-based substances inside the volume. Each volume has an upstream and downstream side with respect to meniscus advancement direction via which it may be filled with or emptied of one or more liquids or liquid-based substances. The apparatus also includes at least one common upstream-side conduit connected to supply a liquid or liquid-based substance via a plurality of the inlet or extraction conduits, a plurality of the phaseguides exhibiting a predetermined level of stability and one or more of the phaseguides exhibiting a predetermined different stability compared with the stability of at least one of the other phaseguides whereby to control the preference order in which the volumes fill and/or empty. The stability is determined by the value and radius of an acute angle along a said phaseguide at the downstream side of the phaseguide.
86 Methods and apparatuses for filtering water fluid by screening ionic minerals US14043732 2013-10-01 US09718711B2 2017-08-01 Kee-Hyun Paik; Yang Liu; Robert W. Dutton; Qiushi Ran
Various aspects of the present disclosure are directed toward apparatus and methods method for filtering water fluid by screening ionic minerals including sodium chloride from the water fluid. In one embodiment, the water fluid is passed into a work zone defined at least in part by oppositely-arranged first and second porous structures, each of which have a plurality of gated channels. The water fluid is processed in the work zone by applying respective electric voltages to electrically bias the first porous structure and the second porous structure. The respective electric voltages deplete sodium chloride ions in the water fluid in the work zone due to ion-flux continuity. In response to processing of the water fluid, ion-filtered water is collected from the work zone.
87 FLUID DELIVERY MANIFOLDS AND MICROFLUIDIC SYSTEMS US15407088 2017-01-16 US20170122904A1 2017-05-04 Ronald F. Renzi; Gregory J. Sommer; Anup K. Singh; Anson V. Hatch; Mark R. Claudnic; Ying-Chih Wang; James L. Van De Vreugde
Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.
88 Disposable integrated polymeric vacuum filtration funnel US14221953 2014-03-21 US09623349B2 2017-04-18 Haitao Chi; Haifeng Zhu; Yawu Thomas Chi
This invention discloses a disposable integrated polymeric vacuum filtration funnel. The integrated polymeric vacuum filtration funnel comprises a filtration funnel body having a filter frit disposed inside at the bottom, an outlet stem connected with an outlet at the outer bottom of the filtration funnel body; the outlet stem is integrated with the filtration funnel body; the filter frit is sealed to the inner bottom and the inner side surface of the filtration funnel body; the integrated polymeric vacuum filtration funnel comprises a sealing joint disposed underneath the outer bottom of the filtration funnel body, the sealing joint having a side-arm for vacuum connection and a standard adaptor to connect the receiving receptacle; the outlet stem protrudes from the standard adaptor; the filter frit, filtration funnel body, and sealing joint are integrated as one device. The invention can effectively reduce or eliminate the loss of the filtrate and filter cake, avoid contamination, easy to use, and cost-effective.
89 Selection device US14411863 2013-07-02 US09606099B2 2017-03-28 Josef Zech
Device for spermatozoa selection comprising a first chamber configured to receive a first, seminal fluid; a second chamber configured to receive a second fluid, the second chamber being in fluid communication with the first chamber by means of at least one duct having a first opening to the first chamber and a second opening to the second chamber; and a displacement means adapted to displace at least some of the first, seminal fluid towards the first opening.
90 Fluid delivery manifolds and microfluidic systems US12900276 2010-10-07 US09579649B2 2017-02-28 Ronald F. Renzi; Gregory J. Sommer; Anup K. Singh; Anson V. Hatch; Mark R. Claudnic; Ying-Chih Wang; James L. Van de Vreugde
Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.
91 Filter funnel for connection to flask US14699814 2015-04-29 US09452373B1 2016-09-27 Shui-Tien Horng
A filter funnel has a funnel seat, a tubular stem, and a seal washer that is sleeved on the tubular stem and abuts against an abutment region of the funnel seat. The seal washer has a slot registering with a port of a vacuum intake duct formed in the funnel seat and is disposed to cover an access opening of a flask. When the flask is connected to a vacuum source through the vacuum intake duct to create reduced pressure in the flask, the seal washer presses against a flask neck of the flask to provide an air-tight seal between the access opening and the slot, thereby facilitating flowing of a liquid fraction of a mixture introduced into the filter funnel into the flask.
92 SOLID WASTE TREATMENT WITH CONVERSION TO GAS AND ANAEROBIC DIGESTION US15015479 2016-02-04 US20160230193A1 2016-08-11 Juan Carlos JOSSE; Yaniv D. SCHERSON
Waste solids are treated by pyrolysis at a temperature over 700 degrees C. to produce char and a gas. The gas is treated in an anaerobic digester. In one system, gas and digestate are brought into contact in a diffusion cone. In another option, headspace gas above the digestate is re-circulated through the digestate, for example by way of an eductor downstream of the diffusion cone.
93 ANALYTICAL AIDS WITH HYDROPHILIC COATING CONTAINING NANOPARTICLES WITH SILICA STRUCTURE AND METHODS OF PRODUCING AND USING THE SAME US15070101 2016-03-15 US20160192870A1 2016-07-07 Branislav Babic; Peter Greiwe
Disclosed herein are analytical aids having a surface coated at least partially with a hydrophilic coating, where the hydrophilic coating includes nanoparticles with silica structure and an average particle size in a range from about 1 nm to about 500 nm. Also disclosed are methods of producing the analytical aids, as well as using the analytical aids in, for example, a sampling device containing the at least partially coated analytical aid.
94 Recovery Assembly for Cryopreservation Applications US14908182 2014-08-05 US20160165881A1 2016-06-16 Petra Arndt; Volker Derdau; Verena Siefke-Henzler
The present invention relates to a recovery assembly for a cooling agent in a cryopreservation device, the recovery assembly comprises a cone-shaped funnel assembly comprising a support for mounting the funnel assembly to an access opening of a container to be at least partially filled with a cooling agent.
95 Liquid channel device and production method therefor US13934320 2013-07-03 US09283562B2 2016-03-15 Shigeru Takahashi; Masaaki Sakurai; Jiro Wakamatsu
The present invention relates to a liquid channel device capable of easily opening the liquid channel from the closed mode, including a base plate in which a liquid channel, through which a liquid containing at least one of a sample and a reagent, flows, and a metering chamber for holding the liquid, are formed to at least one side thereof, the metering chamber has a liquid transport section for transporting the liquid inside the chamber downstream, and this liquid transport section is operated by means of external pressing on a cover plate in the area opposite the metering chamber.
96 Liquid channel device and production method therefor US13934310 2013-07-03 US09283561B2 2016-03-15 Shigeru Takahashi; Masaaki Sakurai; Jiro Wakamatsu
The present invention relates to a liquid channel device capable of easily opening the liquid channel from the closed mode, including a base plate in which a liquid channel, through which a liquid containing at least one of a sample and a reagent, flows, and a metering chamber for holding the liquid, are formed to at least one side thereof, the metering chamber has a liquid transport section for transporting the liquid inside the chamber downstream, and this liquid transport section is operated by means of external pressing on a cover plate in the area opposite the metering chamber.
97 Fluid handling device and fluid handling system US14110086 2012-03-12 US09120098B2 2015-09-01 Tomoki Nakao; Koichi Ono
The present invention relates to a microchannel chip capable of preventing fluid leakage caused by a lamination defect. Bottomed first regions, second regions, and third regions are formed by joining a film to a lower surface of the chip main body of a microchannel chip. The third regions are in communication with the second regions and are formed on carbon inks. The third regions are formed wider than the carbon inks are. The third regions are filled with an electroconductive adhesive.
98 Capillary fluid flow control US14004750 2012-03-15 US09044757B2 2015-06-02 Philip Robertson; Richard Swainson; Patrick Ward
A fluid flow control device controls flow of fluid in a capillary pathway device having a first capillary passage with an inlet and an outlet and a fluid application region for receiving a liquid sample for entry to the capillary passage via the inlet, with the fluid flow control device comprising first sealing means operable for releasably sealing the outlet of the first capillary passage.
99 Focus-activated acoustic ejection US14016909 2013-09-03 US08882226B2 2014-11-11 Richard N. Ellson
To ejecting a droplet from a reservoir, the reservoir holding a fluid is moved with respect to an acoustic ejector. As the reservoir and ejector move closer together, the acoustic ejector sends one or more interrogation pulses towards the reservoir. Based on the interrogation pulses, the system determines when the movement of the reservoir has placed a free surface of the fluid in a position where a droplet can be ejected.
100 BIO CARTRIDGES US13937151 2013-07-08 US20140023568A1 2014-01-23 Jongcheol HONG; Wan Joong KIM; Gun Yong SUNG; Seunghwan KIM
A bio cartridge includes a reaction chamber disposed within a housing and containing a reagent, a specimen transfer channel providing a transfer path through which a specimen supplied to the housing is transferred into the reaction chamber, a mixing unit mixing the specimen with the reagent, and an air pressure unit providing air pressure to the specimen.
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