序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
121 CELL STORAGE METHOD AND USE THEREOF FOR CELL TRANSPORT EP09821833.2 2009-10-23 EP2345714B1 2018-09-12 ITCHODA, Yoko; TAZAKI, Go; FUKUDA, Motohiro; TSURUTA, Hitoshi; TANIGUCHI, Hideki
To provide a cell storage method to store living cells while maintaining the functions of the living cells. An aspect of the cell storage method is a method to store living cells (40) by using a cell culture chamber (20) including a plurality of the microchambers (11), the method including: culturing the living cells by being adhered to the surfaces of a plurality of micro spaces; and after the culturing, pouring the culture medium (50) into the cell culture chamber (20) so as to cover the plurality of microchambers (11), and storing the living cells. The living cells are adhered to a cell culture chamber of an appropriate size and cultured to form a three-dimensional structure. This enables maintaining the three-dimensional structure of the living cells and storage of the living cells while maintaining the functions thereof.
122 MANUFACTURING ARTICLE EP15792577 2015-05-15 EP3143120A4 2018-02-28 SNYDER MITCHELL L; ZOELLNER CLEMENS E; NIXON THOMAS R
A manufacturing article adapted for use in the production of pharmaceuticals comprising a tray comprising a base having a top surface; and a manifold extending from the top surface of the base, the manifold comprising a sidewall and an upper surface, the upper surface further comprising a channel, wherein, when viewed from the top surface, the base has an area, AB, the upper surface of the manifold has an area AM, and AB>AM, and wherein the base is adapted to support a plurality of vessels each adapted to contain a fluid.
123 HEPATOCYTE CULTURE DEVICE CAPABLE OF ENHANCING ACCUMULATION AND EXCRETION OF HEPATIC METABOLITE IN AND INTO BILE CANALICULUS-LIKE STRUCTURE, AND METHOD FOR EVALUATING CANDIDATE COMPOUND SENSITIVE TO EXCRETION INTO BILE OR BLOOD AND HEPATIC METABOLITE OF SAID CANDIDATE COMPOUND USING SAID HEPATOCYTE CULTURE DEVICE EP16772300.6 2016-03-16 EP3275994A1 2018-01-31 TAKEZAWA, Toshiaki

The present invention is a hepatocyte culture device enhancing accumulation and excretion of a hepatic metabolite in and into a bile canaliculus-like structure, the device including: a first cell culture containing a plurality of hepatocytes; a portable culture vessel in which the bile canaliculus-like structure can be established between the hepatocytes in the first cell culture, and that has, on an outer surface of the culture vessel, a membrane through which a physiologically active substance can pass; and a second cell culture capable of improving excretion activity of a hepatic metabolite in the first cell culture, in which the first cell culture cultured in the portable culture vessel is disposed on the second cell culture to be co-cultured.

124 FOLIENSYSTEM ZUM BEREITSTELLEN EINES BIOREAKTORS UND ZUGEHÖRIGE FOLIENSYSTEMROLLE SOWIE VERFAHREN ZUM HERSTELLEN EINES BIOREAKTORS, BIOREAKTOR UND BIOREAKTORSYSTEM EP11716462.4 2011-02-14 EP2536816B1 2018-01-10 THOMSEN, Claudia
125 CELL CULTURE CARRIER EP12860052 2012-11-27 EP2796537A4 2015-08-12 YORI KOUICHIROU
A cell culture transferring instrument (10) includes a cylindrical body (12) held by an operator not shown in the drawing, a plunger (14) inserted through the interior of the cylindrical body (12), a plurality of support members (16) connected to a distal end (14a) of the plunger (14), and an adsorbent (20) capable of adsorbing a sheet-shaped cell culture (18) held by the support members (16). The support members (16) in contact with the distal end of the cylindrical body (12) are elastically deformed by displacing the plunger (14) toward the proximal end (14b) side with respect to the cylindrical body (12) in a state in which the sheet-shaped cell culture (18) is adsorbed to the adsorbent (20), whereby the adsorbent (20) and the sheet-shaped cell culture (18) are deformed and housed in a housing hole (22) in the cylindrical body (12).
126 BEHAELTNIS ZUR AUFNAHME VON NAEHRMEDIEN EP14709539.2 2014-01-24 EP2812423A1 2014-12-17 MUELLER, Rolf
The invention relates to a container for accommodating nutrient media (3), in particular a Petri dish, contact plate, or sedimentation plate, for cultivating microorganisms, cell cultures, bacteria, etc. comprising a main body (1), which has a peripheral wall (4), and a bottom plate (2), and a base surface (1) which has a peripheral wall. The main body (1) and the bottom plate (2) form a dish. The dish is used for filling with nutrient solution, for storage, and for transport. The main body (1) is placed or inserted into the peripheral wall of the bottom plate (6) with at least a slight distance from the base surface of the bottom plate (5). On the side facing away from the bottom plate (2), the main body (1) has a closure, which is attached after the main body (1) has been filled with nutrient medium (3) and closes the main body (1) containing the nutrient medium (3).
127 DEVICE AND METHOD FOR BACTERIAL CULTURE AND ASSAY EP12844273.8 2012-10-29 EP2771456A1 2014-09-03 DERDA, Ratmir; FUNES HUACCA, Maribel Elizabeth; NG, Simon; TJHUNG, Katrina Felicia
The present invention provides a simple culture device that is designed for manufacture and use in areas of limited resources. The device is useful for cell culture in such environments with limited resources because cells grow in paper just as they do in a culture dish. Also provided is a binding assay that employs an activatable dormant bacteriophage carrying a reporter gene to qualitatively or quantitatively detect the presence of a substance of interest in a sample.
128 INKUBATOREINRICHTUNG UND VERFAHREN ZU DEREN BETRIEB EP11711462.9 2011-03-23 EP2550349A2 2013-01-30 RAPOPORT, Daniel; KRUSE, Charli; WENDT, Dennis
A movable incubator facility comprises a culture chamber which is arranged for receiving at least one cell culture, a heating arrangement by means of which the temperature of the culture chamber can be adjusted, a gas feed arrangement by means of which at least one gas can be introduced into the culture chamber, and an energy storage arrangement which is disposed for supplying the heating arrangement and/or the gas feed arrangement with electrical energy.
129 FOLIENSYSTEM ZUM BEREITSTELLEN EINES BIOREAKTORS UND ZUGEHÖRIGE FOLIENSYSTEMROLLE SOWIE VERFAHREN ZUM HERSTELLEN EINES BIOREAKTORS, BIOREAKTOR UND BIOREAKTORSYSTEM EP11716462.4 2011-02-14 EP2536816A1 2012-12-26 THOMSEN, Claudia
Algae are grown under autotrophic and mixotrophic cultivation conditions in photobioreactors and produced in large quantities. Film systems that are in particular flexible are used to produce photobioreactors. Said flexible film systems are delivered in standard sizes that cannot be adapted by users to in situ conditions or are difficult to adapt to said conditions. The solution proposed by the invention to this problem of prior art is a film system that is in particular designed to provide a bioreactor for cultivating photosynthetically active organisms and that consists of a transparent film material. The film system has two opposing inner faces with a separating connection that forms two separate regions and said separating connection is not continuous giving the two separate regions a first unhindered connection.
130 CELL STORAGE METHOD AND CELL TRANSPORT METHOD EP09821833.2 2009-10-23 EP2345714A1 2011-07-20 ITCHODA, Yoko; TAZAKI, Go; FUKUDA, Motohiro; TSURUTA, Hitoshi; TANIGUCHI, Hideki

To provide a cell storage method to store living cells while maintaining the functions of the living cells. An aspect of the cell storage method is a method to store living cells (40) by using a cell culture chamber (20) including a plurality of the microchambers (11), the method including: culturing the living cells by being adhered to the surfaces of a plurality of micro spaces; and after the culturing, pouring the culture medium (50) into the cell culture chamber (20) so as to cover the plurality of microchambers (11), and storing the living cells. The living cells are adhered to a cell culture chamber of an appropriate size and cultured to form a three-dimensional structure. This enables maintaining the three-dimensional structure of the living cells and storage of the living cells while maintaining the functions thereof.

131 INCUBATOR FOR OBSERVATION BY MICROSCOPE EP03791179 2003-03-26 EP1548484A4 2009-08-26 TSUCHIYA HIDEHARU
An incubator capable of observing an observed specimen in a dish (220) by a microscope while cultivating the specimen, wherein light is radiated from a capacitor (C), passed through a hole (273) in a top plate (271), a hole (275a) in an upper side plate (275), and a hole (277a) in a lower side plate (277), and let into an objective lens (T), and the specimen put in the dish (220) is observed by the microscope, whereby the change of the specimen with elapse of time can be continuously observed or recorded on a videotape while cultivating the observed specimen in the dish (220).
132 Portable biotechnology kit EP07380235.7 2007-08-09 EP1890144A3 2008-07-02 Martinez de Pancorbo; Rosique Sola, Melania Julieta; Ramos de Pablo, Rodrigo; Eguskiza Madariaga, Gaizka

Portable biotechnology Kit which object is providing all the necessary material for the performance of laboratory practical lessons in an easy manner and at a low cost which basic structure is a group box containing all the material necessary for carrying out a microbial or molecular biotechnology practical lesson and wherein said group box consist of a flat sheet of cardboard, with folding lines that allow it to be turned into a closed container in which to transport all the material necessary for the practical but which once open, remains unfolded in a flat surface which can be used as a work surface.

133 KLIMAKAMMER FÜR MIKROSKOPE EP04765416.5 2004-09-20 EP1575706A1 2005-09-21 PIRSCH, Matthias; HUMMEL, Stefan
The invention relates to a climatic chamber, which is in particular suitable for chemical and/or biological samples. Said chamber comprises a climatic compartment (26), which is formed by a housing (24). An analysis device (28), such as a microscope is located at least partially inside said climatic compartment (26). In addition, the housing (24) comprises an inlet (38) for supplying a stream (42) of conditioning medium. To prevent condensation forming on condensation-sensitive components (30, 32, 34) the medium stream (42) is positioned in such a way that it flows at least partially onto the analysis device (28) and/or the sample carrier (36).
134 INCUBATOR FOR OBSERVATION BY MICROSCOPE EP03791179.9 2003-03-26 EP1548484A1 2005-06-29 TSUCHIYA, Hideharu

An incubator capable of observing an observed specimen in a dish 220 by a microscope while culturing the specimen, wherein light is radiated from a capacitor(C), passed through a hole 273 in a top plate 271, a hole 275a in a upper side plate 275 and a hole 277a in a lower side plate 277, and let into an objective lens (T), and the specimen put in the dish 220 is observed by the microscope, whereby the change of the specimen with elapse of time can be continuously observed or recorded on a videotape while culturing the observed specimen in the dish 220.

135 PROLIFERATION AND DELIVERY APPARATUS EP03766051.1 2003-07-15 EP1539918A1 2005-06-15 HORN, Charles, Henry
A portable, disposable, unitary microorganism proliferation and delivery apparatus (10) is provided. The apparatus (10) comprises a proliferation chamber (12) for containing a growth medium (14); and an inoculation chamber (16) for containing an inoculum (18). The proliferation and inoculation chambers (12 and 16) are connected by a tube (19) defining a passage (20), which is closed by a separating means in the form of a septum (22). The inoculation chamber (16) is provided or defined by a flexible vial having a mouth (16.1) and the septum (22) closes the mouth. Opening means in the form of a spike (24) is mounted in the passage (20) directed at the septum (22). The mouth (16.1) of the inoculation chamber (16) is connected to one end of the tube (19) by an advancement means in the form of a screw thread connection (26).
136 Device for detection of microorganisms in a sample EP96103336.2 1996-03-04 EP0730026B1 2002-06-12 Benjamin Alspector c/o BATEC Ltd.
137 APPARATUS AND METHOD FOR MAINTAINING AND GROWING BIOLOGICAL CELLS EP96921439.4 1996-06-07 EP0832182B1 2001-08-16 ARMSTRONG, R., Douglas; MALUTA, James; ROECKER, David, W.
An apparatus and related method are disclosed, for receiving, maintaining and growing biological cells ex vivo within a portable cassette, without exposing the cells to the external environment. The portable cassette is used in combination with a processor instrument that facilitates an initial inoculation of the cassette with cells of the kind to be grown and to distribute those cells in a predeterminded pattern (e.g., uniformly) throughout a cell growth chamber. Thereafter, the portable cassette is used in combination with an incubator instrument that incubates the cell growth chamber so that the cells are optimally expanded. The same processor instrument then is used to harvest the expanded cells from the portable cassette. Both instruments are configured to condition the portable cassette during stages of the cell growth process, without disturbing the cassette's sterile system. In addition, an updatable memory device associated with the cassette stores significant information about the cassette and its condition during the various steps of the cell growth process. Such information is useful both for subsequent archival purposes and for facilitating a resumption of the cell growth process in the event of any instrument failure or significant alarm condition.
138 미생물 수송배지 용기 KR1020100069402 2010-07-19 KR1020120008600A 2012-02-01 박승범
PURPOSE: A microorganism transport container is provided to enhance a user's convenience and to improve sample collection efficiency. CONSTITUTION: A microorganism transport container(100) comprises: a collection rod(130) with a collection part(131) at one side; a head cap(110) which is fixed and coupled with the other side of the collection rod; a container(140) having a medium on a part of the collection part; and an anti-contact member(120) for preventing contact of the collection part with the medium. The head cap is coupled with one side of the container.
139 검체수송용기 KR1020100105724 2010-10-28 KR1020100120278A 2010-11-15 염성희
PURPOSE: A specimen container used for transferring and culturing specimen is provided to prevent leakage of reagent and to reduce inconvenience of opeining. CONSTITUTION: A specimen container comprises: a container(10); a specimen bar(20) having at least one penetration-inducing hole(25) inside; a brush or cotton swab(30) containing inside the container; a reagent container(40) having a closing thin film(41) at the lower end; the upper side(51) closing reagent storing space; a pressurizing cover(50) having a cutter(52); and the reagent storing space(53) inside the pressurizing cover.
140 역류방지수단이 구비된 검체수송용기 KR1020080073631 2008-07-28 KR100987952B1 2010-10-18 염한림
본 발명은 역류방지수단이 구비된 검체수송용기에 관한 것으로, 더욱 구체적으로는 시약과 면봉을 각각 하나의 조립체인 커버에 포장 가능하면서도 내부의 역류방지수단에 의해서 시약이 면봉과 격리된 상태에서 저장되게 하여 면봉의 별도 밀봉 포장을 배제할 수 있게 하여 생산성과 검사자의 편의성을 향상시킬 수 있고, 또한 검체 채취 후에 간편한 조작에 의해서 시약이 면봉 측으로 유입되게 하며, 면봉에 유입된 시약이 역류방지수단에 의해서 다시 최초의 저장소인 커버 측으로 역류하지 않게 하여 검사의 정밀도와 신뢰성을 향상시킬 수 있는 검체수송용기를 제공할 목적으로, 연질의 유연성과 탄성이 있는 고무, 실리콘 또는 플라스틱 재료로 되고, 내향 함몰된 요홈(11)이 형성된 커버(10)와, 상단에 결속부(21)가 구비되고 상단이 개방된 본체(20)와, 상기 요홈의 내면과 접하는 실링부(31)가 형성된 밸브(30)와, 상기 커버(10)의 하부에 고정되되, 저부에 상기 본체의 결속부와 착탈 가능한 결합부(41)가 형성되고, 상기 본체 내로 삽입되는 채집부(44)를 포함하는 면봉(43)이 구비되며, 상하를 관통한 적어도 하나의 홀(42)이 구비된 채집기(40)로 구성되어, 상기 밸브가 커버 내의 시약(R)의 누설 또는 역류를 방지하도록 상기 커버(10)의 요홈(11)에 위치되는 검체수송용기가 개시된다.
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