| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | C1 INHIBITOR PRODUCED IN THE MILK OF TRANSGENIC MAMMALS | PCT/NL0100068 | 2001-01-31 | WO0157079A2 | 2001-08-09 | NUIJENS JOHANNES HENRICUS; VAN VEEN HENRICUS ANTONIUS; PIEPER FRANK R; HEUS JORIS JAN |
| The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring immunosuppression. | ||||||
| 62 | LYSOSOMAL PROTEINS PRODUCED IN THE MILK OF TRANSGENIC ANIMALS | PCT/EP9603421 | 1996-07-31 | WO9705771A3 | 1997-04-03 | REUSER ARNOLD J J; VAN DER PLOEG ANS T; PIEPER FRANK R; VERBEET MARTIN PH |
| The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy. | ||||||
| 63 | TREATMENT OF ACNE VULGARIS; ROSACEA AND RHINOPHYM | PCT/EP2009051749 | 2009-02-16 | WO2009101199A2 | 2009-08-20 | MELNIK BODO |
| A composition for the treatment of acne vulgaris, rosacea and/or rhinophym comprising at least one inhibitor of the FGFR2 signal pathway and/or IGFR1 signal pathway. | ||||||
| 64 | METHOD FOR REDUCING OR PREVENTING MODIFICATION OF A POLYPEPTIDE IN SOLUTION | PCT/US0337238 | 2003-11-21 | WO2004048517A3 | 2004-09-02 | SANTORA LING C; STANLEY KRISTA H |
| The present invention encompasses a novel approach to reduce or to prevent modification of polypeptides in solution and to polypeptides obtained by such methods. Specifically, the invention relates to a method for reducing or preventing modification of polypeptides in milk, particularly milk obtained from a transgenic animal, and to polypeptides isolated using such methods. | ||||||
| 65 | ANIMALS EXPRESSING EXOGENOUS IGF-I IN THEIR MILK | PCT/US0125583 | 2001-08-15 | WO0214473A8 | 2002-07-04 | WHEELER MATTHEW B; DONOVAN SHARON M; BLECK GREGORY T; MONACO-SEIGEL MARCIA |
| The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase activity. the present invention thus provides a method of facilitating piglet development and decreasing piglet mortality. | ||||||
| 66 | ANIMALS EXPRESSING EXOGENOUS IGF-I IN THEIR MILK | PCT/US0125583 | 2001-08-15 | WO0214473A2 | 2002-02-21 | WHEELER MATTHEW B; DONOVAN SHARON M; BLECK GREGORY T; MONACO-SEIGEL MARCIA |
| The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase activity. the present invention thus provides a method of facilitating piglet development and decreasing piglet mortality. | ||||||
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