| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | LYSOSOMAL PROTEINS PRODUCED IN THE MILK OF TRANSGENIC ANIMALS | PCT/EP9603421 | 1996-07-31 | WO9705771A3 | 1997-04-03 | REUSER ARNOLD J J; VAN DER PLOEG ANS T; PIEPER FRANK R; VERBEET MARTIN PH |
| The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy. | ||||||
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