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US11428016B2 |
Floor or wall covering panel with rigid composite core layer
A floor or wall covering panel has a top and a bottom surface, and at least four sides, where a first and a second side include a first and a second connection profile, respectively, the first profile being configured for mechanically engaging and interlocking with the second profile of another panel, the first profile including a tongue protruding beyond the top edge of the first side, where the second profile includes a groove recessed with respect to the top edge of the second side, the groove is delimited at its bottom by a base, the panel is of laminar structure including a rigid core layer and a wear layer arranged on the core layer, where the core layer includes a first and a second sublayer of a first and a second composite material, respectively, the second sublayer being arranged atop the first sublayer, where both composite materials comprise thermoplastic material and filler material but are of different formulations, and the base delimiting the groove bottom is realized essentially within the first core sublayer. |
US11428015B2 |
Modular platform system and method of assembly
A modular platform system includes a plurality of tiles, legs, beams, and brackets. Peripheries of the tiles and top surfaces of the beams are configured so that the tiles can snap on to the beams, allowing for easy creation of a platform. The beams, legs, and brackets are all configured so that the beams and legs are easily connected together for platform system creation. |
US11428013B2 |
Mounting member and building wall structure
Provided are a mounting member and a building wall structure that allow a mounting operation to be performed with ease. A mounting member 10 can be equipped with an abutment member 30. The mounting member 10 includes a substrate portion 11, a wall portion 12, a protruding portion 13, a supporting portion 14, a first locking portion 15, and a second locking portion 16. The wall portion 12 protrudes from one side edge 11A of the substrate portion 11 relative to the substrate portion 11. The protruding portion 13 protrudes from the other side edge 11B side of the substrate portion 11 to the same side as the wall portion 12, and has a length L13 of protrusion from the substrate portion 11 shorter than the length of protrusion of the wall portion 12 from the substrate portion 11. The abutment member 30 includes a mounting portion 31 that can be fixed onto at least one of the substrate portion 11 and substantially the same plane 8P as the substrate portion 11 from the protruding portion 13 side, an erect piece 32 that is provided erecting in a direction intersecting the mounting portion 31, and that protrudes toward the side opposite to the substrate portion 11, and a clamping portion 33 that is formed as a single piece with the mounting portion 31, and that is capable of clamping the protruding portion 13 from a direction intersecting the substrate portion 11. |
US11428006B2 |
Cementitious composite constituent relationships
A cementitious composite includes a first layer, a second layer, and a cementitious mixture disposed between the first layer and the second layer. The cementitious mixture includes (i) cementitious materials and (ii) a viscosity modifier and/or an accelerator. The cementitious materials provide a void fraction between 0.64 and 1.35. The void fraction is defined as the ratio of the volume of the voids within the cementitious mixture per unit area of the cementitious composite to the volume of the cementitious materials per unit area of the cementitious composite. The cementitious mixture is configured to absorb a mass of water that provides a maximum 28 day compressive strength of the cementitious composite. A ratio of the mass of the water relative to the mass of the cementitious materials of the cementitious mixture per unit area of the cementitious composite that provides the maximum 28 day compressive strength of the cementitious composite is between 0.25 and 0.55. |
US11428004B2 |
Omni-directional shape-morphing panel mechanism
A morphing panel mechanism may include a central panel and a side panel, where a first edge of the side panel may be pivotally coupled to a first edge of the central panel. A morphing panel mechanism may further include a guide panel that may be coupled with a first corner of the central panel via a ball joint, where the guide panel may include a first slit. A morphing panel mechanism may further include a flexible panel, where a first edge of the flexible panel may be pivotally coupled with a second edge of the side panel, and a second edge of the flexible panel may be slidably disposed within the slit of the guide panel. |
US11428000B2 |
Means of mounting a main carrier of a ceiling lightweight steel structure
Disclosed is a main carrier mounting mechanism having a ceiling lightweight steel structure, which includes: an upper horizontal portion mounted on a rod hanger; having an upper end integrally coupled to one end of the upper horizontal portion and a lower end extending downward; a lower panel having one end integrally coupled to the lower end of the main standing portion and having an opposite end extending parallel to the upper horizontal portion; and a lower standing portion having a lower end integrally coupled to the opposite end of the lower panel, and an upper end extending toward an opposite end of the upper horizontal portion, and further includes a main carrier separation prevention fastener having one end integrally coupled to the upper end of the lower standing portion and an opposite end extending toward the opposite end of the upper horizontal portion and extending toward the main standing portion. |
US11427997B2 |
Low profile drain
A low profile drain includes a first extrusion channel extending lengthwise in a first direction, a second extrusion channel extending lengthwise in the first direction, and a connection channel extending lengthwise in the first direction. The connection channel is configured to interlock with an end of the first extrusion channel via a first interlocking mechanism, and interlock with an end of the second extrusion channel via a second interlocking mechanism. The first interlocking mechanism includes at least one first angular protrusion disposed on the first extrusion channel, and a first angular recess disposed on the connection channel. The at least one first angular protrusion is configured to interlock with the first angular recess. |
US11427994B2 |
Pressurized toilet
A pressurized tank assembly and method. The pressurized tank assembly may include a first siphon tank, a second siphon tank, an inlet assembly, and a discharge assembly. The first tank and second tank may be arranged vertically within the base of the toilet. The first tank and the second tank may be arranged with endcaps located at the top of each tank. The first tank and the second tank may include siphon tubes to assist in delivering fluid flow from the inlet assembly to the discharge assembly. |
US11427992B2 |
System for monitoring backflow preventer condition
A backflow preventer including a body having an inlet for connection to an upstream portion of a plumbing system and an outlet for connection to a downstream portion of the plumbing system, a first check valve and a second check valve located in the body for preventing the reverse flow of water between the outlet and the inlet. An inlet pressure zone is positioned between the inlet and the first check valve, an outlet pressure zone is positioned between the outlet and the second check valve, and an intermediate pressure zone is positioned between the first and the second check valves. Position sensors sense the positions of the check valves, and pressure sensors sense the pressures in the zone. A controller in communication with the position sensors and the pressure sensors calculates the opening and closing pressures of the check valves. |
US11427988B2 |
Display control device and display control method
A captured image acquisition unit acquires an image captured by an imaging device provided at a place of a work machine where a bucket is included in an imaging range. A posture acquisition unit acquires posture information of the bucket. A topography acquisition unit acquires topographical information indicating a three-dimensional shape of a construction target of the work machine. A projected image generation unit generates, based on the posture information of the bucket and the topographical information, a projected image obtained by projecting teeth of the bucket on the construction target. A display control unit outputs a display signal for displaying by superimposing the projected image on a place where at least the bucket appears, in the captured image. |
US11427987B2 |
Hydraulic system for a fall-back support and work machine
A hydraulic system for operating a hydraulic fall-back support of a work machine including at least one hydraulic fall-back support cylinder for tracking and limiting movements of a boom of the work machine and a hydraulic pump by means of which the fall-back support cylinder and at least one further hydraulic consumer can be supplied with hydraulic fluid. A stop valve having a blocking position and a passage position is connected between the hydraulic pump and the fall-back support cylinder, by means of which the stop valve and a load-bearing cylinder space of the fall-back support cylinder is blockable and a hydraulic store connected to the load-bearing cylinder space is provided between the stop valve and the fall-back support cylinder. |
US11427983B2 |
Below grade, blind side, improved dual waterproofing membrane assembly incorporating a sheet membrane with adhesive to fully bond to concrete/shotcrete, and a method of making, and using same
The present invention relates generally to an improved below grade, blind side, dual waterproofing membrane assembly incorporating a sheet membrane with adhesive to fully bond to concrete/shotcrete, and a method of making and using same. More particularly, the invention encompasses a dual membrane system that acts as a barrier, and prevents, and blocks water and moisture, from passing from one side of the structure to the other side. The innovative barrier layer system can be used along a wall, a floor, a ceiling, or along any structure which requires water or moisture proofing. The invention can be most effectively used between a concrete or shotcrete layer and the surrounding earth, such as, along an area that has a high water table or ground moisture or hydrostatic pressure that may creep into a foundation or a wall. The inventive system comprises two different waterproofing layers, and materials. |
US11427978B2 |
Snow plow and mount assembly
A snow plow and mount assembly has a mount frame, an A-frame, a lift frame, a plow blade, an actuator, arms, receivers, recesses, hitch pins, a latch mechanism, and a latch lever. The elements are arranged such that the vehicle is driven toward the snow plow so that the arms are received in the receivers, the actuator is energized to pivot the lift frame relative to the A-frame so that the hitch pins are received in the recesses, and the lever is moved to move the latch mechanism to the latched position. The snow plow frame is thereby removably secured to the mount frame. |
US11427971B2 |
Aragonite based ground covering
Compositions and methods in which aragonite, and especially oolitic aragonite particles are used as infill material in an artificial turf structure or as sub-growth substrate for natural grass. Advantageously, oolitic aragonite particles provide: a superior microporous surface for effective water saturation to impart thermal control and environmental compatibility; ammonia neutralization of urine by reducing urea hydrolysis with the free calcium presented in the aragonite particles; and aragonite particle uniformity allowing for reduced compaction and desirable water draining. |
US11427962B2 |
Paper comprising microfilaments
Paper with a grammage of 10-100 g/m2 including at least 20 wt. % of microfilaments and at least 20 wt. % of a non-resinous binder, the microfilaments having an average filament length in the range of 2-25 mm and titer less than 1.3 dtex, the non-resinous binder comprising at least one of fibril or pulp. The paper shows high strength and other attractive properties. |
US11427961B2 |
Unitary deflection member for making fibrous structures having increased surface area and process for making same
A unitary deflection member. The unitary deflection member can have a fluid pervious reinforcing member and a patterned framework. The patterned framework can have a plurality of regularly spaced protuberances extending from the reinforcing member. At least two of said protuberances can be similar in size and shape, and each protuberance can have a transition portion having a transition portion width and a forming portion having a forming portion width. The transition portion width can be less than the forming portion width. |
US11427959B2 |
Rubber-reinforcing cord and rubber product using same
A rubber-reinforcing cord (10) includes a first fiber strand (11) and a plurality of second fiber strands (12) disposed around the first fiber strand (11). The second fiber strand (12) has a tensile elastic modulus higher by 20 GPa or more than that of the first fiber strand (11). |
US11427956B2 |
Fabric steamer apparatus
A handheld appliance delivers heat and steam to a clothing garment or fabric. The appliance has a housing that contains a removable water reservoir, a pump, a control board, and a steam generator. The steam generator has a steam outlet that is a single nozzle connected to one of a plurality of output heads are interchangeably connected. Each output head has a steam outlet of different configurations to selectively vary one or more of steam emission pressure, steam emission distance and steam emission area. One or more output heads include physical components for direct contact with the garment or fabric. |
US11427955B2 |
Method, device and system of controlling clothing treating courses according to clothing materials
The present disclosure discloses a clothing course control system including a clothing treating course controller according to a clothing material and a server. The clothing treating course controller includes a hanger, a motor configured to vibrate the hanger, a motor current sensor configured to sense a motor current pattern, a clothing material classifier configured to classify a clothing material based on the motor current pattern, and a course controller configured to execute a clothing treating course according to the classified clothing material, the server includes an artificial intelligence model learner configured to generate a clothing material classifying engine trained with data related to the received motor current pattern through an artificial neural network. According to the present disclosure, a clothing treating course of a clothing treating device may be controlled using an artificial intelligence (AI) based clothing material classifying technique and a 5G network. |
US11427952B2 |
Laundry treating apparatus
A laundry treating apparatus may include a main body having a laundry inlet port disposed at a front surface thereof and configured to receive laundry through the laundry inlet port, and a door rotatably coupled to a front surface of the main body to open and close the laundry inlet port. The door may include an outer frame provided with an opening and facing an outside of the main body; a front glass coupled to a front surface of the outer frame to cover the opening; an inner frame coupled to a rear surface of the outer frame and facing an inside of the main body; and a plurality of hooks that extends from each of the outer frame and the inner frame to fasten the outer frame and the inner frame, thereby enhancing a fastening force between the outer frame and the inner frame. |
US11427951B2 |
Wall mounted washing machine
A wall mounted washing machine includes a cabinet having a front surface and a rear surface to be opened to form an appearance; a tub disposed in the cabinet to store wash water; a front panel installed in the tub; a drum rotatably installed in the tub: a cover installed in the front panel and having a door hinge; a door rotatably coupled to the door hinge and having a door glass; and a door opening and closing device having an electronic opening and closing type adapted for locking or unlocking the door to/from the door. The door hinge adapted for rotatably supporting the door based on the cover to open and close the laundry inlet of the cover and includes a cable guide tunnel which forms a path through which a cable extending from the inside of the door into the cabinet. |
US11427949B2 |
Washing machine
A washing machine includes a cabinet; a tub disposed in the inside of the cabinet; at least one suspension apparatus configured to reduce vibrations of the tub, and to connect the tub to the cabinet such that the tub is supported on the cabinet; and a position guide apparatus having one end connected to the at least one suspension apparatus, and the other end connected to the tub, and configured to limit a movement range in horizontal direction of the tub. |
US11427948B2 |
Sealing valve installation structure and cleaning-free washing machine
A support plate mounted on the inner side wall of an inner drum has a through hole corresponding to drain openings formed in the wall of the drum, and a gap between the support plate and the side wall of the inner drum forms a space for valve plugs of sealing valves to move up and down; a mounting sleeve installed on the upper side of the support plate has an inner through hole coaxially arranged with the through hole in the support plate, so that the valve plugs of the sealing valves are coaxially installed in the inner through hole and can move up and down. A drain opening formed in the side wall of the inner drum is provided with a sealing valve installed on the inner drum via the sealing valve structure. |
US11427945B2 |
Arrangement comprising a visible seam and a lighting apparatus, use thereof, and method for producing the arrangement
The invention relates to an arrangement comprising a visible seam, which is arranged in a sheet material part. The arrangement also includes a lighting apparatus, which is arranged beneath an underside of the sheet material part. The visible seam has an upper thread and a lower thread. The lower thread extends along the underside of the sheet material part in a direction (R). The upper thread has first thread portions along the upper side of the sheet material part and is guided, at stitch holes formed during the sewing process, through said stitch holes via second thread portions. By means of the lighting apparatus, emitted light passes into the second thread portions, into the stitch holes, and from there into the first thread portions. Some of the light propagates along the first thread portions, starting from an adjacent second thread portion, whereas another portion of the light exits from the first thread portion. In this way, the upper thread of the visible seam is illuminated. |
US11427940B2 |
Methods and systems for triggered on-loom fabric inspection
On-loom fabric inspection system (500) including an imaging device (522) configured to collect images of a weaving area (518) of a loom (502). An image-capture trigger-mechanism (529) triggers the imaging device (522) to capture images at required instants during the weaving cycle. An image processor (524) receives data from the imaging device (522) and further detects irregularities in the data. |
US11427934B2 |
Digital electrospinning array
A method includes applying pressure to a liquid feed of nanofiber material at a first nozzle of an array of nozzles having a first electrode voltage applied to a first electrode within an array of nozzles to form a first enlarged meniscus having a nanofiber attached, applying pressure to the liquid feed at a second nozzle having a second electrode voltage applied to a second electrode and adjacent the first nozzle within the array to form a second enlarged meniscus, increasing the second electrode voltage applied to the second electrode to a voltage level equal to voltage applied to the first electrode when the first and second enlarged menisci meet and form a combined meniscus with the nanofiber attached, decreasing the first electrode voltage to zero, and decreasing pressure on the liquid feed at the first nozzle to separate the first enlarged meniscus at the first nozzle from the second enlarged meniscus at the second nozzle having the nanofiber attached. |
US11427929B2 |
Wafer supporting mechanism, chemical vapor deposition apparatus, and epitaxial wafer manufacturing method
A wafer supporting mechanism including: a wafer supporting table; and a movable part supported by the wafer supporting table, wherein the wafer supporting table includes a wafer supporting portion for transfer that stands up from a first surface opposing a back surface of a wafer to be placed and is provided further toward an inner side than an outer peripheral edge of the wafer to be placed, and the movable part includes a wafer supporting portion for film formation that is positioned further toward an outer peripheral side of the wafer to be placed than the wafer supporting portion for transfer and is relatively movable with respect to the wafer supporting table in a standing direction of the wafer supporting portion for transfer. |
US11427927B2 |
SiC single crystal manufacturing apparatus and structure having container and filler for manufacturing SiC single crystal
A SiC single crystal manufacturing apparatus of the present invention includes a growth container having a growth space in which a SiC single crystal is grown in a first direction and a heat insulating material which covers the growth container and includes a plurality of units, and the plurality of units include a first unit and a second unit having at least a thermal conductivity different from that of the first unit, and the first unit includes a container made of at least one of graphite and a metal carbide and a filler filled into the container in a replaceable manner. |
US11427924B1 |
Apparatus for electro-chemical plating
An electrochemical plating apparatus for depositing a conductive material on a wafer includes a cell chamber. The plating solution is provided from a bottom of the cell chamber into the cell chamber. A plurality of openings passes through a sidewall of the cell chamber. A flow regulator is arranged with each of the plurality of openings configured to regulate an overflow amount of the plating solution flowing out through the each of the plurality of openings. The electrochemical plating apparatus further comprises a controller to control the flow regulator such that overflow amounts of the plating solution flowing out through the plurality of openings are substantially equal to each other. |
US11427920B2 |
Electrolytic processing jig and electrolytic processing method
An electrolytic processing jig configured to perform an electrolytic processing on a processing target substrate by using a processing liquid supplied to the processing target substrate includes a base body having a flat plate shape; and a direct electrode provided on a front surface of the base body and configured to be brought into contact with the processing liquid to apply a voltage between the processing target substrate and the direct electrode. An irregularity pattern is formed on a front surface of the electrolytic processing jig at a processing target substrate side. |
US11427919B2 |
Gallium oxynitride-zinc oxide photoelectrode for solar water splitting
A GaON/ZnO photoelectrode involving a nanoarchitectured photocatalytic material deposited onto a surface of a conducting substrate, and the nanoarchitectured photocatalytic material containing gallium oxynitride nanoparticles interspersed in zinc oxide nanoparticles, as well as methods of preparing the GaON/ZnO photoelectrode. A method of using the GaON/ZnO photoelectrode for solar water electrolysis is also provided. |
US11427918B2 |
Electrochemical and photoelectrochemical reduction of furfurals
Electrochemical cells and photoelectrochemical cells for the reduction of furfurals are provided. Also provided are methods of using the cells to carry out the reduction reactions. Using the cells and methods, furfurals can be converted into furan alcohols or linear ketones. |
US11427915B2 |
Method for metallising a porous structure made of carbon material
Method for metallising a porous structure made of carbon material, the method comprising the following steps: supplying a porous structure made of carbon material, immersing the porous structure in a solution comprising an ionic liquid, formed by a cation and an anion, and a metal precursor, placing the porous structure in a vacuum, immersed in the solution, in such a way as to cause the solution to penetrate into the porosity of the porous structure, adding a hydrogenated reducing agent, in such a way as to metallise the porous structure to within the porosity of the porous structure. |
US11427909B2 |
Plasma processing apparatus
In a plasma processing apparatus for generating a plasma in a processing space of a processing chamber and performing plasma processing on a target object, the apparatus includes an antenna configured to radiate a microwave for plasma generation into the processing chamber through a ceiling plate. The plasma processing apparatus further includes a pressing mechanism provided above the antenna and configured to press the antenna against the ceiling plate by a pressure of fluid supplied thereinto. |
US11427908B2 |
Manifold valve for multiple precursors
Various embodiments include an apparatus to supply precursor gases to a processing tool. In various examples, the apparatus includes a point-of-use (POU) valve manifold that includes a manifold body to couple to a processing chamber of the processing tool. The manifold body has a multiple precursor-gas outlet ports surrounded by an annulus. A purge-gas outlet port of the manifold body is directed substantially toward interior walls of the annulus. For each of multiple precursor gases, the POU-valve manifold further includes: a first valve coupled to the manifold body and a divert valve coupled to the first valve. The first valve can be coupled to a precursor-gas supply and has a separate precursor-gas flow path internal to the manifold body. The divert valve diverts the precursor gas during a period when the precursor gas is not to be directed into the processing chamber by the first valve. Other examples are disclosed. |
US11427905B2 |
Controlled variable thickness film deposition on a non-flat substrate for high volume manufacturing
A system and method for controllably varying the thickness of film deposition on a spherical or other non-flat substrate during high volume manufacturing is described. A gripping X-Y transfer stage rotates a substrate in-situ in a direction film deposition chamber. The transfer stage is driven at variable speeds to realize a desired distribution of film thickness variation around the surface of the substrate. Spatial variations in disposition thickness can be smoothly and continuously variable or abruptly changed. |
US11427904B2 |
Coating system for internally-cooled component and process therefor
A method of coating includes applying a metallic coating slurry without a filler to a component; draining the metallic coating slurry; drying the metallic coating slurry to drive off the organic binder; and heat treating the component. |
US11427899B2 |
NPR steel material for rock bolt and production method thereof
An NPR steel material for rock bolt and a production method thereof are disclosed. The NPR steel material for rock bolt has a composition, in weight percent, consisting of: C: 0.4-0.7%, Mn: 15-20%, Si: ≤0.1%, Cu: ≤0.03%, Cr: ≤0.01%, Ni: ≤0.02%, S: ≤0.001%, P: ≤0.001%, and the rest being Fe and unavoidable impurity elements. The NPR steel material for rock bolt and the production method thereof effectively solve the problem that rock bolts in the prior art have low tensile strength and low effective elongation. The NPR steel material for rock bolt has a yield strength adjustable in the range of 500-1100 MPa, and an elongation adjustable in the range of 10-80%. |
US11427896B2 |
Soft magnetic alloy ribbon and magnetic device
A soft magnetic alloy thin strip which has high saturation magnetic flux density and low coercivity, which enables a core with high space factor and high saturation magnetic flux density. A soft magnetic alloy thin strip including a main component that has a composition formula (Fe(1−(α+β))X1αX2β)(1−(a+b+c+d+e+f))MaBbPcSidCeSf. In the formula, X1, X2 and M are selected from a specific element group; 0≤a≤0.140, 0.020≤b≤0.200, 0≤c≤0.150, 0≤d≤0.090, 0≤e≤0.030, 0≤f≤0.030, α≥0, β≥0, and 0≤α+β≤0.50; and at least one of a, c and d is larger than 0. The strip has a structure that is composed of an Fe-based nanocrystal; and the surface roughness of a release surface satisfies 0.85≤Rae/Rac≤1.25 (wherein Rac is the average of arithmetic mean roughnesses in the central portion, and Rae is the average in the edge portion). |
US11427890B2 |
Lubricant-compatible copper alloy
A copper alloy having a high corrosion resistance for a wide range of different lubricants, in particular different base oils and a variation of lubricant additives. The property of a low corrosion tendency for different tribological systems is also combined with good mechanical properties, and a high strength in particular. The alloy has a low wear and coefficient of friction. The lubricant-compatible copper alloy is suitable for producing components that come in contact with lubricant and are exposed to friction stresses, such as gear components, for example synchronizer rings. A method for manufacturing such components and a gear having at least one such component is also disclosed. |
US11427886B2 |
Methods for simultaneous leaching and extraction of precious metals
The present application relates to methods for the simultaneous leaching and extraction of precious metals. For example, the present application relates to methods of leaching and extracting gold and/or palladium from a substance comprising gold and/or palladium such as a gold- and/or palladium-containing ore in one step using a compound of Formula I:(I). |
US11427876B2 |
Cell-free nucleic acids for the analysis of the human microbiome and components thereof
Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with an therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like. |
US11427873B2 |
Methods and systems for assessing proliferative potential and resistance to immune checkpoint blockade
A method for characterizing tumor response to immune checkpoint blockade therapy, comprising: (i) obtaining tissue from the tumor; (ii) measuring, using the tissue, expression of one or more cell proliferation gene markers; (iii) determining, based on the measured expression of the one or more cell proliferation gene markers, a proliferation profile of the tumor; (iv) predicting, based on the determined proliferation profile, response of the tumor to immune checkpoint blockade therapy; and (v) determining, by a physician using the predicted response of the tumor to immune checkpoint blockade therapy, a therapy for the tumor. |
US11427864B2 |
Methods and compositions to detect mutations in plasma using exosomal RNA and cell free DNA from non-small cell lung cancer patients
The present invention relates generally to methods and kits for detecting one or more biomarkers, such as an Epidermal Growth Factor Receptor (EGFR) mutation, e.g., T790M mutation, L858R mutation, one or more exon19 insertions and/or one or more exon19 deletions in the EGFR gene, in a biological sample to aid in diagnosis, prognosis, monitoring, or therapy selection for a disease such as, for example, cancer. The methods and kits are useful in aiding in diagnosis, prognosis, monitoring, or therapy selection for lung cancer, e.g., non-small cell lung cancer (NSCLC). |
US11427863B2 |
Compositions and methods for quantifying a nucleic acid sequence in a sample
The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction. |
US11427860B2 |
Identification of selected spectrum antibiotics
Methods are disclosed for identifying antibacterial compounds which inhibit propagation of selected spectrum bacteria, which bacteria use specific tRNA to code for Ala, Met, Ser, or Leu that other bacteria do not use. In one embodiment, the selected spectrum bacteria use GCA to code for Ala, whereas other bacteria use a different codon to code for alanine. The methods involve determining whether putative inhibitors promote or inhibit complex formation between the tRNA and a bacterial ribosome, or between the tRNA and an aminoacyl synthetase. Compounds which promote or inhibit complex formation can disrupt protein production, which bacteria need to propagate. The identified antibacterial compounds can selectively inhibit bacterial propagation. By limiting their effects to the selected spectrum bacteria, these compounds can treat or prevent specific bacterial infections without disrupting the normal bacterial flora, the patients' microbiome, or causing antibacterial resistance. |
US11427851B2 |
Use of a fluidic device
A fluidic device has a culture chamber configured to house a 3D culture matrix comprising a culture of microorganisms. A concentration gradient of a test substance is established over the 3D culture matrix by providing respective fluid flows at different end portions of the culture chamber and comprising different concentrations of the test substance. The response of the microorganisms to the test substance is determined based on the position of a border zone in the 3D culture matrix. |
US11427849B2 |
Culture medium method and device
Culture medium devices and systems are shown and described. In one embodiment, the device comprises a culture medium adapted for test fluid inoculation without the concerns associated with a spreading step. In particular examples, a printed grid on the outer surface of a culture device is visible on the inner surface for colony counting after a test has been developed. The result is a device that allows for detection, identification, and transportation of various microorganisms without preparation or spreading steps, and more particularly to a culture medium in which a test fluid inoculated thereto diffuses rapidly. |
US11427847B2 |
Methods for producing polypeptides in protease-deficient mutants of Trichoderma
The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants. |
US11427832B2 |
Downy mildew resistant cabbage and breeding method therefor
The present application discloses a cabbage having resistance against downy mildew or its progeny. The present application further discloses a method for breeding downy mildew resistant cabbage, including introducing downy mildew resistance from a Brassica oleracea plant having resistance against downy mildew into desired cabbage. One embodiment of the present invention provides a novel cabbage line showing high resistance against downy mildew and having a high commercial value as cabbage, and enables breeding such cabbage. |
US11427830B2 |
U6 polymerase III promoter and methods of use
The disclosure relates to gene expression regulatory sequences, specifically to the promoter of a U6 polymerase III gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, mutated plants, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same. |
US11427828B2 |
Stable Fc binding protein, method for producing said protein, and antibody adsorbent in which said protein is used
The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn α chain and/or a β2 microglobulin region of a human FcRn β chain by another specific amino acid. |
US11427823B2 |
Targeted compositions
The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D). |
US11427820B2 |
Methods and means for efficient skipping of exon 45 in Duchenne muscular dystrophy pre-mRNA
The. invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method. |
US11427818B2 |
S. pyogenes CAS9 mutant genes and polypeptides encoded by same
This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant Cas9 protein is active in a CRISPR/Cas endonuclease system, wherein the CRISPR/Cas endonuclease system displays reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system. The invention also includes isolated nucleic acids encoding mutant Cas9 proteins, ribonucleoprotein complexes and CRSPR/Cas endonuclease systems having mutant Cas9 proteins that display reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system. |
US11427817B2 |
Compositions and methods of improving specificity in genomic engineering using RNA-guided endonucleases
Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs. |
US11427815B2 |
Nucleic acid purification system using a single wash and elution buffer solution
A simplified method of obtaining purified nucleic acids uses a single buffer solution to both wash and elute nucleic acids bound to a binding phase. Use of a single buffer solution avoids the time-consuming aspect of using different wash and elution buffer solutions during multiple nucleic acid purification steps. The method for purifying nucleic acids using a single buffer solution includes steps of: exposing a sample comprising nucleic acids to a nucleic acid binding phase, where the nucleic acid binding phase may include magnetic particles, silica particles, or a mixture thereof; and allowing the nucleic acids to bind to the nucleic acid binding phase; washing the nucleic acids bound to the nucleic acid binding phase at least once with the single buffer solution at room temperature; and eluting the nucleic acids from the nucleic acid binding phase with ≤50 μl of the single buffer solution, at a temperature of ≥40° Celsius. |
US11427814B2 |
Modified cleavases, uses thereof and related kits
Provided herein are modified cleavases for removing amino acids from peptides, polypeptides, and proteins. Also provided are methods of using the modified cleavases for treating polypeptides, and kits comprising the modified cleavase. In some embodiments, the methods and the kits also include other components for macromolecule sequencing and/or analysis. |
US11427808B2 |
Method for serum-free culture of chondrocytes and serum-free culture medium
To provide a method for serum-free culture of human cartilage cells and a serum-free culture medium. A method for serum-free culture of cartilage cells, said method comprising: an enzymatic treatment step for treating a human cartilage cell-containing tissue with a protease; an inhibitor-treatment step for, after the enzymatic treatment step, treating the tissue with an inhibitor for the aforesaid protease; and a culture step for, after the inhibitor-treatment step, culturing the tissue in a serum-free culture medium that contains kartogenin and/or SAG, ITS, FGF2 and hydrocortisone. A serum-free culture medium for culturing cartilage cells, said serum-free culture medium containing kartogenin and/or SAG, ITS, FGF2 and hydrocortisone. |
US11427807B2 |
Serum-free medium containing PDGF for DS cells
The present disclosure relates to a serum-free medium for culturing of DS cells containing platelet derived growth factor (PDGF), or to a method for culturing of dermal sheath (DS) cells, using serum-free medium comprising PDGF. |
US11427802B2 |
Method and apparatus for printing biological tissues and organs
The invention relates to medicine and biology, particularly to the means for artificial manufacturing of biological tissues and organs, and can be used in biotechnology, bioengineering, tissue engineering, regenerative medicine, and in the 3D-printing of biological tissues and organs.Technical character of the invention consists in the development of a method of printing living tissues and organs as well as of the apparatus for its implementation. The proposed apparatus consists of at least: a printing platform, a bioink printing module with at least one nozzle designed for bioink dosing, a gel-forming composition printing module, containing a UV-module, and at least one nozzle capable of dosing gel-forming composition that starts polymerizing under the influence of UV radiation, a module for relatively displacing the nozzles and/or the platform, and in which the bioink printing module is separated from the gel-forming-composition printing module in such a way so as to prevent UV radiation from reaching the bioink printing module, the radiation from the UV module being directed predominantly parallel to the platform for printing, in such a way so as to prevent UV radiation from reaching the biological tissues and/or organs being printed.The technical result of the invention is the development of a multi-functional device capable of combining various printing modes, providing a method of high-resolution printing of living tissues and organs based on UV-induced hydrogel polymerization, and a method of cell protection from UV radiation during the printing process. |
US11427801B2 |
Scatter labeled imaging of microvasculature in excised tissue (SLIME)
The present disclosure relates to a simple, fast, and low cost method for 3D microvascular imaging, termed “scatter labeled imaging of microvasculature in excised tissue” (SLIME). The method can include perfusing a contrast agent through vasculature of a tissue sample with a contrast perfusing unit (22). The contrast agent can include colloids and a dispersant. After the contrast agent is perfused through the vasculature, the vasculature of the tissue sample can be treated with a cross-linking agent delivery unit (24) providing a molecule that cross links with at least a portion of the dispersant to form a sticky, non-Newtonian polymer that prevents leakage of the contrast agent out of the vasculature of the tissue sample. The tissue sample can then be immersed in a solution comprising a clearing agent with an optical clearing unit (26) and subsequently imaged. |
US11427799B2 |
Method for enriching protists with lipids rich in polyunsaturated fatty acids
The invention relates to a method for enriching protists with lipids rich in polyunsaturated fatty acids (PUFA) in particular of the omega 3 (ω3) class, said method comprising the culture of protists in a culture medium comprising a selenium-containing compound as well as the protists enriched with lipids rich in PUFA obtained by this method.The invention also relates to a method for producing lipids rich in PUFA, comprising, after the enrichment method according to the invention, a method for treating the protists by extraction from the biomass of selenium-containing lipids rich in PUFA.The invention finally relates to any food, cosmetic or pharmaceutical product comprising either selenium-containing lipids thus extracted, or selenium-containing biomass originating from the enrichment method. |
US11427798B2 |
Microfluidic tissue dissociation device and method
A tissue dissociation device includes an inlet coupled to a first stage having a single channel having an upstream end and a downstream end; a plurality of serially arranged intermediate stages, wherein a first intermediate stage of the plurality is fluidically coupled to the downstream end of the first stage, and wherein each subsequent intermediate stage of the plurality has an increasing number of channels (with channels of smaller dimensions); and an outlet coupled to a last stage of the intermediate stages. |
US11427797B2 |
Lung bioreactor
Presented is an airway organ bioreactor apparatus, and methods of use thereof, as well as bioartificial airway organs produced using the methods, and methods of treating subjects using the bioartificial airway organs. The bioreactor comprises: an organ chamber; an ingres line connecting the organ chamber and a reservoir system and comprising an arterial line, a venous line and a tracheal line; an egress line connecting the chamber and the reservoir system, pumps in ingress and egress lines; a controller to control fluid exchange; a chamber pressure sensor connected to the organ chamber. |
US11427794B2 |
Low density unit dose detergents based on butyl cellosolve with encapsulated fragrance
The present disclosure is in the fields of household and industrial cleaning, particularly in applications for cleaning laundry. In one aspect the present disclosure provides liquid unit dose detergent product, having: (a) a container formed from a water-soluble or water-dispensible film material; and (b) a liquid composition having: (i) at least one surfactant; (ii) at least one encapsulated fragrance; and (iii) a solvent system that includes at least one low density organic solvent having a density less than 1.0 g/mL and at least one high density organic solvent having a density greater than 1.0 g/mL; wherein the water-soluble or water-dispensible film material forms a container that entraps the liquid composition. |
US11427789B2 |
Composition comprising a quaternary ammonium compound, a cationic polysaccharide, a nonionic polysaccharide and a fragrance material or perfume
The present invention relates to a composition, in particular, a fabric conditioning composition, comprising at least a quaternary ammonium compound, a cationic polysaccharide, a nonionic polysaccharide and a fragrance material or perfume. In particular, the quaternary ammonium compound is a biodegradable quaternary ammonium compound. The composition has excellent softening performance and improved perfume longevity. |
US11427788B2 |
Composition comprising a quaternary ammonium compound, a cationic polysaccharide and a nonionic polysaccharide
The present invention relates to a composition, in particular, a fabric conditioning composition, comprising at least a quaternary ammonium compound, a cationic polysaccharide and a nonionic polysaccharide. In particular, the quaternary ammonium compound is a biodegradable quaternary ammonium compound. The composition has excellent softening performance and improved perfume longevity. |
US11427787B2 |
Surfactant blend for removal of fatty soils
Alkaline cleaning compositions with a blend of an amine and a nonionic alcohol ethoxylate between about 1:2 to about 1:10, preferably about 1:5 to about 1:10, with an alkalinity source and chelant are provided. The cleaning compositions provide efficacious cleaning of fatty soils to enhance fatty soil removal. Methods of cleaning surfaces using the cleaning composition are also disclosed. |
US11427785B2 |
Detergent composition for textile products
The present invention is a detergent composition for textile products, containing the following component (A) and the following component (B): component (A): an internal olefin sulfonate with 16 or more and 24 or less carbons, wherein a mass ratio between an internal olefin sulfonate (IO-1S) with 16 or more and 24 or less carbons having a sulfonate group present at position 2 or higher and position 4 or lower and an internal olefin sulfonate (IO-2S) with 16 or more and 24 or less carbons having a sulfonate group present at position 5 or higher, which is (IO-2S)/(IO-1S), is 0.30 or more and 5 or less; and component (B): a soil release agent. |
US11427782B2 |
Purification of recycled and renewable organic material
A method is disclosed of purifying a recycled or renewable organic material, wherein the recycled or renewable organic material contains more than 20 ppm Cl. Exemplary methods include (a) providing the recycled or renewable organic material; (b) purifying the organic recycled or renewable organic material to obtain a purified recycled or renewable organic material, and (c) hydrotreating the purified recycled or renewable organic material in a presence of a hydrotreating catalyst at a temperature from 270 to 380° C. under pressure from 4 to 20 MPa and under continuous hydrogen flow; to obtain purified hydrotreated recycled or renewable organic material. |
US11427781B2 |
Products produced from distillers corn oil
Products produced from distillers corn oil include once refined corn oil product, food grade corn oil product, and free fatty acid product which may be used in a variety of applications. The products have varying specifications for free fatty acid content and moisture content. The applications include food, feed, additives, and manufacture of industrial products. |
US11427780B2 |
Total base number boosters for marine diesel engine lubricating compositions
A lubricating composition includes an oil of lubricating viscosity and a low-ash additive system including a low molecular weight amine with a Total Base Number of at least 150, and an N-substituted hydrocarbyl-substituted succinimide dispersant. The low-ash additive system provides the lubricating composition with a significant boost in TBN without substantially lowering the flashpoint. The composition is particularly suited to use as a marine diesel engine lubricant. |
US11427771B2 |
Process and apparats for recovering cracked hydrocarbons
A slurry separator comprising a moving blade that wipes slurry oil onto a wall of the slurry separator for separating a recovered oil stream from a concentrated residue stream has the capability of maximizing recovery of the LCO from slurry oil as well as removing both the catalyst fines as well as coke particles suspended in the slurry oil. The slurry separator can be fed directly from the main column bottoms. Advantageously, the process and apparatus can enable the FCC unit to achieve higher production of LCO and higher value clarified slurry oil more efficiently. |
US11427766B2 |
Deterring aggregation of asphaltenes by resins
Provided herein are methods of inhibiting the aggregation of asphaltenes, as well as methods of identifying appropriate aggregation inhibitors for asphaltenes. |
US11427765B2 |
Systems and methods for preparing and co-processing biocrude oil
The present application generally relates to catalytically preparing liquid fuel products with an improved product mix by co-processing a plurality of reactants in in refinery or field-upgrading operations. The reactants may include, for example, petroleum fraction and a biocrude oil having an alcohol additive. |
US11427764B2 |
FCC catalyst with more than one silica, its preparation and use
Process for the preparation of a catalyst and a catalyst comprising the use of more than one silica source is provided herein. Thus, in one embodiment, the invention provides a particulate FCC catalyst comprising about 5 to about 60 wt % one or more zeolites, about 15 to about 35 wt % quasicrystalline boehmite (QCB), about 0 to about 35 wt % microcrystalline boehmite (MCB), greater than about 0 to about 15 wt % silica from sodium stabilized basic colloidal silica, greater than about 0 to about 30 wt % silica from acidic colloidal silica or polysilicic acid, and the balance clay and the process for making the same. This process results in attrition resistant catalysts with a good accessibility. |
US11427763B2 |
Pyrolysis tube for manufacturing olefin and method for manufacturing dehydrogenating catalyst
The present invention provides a pyrolysis tube for manufacturing olefin which tube can improve a yield of olefin in a pyrolysis reaction of a hydrocarbon raw material. The pyrolysis tube (1A) for manufacturing olefin includes a tubular base material (2) made of a heat resistant metal material and a dehydrogenating catalyst (4A) which is supported on an inner surface of the tubular base material (2). |
US11427757B2 |
Perovskite materials and methods of making the same
The present disclosure relates to a perovskite sheet that includes two outer layers, each including A′X′; and a first layer that includes BX2, where B is a first cation, A′ is a second cation, X is a first anion, X′ is a second anion, and the first BX2 layer is positioned between the two outer layers. |
US11427754B2 |
Photochromic polyurethane laminate
Photochromic polyurethane laminates and methods for the formation of same wherein the photochromic polyurethane layer of the laminate has been crosslinked with a isocyanate-active prepolymer using a crosslinking agent. The crosslinking agent is formulated to have at least three functional groups that are reactive with functional groups of the polyurethane or of the isocyanate-active prepolymer. |
US11427751B2 |
Flow control in subterranean wells
A flow conveyed plugging device for use in a well, the device can include a body, and one or more lines extending outwardly from the body, each of the lines having a lateral dimension that is substantially smaller than a size of the body. A method of plugging an opening in a well can include deploying at least one flow conveyed plugging device into the well, the flow conveyed plugging device including a body and, extending outwardly from the body, at least one of the group consisting of: a) one or more fibers and b) one or more lines, the flow conveyed plugging device being conveyed by flow in the well into sealing engagement with the opening. Another flow conveyed plugging device can include a body, and fibers extending outwardly from the body. The flow conveyed plugging device degrades and thereby permits flow through an opening in the well. |
US11427747B2 |
Sequenced polymers for monitoring the filtrate
The present invention relates to the use of a sequenced polymer as an agent for monitoring the filtrate in a fluid injected under pressure into an oil rock, wherein the fluid comprises solid particles and/or is brought into contact with solid particles within the oil rock after being injected, the polymer comprising at least three blocks, including: at least one first block which is adsorbed, preferably irreversibly, onto at least some of the particles (p); a second block (B) having a composition other than that of the first and a mean molecular weight of more than 10,000 g/mol, and which is soluble in the fluid (F); and at least one third block of type (A) or type (B). |
US11427742B2 |
Fluorescent dye loaded polymeric taggants for depth determination in drilling wells
A method of surface logging a well includes adding each of multiple polymeric taggants to a circulating drilling fluid in an addition sequence while drilling the well. Each polymeric taggant includes a polymer and a respective fluorescent dye having an emission wavelength or excitation wavelength different from that of each other fluorescent dye. The method includes taking a sample of drill cuttings carried by a drilling fluid while drilling a well, wherein the sample of drill cuttings includes polymeric taggants attached to the drill cuttings. The method includes extracting the dyes from the sample of drill cuttings into an extract solution; determining an indication of the type of and the concentration of each of the dyes in the extract solution; and determining a depth associated with the sample of drill cuttings based on the indication of the concentration of each of the dyes and on the addition sequence. |
US11427741B2 |
Cryogenic, kinetically active formulations and systems for their dispensing
A cryogenic, kinetically active formulation in a pressurized package; the package; and a method of making the formulation and the package. |
US11427739B2 |
Optically clear pressure sensitive adhesives and uses thereof
Optically clear adhesives (OCA) with UV blocking below 380 nm are described. The OCA comprise a UV blocking package of UV absorbers and hindered amine light stabilizers. The UV blocking package is suitable for a variety of OCA, including PIB-based OCA, styrenic block copolymer-based OCA, silicone-based OCA, or acrylic-based OCA. The OCA with UV blocking in the invention are particularly suitable as laminating films, tapes or encapsulants for adhering display electronic devices, e.g., LCD displays, LED displays, flexible and foldable displays, and touch screens. |
US11427730B2 |
Dispersion liquid of silica particles and production method therefor
Provided is a dispersion liquid of silica particles, comprising silica particles having an average particle diameter of 5 to 300 nm determined from an electron micrograph and a density of 1.20 g/cm3 or more determined from a specific surface area determined by a BET method using nitrogen adsorption, wherein the dispersion liquid has a pH of less than 8, a silica concentration of 12 to 40% by mass, and a viscosity in terms of a silica concentration of 20% by mass of 40 mPa·s or less. When this silica particle is used as an abrasive, it is possible to realize a sufficient polishing speed and a smooth polished surface on which occurrence of scratches is suppressed. |
US11427728B2 |
Method for producing aqueous dispersions
The present invention relates to a process for preparing an aqueous dispersion of polymer particles by radical aqueous emulsion polymerization and also to the use thereof in paints, paper coatings, foams, crop protection compositions, cosmetic compositions, liquid inks, or thermoplastic molding compounds. |
US11427725B2 |
Photoluminescent material sets
The present disclosure is drawn to material sets for 3-dimensional printing, 3-dimensional printing systems, and 3-dimensional printed parts. A material set can include a thermoplastic polymer powder having an average particle size from 20 μm to 100 μm, a photoluminescent ink including a photoluminescent agent, and a fusing ink. The fusing ink can include a fusing agent capable of absorbing electromagnetic radiation to produce heat. |
US11427724B2 |
Pigment printing ink jet ink composition and pigment printing ink jet recording method
A pigment printing ink jet ink composition includes a pigment, a resin particle, an organic solvent, and water. The organic solvent includes an amide compound represented by the following general formula (1). In the general formula (1), R1 represents a straight chain or branched alkyl group having 1 to 6 carbon atoms, and R2 and R3 each independently present hydrogen atoms or a straight chain or branched alkyl group having 1 to 4 carbon atoms. |
US11427717B2 |
Methods and compositions for direct print having improved recyclability
The disclosure relates to ink compositions for digital printing on an external surface of a plastic article. The ink compositions comprise an ink removal-promoting additive. In some aspects, the ink removal-promoting additive can facilitate the separation or loosening of the image from the external surface of the article when the image is exposed to a liquid-based solution at an elevated temperature. Also disclosed are recyclable plastic articles having an external surface with an image printed thereon using the disclosed ink composition and methods for removing cured ink from a plastic container. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
US11427716B2 |
Highly structured composite material and process for the manufacture of protective coatings for corroding substrates
A highly structured composite material, which can be applied and cured as a protective layer on corroding metal substrates, particularly on steel is provided. Due to its highly structured composition it is a particularly effective barrier to protect metals against attack by corrosive substances such as hydrogen sulfide, carbon dioxide and sea water, if necessary under hydrothermal conditions. At the same time it is also abrasion stable, for example against a grinding effect by sand, as well as resistant to the impact of mechanical load e.g. by tools. This is achieved by a coating composition comprising a binder comprising at least one cross-linkable resin, wherein the resin comprises at least one of polar group; at least one type of hydrophilic flakes with an aspect ratio of more than 10, wherein the surface of the flakes at least partially comprises a metal oxide; and an organic solvent. |
US11427715B2 |
Coating material for gas barrier, gas barrier film, and laminated body
A coating material for a gas barrier includes polycarboxylic acid, a polyamine compound, a polyvalent metal compound, and a base, in which (molar number of —COO— groups included in the polycarboxylic acid)/(molar number of amino groups included in the polyamine compound)=100/20 to 100/90. |
US11427713B2 |
Fingerprint detection powder
ABSTRACT A fingerprint detection powder that is capable of collecting a clear fingerprint image even from a sample with a smaller amount of fingerprint constituents adhered thereto and a sample with a smooth glassy surface. The fingerprint detection powder contains pigment particles and calcium lactate. The pigment particles preferably contain at least one selected from titanium oxide, aluminum oxide, zinc oxide, zirconium oxide, colcothar, yellow iron oxide, black iron oxide, silica, carbon black, aluminum powder, and copper powder. The surface of the pigment particles is preferably covered with the calcium lactate. The fingerprint detection powder further contains a silane coupling agent. Preferably, the silane coupling agent is n-octyltriethoxysilane. The surface of the pigment particles is preferably covered with the n-octyltriethoxysilane as well as the calcium lactate. |
US11427712B2 |
Thin aluminum pigments having a narrow thickness distribution, method for producing same, and use of aluminum pigments
The invention relates to aluminum pigments which are at least partially coated with lubricant, wherein the aluminum pigments have a relative breadth of thickness distribution Δh of from 30% to less than 70%, as determined by a scanning electron microscope thickness count and as calculated on the basis of the corresponding cumulative breakthrough curve of the relative frequencies of occurrence, according to the formula Δh=100×(h90−h10)/h50, and an X-ray diffractogram, measured on pigments in substantially plane-parallel orientation, having one or two main peaks which do not correspond to the [111] reflexes.The invention further relates to a method for the production of said aluminum pigments and to uses thereof and also to nail varnishes and printing inks containing said aluminum pigments of the invention. |
US11427711B2 |
Liquid sealant with thermally adaptive properties
A composition for sealing defects in structural materials such as roads or paved surfaces, the composition preferably comprising one or more shape memory polymer (SMP) components capable of responding to increased temperature by decreasing in volume. |
US11427707B2 |
Curable epoxy resin composition and fiber-reinforced composite material using same
Provided is a resin composition for a fiber-reinforced composite material that has low tackiness when turned into a prepreg, has satisfactory handleability, and can be suppressed in deformation at the time of its release from a mold in a PCM method. The resin composition is a resin composition for a fiber-reinforced composite material including, as essential components: a liquid epoxy resin (A); a novolac-type epoxy resin (B); a polymer component (C) having a molecular weight of 10,000 or more; dicyandiamide (D); and an imidazole-based curing aid (E), wherein the resin composition includes 10 parts by mass to 35 parts by mass of the liquid epoxy resin (A), and 10 parts by mass to 25 parts by mass of the polymer component (C) out of 100 parts by mass of the total of the components (A) to (E), and has a glass transition temperature of 0° C. or more before its curing. |
US11427706B2 |
Platability improver, molded article for plating, pellet composition for plating, plated molded object, and plating method
The platability improver of the present invention comprises heterophasic-polymer particles having a coefficient of variation in particle diameter of 40%-90%. It is preferable that the proportion of polymer particles each having a particle diameter of 0.05 μm or larger be 80% by volume or more with respect to all the heterophasic-polymer particles and the proportion of polymer particles each having a particle diameter of 0.05 μm or larger but smaller than 0.15 μm be 10%-60% by volume with respect to all the heterophasic-polymer particles. |
US11427700B2 |
Method of manufacturing rubber composition
A method of manufacturing a rubber composition is provided. The method includes: (a) allowing a mixture including a conjugated diene-based monomer to react in the presence of a first catalyst; (b) introducing a carboxylic acid-based compound into the product of the step (a) to deactivate the first catalyst; and (c) introducing a second catalyst and a conjugated diene-based monomer into the product of the step (b) and allowing the second catalyst and the conjugated diene-based monomer to react with the product of the step (b). |
US11427692B2 |
Polyimide precursor solution and polyimide film
A polyimide precursor solution contains resin particles and a polyimide precursor. The resin particles in the polyimide precursor solution have a volume particle size distribution with one or more peaks. The volume frequency of a peak having the highest volume frequency of the one or more peaks accounts for 90% to 100% of the total volume frequency of all peaks of the volume particle size distribution. |
US11427688B2 |
Copolyesters plasticized with polymeric plasticizer
Polyester-based films contain certain copolyesters (A) and polyester plasticizers (B). The copolyesters (A) may be selected from those in which the force required to stretch a film of the copolyester (A) by itself, from 2× to 5×, increases by less than 200%. The polyester plasticizers (B) have a weight-average molecular weight of 900 to 12,000 g/mol, and contain (i) a diol component comprising residues of diols having 2 to 8 carbon atoms, and (ii) a diacid component comprising residues of dicarboxylic acids having 4 to 12 carbon atoms. These polyester-based films are particularly useful for preparing ultra-thin LCD or OLED polarizers, because they can be stretched very thin with a high stretch ratio at lower temperatures. |
US11427687B2 |
Noodle comprised of a matrix of discontinuous filaments
A method and apparatus for manufacturing a filler for a composite structure. The apparatus may comprise a filler. The filler may comprise a fiber matrix that is uniform in all directions. The fiber matrix may comprise a first plurality of discontinuous filaments and a second plurality of discontinuous filaments. Each filament of the first plurality of discontinuous filaments may be comprised of a stiffening material. Each filament of the second plurality of discontinuous filaments may be comprised of a binding material. Discontinuous filaments of both the first plurality of discontinuous filaments and the second plurality of discontinuous filaments may be randomly oriented and entangled with each other. |
US11427685B2 |
Method for making silicone hydrogel contact lenses
The invention provides a method for making silicone hydrogel contact lenses. The method of the invention is characterized by using an organic solvent as a processing-aid tool for controlling lens diameter without significantly affecting lens equilibrium water content during cast-molding of soft contact lenses from a polymerizable composition. By adjusting the weight percentage of the organic solvent in a polymerizable composition for making SiHy contact lenses, one can adjust lens diameter of produced SiHy lenses to meet target without affecting adversely the lens properties. |
US11427673B2 |
Alternative crosslinking mechanisms for polyurethane-based systems
The present invention provides compositions comprising the reaction product of an aliphatic diisocyanate, and a reactive intermediate made from one selected from the group consisting of oxazolidinones, benzoic sulfimides (saccharins), 1H-indole-2,3-diones (isatins), succinamides, N-hydroxysuccinamides, 4-hydroxy-3-methoxybenzaldehydes (vanillins), α-ketoamides, piperazines, benzofuranones, 3,4-dihydroxycyclobut-3-ene-1,2-diones (squaric acids), squaric acid esters, α-ketoamides, anilines, and α-ketoamide, phenols. The aliphatic diisocyanate comprises one selected from the group consisting of isocyanurates, biurets, iminooxadiazine diones, urethanes, uretdiones, carbodiimides, and allophanates. The resulting compositions may be useful in producing coatings, adhesives, sealants, castings, composites and films having durability, color stability, high gloss, and chemical resistance properties similar to those made from polyurethane. |
US11427666B2 |
Silicone-containing acrylic polymers for transdermal drug delivery compositions
Described herein are silicone-containing acrylic polymers useful, for example, in transdermal drug delivery compositions, to methods of making and using them, to transdermal drug delivery compositions comprising them, and to methods of making and using such transdermal drug delivery compositions. The polymers are particular suitable for formulating amine drugs, such as amphetamine, methylphenidate, rivastigmine, paroxetine and clonidine. |
US11427659B2 |
Method of preparing acrylonitrile-based polymer for producing carbon fiber
A method of preparing an acrylonitrile-based copolymer for a carbon fiber. The method includes: preparing a reaction solution including a (meth)acrylonitrile-based monomer and a first reaction solvent; adding a first portion of a radical polymerization initiator to the reaction solution to initiate polymerization; and adding a second portion of the radical polymerization initiator to the reaction solution when a polymerization conversion ratio is between 70 to 80%. |
US11427658B2 |
Method for manufacturing low molecular weight acrylic resin
A method for manufacturing a low molecular weight acrylic resin, and more particularly, to a method for manufacturing a low molecular weight acrylic resin having a high conversion rate and a low poly dispersion index includes maintaining the temperature of a reacting part with a screw stirrer at a specific temperature during a continuous polymerization of a solvent-free acrylic composition in a continuous flow reactor having the reacting part. |
US11427656B2 |
Photosensitive composition for hologram recording, hologram recording medium, and hologram
To provide a photosensitive composition for hologram recording that enables further improvement in diffraction characteristic. A photosensitive composition for hologram recording that includes at least two kinds of photopolymerizable monomers, a photopolymerization initiator, a binder resin, and a polymerization inhibitor. The at least two kinds of photopolymerizable monomers are a monofunctional monomer and a polyfunctional monomer. |
US11427644B2 |
Dual antigen-induced bipartite functional complementation
The present invention relates to a set of polypeptides and its uses. In particular, the present invention relates to a set of polypeptides whereby this set comprises two polypeptides each of which comprises a targeting moiety “T” binding to an antigen “Λ” and a fragment of “F” of a functional domain, wherein said two polypeptides are not associated with each other in absence of a substrate that has “A” at (on) its surface and wherein, upon dimerization of “F”, the resulting dimer becomes functional. Furthermore, medical and diagnostic uses of said set are described. Moreover, the present invention relates to nucleic acid molecule(s) encoding said set of polypeptides. The present invention also relates to a vector comprising the nucleotide sequence of nucleic acid molecule(s) encoding said set of polypeptides. Furthermore, the present invention relates to pharmaceutical compositions comprising said set of polypeptides. Moreover, the present invention relates to a kit comprising said set of polypeptides. |
US11427643B2 |
Targeted protein degradation
The invention relates to a method of controlling the level of a polypeptide sequence comprising administering a polypeptide sequence fused to a ubiquitin targeting protein which comprises a minimal degron structural motif. In particular, the polypeptide sequence comprises a chimeric antigen receptor therefore the present invention is useful in methods of cell and gene therapy where the activity of the chimeric antigen receptor needs to be controlled. |
US11427642B2 |
Anti-BCMA heavy chain-only antibodies
Anti-BCMA heavy chain-only antibodies (UniAb) and disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat B-cell disorders characterized by the expression of BCMA. |
US11427631B2 |
Anti-ACTH antibodies and use thereof
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-ACTH antibodies and binding fragments thereof for the diagnosis, assessment, prevention and treatment of diseases and disorders associated with ACTH, such as Cushing's Disease, Cushing's Syndrome, Parkinson's disease, obesity, diabetes, sleep disorders depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimer's disease, galactorrhea, stress related conditions, cardiac conditions, metabolic syndrome, hyperaldosteronism, Conn's syndrome and familial hyperaldosteronism. |
US11427629B2 |
Anti-Tau antibodies and methods of use
The invention provides anti-Tau antibodies and methods of using the same. |
US11427627B2 |
Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles
The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to largescale production of therapeutic molecules containing such variant Fc. Described herein are compositions and methods to improve glycosylation maturation of and to minimize the culture process-dependent effects of Fc-containing molecules, e.g., Fc-fusion molecules and antibodies. Creating single and multiple amino acid substitutions within the Fc domain with the aim to improve high mannose processing and glycosylation maturation. |
US11427625B2 |
Expression of NKG2D activating ligand proteins for sensitizing cancer cells to attack by cytotoxic immune cells
Provided is a recombinant viral vector that expresses a NKG2D activating ligand, such as a UL-16 binding protein. When introduced into a cancer cell, the vector can cause expression of the NKG2D activating ligand, thereby overcoming repression of NK-mediated (or other effector cell, e.g., macrophage) cytotoxicity and causing effector cell-mediated death of the cancer cell. Expression of the NKG2D activating ligand can be controlled by a miRNA present in greater concentration in noncancerous cells than in cancer cells, which can permit selective expression of the ligand in cancer cells and reduced cytotoxicity toward noncancerous cells. The vector can cause expression of an oncolytic factor. When formulated into a pharmaceutical composition and administered to a patient, the vector can be used to treat cancer. The cancer can be a glioma, such as glioblastoma including one with an isocitrate dehydrogenase (IDH) mutation. The vector can be a herpes simplex virus vector, among others. |
US11427624B2 |
T cell receptors
The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease. |
US11427623B1 |
Methods of treatment using mutant FGF-21 peptide conjugates
Therapeutic regimens and uses of mutant Fibroblast Growth Factor-21 (FGF-21) peptide conjugates comprising a polyethylene glycol (PEG) moiety attached to a mutant FGF-21 peptide via a glycosyl moiety thereof in the treatment of nonalcoholic steatohepatitis are provided. |
US11427616B2 |
PCSK9 antagonist compounds
Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions. |
US11427615B2 |
Peptide compound and application thereof, and composition containing peptide compound
Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound represented by formula (1), and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R. Cap-AA1-AA2-XX3-Asn-AA5-AA6-AA7-Leu-AA9-AA10-P (1) |
US11427614B2 |
Peptides and combination thereof for use in the immunotherapy against cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules. |
US11427612B2 |
Epimerization-free N to C solid-phase peptide synthesis
The present disclosure provides a method of solid-phase peptide synthesis from the N terminus to C terminus without detectable epimerization of the C-terminal amino acid. The method includes using derivatized amino acids comprising a diamino-aryl group. |
US11427610B2 |
Cyclic dinucleotides as anticancer agents
The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders. |
US11427608B2 |
Dihydrocarbyl-silyl-bridged-1,3 disubstituted-2-indenyl metallocene complexes for olefin polymerization
The invention relates to a metallocene complex according to formula (A): wherein R1 is selected from C1-C10 alkyl, C6-C20 aryl, C7-C20 aralkyl groups, and C1-C10 alkoxy groups, wherein R2 is selected from H, C1-C10 alkyl; wherein R3-R6, R10 are independently selected from H, C1-C10 alkyl, C6-C10 aryl, and wherein R3 and R4, R4 and R5, or R5 and R6 can be connected to form a ringstructure; wherein M is selected from Ti, Zr and Hf, X is an anionic ligand to M, z is the number of X groups and equals the valence of M minus 2, and wherein each R7 independently is selected from C1-C6 alkyl or aryl groups. The invention also relates to a catalyst comprising the reaction product of the metallocene complex and a cocatalyst. Further the invention relates to a (co)polymerization process of olefinic monomers. |
US11427603B2 |
Protective groups and methods for protecting benzoxaboroles or oxaboroles
The present invention relates in part to protective groups that can be used to reversibly protect benzoxaboroles and/or oxaboroles and yield the corresponding protected complexes. The invention further relates to the use of these protective groups to protect benzoxaboroles and/or oxaboroles. |
US11427602B2 |
Bimetallic nanoparticles with stimuli-responsiveness, process for producing the same, and use thereof
The present disclosure provides a bimetallic nanostructure with stimuli-responsiveness, including: a metal seed; a nanogap including a dopamine-modified stimuli-responsive copolymer attached to only a portion of the metal seed; and a metal shell surrounding the nanogap. The bimetallic nanostructure has a controllable interior nanogap, and may be used as a surface-enhanced Raman scattering (SERS) nanoprobe with improved SERS signals by virtue of the presence of the interior nanogap. |
US11427599B2 |
Simplified procedure for the preparation of darunavir
The present invention relates to an improved process for preparing [(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester—which compound is also known under its INN as darunavir—by reacting carbonic acid 2,5-dioxo-1-pyrrolidinyl [(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]ester with 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-benzenesulfonamide in ethanol as solvent. Furthermore said process allows for darunavir to be isolated immediately in its ethanolate form, i.e. darunavir monoethanolate, which is the marketed form of darunavir under the tradename Prezista™. |
US11427598B2 |
Spiro-cyclic amine derivatives as S1P modulators
The present invention relates spiro-cyclic amine derivatives of the formula (I) wherein R1; R2; R3; Q; —W-T-; R5; Z; and A have the definitions provided in the claims; or a pharmaceutically acceptable salt, a solvate or hydrate thereof or one or more N-oxides thereof. The compounds of the invention have affinity to S1P receptors and may be used in the treatment, alleviation or prevention of diseases and conditions in which (a) S1P receptor(s) is(are) involved. |
US11427594B2 |
Non brain penetrant A2A inhibitors and methods for use in the treatment of cancers
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention further relates to the use of the compounds of Formula (I) as A2A inhibitors. The invention also relates to the use of the compounds of Formula (I) for the treatment and/or prevention of proliferative disorders, including cancers. |
US11427592B2 |
Imidazopyridazine and imidazopyridine compounds and uses thereof
Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer. |
US11427591B2 |
Kinase inhibitors
A DDR1 inhibitor compound can have a structure of Formula A, derivative thereof, prodrug thereof, salt thereof, stereoisomer thereof, tautomer thereof, polymorph thereof, or solvate thereof, or having any chirality at any chiral center, ring A is a ring structure; ring B is a ring structure; the X1, X2, X3, X4, and X5 are each independently a carbon or a hetero atom with or without a substituent; the Y is a linker; and each R1, R2, R3, R5, and R6 is independently a substituent; and each n is an integer, such as from 0 to the maximum number of allowed substituents on the linker or ring, wherein R5 and/or R6 is optionally nothing. |
US11427590B2 |
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer, are provided. |
US11427587B2 |
Organic compounds
The invention relates to particular prodrugs of substituted heterocycle fused gamma-carbolines, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the μ-opioid receptor. |
US11427585B2 |
Spiro-lactam NMDA modulators and methods of using same
Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed. |
US11427582B2 |
Ligands selective to alpha 6 subunit-containing GABAA receptors and their methods of use
Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus. |
US11427578B1 |
Substituted pyrrolopyridine-derivatives
The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I), in which A, X, R1, R2a, R2b, R3a, R3b, R4a and R4b are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control. |
US11427577B2 |
Inhibiting agents for Bruton's tyrosine kinase
Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production. |
US11427567B2 |
Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same. |
US11427553B2 |
Dihydrooxadiazinones
The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients. |
US11427551B2 |
Triazine derivative and photosensitive composition comprising same
The present invention relates to a compound represented by any one of the following formula A to formula C, and a photosensitive composition comprising the same, wherein the structure of the compound represented by any one of formula A to formula C is as described in the detailed description of the invention. |
US11427546B2 |
Form of isoquinoline sulfonamide
A stable crystal of a salt of N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide may have desirable properties for a pharmaceutical drug substance, and more specifically N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide dihydrochloride anhydride. A crystal of the anhydride may have characteristic peaks at 2θ angles of 6.8±0.1°, 10.0±0.1°, 12.7±0.1°, 14.6±0.1°, 14.8±0.1°, 16.2±0.1°, 17.4±0.1°, 17.8±0.1°, 19.5±0.1°, 20.0±0.1°, 21.6±0.1°, 24.7±0.1°, 25.5±0.1°, 25.8±0.1°, 29.8±0.1°, 39.5±0.1°, and/or 44.9±0.1° in powder X-ray diffraction spectrum. |
US11427544B2 |
Histone deacetylase 6 inhibitors and use thereof
Disclosed is hydroxamic acid compounds of Formula (I) set forth herein. Also disclosed are a pharmaceutical composition containing such a compound and a method of using the compound for treating a condition associated with histone deacetylase 6. |
US11427541B2 |
Salt forms of a complement component C5A receptor
Provided herein are salt forms of a complement component 5a receptor having the formula of Compound 1 Also provided herein are pharmaceutical compositions and methods of treatment using the salt forms of Compound 1, described herein. |
US11427540B2 |
Formulations of T-type calcium channel modulators and methods of use thereof
Described herein, in part, are dosage forms and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel. |
US11427539B2 |
Beta-hydroxy heterocyclic amines and their use in the treatment of hyperglycaemia
There is herein provided a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1, ring A, m and n have meanings as provided in the description. |
US11427538B2 |
Organic tellurium compound, method for producing same, living radical polymerization initiator, method for producing vinyl polymer, and vinyl polymer
An organic tellurium compound is disclosed having a versatility that, when used as a living radical polymerization initiator, it is applicable to polymerization of a vinyl monomer in an aqueous vehicle without using any surfactant or dispersant. The organic tellurium compound is represented by a general formula (1), where R1 and R2 each independently represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, A represents an alkali metal atom or an alkaline earth metal atom, x=1 when A is monovalent, x=½ when A is divalent, and R3 is represented by a general formula (2), where in the general formula (2) R4 represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, R5 and R6 each independently represent an alkylene group having 2 to 8 carbon atoms, and a represents an integer from 0 to 10. |
US11427533B2 |
Crystalline polymorphs of bardoxolone methyl
Disclosed are crystalline polymorphs of Bardoxolone methyl, and pharmaceutical compositions thereof. |
US11427530B2 |
Synthesis of 4-chlorokynurenines and intermediates
The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine. |
US11427529B2 |
Compound, core-shell dye, photosensitive resin composition including the same, and color filter
A compound represented by specific chemical formula, a core including the same, and core-shell dye including a shell surrounding the core, a photosensitive resin composition including the same, and a color filter manufactured using the photosensitive resin composition are disclosed. |
US11427525B2 |
Solid-solid separation process for long chain dicarboxylic acids
The present disclosure provides method for isolating a long chain dicarboxylic acid such as a substantially pure or pure long chain dicarboxylic acid from a fermentation broth containing microbial cells. |
US11427524B2 |
Process for dehydrating methanol to dimethyl ether product
A process for dehydrating methanol to dimethyl ether product in the presence of a solid Brønsted acid catalyst which is an aluminosilicate zeolite or a heteropolyacid and a promoter which is (i) a ketone of formula R1COR2 (Formula I) in which R1 and R2 are identical or different and are each a C1-C11 alkyl group and furthermore R1 and R2 together with the carbonyl carbon atom to which they are bonded may form a cyclic ketone; or (ii) a ketal derivative of a ketone of Formula I; and the molar ratio of promoter to methanol is maintained at 0.5 or less. |
US11427523B2 |
Bisphenol composition containing aromatic alcohol sulfonate and method for producing same, polycarbonate resin and method for producing same, and bisphenol production method
A bisphenol composition including a specific amount of aromatic alcohol sulfonate, and a simple method of producing it are provided. Also provided is a method of producing a polycarbonate resin in which, by using the bisphenol composition including a specific amount of aromatic alcohol sulfonate, melt polymerization reaction can be efficiently allowed to proceed to produce a polycarbonate resin having an excellent color tone. A bisphenol composition including an aromatic alcohol sulfonate at not less than 0.1 ppb by mass with respect to a bisphenol. A method of producing a bisphenol composition, including reacting a ketone or an aldehyde with an aromatic alcohol in the presence of sulfuric acid to produce a bisphenol composition. A method of producing a polycarbonate resin, including producing a polycarbonate resin using the bisphenol composition. A polycarbonate resin including a specific amount of aromatic alcohol sulfonate. |
US11427516B2 |
Multistage nanoreactor catalyst and preparation and application thereof
The present disclosure discloses a multistage nanoreactor catalyst and preparation and application thereof, belonging to the technical field of synthesis gas conversion. The catalyst consists of a core of an iron-based Fischer-Tropsch catalyst, a transition layer of a porous oxide or porous carbon material, and a shell layer of a molecular sieve having an aromatization function. The molecular sieve of the shell layer can be further modified by a metal element or a non-metal element, and the outer surface of the molecular sieve is further modified by a silicon-oxygen compound to adjust the acidic site on the outer surface and the aperture of the molecular sieve, thereby inhibiting the formation of heavy aromatic hydrocarbons. According to the disclosure, the shell layer molecular sieve with a transition layer and a shell layer containing or not containing auxiliaries, and with or without surface modification can be prepared by the iron-based Fischer-Tropsch catalyst through multiple steps. The catalyst can be used for direct preparation of aromatic compounds, especially light aromatic compounds, from synthesis gas; the selectivity of light aromatic hydrocarbons in hydrocarbons can be 75% or above, and the content in the liquid phase product is not less than 95%; and the catalyst has good stability and good industrial application prospect. |
US11427510B1 |
Method and article for improving the strength of carbonated calcium hydroxide compacts
The present disclosure discloses a method and an article for improving the strength of carbonated calcium hydroxide compacts. The method includes the following steps: calcium hydroxide-rich materials, ordinary portland cement, magnesium hydroxide, pottery sand and water are mixed according to the mass ratio of 100:15-20:15-20:40-80:10-20, then the mixture was compressed, carbonated and naturally cured to obtain the carbonated compacts. The present disclosure utilizes cement hydration and magnesium hydroxide carbonation to consume the water produced by calcium hydroxide carbonation, the C-S-H gelation effect produced by cement hydration, the cementation effect of magnesium hydroxide carbonation products, the volume expansion effect of magnesium hydroxide carbonation and the gas transmission channel and internal curing effect of pottery sand further improve the carbonation degree, product gelation, thus greatly improving the strength of carbonated calcium hydroxide compacts. |
US11427500B2 |
Radiative cooling device
Provided is a radiative cooling device that provides coloration of the radiative surface while maximally avoiding reduction in its radiative cooling performance due to absorption of solar light. An infrared radiative layer for radiating infrared light from a radiative surface and a light reflective layer disposed on the side opposite to the presence side of the radiative surface of the infrared radiative layer are provided in a mutually stacked state. The light reflective layer is arranged such that a first metal layer made of silver or silver alloy and having a thickness equal to or greater than 10 nm and equal to or less than 100 nm, a transparent dielectric layer and a second metal layer reflecting light transmitted through the first metal layer and the transparent dielectric layer are stacked in this order on the side closer to the infrared radiative layer. The transparent dielectric layer has a thickness that causes a resonance wavelength of the light reflective layer to be a wavelength included in wavelengths equal to or greater than 400 nm and equal to or less than 800 nm. |
US11427499B2 |
Process for depositing a layer
A process for depositing on a surface of a substrate a layer based on a metal oxide doped with magnesium or a mixed metal oxide containing magnesium. The process includes providing a substrate having a surface, forming a gaseous mixture comprising a non-halogenated source of a metal and a source of magnesium, delivering the gaseous mixture to the surface of the substrate, and depositing the layer based on a metal oxide doped with magnesium or a mixed metal oxide containing magnesium on the surface of the substrate. |
US11427498B2 |
Three-dimensional printing of a porous matrix on a container
This disclosure describes container(s) having an ultraviolet (UV)-cured matrix and methods to create the same. For example, a glass container according to this disclosure has a bottom and a body extending in a direction away from the bottom along a longitudinal axis. The body has a surface having an UV-cured matrix including UV-curable varnish drops arranged in a plurality of layers and having voids existing therebetween to form a porous matrix structure. One method to form the glass container is to apply a layer of UV-curable varnish to an outer surface of the glass container as a plurality of varnish drops, so as to establish a plurality of voids between the varnish drops, cure the layer of UV-curable varnish, apply one or more additional layers of UV-curable varnish, and cure the additional layer(s) of UV-curable varnish, wherein all of the varnish drops and the voids form the UV-cured matrix. |
US11427497B2 |
Toughenable glass with high hydrolytic resistance and reduced color tinge
Glasses and glass products suitable for pharmaceutical packaging are provided and methods of making and using such glass and glass products are provided. The glasses combine chemical temperability with very good hydrolytic resistance as well as reduced color tinge. The invention also includes methods for the production of such glasses and their uses. |
US11427494B2 |
Tempering furnace and method for tempering a glass object
A tempering furnace for tempering a glass object may include a housing, a heating device for heating the glass object, and a cooling device for cooling the glass object. Additionally, the tempering furnace may further include a turning device provided for turning the glass object inside the housing. The turning device is configured to counteract an effect of gravitational forces on the glass object when the glass object is heated to its softening phase. |
US11427493B2 |
Method and apparatus for managing glass ribbon cooling
A method and apparatus for manufacturing a glass article includes flowing a glass ribbon through a transition region, heating the glass ribbon with a heating mechanism housed in the transition region, cooling the glass ribbon with a cooling mechanism housed in the transition region, wherein the cooling mechanism extends between the heating mechanism and the glass ribbon, and shielding the glass ribbon with a shielding mechanism that extends between the cooling mechanism and at least one of first and second bead regions of the glass ribbon. |
US11427490B2 |
Water purification replicating a known popular source
A water replicating system comprises a water analyzer for analyzing a target water to determine relative content of selected components. The system further comprises a water treatment apparatus for receiving source water, the water treatment apparatus having a first treatment portion for removing or reducing the relative content of selected components and a second treatment portion for adding components so that the source water will substantially replicate the target water. |
US11427489B2 |
Carrier for retaining anammox bacteria for use in wastewater treatment, anammox bacteria-adhered particle, and wastewater treatment apparatus using the carrier
[Problem] A carrier for retaining anammox bacteria, an anammox bacteria-adhered particle, and a wastewater treatment apparatus are provided that can remarkably reduce the start-up period for obtaining a nitrogen removal speed of 1 kg-N/m3/day.[Solution] A carrier for retaining anammox bacteria includes carbon particles. The carbon particles are desirably graphite particles, particularly isotropic graphite particles. The carbon particles desirably have a zeta potential of −35 mV to 0 mV and an average particle size of 2 μm to 1000 μm. |
US11427486B2 |
Media filter having nonpowered mixing and coagulation basin, and seawater desalination plant and dissolved air floatation apparatus using same
A nonpowered mixing and coagulation basin is provided, which generates turbulences of at least two kinds inside the mixing and coagulation basin to which the raw water flows so that foreign matters contained in the raw water come into contact with each other while circulating by a water flow to be coagulated into a predetermined size, and a dissolved air floatation device using the same. The nonpowered mixing and coagulation basin has multiple stages with different packing materials and packing densities to form turbulent flows inside the raw water and control a flow speed, thereby uniformly mixing raw water and coagulant to enhance coagulation efficiency. The nonpowered mixing and coagulation basin simultaneously carries out mixing and coagulation at the front end part of the water treatment system, reduces equipment expenses by having no electric motor and agitator, and reduces power consumption because it does not use any power unit. |
US11427482B2 |
System and method for monitoring process water treated with a biocide using an oxygen sensor
A system and method for monitoring process water treated with a biocide is provided. The system includes a biocide feeding unit and a dissolved oxygen sensor. The dissolved oxygen sensor works in two modes, a biocide feeding mode and a background mode, and alerts an operator when the dissolved oxygen value indicates a fault in the system. A drop in dissolved oxygen during feeding can indicate faulty production of biocide or biocide degradation, both of which can lead to unwanted disinfection by-products. |
US11427481B2 |
Method for the synthesis of negatively charged manganese feroxyhyte for the selective removal of mercury from water
The present invention refers to the method for synthesis an absorbent material consisting of a phase of tetravalent manganese feroxyhyte (δ-Fe(1-x)MnxOOH) with a negatively charged grain surface in which a percentage of iron has been isomorphically substituted by manganese atoms at 0.05-25%. Its' production is carried out in two continuous flow stirred-tank reactors arranged in serial configuration, where mild acidic conditions (pH 5-6) prevail in the first reactor and mild alkaline conditions (pH 9-10) together with high redox potential (600-700 mV) in the second reactor. The material can be used to uptake mercury, as well as other heavy metals from both water and hot gas streams. Specifically, the adsorption capacity is determined by the magnitude of the negative surface charge and the isoelectric point that can be both adjusted by the synthesis process parameters. |
US11427470B2 |
Aluminum nitride powder containing no coarse particles
An aluminum nitride powder containing a very small amount of coarse particles. An aluminum nitride powder which provides a resin composition having high affinity for resins and high moisture resistance.The aluminum nitride powder has a volume average particle diameter D50 of 0.5 to 7.0 μm in particle size distribution measured with a laser diffraction scattering particle size distribution meter, a D90/D50 ratio of 1.3 to 3.5 and a BET specific surface area of 0.4 to 6.0 m2/g and classified by removing coarse particles whose particle diameter is more than 5 times as large as D90. When resin paste obtained from this aluminum nitride powder and a resin is measured with a grind gauge, the upper limit particle diameter at which a streak is produced is not more than 5 times as large as D90. Since the classified aluminum nitride powder is surface modified, the aluminum nitride powder which has high filling property in a resin and is excellent in the moisture resistance and insulating property of a resin composition is obtained. |
US11427466B2 |
Semiconductor package structure and method for manufacturing the same
A semiconductor package structure includes an electronic device having an exposed region adjacent to a first surface, a dam surrounding the exposed region of the semiconductor die and disposed on the first surface, the dam having a top surface away from the first surface, an encapsulant encapsulating the first surface of the electronic device, exposing the exposed region of the electronic device. A surface of the dam is retracted from a top surface of the encapsulant. A method for manufacturing the semiconductor package structure is also provided. |
US11427465B2 |
Capacitive sensors having temperature stable output
In an embodiment a system includes a sensor including a base having a base electrode and a first membrane suspended above the base, wherein the first membrane has a first membrane electrode, wherein the first membrane is configured to deflect with respect to the base electrode in response to an environmental condition, and wherein the sensor is configured to measure a capacitance between the base electrode and the first membrane electrode. The system further includes a first device of the system configured to generate electrical interference signals, a first electrically conductive shield layer positioned between the sensor and the first device of the system, wherein the first electrically conductive shield layer defines a plurality of first apertures extending through the first electrically conductive shield layer and a dielectric material disposed in the plurality of first apertures. |
US11427464B2 |
Packaged pressure sensor device
Embodiments of a packaged electronic device and method of fabricating such a device are provided, where the packaged electronic device includes: a pressure sensor die having a diaphragm on a front side; an encapsulant material that encapsulates the pressure sensor die, wherein the front side of the pressure sensor die is exposed at a first major surface of the encapsulant material; an interconnect structure formed over the front side of the pressure sensor die and the first major surface of the encapsulant material, wherein an opening through the interconnect structure is generally aligned to the diaphragm; and a cap attached to an outer dielectric layer of the interconnect structure, the cap having a vent hole generally aligned with the opening through the interconnect structure. |
US11427463B2 |
Piezoelectric MEMS device having a suspended diaphragm and manufacturing process thereof
A MEMS device comprising a body, having a first surface and a second surface; a diaphragm cavity in the body extending from the second surface of the body; a deformable portion in the body between the first surface and the diaphragm cavity; and a piezoelectric actuator, extending on the first surface of the body, over the deformable portion. The MEMS device is characterized in that it comprises a recess structure extending in the body and delimiting a stopper portion for the deformable portion. |
US11427462B2 |
Product dispensing system
A system for controlling selection and distribution of a product in a product dispensing system. The system includes a user interface for prompting a selection and selecting the product, a machine control processor in communication with the user interface, a power distribution module connected to the machine control processor, and a power supply unit for supplying power to the system through the power distribution module. |
US11427458B2 |
Re-fillable drinking container for use with a water-dispensing system
The refillable drinking container for use with a water-dispensing system. The refillable drinking container for use with a water-dispensing system stores a fluid that is consumed as a beverage. The refillable drinking container for use with a water-dispensing system measures the stored fluid. The refillable drinking container for use with a water-dispensing system refills the fluid when the volume of the stored fluid falls below a previously determined level. The refillable drinking container for use with a water-dispensing system heats the stored fluid at a previously determined temperature. |
US11427456B2 |
Chilled N2 infused beverage dispensing system and method to prepare and dispense a chilled N2 infused beverage
A system and method to prepare and dispense a N2 or N2/CO2 gas infused chilled beverage is provided. The beverage may be any non-carbonated liquid and in one embodiment the beverage is coffee. The dispensed N2 or N2/CO2 gas infused chilled coffee has a unique appearance and enhanced flavor and aroma. The system may be provided as a self-contained unit. |
US11427452B2 |
Container filling arrangement for filling bottles and similar containers with a beverage and a method of operating the container filling arrangement
In order to perform a cleaning-in-place or CIP cleaning of a filling element of a filling machine for the filling of containers with a liquid filling content, at least one closure element can be used, together with the filling element, to form a flushing chamber, in which a filling valve and a filling-level probe are at least partially disposed for the cleaning-in-place cleaning of the filling element. A control unit controls the flow of cleaning medium into the flushing chamber and the performance of at least one electrical measurement with the filling-level probe during the cleaning-in-place cleaning of the filling element. |
US11427450B2 |
Lift truck having advantageous design elements
Lift trucks designed with a common chassis can include an ergonomically improved operator compartment, wheels, lift assembly, power plant, energy source, steering, seat, and counterweight components. Modular chassis designs can accommodate different form factors and different energy sources to accommodate different end uses of the lift truck, including lift trucks having a low floor, seatside steering, and/or a combination of operator-inaccessible compartments for high-reliability components and operator-accessible components for components that may require more frequent or convenient access. In one embodiment, the energy source is a lithium-ion battery bank in an operator-inaccessible compartment under a low, broad floor that facilitates easy entry into and exit from the operator compartment as well as ergonomic operation by the operator. |
US11427449B2 |
Forklift apparatus, forklift control method, and non-transitory computer-readable medium
A forklift apparatus includes: an error prediction unit configured to predict a first positional error which is a positional error after picking-up between a standard position of a fork and a central position of a pallet on the fork after the pallet is picked up and a first angle error which is an angle error after picking-up with respect to the fork in the pallet; a travel route correction unit configured to correct a travel route from a picking-up position of the pallet to a stacking position of the pallet to offset the first positional error and the first angle error when the pallet is stacked; and a conveyance travel control unit configured to perform travel control such that the pallet is conveyed along the corrected travel route. |
US11427447B2 |
Angulated parking
A parking robot includes a lifting rail, a wheel clamp, and a lift motor. The wheel clamp is disposed on the lifting rail and is moveable from a first position to a second position along the lifting rail. The lift motor is operatively connected to the lifting rail and moves the wheel clamp from the first position to the second position. |
US11427446B2 |
Vehicle crane having a telescoping jib and vehicle crane system and method for mounting a bracing apparatus on the telescoping jib of a vehicle crane
A vehicle crane having a telescoping jib, comprising a basic box with linearly displaceable inner boxes and a lifting cable with a load picking-up device. A fastening region is arranged on the basic box or on a head end of one of the inner boxes, and a bracing apparatus is securable to the fastening region by a connecting end. To simplify rigging/de-rigging of the vehicle crane in relation to the bracing apparatus, the fastening region is formed for mounting the bracing apparatus on the basic box or on one of the inner boxes such that a bracing apparatus that is freely suspended on the lifting cable is coupled to the fastening region with the connecting end being brought close to the fastening region by movements of the vehicle crane, retraction and extension of the inner boxes, raising and lowering of the load picking-up device, and/or luffing of the telescoping jib. |
US11427444B2 |
Cable rotation blocking system
A cable rotation blocking system (CRBS) (300) is described herein. The CRBS extends along an axis X between a first end (305) and a second end (303), and comprises a first section provided at the first end (305), the first section being configured to be connectable to a cable (100). The CRBS further comprises a second section provided at the second end (303), the second section being configured to be attachable to a load. With the CRBS described herein, when no load, or a load up to an upper load threshold is attached to the second section, the second section is rotatable about the axis X, relative to the first section, however, when a load higher than the upper load threshold is attached to the second section, the second section is prevented from rotation about the axis relative to the first section. |
US11427438B2 |
Braking unit for a stairlift
A braking unit (4) for a stairlift, wherein the stairlift comprises a guide rail (2) and a braking carriage (1) slidable on the guide rail (2), the braking carriage (1) comprising the braking unit (4). The braking unit (4) comprises: a safety device (5) which can be moved to a safe condition to engage with the guide rail (2) blocking a sliding of the braking carriage (1); a detection device (6) designed to detect a speed of the braking carriage (1), when the braking carriage (1) slides on the guide rail (2), and is configured to connect to the safety device (5) to cause the movement of the safety device (5) in the safe condition, if the speed of the braking carriage (1) exceeds a predetermined maximum speed. The safety device (5) comprises a safety rotor (501). The detection device (6) comprises: a friction rotor (601), rotating relative to the safety rotor (501) around a first axis of rotation (R1) by the sliding of the braking carriage (1); a variation mechanism (603) acting in conjunction with and coupled to the friction rotor (601) and is configured to connect in a rotationally integral matter the safety rotor (501) with the friction rotor (601) when the speed of the carriage (1) is greater than the predetermined speed. The safety rotor (501) is configured to be rotated around a second axis of rotation (R2), parallel to the first axis of rotation (R1) when the safety rotor (501) and the friction rotor (601) are connected in an integral manner, the safety device (5) also comprising a tapered element (506) fixed to the safety rotor (501) which is configured to be positioned between the friction rotor (601) and the guide rail (2) for locking the safety device (5) in the safe condition and stopping the sliding of the braking carriage (1). |
US11427435B2 |
System and method for maintenance of Shabbat elevators
A method for maintenance of an elevator in Shabbat mode, the method including providing a Shabbat elevator maintenance system, where the system is in communication with the elevator, detecting a malfunction in the elevator by the maintenance system, notifying a technician about the malfunction by the maintenance system, following repair of the elevator by a repairing technician, verifying by the maintenance system that the elevator has been repaired and that Shabbat mode has been reactivated, and activating remuneration for the repairing technician by the maintenance system. |
US11427433B1 |
Portable garden hose stand
An improved apparatus, kit, system, and method for a portable garden hose stand is disclosed and described. In one embodiment, a portable garden hose includes a post and a butler. The post may support a garden hose in a raised position above a ground surface. The butler may be separable from the post for winding the garden hose in a hanging position upon the butler. The butler may include an attachment extending from the butler, the attachment including more than one opening, each of the more than one openings including an upper narrower slot and a lower wider slot. A primary support projection and a secondary support projection may extend from a first side of the post, and the primary support projection and the secondary support projection may mate with the more than one openings to support the butler on the post. |
US11427431B2 |
Method and system for feeding a twisted braided metal cable or flat wire from a corresponding support without altering the structure or shape of the wire
Method and system for feeding a twisted metal cable braided into a plurality of braids or a flat wire from a support or spool to a winder or winding machine, including unwinding the cable or wire from the spool, measuring a property of the cable or wire from among its tension, velocity and quantity, possible adjustment of the property and feeding the cable or wire to the machine with the property constant. The cable or wire is unwound in a controlled way in a direction at right angles to the axis of the spool directly from such spool or through a return member which receives the cable or wire from the spool from which it is unwound in an uncontrolled way, such controlled unwinding preventing the cable changing the structure of its braids through loosening or stretching and the wire undergoes torsion before its property is measured. |
US11427429B2 |
Stacker and medium processing device
A stacker includes a medium stacking portion for receiving and stacking a medium processed and discharged by a processing unit, a medium butting portion for aligning the medium by contacting a leading end of the medium, and a paddle that includes a feeding portion and is for transporting the medium received by the medium stacking portion in a direction toward the medium butting portion by rotating. Furthermore, the stacker has a first mode in which the paddle stops in a state in which the feeding portion does not contact the medium on the medium stacking portion and a second mode in which the paddle stops in a state in which the feeding portion comes into contact with the medium on the medium stacking portion and is deformed. |
US11427420B2 |
Sheet handling apparatus
A sheet handling apparatus includes: a transport path along which a sheet is transported; a first transport member disposed on one side of the transport path; and a second transport member disposed opposed to the first transport member with the transport path interposed therebetween. The first transport member and the second transport member are driven to rotate. The sheet is transported by the first transport member rotating with an outer peripheral surface thereof being in contact with a first face of the sheet, and by the second transport member rotating in a direction opposite to a rotation direction of the first transport member, with an outer peripheral surface thereof being in contact with a second face of the sheet different from the first face. |
US11427419B2 |
Sheet feeder and image forming apparatus including sheet feeder
A sheet feeder includes a frame, a roller holder, and a holder stopper. The roller holder includes a feed roller for feeding a sheet. The roller holder is detachably attachable to the frame. The holder stopper is configured to move between a restricting position and a non-restricting position. In a case where the holder stopper is located at the restricting position, the holder stopper restricts the roller holder from moving from an attached position at which the roller holder is fixed to the frame. In a case where the holder stopper is located at the non-restricting position, the holder stopper allows the roller holder to move relative to the frame. |
US11427415B2 |
Automatic loading and unloading device
An automatic loading and unloading device includes a frame, an unloading unit, a receiving unit and a receiving link unit. The frame defines a processing area, an unloading area and a receiving area. The unloading unit includes an unloading slide rail, and an unloading drive group movably disposed on the unloading slide rail for driving at least one plate to move from the processing area to the unloading area. The receiving unit includes a receiving slide rail, and a receiving lift group movably disposed on the receiving slide rail for driving the at least one plate to move from the unloading area to the receiving area. The receiving link unit interconnects the unloading drive group and the receiving lift group. |
US11427413B2 |
Flotation conveyance apparatus and laser processing apparatus
A flotation conveyance apparatus according to an embodiment is for conveying a substrate while floating the substrate by ejecting a gas to a lower surface of the substrate. The flotation conveyance apparatus includes a plurality of ejecting ports configured to eject the gas to the substrate, a downstream flow-path configured to supply the gas to the plurality of ejecting ports, a upstream flow-path configured to supply the gas to the downstream flow-path, and a gas supply port configured to supply the gas to the downstream flow-path. A cross-sectional area of the upstream flow-path is configured to be larger than a cross-sectional area of the downstream flow-path. |
US11427409B2 |
Apparatus and method for packing heterogeneous objects
Embodiments herein provide automated bin packing of heterogeneous objects to fill maximum number of objects in an available bin space in an efficient manner. Conventional methods are less efficient in packing heterogeneous objects in a space and time efficient manner. The apparatus receives a plurality of 3D objects through a primary conveyor and diverts each of the plurality of 3D objects to an identified cuboidal bin through a corresponding secondary conveyor. Each of the plurality of 3D objects are diverted based on a tracking code associated with each of the plurality of 3D objects and a computed available bin space of the identified cuboidal bin corresponding to each of the plurality of 3D objects. Here the available bin space is computed based on a bin space information received from a corresponding bin vision sensor and a corresponding state space of the identified cuboidal bin. |
US11427403B2 |
High density, robotic warehouse system
High density, robotic warehouse systems and processes may include one or more blocks of a storage system, each block including a plurality of floors, and each floor including a plurality of storage grid locations for respective totes. A plurality of first robotic drive units may transfer barges carrying totes between various processing stations and the storage system. A plurality of second robotic drive units may operate within the storage system and traverse the storage grid locations using a plurality of highway grids and elevators to move totes between barges and storage grid locations. The freely movable robotic drive units, barges, and totes enable high flexibility, modularity, scalability, and serviceability of the high density, robotic warehouse systems. |
US11427397B2 |
Pack for smoking articles provided with two rigid containers inside one another and with a reusable closing tab and method to manufacture the closing tab
A pack for smoking articles having: an inner container housing a group of smoking articles and provided with an extraction opening for the smoking articles; a closing tab coupled to the inner container in the area of the extraction opening to close the extraction opening, the closing tab being glued to the inner container in a releasable manner; a rigid outer container that houses the inner container; and a cup-shaped lid hinged to the outer container so as to rotate, relative to the outer container, between an opening position and a closing position. The closing tab has: a plastic layer arranged internally, a through opening arranged in the area of the extraction opening, and directly glued to an outer surface of the inner container using re-stick glue; and a paper layer arranged in contact with the plastic layer and more on the outside than the plastic layer. |
US11427396B2 |
System, method, and device for foiling hair
A system, method, and device for foiling hair while using a technique similar to balayage. The system uses hair foils with at least one jagged edge, essentially functioning as a stencil for the balayage design technique. As such, the foil may not leave a straight demarcation when color is brushed off the ends of the foil onto the hair underneath from the previous foil layer, allowing the hair artist to employ a foiling process that is a combination of a paneled layering technique and a balayage technique. |
US11427395B2 |
Device for storing and dispensing at least one bulk product
Disclosed is a storage and dispensing device which includes: —a container for at least one bulk product in the form of a rigid or semi-rigid box used to package the bulk product from a production and/or packaging location to a sales point, the container including at least one opening configured to allow the bulk product to flow out of the container, —a dispensing system which has an orifice and a closing unit that is movable between an open state, in which it at least partially frees up the orifice and allows the bulk product to flow, and a closed state, in which it closes off the orifice and prevents the bulk product from flowing, —a slide link ensuring a reversible connection between the container and the dispensing system positioned in line with the opening of the container. |
US11427392B2 |
Packaging for food and beverage
Food packaging and beverage packaging for use in home delivery. The food packaging includes a tray having first walls that define an outer profile of the tray and second walls that are arranged to form partitions. A height of the second walls is different than a height of the first walls. The packaging includes a sealing member and a beverage container having an open end and a sidewall. The sealing member includes a first panel and a second panel and also has a first end, a second end, and first and second sides that extend between the first end and the second end. The first and the second panels are connected one another along the first side, the second side, and the second end of the sealing member. The sealing member is attached to the container by a machine having a rotatable platform and an element for heating the member. |
US11427389B2 |
Compartment for preparation as bottle cap of drinking water
Present invention provides a compartment as bottled beverages cap for a formula of liquid or powder preparation which may be mixed-up easily with beverages inside of another bottle into a liquid composition. The user simply changes bottle beverage cap with a compartment according to present invention, expel the content into bottle with tear-off mechanism thus the content is mixed-up with water inside of bottle, and creates a ready-to-drink liquid composition. Further present invention provides a breaker having a stopper to against unintentional movements, specifically due to user's accidentally movement, such that said breaker does not tear beverages. This avoids seal becomes leaked which further may create caking of the content and reduced its quality. |
US11427387B2 |
Child-resistant bottle cap overshell and method of construction thereof
A child-resistant bottle cap overshell and method for construction thereof is provided. A top cover has a rounded shape. A body extends from an outer perimeter of the top cover and is sized to fit over a bottle cap on a bottle. At least two cutouts are formed in the top cover adjacent to the outer perimeter. A plurality of ridges are formed on an inner surface of the body on a bottom end opposite the top cover. |
US11427386B2 |
Thermos with locking device for liner
The present invention discloses a locking device for replacing a liner in a thermos. The locking device locks and positions a liner stably by a high-pressure assembling force resulted from an elastic effect, after replacing and assembling the liner in a drinking container. A tightening ring with an elastic force is utilized primarily. The tightening ring is clamped between a mineral liner and a barrel by filling, forming a strong elastic reaction force to press and lock the elements, through a spinning action of a connecting ring. |
US11427376B2 |
Packaging insert for an advent calendar and/or beer packaging container
A packaging insert includes first and second insert members each having a first layer or surface including at least one first container receiving opening and a second layer or surface spaced from the first layer or surface and includes at least one second container receiving opening. The at least one first container receiving opening is offset from said at least one second receiving opening so as to retain an inserted container in an angular orientation. At least the first container receiving opening is sized and configured to receive two different types of containers. A method making and using the same is also disclosed. |
US11427375B2 |
Cross-brace assembly and method of assembling and use
A cross-brace assembly for a package for a household appliance and method of assembling are provided. The cross-brace assembly can include a holder having a body having opposing first and second sides. The body includes first and second inner tabs that include first and second apertures, respectively. A first outer tab projects from the first side of the body, adjacent to the first inner tab, and a second outer tab projects from the second side of the body, adjacent to the second inner tab. A brace having opposing first and second ends can be received within the first and second apertures such that the first end of the brace is disposed adjacent the first outer tab and the second end of the brace is disposed adjacent the second outer tab to retain the brace relative to the holder. |
US11427368B2 |
Manufacturing method for double walled container
A manufacturing method of double walled container comprises preparing a parison having a rigid outer layer and a flexible inner layer, enclosing the parison within a mold including split mold halves, thereby forming a molded parison including a pre-blow cylindrical section, a pre-blow conical bottom section, a pre-blow bottom projection, and a lower parison excessive burr, blowing gas into an inside of the molded parison, thereby forming a blown parison including a cylindrical section and a bottom section, the bottom section including a bottom projection, and removing the lower parison excessive burr from the blown parison, wherein the flexible inner layer is fixed to the rigid outer layer in the bottom projection. |
US11427366B2 |
Core for wrap dispenser and method of its use
A film roll compatible with a wrap dispenser comprising a core with a first end with a notch, a second end with a notch, an outer surface and a lumen, a stretch film wrapped around the core, a wrap dispenser comprising a first frame member and a second frame member, a handle connecting the first frame member to the second frame member, a first roller operationally associated with a second roller with each being connected to the first frame member and the second frame member, an upper boss secured to the first frame member with one or more lugs emanating out of the upper boss, a boss handle operationally associated with the upper boss allowing for the raising and lowering of the upper boss, and a lower boss secured to the second frame member with one or more lugs emanating out of the lower boss. |
US11427365B2 |
Bag-making and packaging machine
A bag-making and packaging machine includes a film supply unit that supplies film to a bag-making and packaging unit. The film supply unit has a film roll holding unit that rotatably holds a first film roll, a film temporary placement member on which a vicinity of a leading end portion of a first film wound into the first film roll is manually temporarily placed when attaching the first film roll to the film roll holding unit, a leading end portion detection sensor configured to detect that the leading end portion of the first film is positioned in a prescribed position, and a controller configured to control a rotating mechanism to convey the first film along a predetermined conveyance path until the leading end portion detection sensor detects that the leading end portion of the first film is positioned in the prescribed position. |
US11427361B2 |
Device and method for filling containers with value documents, in particular banknotes, and system for processing value documents
An apparatus and method for filling containers with value documents and to a system for processing value documents, wherein the apparatus has: a container receiving device which is adapted to receive a container stack having two or several containers for receiving value documents, a lid receiving device which is adapted to receive a lid stack having two or several lids for closing the containers, a container removal device which is adapted to remove, preferably, the respectively lowermost container from the container stack, a closing device and a transport device which is adapted to convey the container removed from the container stack to a filling station, in which the container can be filled with value documents, and to convey the container filled with value documents to the closing device which is adapted to remove a lid from the lid stack and close the filled container with the removed lid. |
US11427359B2 |
Tensioner
The invention discloses a tensioner comprising a belt shaft, a first bracket and a second bracket, a belt shaft hole is provided at a front end of the first bracket, the belt shaft passes through the hole and is hinged with the first bracket; a surface of the belt shaft is provided with a ratchet fixedly connected thereto and gaskets provided on two sides of the ratchet; one end of the second bracket is provided with a clamping portion, the clamping portion clamps two ends of the belt shaft and protrudes outwardly to form an accommodating cavity, balls are provided inside the accommodation cavity, and the balls are installed on an outer gasket of the belt shaft. The plastic gaskets greatly reduce the friction between the ratchet and the bracket, the balls provide a certain degree of freedom for the belt shaft to prevent the belt shaft from jamming. |
US11427358B2 |
Pipe compression equipment
A system for compressing and packing pipe insulation includes a compression member that is movable along a first axis to compress pieces of pipe insulation. A stacking bay includes opposing walls that are spaced apart from one another. At least one of the two opposing walls is movable relative to the other of the two opposing walls along a second axis to adjust a lateral distance between the opposing walls to accommodate an increasing size of the pieces of pipe insulation along the second axis. The first axis is generally orthogonal to the second axis. A packing member that applies a force along a third axis to the pieces of pipe insulation after being compressed. The third axis is generally orthogonal to the first and second axes. The first axis is generally orthogonal to the second axis. The compression member is aligned with a space formed between the opposing walls. |
US11427351B2 |
Carrier and operational frame system and methods of assembling a structure
A carrier and operational frame system and methods of assembling a structure are presented. The carrier and operational frame system comprises a plurality of panel carriers, each panel carrier comprising a frame configured to act as a strongback to a panel and indexing features configured to interface with at least one other panel carrier of the plurality of panel carriers. |
US11427348B2 |
Method and device for optimizing tests of systems in particular of an aircraft
A method and device for optimizing tests of systems, in particular of an aircraft, including a first display module displaying a list of tests that can be executed by systems, a selection module allowing an operator to select a set of tests to be executed and communicate it to an optimization module which determines a sequence of tests representing an optimized execution of the set of tests to be executed, the sequence of tests being displayed by a second display module for an operator, a decision module generating either a first signal if the operator validates the sequence of tests, or a second signal if the operator cancels the sequence of tests, and a control module which, if the first signal is generated, commands the execution of the sequence of tests by each of the systems, and generates results of the execution thereof. |
US11427345B2 |
Assisted boom actuator
Described are systems and methods for deploying and stowing a refueling boom. In certain examples, deploying the refueling boom includes lowering a refueling boom structure with a hoist while a boom aerodynamic control surface of the refueling is deactivated, determining that first transition conditions have been met, switching the hoist actuator state mode, and activating the boom aerodynamic control surface. In other examples, stowing the refueling boom includes flying the refueling boom towards a fuselage, determining that second transition conditions have been met, switching the hoist actuator state mode, and raising a refueling boom structure of the refueling boom with the hoist. |
US11427342B2 |
Air inlet for a nacelle for an aircraft and its process for manufacturing
An air inlet (3) for a nacelle (2) for an aircraft (1) includes at least one acoustic panel (5), adapted to lower noise generated by the engine (21) to which the air inlet (3) is connected. At least one lip (6) defines the profile upon which an airflow flowing into the air inlet (3) acts. If necessary, at least one engine ring (4) is adapted to allow the air inlet (3) to be connected to an engine (21) of the nacelle (2). If necessary, at least one outer barrel (7) is adapted to define the outer shape of the air inlet (3) upon which an airflow acts. The air inlet (3) is manufactured as one single piece, made of a composite material. |
US11427334B2 |
Aircraft cabin air monitor
An environmental control system that includes a first environmental control system pack, a first recirculation fan assembly, and a cabin air sensor unit. The first environmental control system pack is arranged to provide conditioned air to an aircraft cabin. The first recirculation fan assembly is arranged to recirculate a first cabin air fluid flow back to the aircraft cabin. The cabin air sensor unit is arranged to provide a first air quality signal indicative of an air quality of the first cabin air fluid flow to a controller. |
US11427333B2 |
Passenger service unit with cover
A passenger service unit assembly that includes a frame that defines at least an oxygen opening and a service opening, an oxygen mask housing positioned adjacent the oxygen opening, an oxygen mask housing cover positioned to cover the oxygen opening, and a service cover positioned to cover the service opening. An oxygen mask that is movable between a stowed position and a deployed position is positioned in the oxygen mask housing. The oxygen mask housing cover maintains the oxygen mask in the stowed position. The oxygen mask housing cover is movable between a closed position and an open position. When the oxygen mask housing cover is moved to the deployed position, the oxygen mask drops to the deployed position via gravity. The service cover is movable between a closed position and an open position and includes at least a first passenger service unit component associated therewith. |
US11427332B2 |
Flight deck constant outside airflow for all flight conditions
Example implementations for maintaining airflow into a flight deck of an aircraft are described herein. An example method may involve detecting, at a computing system and using a flow sensor, a decrease in a level of airflow entering into the flight deck such that the level of airflow is below a threshold level. The aircraft may include air sources configured to direct airflow towards occupancy areas (e.g., the cabin and flight deck) of the aircraft. The method may further involve adjusting a control valve to cause an increase in the level of airflow entering into the flight deck based on detecting the decrease in level of airflow entering into the flight deck. The control valve may be configured to enable and disable airflow from entering into the flight deck. |
US11427328B2 |
Seat indexing systems and methods
A seat indexing system and method for an internal cabin of a vehicle include a seat assembly, and an indexing wheel coupled to the seat assembly. The indexing wheel is configured to be moved between a stowed position, in which the indexing wheel is disengaged from a seat track, and a deployed position, in which the indexing wheel engages the seat track. |
US11427324B2 |
Lavatory, first class, and business class seat integration
Described are aircraft cabin arrangements (12) with at least one lavatory unit (14) with a first side wall (1402) and at least one seat unit (16) positioned adjacent the first side wall. A separate wall is not positioned between the first side wall and the at least one seat unit. The first side wall includes a recessed portion, and the at least one seat unit includes a foot support surface (1606) incorporated into the recessed portion of the first side wall. |
US11427320B2 |
Aircraft store ejector system
An aircraft store ejector systems and subsystems thereof. Embodiments can include a two-reservoir re-pressurization system wherein a remote reservoir is used to maintain desired pressure in a local ejector reservoir. The system can include a release valve having a vent valve and valve piston. The release valve can control release of pressurized gas to a pitch control valve. The pitch control valve can be configured to distribute the pressurized gas between two or more ejector piston assemblies. One or more of the ejector piston assemblies can include multiple concentric piston stages and piston chambers, the piston chambers configured to contain a volume of gas. The ejector piston assemblies can be configured to compress the volume of gas within the piston chambers as the piston stages are extended out from the aircraft. Such compression can provide a return force to the piston stages. |
US11427315B2 |
Rotor blade control system
A rotor blade control system and methods therefor including a hub assembly pivotally attached to a rotor blade; a mast attached to the hub assembly; a swashplate assembly engaged with the mast and including a swashplate actuation mechanism pivotally coupled with the non-rotating ring at a plurality of coupling locations for moving the non-rotating ring and pivotally coupled with the base at a plurality of base locations, the swashplate actuation mechanism comprises a plurality of substantially triangular dual actuator assemblies that are independently and concurrently operable to move the respective coupling location so as to impart movement on the non-rotating ring. The swashplate actuation mechanism is configured to move the swashplate assembly about a longitudinal axis and a lateral axis in response to a cyclic input. The swashplate actuation mechanism is configured to move the swashplate assembly along the mast in response to a collective input. |
US11427312B2 |
Landing gear and stiffening member
A landing gear includes a pair of skids, a cross tube and a stiffening portion. The pair of skids is arranged in parallel with a front-rear axis of an airframe of a rotary wing aircraft. The cross tube is attached to the airframe and coupling the pair of skids to each other. The cross tube includes curved portions located closer to end portions of the cross tube than to portions of the cross tube attached to the airframe. The stiffening portion suppresses flattening of the cross tube and is arranged in at least one of internal spaces of the curved portions or a stiffened portion located between a pair of curved portions. The stiffening portion includes an enlarged diameter portion which increases in diameter by an axial fastening power acting in an axial direction of the cross tube, and a fastening portion configured to generate the axial fastening power. |
US11427303B2 |
Noise abatement systems for retractable leading edge wing slats of an aircraft wing assembly
Noise-abatement systems provide noise abatement to a wing assembly provided with a forward edge slat and include an elongate shield element which is unconnected but positionable adjacent to a lower trailing edge of the edge slat along a lengthwise extent thereof, and a support web having a distal end fixed to the shield element and a proximal end capable of fixation to an interior cove surface of the edge slat adjacent an upper trailing edge thereof. The support web will therefore allow movement of the shield element towards and away from the lower trailing edge of the edge slat between an operative position wherein the shield element is positioned adjacent to the lower trailing edge of the edge slat along the lengthwise extent thereof and an inoperative position wherein the edge slat is spaced from the trailing edge of the edge slat and positioned in the cove region thereof, respectively. |
US11427298B2 |
Advanced plume suppressing segmented heat shield
An aircraft structure including a heat shield. A heat shield including an interior; a skin enclosing the interior; a plurality of barriers attached in the interior to the skin, each of the barriers spaced to separate a plurality of thermal insulation layers disposed in the interior; and wherein the barriers suppress heat flow between the thermal insulation layers. |
US11427295B2 |
Marine propulsion system and control method
A marine propulsion system includes a marine propulsion device, a battery, and a controller. The marine propulsion device includes a propeller shaft, an engine, and an electric motor. The marine propulsion device transmits mechanical power from at least one of the engine and the electric motor to the propeller shaft. The battery supplies electric power to the electric motor. The controller controls the marine propulsion device such that the marine propulsion device is switchable among drive modes including a first drive mode and a second drive mode. In the first drive mode, mechanical power is transmitted from only the engine to the propeller shaft. In the second drive mode, mechanical power is transmitted from only the electric motor to the propeller shaft when the engine is in an idling state. |
US11427289B2 |
Gyroscopic boat roll stabilizer
A gyroscopic roll stabilizer comprises a gimbal having a support frame and enclosure configured to maintain a below-ambient pressure, a flywheel assembly including a flywheel and flywheel shaft, one or more bearings for rotatably mounting the flywheel inside the enclosure, a motor for rotating the flywheel, and bearing cooling system for cooling the bearings supporting the flywheel. The bearing cooling system enables heat generated by the bearings to be transferred through the flywheel shaft to a heat sink disposed within a cavity in the end of the flywheel shaft, or to a liquid coolant circulating within the cavity. |
US11427284B1 |
Personal watercraft hull
A personal watercraft hull has a bow, a keel, starboard and port upper edges, a starboard portion extending between the keel and the starboard upper edge, a port portion extending between the keel and the starboard upper edge, and a transom. The starboard portion has a starboard row of grooves. The port portion has a port row of grooves. The rows of grooves extend in a longitudinal direction and are laterally offset from the longitudinal centerline and from their corresponding upper edge. The grooves of the rows of grooves define recesses in an outer surface of the hull. A personal watercraft having the personal watercraft hull is also disclosed. |
US11427282B2 |
Rear deraileur of bicycle
A rear derailleur of a bicycle includes a fixing portion connected to a frame of the bicycle, a linkage assembly, a moving portion, a chain guide assembly, and a driving assembly. The linkage assembly is pivotally connected to the fixing portion. The moving portion is pivotally connected to the linkage assembly. The chain guide assembly is connected to the moving portion. The driving assembly includes a motor and a driving gear assembly connected to the linkage assembly. The motor includes an output shaft for driving the driving gear assembly. The output shaft of the motor drives the linkage assembly to pivot via the driving gear assembly, thereby to drive the moving portion and the chain guide assembly to move. A pivot shaft and a detachable battery module are disposed on the moving portion. The chain guide assembly is pivotally connected to the pivot shaft. The battery module provides an electric power to the motor. |
US11427280B2 |
System and braking kit for enabling a vehicle trailer and a tow bar to be interconnected in either a braking or a non-braking configuration
A system, generally for use with light personal vehicles such as bicycles or e-bikes, for enabling a vehicle trailer and a tow bar to be interconnected in either a braking configuration or a non-braking configuration, is described. Also described is a braking kit for interconnecting a tow bar and a vehicle trailer in a braking configuration, wherein the vehicle trailer comprises a connection interface dimensioned to be connected with an end of the tow bar in a non-braking configuration. When the tow bar and the trailer are interconnected in the braking configuration, at least a threshold amount of rearward force imparted via the tow bar during vehicle braking causes the actuation of at least one brake associated with the trailer wheels. The same tow bar can be used in either braking or non-braking configuration. |
US11427278B2 |
Self-balancing vehicle
Disclosed is a self-balancing vehicle including a left housing assembly, a right housing assembly, a left wheel train, a right wheel train and a rotation mechanism. The left wheel train is connected with the left housing assembly. The first end of the rotation mechanism is connected with the right wheel train and the right housing assembly, and the second end of the rotation mechanism is inserted into the left housing assembly and rotationally connected with the left housing assembly. The rotation mechanism is just arranged in the right housing assembly, but connected with the right housing assembly and the right wheel train respectively, thus reducing the strength requirements of the self-balancing vehicle on the left housing assembly and simplifying the components of the left housing assembly. |
US11427277B2 |
Two-wheeled vehicle
A two-wheeled vehicle includes a frame having a front frame portion, a mid-frame portion, and a rear frame portion. The mid-frame portion is coupled to the rear frame portion and the front frame portion. The vehicle further includes a plurality of ground-engaging members for supporting the frame. The engine includes an air deflector to assist in cooling a rear cylinder of a V-twin engine. An accessory windshield is also shown which may be coupled to the handlebars and front forks of the vehicle. Also, a rear accessory attachment is shown mountable to the rear fender. |
US11427274B2 |
Angle adjustable bicycle saddle
An angle adjustable bicycle saddle contains a seat post, a cushion, and a locking unit. The seat post includes an inwardly curved groove having multiple protrusions, and the seat post includes multiple troughs. The cushion includes a body and a cap. The body has a curved holder, an arcuate abutting projection, multiple engagement portions, and multiple through holes corresponding to the multiple troughs. The cap is covered on the curved holder of the body so that the curved holder has a hollow portion. The locking unit includes multiple fixing elements and multiple stepped nuts. A respective fixing element is inserted through a respective trough and a respective through hole. A first end of a respective fixing element is adjustably received in a respective trough, and a second end of the respective fixing element is accommodated in the hollow portion of the curved holder. |
US11427271B2 |
Suspension system with damping and buffering property and track-type mobile platform
The present disclosure provides a suspension system with damping and buffering properties, comprising a suspension assembly, a wheel train assembly and a track assembly, the suspension assembly comprises a suspension lateral plate, an approach plate, a first elastic element, a tensioning assembly, a second elastic element, an oscillating arm plate and a damping element; the wheel train assembly comprises a first approach wheel, a second approach wheel, a first load-bearing wheel, a second load-bearing wheel, a track supporting wheel and an actuation wheel. A high stability of a mobile platform moving through obstacles can be realized by assembling the approach plate, the first elastic plate and the damping element into a loading and shock absorbing module in the present disclosure. |
US11427267B2 |
Deployable fairing system for use with vehicles
Systems and methods are disclosed for providing a deployable fairing system to a tractor trailer. The deployable fairing system includes an actuator used to extend the deployable fairing from an unextended configuration to an extended configuration to occupy a portion of a gap area that exists between a tractor and an attached trailer. The deployable fairing includes deployable upper and/or lower horizontal assemblies that are pivotally coupled to a frame attached to the tractor/cab, and two side panels that are pivotally coupled to one or both of the upper and lower horizontal assemblies. The deployable upper and lower horizontal assemblies and the two side panels fold in on one another along multiple hinged axes in the unextended configuration, and extend rearward from the top and sides of the tractor in the extended configuration to cover a portion of the gap. The fairing may advantageously flair from front to the rear. |
US11427261B2 |
Vehicle body structure and method for manufacturing vehicle body
A vehicle body structure includes a resin floor part provided with a flange portion bent toward an upper side or a lower side at an end in a vehicle width direction, and a metal side sill part joined to the flange portion of the floor part. The side sill part includes a rim portion, a peak portion, and intermediate portions that link the rim portion to the peak portion. The peak portion and the intermediate portions form a protruding portion projecting from the rim portion toward the floor part. The flange portion of the floor part is joined to the peak portion of the protruding portion. |
US11427260B2 |
Reinforcement and reinforcement module
A reinforcement is formed into an elongated shape, and includes a reinforcement body in which a housing part opened toward an outer peripheral side is formed and a covering part attached to close an opening of the housing part. A module component which is an electrical component or a wiring component may be housed in the reinforcement while being attached to the covering part. |
US11427249B2 |
Control system for a tiltable vehicle
A vehicle of the present disclosure may include at least one pair of opposing wheels coupled to a tiltable central chassis by a four-bar linkage or the like, such that the wheels are configured to tilt in unison with the central chassis. A steering actuator and/or a tilting actuator may be discretely controllable by an electronic controller of the vehicle. The controller may include processing logic configured to maintain alignment between a median plane of the chassis and a net force vector caused by gravity and any induced centrifugal forces. Various control algorithms may be utilized to steer the vehicle along a desired path, either autonomously or semi-autonomously. |
US11427246B2 |
Steering system
A steering system includes a prioritized torque sensor, a redundant torque sensor, a controller, a first signal line, a second signal line, and a common signal line. Each of the first signal line and the second signal line connects the prioritized torque sensor and the controller. The common signal line connects the redundant torque sensor and the controller. The prioritized torque sensor is configured to transmit, via the first signal line, a first prioritized detection signal. The prioritized torque sensor is configured to transmit, via the second signal line, a second prioritized detection signal. The redundant torque sensor is configured to transmit, via the common signal line, a first redundant detection signal and a second redundant detection signal. |
US11427245B2 |
Steering system actuator, and use of the actuator in a steer-by-wire steering system
An actuator of a steering system having a housing (2), a spindle drive arranged in the housing (2) which includes an axially movable spindle (5) that engages with a spindle nut (6) mounted in a fixed position. The spindle has at least one fastening end (8, 9), and at least one bearing journal (10, 11) arranged and able to move in the housing (2). The journal is connected to the at least one fastening end (8, 9) of the spindle (5), with at least one joint connection component (3, 4) which is arranged outside the housing (2) and is connected to the at least one bearing journal (10, 11). The at least one bearing journal (10, 11, 110) has a constriction (10v, 11v) that forms a flexible zone (122). |
US11427236B2 |
Vehicle having a detection device for detecting a route-side transmitter device and method for operating same
A vehicle has a detection device for detecting a route-side transmitter device. The detection device has at least two receiving antennas which are suitable for receiving a magnetic field component, oriented in a longitudinal direction of the vehicle, of electromagnetic radiation which is emitted by the route-side transmitter device. The at least two receiving antennas are arranged with an offset in the longitudinal direction of the vehicle. |
US11427234B2 |
Railroad car location, speed, and heading detection system and methods with self-powered wireless sensor nodes
A railroad car location, speed and heading sensor system including at least one self-powered, tie-mounted sensor node that is applicable universally to different railroad settings without using track circuits, inductive loops, radar systems, and wheel counters and associated disadvantages. Reliable and relatively low cost deterministic and redundant car presence detection is realized when multiple sensor nodes are arranged in a network, which may be a wireless mesh network, that is not affected by environmental conditions. |
US11427233B2 |
Method for calibrating a wheel sensor, corresponding wheel sensor, and railway installation with a wheel sensor of this kind
A particularly flexible method for automatically calibrating a wheel sensor includes using the wheel sensor to determine that a calibration must be carried out. The wheel sensor determines a point in time suitable for carrying out the calibration and the calibration itself is carried out by the wheel sensor at the determined point in time. A wheel sensor for carrying out the method is also provided. |
US11427232B2 |
Systems and methods for auditing assets
In one embodiment, a method includes receiving first Light Detection and Ranging (LiDAR) data associated with a railroad environment, extracting an asset from the first LiDAR data associated with the railroad environment, and superimposing the asset into a spatial model. The method also includes receiving a field indication associated with a modification to the railroad environment and modifying the spatial model in response to receiving the field indication associated with the modification to the railroad environment. The method further includes receiving second LiDAR data associated with the railroad environment and comparing the second LiDAR data to the modified spatial model. |
US11427227B2 |
Safety device for use in a vehicle, vehicle, and method for operating a vehicle
A safety device for use in a vehicle which is configured to be operated at least intermittently in an automated driving mode, in which the vehicle drives in an automated manner, and which includes a first data source which is designed as a human machine interface and configured to output data about a driving status, including computing device and a first data interface, the safety device being configured to receive data about the driving status from the first data source via the first data interface, the safety device being configured to receive data about the driving status from a second data source different from the first data source, and the safety device being configured to output pieces of information about the driving status to a driver, using an information output device and based on the data received from the first data source and the second data source. |
US11427226B1 |
Positional gaps for driver controllability
The technology involves determining a minimum lateral gap distance between a vehicle configured for autonomous driving and one or more other objects in the vehicle's environment. The minimum lateral gap is used when determining whether to have a driver take over control of certain driving operations. This provides a measure of safety during disengagements or other change of control events. Determining the minimum lateral gap includes calculating a budgeted distance based on a cross-track error for a lateral position of the vehicle, an allowed actual gap distance to an object in the vehicle's environment, and a perception error associated with a location of the object in the vehicle's environment. This determination can be done for a set of possible operating speeds and steering rate limit combinations. The vehicle's control system may notify the driver to take control, for instance with audible, visual and/or haptic notifications. |
US11427218B2 |
Control apparatus, control method, program, and moving body
A laser range finder projects light while changing a direction in a horizontal direction at a predetermined angle with respect to a vertical direction to also receive reflected light of the light, and detects a direction and a distance in which the light is reflected from an obstacle or the like, according to a difference time between a time of light projection and a time of light reception. A normal direction of a flat plane forming a road surface is detected on the basis of a polarized image. The laser range finder projects light such that the light has a predetermined angle with respect to the vertical direction so as to be orthogonal to the normal direction of the flat plane forming the road surface. The laser range finder can be applied to in-vehicle systems. |
US11427214B2 |
Method of synchronizing driving characteristics of different vehicles
The present disclosure provides a method of displaying the driving characteristics of a current vehicle in comparison with those of a previous vehicle and synchronizing the driving characteristics of the current vehicle with those of the previous vehicle by changing driving-characteristic-related setup data of the current vehicle in response to a driver request. Accordingly, the driving characteristics of the current vehicle is synchronized with the driving characteristics of the previous vehicle, and thus even if a driver drives a completely different type of vehicle, a familiar sense of traveling and sense of driving is provided. |
US11427202B2 |
Trailer brake control device, method and software for same, and trailer vehicle comprising same
A method, for a trailer brake control device of a vehicle trailer with an electric drive, includes receiving at least one acceleration request signal with a requested positive acceleration or a requested negative acceleration and further receiving a status signal with at least one status variable of the electric drive of the vehicle trailer. The method also includes generating, with a controller of the trailer brake control device, at least one brake actuation signal for at least one friction brake of the vehicle trailer and a torque request signal for the electric drive, each based on the at least one acceleration request signal and the status signal. Furthermore, the method includes outputting the brake actuation signal and the torque request signal via at least one output and/or at least one interface of the trailer brake control device. |
US11427201B2 |
Braking control system for a hybrid or electric vehicle
A vehicle includes active grill shutters and a controller. The active grill shutters are configured to open to increase a drag on the vehicle and to close to decrease the drag on the vehicle. The controller is programmed to, in response to regenerative braking via an electric machine and an absence of friction braking, transition or maintain the active grill shutters to or in a closed position. The controller is further programmed to, in response to friction braking, transition or maintain the active grill shutters to or in the open position. |
US11427200B2 |
Automated driving system and method of autonomously driving a vehicle
An automated driving system and method of autonomously driving a vehicle. The system includes for a vehicle including at least one sensor device configured to detect the vehicle position and sense environment characteristics of the vehicle, an electronic control device configured to control autonomous driving of the vehicle based on an output of the sensor device, in which the controlling of autonomous driving includes an autonomous overtaking functionality for overtaking by changing the lane, and disable the autonomous overtaking functionality, in case at least one of a set of predetermined overtaking conditions is not satisfied. |
US11427198B2 |
Device and method for controlling travel of vehicle, and processor-readable storage medium
A device, method, and processor readable storage medium for controlling travel of a vehicle. The device includes a processor and a controller; the processor is configured to set a speed curve of the vehicle according to a relative speed and distance between the vehicle and the front subject, and the controller is configured to control the vehicle to travel according to the set speed curve. |
US11427196B2 |
Systems and methods for managing tractor-trailers
Systems and methods for causing a vehicle to avoid an adverse action are described. In one aspect, a sensor on first vehicle may determine the existence and location of lane markers or objects, and use that information to cause a second vehicle to avoid exiting its lane or colliding with an object. Data transmitted from a first vehicle to a second vehicle may be used to determine a path for the second vehicle, such that it avoids an adverse action. This data may include information used to determine a pose of the second vehicle, kinematics of the second vehicle, determine dimensions of the second vehicle, and potential adverse actions. This data may be transmitted while the vehicles are platooning. |
US11427191B2 |
Obstacle avoidance action
A vehicle can traverse an environment along a first region and detect an obstacle impeding progress of the vehicle. The vehicle can determine a second region that is adjacent to the first region and associated with a direction of travel opposite the first region. A cost can be determined based on an action (e.g., an oncoming action) to utilize the second region to overtake the obstacle. By comparing the cost to a cost threshold and/or to a cost associated with another action (e.g., a “stay in lane” action), the vehicle can determine a target trajectory that traverses through the second region. The vehicle can traverse the environment based on the target trajectory to avoid, for example, the obstacle in the environment while maintaining a safe distance from the obstacle and/or other entities in the environment. |
US11427184B2 |
Breadth first search-depth first search three dimensional rapid exploring random tree search with physical constraints
An example operation includes one or more of, determining an initial position and at least one vehicle constraint, predetermining a distance to a new position, determining a minimum turn radius based on the at least one vehicle constraint, selecting a vehicle turn radius that is at least as large as the minimum turn radius, determining a candidate position based on the at least one vehicle constraint and the vehicle turn radius, verifying whether the candidate position is valid with respect to the new position and converting the new position to the candidate position. |
US11427182B2 |
Control device and control method for hybrid vehicle
A control device for a hybrid vehicle is provided. When a first drive mode is selected as the drive mode of the hybrid vehicle, a control section shifts the drive mode to a second drive mode when a charge amount of a battery for an electric motor becomes smaller than or equal to a determination charge amount. The first drive mode operates the electric motor while an internal combustion engine is stopped. The second drive mode permits the operation of the internal combustion engine. The control section executes a shifting process when the upper limit system output is lower than or equal to a startup determination output even though the charge amount of the battery is greater than the determination charge amount. The shifting process shifts the drive mode to the second drive mode to start the internal combustion engine. |
US11427179B2 |
Power supply system
The power supply system includes: a first power circuit having a first battery, a second power circuit having a second battery, a voltage converter which converts voltages between both circuits, voltage sensors which acquire a first circuit voltage value V1 and second circuit voltage value V2, a current sensor which acquires a passing current value Iact, and a passing power control unit which operates the voltage converter. The passing power control unit performs PWM control under a control duty ratio obtained by summing a correction duty ratio calculated based on the current deviation change rate and a base duty ratio, in a case of, after starting PWM control under the base duty ratio decided based on the voltage values V1, V2 during activation of the voltage converter, the value of current deviation between a passing current value Iact and activation target value Itrg exceeding a permitted range. |
US11427176B2 |
Remotely actuated vehicle pedal depression apparatus
A remotely actuated vehicle pedal depression apparatus includes a handheld unit operatively coupled to a distal unit. Manual compression of an actuator disposed on the handheld unit effectuates extension of an extendable member forwardly from an anterior member disposed on the distal unit. Distal unit may be positioned in a footwell of an automobile to effectuate depression of a targeted pedal while a user performs observational diagnostics on the automobile without the assistance of another person. |
US11427175B2 |
Vehicle braking systems and methods
Techniques for braking an autonomous vehicle include providing a pressurized fluid stream from a plurality of pressurized fluid sources to a plurality of pressure-controlled electronic braking assemblies; providing the pressurized fluid stream from a pressurized fluid control output of a first pressure-controlled electronic braking assembly directly to a pressurized fluid control input of a second pressure-controlled electronic braking assembly; providing the pressurized fluid stream from the second pressure-controlled electronic braking assembly to at least one vehicle brake set; providing sensor output data from one or more vehicle sensors to a plurality of electronic control units; and based at least in part on the sensor output data, controlling at least one of the first or second pressure-controlled electronic braking assemblies to adjust a pressure of the pressurized fluid stream from at least one of the first or second pressure-controlled electronic braking assemblies to the vehicle brake set. |
US11427172B2 |
Lateral dynamic control for regenerative and friction brake blending
Methods and systems are described for controlling a vehicle braking system. A braking force is applied to the vehicle by applying friction only braking to the wheels of one axle and applying a blended braking force (including a regenerative braking force and a friction braking force) to the wheels of another axle. Using vehicle and tire modeling techniques, a set of side-slip angles is calculated that is estimated to occur if the total braking force were applied using only friction braking. A compensatory yaw moment is then determined based on differences between the estimated side-slip angles and the actual side-slip angles of the vehicle under the blended braking. The compensatory yaw moment is then applied to the vehicle to enable the vehicle to utilize regenerative braking while exhibiting the same vehicle dynamics that occur when using friction braking only. |
US11427169B2 |
Apparatus, method and system for determining the position of vehicles connected to a tractor by the use of a global positioning satellite (GPS)
Various examples of a controller, method and system for determining positions of a tractor-trailer vehicle train are disclosed. In one example a tractor controller is manually-initiated or a user-initiated tractor controller and includes an electrical control port for receiving an electrical start signal, and a communications port for receiving data. A processing unit of the tractor controller includes control logic and is in communication with the electrical control port. The control logic is capable of receiving, in response to the electrical start signal, a data signal at the communications port which includes a GPS signal and a unique identification which corresponds to the towed vehicle. At a predetermined response time, the tractor controller determines the position of the towed vehicle in the tractor-trailer vehicle train based on the data received from the towed vehicles. |
US11427167B2 |
Method for performing emergency braking in a motor vehicle and emergency braking system for performing the method
A method for performing emergency braking in a vehicle includes registering at least one object in surroundings of the vehicle and ascertaining a probability of collision for the vehicle with the at least one registered object to detect an emergency braking situation, autonomously activating service brakes of the vehicle using a vehicle setpoint deceleration to perform emergency braking if an emergency braking situation has been detected, and adapting the vehicle setpoint deceleration during the autonomously performed emergency braking. Adapting the vehicle setpoint deceleration takes place in dependence on at least one driving dynamics parameter. The driving dynamics parameter characterizes a real reaction of the vehicle to the performed emergency braking. The driving dynamics parameter is ascertained during the emergency braking. |
US11427166B2 |
Adaptive AEB system considering steerable path and control method thereof
Disclosed is an adaptive autonomous emergency braking (AEB) control method. An adaptive AEB control method includes identifying a front vehicle to be avoided on the basis of front-view information acquired through a front-view sensor, setting a steering avoidable area on the basis of speed information and lateral acceleration information of a host vehicle, adaptively determining an AEB activation time point on the basis of whether a vehicle is present in the set steering avoidable area, and controlling AEB activation on the basis of the adaptively determined AEB activation time point. |
US11427164B2 |
Truck trackout cleaning system
A system for cleaning tires of a vehicle traveling along a longitudinal direction over the system includes modular tire cleaning units with debris removal elements. Each unit includes debris removal elements, such as a first chain assembly supported between supports and over a substrate and extending substantially transverse to the longitudinal direction, the first chain assembly defining a first tire track. A second chain assembly is supported between second sets of supports and over the substrate and extending substantially transverse to the longitudinal direction, the second chain assembly defining a second tire track parallel and spaced apart from the first tire channel. The system may include a second modular tire cleaning unit with longitudinally extending chains and/or a trough holding water and/or sprayers at the side of the system. |
US11427163B2 |
Vehicle cleaner system and vehicle including vehicle cleaner system
A vehicle cleaner system includes: a window washer configured to clean a front window of a vehicle; a lamp cleaner configured to clean a headlamp; a sensor cleaner configured to clean a sensor that detects information outside the vehicle; and a cleaner control unit configured to operate at least one of the window washer, the lamp cleaner, and the sensor cleaner in accordance with input of a signal. The cleaner control unit is configured to operate the window washer, the lamp cleaner, and the sensor cleaner such that at least two or more of a number of operations of the window washer, a number of operations of the lamp cleaner, and a number of operations of the sensor cleaner are different in accordance with a predetermined number of signals. |
US11427162B2 |
Contaminant removal apparatus for windshields
A contaminant removal apparatus for windshields includes: driving belts located at both side surfaces of a windshield; a drive unit configured to apply driving force to the driving belts; a wiper assembly located on the windshield; rotary rollers configured to be shifted along the driving belts; idle gears located at ends of the driving belts to change a rotating direction of the rotary rollers; frame connection shafts coupled to both ends of the wiper assembly and located within the rotary rollers so as to contact the idle gears to change the rotating direction of the rotary rollers; and a controller configured to change a rotating direction of the rotary rollers when the idle gears and the frame connection shafts contact. |
US11427160B2 |
Field superposition method and system
Disclosed is a method of wireless communication between a vehicle base station and a transponder, the method comprising: i) driving first and second antennae on the vehicle by the vehicle base station using first driving currents, the first antenna being separated from the transponder by a portion of a vehicle in which the vehicle base station resides; ii) detecting three separate mutually orthogonal vector components of the respective fields emitted by the first and second antennae and received at the transponder; iii) calculating superposition factors for the first and second antennae based upon the separate vector components; iv) concurrently driving the first and second antennae using the same phase, respectively using the first driving currents multiplied by the calculated superposition factors; v) detecting three mutually orthogonal vector components of a superposed signal including signals from both antennae received at the transponder; vi) determining whether two of the three detected vector components are above a threshold noise level; vii) if fewer than two of the three detected vector components are above the threshold noise level, repeating step iv) with one of the first and second antennae being driven by the first driving current multiplied by the calculated superposition factors and by an adjustment factor; and viii) if two of the three detected vector components are above the threshold noise level, authenticating the transponder in response to the detected superposed vector components being within an error-based range of the sum of the separate vector components for each of the first and second antennae as multiplied respectively by the superposition factors for the first and second antennae. |
US11427158B2 |
Method and device for smart control of vehicle while defending against RSA by using mobile device
Provided are a method and a device for smart control of a vehicle while defending against an RSA by using a mobile device. The method includes the steps of: establishing a communication network to be able to transmit/receive information to/from a mobile device of a driver through Bluetooth or Wi-Fi; and determining, when an RSS value of a Bluetooth or Wi-Fi signal received from the mobile device of the driver is measured to be equal to or larger than a predetermined reference value, that the position of the mobile device of the driver is within a predetermined primary range (25 m) and transmitting a sound wave of 2 to 24000 Hz that can be recognized through three or more speakers mounted in the vehicle. |
US11427155B2 |
Smart alarm module for automobile security system
A smart alarm module includes a first connector terminal providing conductive paths from the fused box and the audio device to the smart alarm module, a second connector terminal providing conductive paths from the on-board electronics to the smart alarm module, an input interface connecting the on-board electronics to detect communication protocol and receive information from the remote controller, a microcontroller arming the smart alarm module responsively to the content of the information to provide judgment operation, a sensor quantizing shock waves on the vehicle then feeding a first activating signal to the microprocessor when the quantized values exceeds a predetermined value, a power supply regulator regulating and providing power to the input interface, the microprocessor, and the sensor, and an output interface sounding the audio device, drive the vehicle's door switch in response to output signal from the microprocessor, and detect vehicle's speed from the on-board electronics. |
US11427146B2 |
Collision protection
Systems, methods, and non-transitory computer-readable media are provided for collision prevention. In some embodiments, a trajectory of a vehicle with respect to an object can be determined using a trajectory prediction model and sensor data associated with the vehicle and the object. Based on the trajectory, a collision event involving the vehicle and the object can be determined and one or more collision protection devices can be activated. |
US11427140B2 |
Shared vehicle I/O expander
System, apparatus, device and methods relating to a telematic vehicle sharing platform ecosystem and a telematic vehicle share I/O expander to automate sharing and management of a vehicle that is shared by more than one operator. |
US11427137B2 |
Emblem arrangement for a motor vehicle
An emblem arrangement for a motor vehicle has an emblem support part, an element forming a brand emblem, and at least one luminous element for illuminating the emblem arrangement. The element forming the brand emblem is a layered structure having at least two layers, which layered structure has, when viewed in a plan view of the emblem arrangement, translucent and non-translucent regions. The translucent regions are able to depict the shape of the brand emblem in its entirety or wherein the translucent regions are able to depict merely the contour of the brand emblem. |
US11427133B2 |
Ladder rack
A ladder rack with improved utility may feature a rugged single body construction with multiple bends forming a pocket between two arms. The ladder rack is mountable upon a surface, such as a vehicle roof, and contains a portion of a ladder within it. The ladder is secured transversely within the pocket as the opening is smaller than the width of a ladder rail and the use of two ladder racks, since one arm projects around a ladder rail, will secure against translational movement along the car's length if positioned to abut ladder rungs. An optional S-bend can be utilized to further control of the ladder in stowage and in securing against movement in transit. |
US11427132B2 |
Automotive clothes hanging device
An automotive clothes hanging device for hanging multiple clothes hangers with clothes without impeding visibility includes a strap, which has a pair of holes positioned therein. Each hole is positioned proximate to a respective opposed end of the strap. A fixed hanger hook of a vehicle is inserted into one of the holes so that the strap is engaged thereto. A hook of a clothes hanger is inserted into the other of the holes is configured so that the clothes hanger is engaged to the strap. The strap also can be folded so that holes of the pair of holes are aligned. The strap defines a loop when the fixed hanger hook of the vehicle is inserted into the pair of holes. The hook of the clothes hanger can be inserted into the loop. Multiple clothes hangers with clothes thereon can be hung from the strap without impeding visibility. |
US11427131B2 |
Motor-vehicle accessory
The invention relates to an accessory, with a base (11) and an adjustment part (12), movable in translation and/or in rotation relative to the base, that is movable along a path between a first end position and a second end position and can be locked in at least one position with a locking device (13) with first locking formations that are associated with the adjustment part (12) and second locking formations that are associated with the base (11), with a control system with a first controller associated with the adjustment part (12) and a second controller associated with the base (11), with which controller the locking device (13) is adjustable between a catch position and a release position depending on the position of the adjustment part (12).The special feature consists in that the one set of controller comprises a first switching element (21) on a first end region of the path and a second switching element (22) on a second end region, wherein a movable setting device (37) of the other set of controller can be actuated by of the switching element (21, 22) in such a way that locking formations that are in an operative connection with the setting device (37) are movable between a catch position and a release position. |
US11427129B2 |
Telescoping bed platform
Disclosed is a bed platform and system for use in an enclosed or partly enclosed space, such as, a cargo space of a vehicle, such as, a van, camper, or truck, among others. By one approach, the bed platform consists of interleaved portions of panel portions that permit relative lateral motion of the panels. In some configurations, the panel portions are adjustable such that the bed platform can be fit into differently sized vehicle cargo spaces. In addition, the systems described herein also may permit the bed platform to be adjusted or moved to different heights even though the wall configurations may be different along the height thereof. |
US11427126B2 |
Rear view mirror
The invention relates to a rear view mirror assembly for a vehicle comprising a housing configured for mounting to a vehicle; one or more mirror units disposed in the housing, wherein each mirror unit comprises a reflective mirror element and a mirror mount for securing the mirror element within the housing, wherein at least one mirror unit is an overhead mirror unit that is positioned to allow an operator in the vehicle to see an area that is behind the operator and above the vehicle. |
US11427123B2 |
Vehicle lamp system
This vehicle lamp system, which is used together with a vehicle control unit that controls the travel state of a vehicle and a mode determination unit that can determine an automatic driving mode of another vehicle, comprises a lamp mounted on the vehicle, and a lamp control unit which, depending on the mode signal outputted by the mode determination unit, controls the lamp in different ways (for example, displaying an arrow with road surface rendering). |
US11427122B2 |
Headlight control system
A headlight control system has a headlight including a plurality of LED light sources, a camera and a radar that detect a predetermined target object present ahead of a vehicle, and a controller configured to control the headlight such that, when the target object is present, of the plurality of LED light sources, the LED light source irradiating a region where the target object is present is turned off, and such that, thereafter, when the target object is no longer present in the region, the turned-off LED light source is turned on again. The controller controls the headlight such that, at the time of turning on the turned-off LED light source again, a change rate of luminance of the LED light source is changed according to a position of an irradiation region of the LED light source. |
US11427121B2 |
Vehicle for container transport
A vehicle can include a base assembly, a rack assembly, and a processing system. The base assembly can include a platform, a plurality of wheels and a motor for driving at least one of the plurality of wheels. The rack assembly can include a storage shelf connected to the base assembly through a coupling, which includes a bearing assembly enabling the storage shelf to rotate with respect to the platform. The processing system can be configured to communicatively couple with the rack assembly and include one or more processors configured to: determine a location of a target good; cause the storage shelf to move based on the determined location. |
US11427118B2 |
Headrest for a vehicle seat
A vehicle seat headrest has a first sub-piece facing a seat occupant head, a second sub-piece and an energy storage device with a trigger actuator arranged between the first sub-piece and the second sub-piece. The first sub-piece is moveable relative to the second sub-piece out of a use position into a safety position along a movement direction towards the a seat occupant head as a result of an accident under the effect of a discharge of the energy storage device, which is actuated by the trigger actuator. The headrest is configured such that the volume of an expansion area is increased while the first sub-piece is moved relative to the second sub-piece as a result of an accident and by the effect of the discharge of the energy storage device. The headrest has a sealing device between the first sub-piece and the second sub-piece to delimit the expansion area. |
US11427115B2 |
System and method for seat vibration cancellation
A method for cancelling seat vibration includes receiving, from an accelerometer, a plurality of accelerometer measurements and applying a first filter to the plurality of accelerometer measurements to remove accelerometer measurements of the plurality of accelerometer measurements having a frequency above a first threshold frequency. The method also includes applying a second filter to an output of the first filter to remove accelerometer measurements of the output of the first filter having a frequency above a second threshold frequency and applying a third filter to an output of the second filter to generate an accelerometer measurement output having a center frequency corresponding to a resonant frequency of the vibration of the at least one component of the seat. The method also includes determining an absolute magnitude value of the accelerometer measurement output and selectively controlling a motor based on the absolute magnitude value of the accelerometer measurement output. |
US11427112B2 |
Moving and locking device for vehicle seat
A moving and locking device for a vehicle seat includes: a lower frame mounted on a bottom surface of a seat cushion; a plurality of wheels disposed underneath the lower frame in such a manner that the plurality of wheels roll on a floor panel; and a vacuum adsorption device disposed inside the lower frame and configured to be adsorbed on the floor panel by vacuum force. The vehicle seat is configured to be moved to the desired position through the rolling motion of the plurality of wheels, and configured to be locked at the desired position through vacuum adsorption of the vacuum adsorption device on the floor panel. |
US11427107B2 |
Vehicle and vehicle control method
A vehicle includes: a PCU cooling system; a PCU that is cooled by the PCU cooling system; a buck converter; an auxiliary battery that is charged through a buck operation of the buck converter; and an ECU that outputs a first target voltage and a second target voltage respectively to the buck converters. The buck converter is disposed inside the PCU, performs a buck operation so that a target voltage is generated, and outputs a stepped-down electric power to a power line. The buck converter is disposed outside the PCU, performs a buck operation so that a target voltage is generated, and outputs a stepped-down electric power to the power line. The ECU sets the target voltage higher than the target voltage when the ECU causes PCU to operate. |
US11427105B2 |
Battery module parallel switching device systems and methods
The present disclosure includes an automotive battery system that uses switching devices to increase operational performance and reliability. The battery system includes a battery cell, a primary switching device electrically coupled to a terminal of the battery cell, and a secondary switching device electrically coupled to the terminal of the battery cell and in parallel with the primary switching device. The primary switching device includes an electromechanical switching device that enables charging or discharging of the battery and generates a boosted voltage. A secondary switching device includes a solid-state switching device and a diode, electrically coupled in series, which detect short circuit conditions in a power-efficient manner and remove the short circuit condition by using the boosted voltage to actuate the armature. Furthermore, parallel switching devices work together to deliver appropriate amounts of power as required by an electrical device, increasing the performance, reliability, and life-span of a battery system. |
US11427104B2 |
Method and apparatus for controlling charging of vehicle battery
An apparatus of controlling charging of a vehicle battery may include a charging device of a vehicle, the charging device configured to generate a boosted voltage higher than a charging voltage of electric vehicle supply equipment provided outside the vehicle and to charge a battery storing power for driving the vehicle, and a vehicle control unit configured to determine whether power line communication transmitting information for charging the battery performed with the electric vehicle supply equipment provided outside the vehicle and providing the charging voltage to the charging device of the vehicle is off while the battery is charged by the boosted voltage. |
US11427101B2 |
Methods and systems for automatic electric vehicle identification and charging via wireless charging pads
A system for charging a battery of a vehicle using inductive charging is provided. The system includes a charging pad for inductive charge transfer. The charge pad is configured with electronics that enables wireless communication. A self-aligning mechanism is part of the charging pad, and the self-aligning mechanism is configured to adjust positioning of the charging pad when the vehicle is disposed over the charging pad. A computer associated with the charging pad is configured to execute method operations for communicating with electronics of the vehicle to enable charging of the battery of the vehicle. The electronics of the vehicle is configured to identify a user account for charging the vehicle. An application associated with the user account is configured to receive updates regarding a charging status of the vehicle responsive to said inductive charge transfer being enabled. |
US11427099B2 |
Temperature sensor for terminal of charging inlet assembly
A terminal for a charging inlet assembly includes a head secured in a terminal channel of a housing of the charging inlet assembly having a terminating end configured to be terminated to a power cable. The head has a temperature sensor channel extending longitudinally therethrough open at the rear of the terminal. The terminal includes a pin at a front of the terminal. The pin has an outer surface defining a separable mating interface for mating engagement with a charging conductor of a charging connector. The terminal includes a temperature sensor assembly received in the temperature sensor channel. The temperature sensor assembly includes a temperature sensor and a lead extending from the temperature sensor through the temperature sensor channel. The temperature sensor is axially aligned with the separable mating interface of the pin within an interior of the terminal for sensing a temperature of the pin. |
US11427097B2 |
Charging ports with integrated contactless communication units
Embodiments discussed herein refer to electric vehicle charging ports having integrated contactless communication units (CCUs). The electric vehicle charging ports include male and female connector assemblies that can be coupled together in a manner that enables consistent and reliable operation of contactless communications and power transfer. The connector integrates power and alignment such that when two connector assemblies are coupled together, power connections are made in combination with establishing contactless communications links between counterpart CCUs in both connector assemblies. The fixed alignment of the connector assemblies ensures that contactless communication channels, spanning between the connector assemblies, are aligned to enable consistent and reliable operation of contactless communications. The CCUs, which conduct contactless communications, may be integrated in the connector assemblies at fixed positions that enable CCUs of one connector assembly to be aligned with CCUs of another connector assembly when they are coupled together. |
US11427096B2 |
Vehicle power transmitting device with alignment and function check
A power transmitting device includes: a power transmitting unit that contactlessly transmits alternating-current power to be transmitted to a power receiving unit of a vehicle; a camera that detects a positional relationship between the power transmitting unit and the power receiving unit; and a power supply ECU. The power supply ECU is configured to perform an “alignment process” performing a process using the positional relationship detected by the camera for aligning the power receiving unit with the power transmitting unit, and a “power transmission function check process” causing the power transmitting unit to output a checking power to check whether a power transmission function of the power transmitting unit functions properly. When wireless communication is established with the vehicle, the power supply ECU initially performs the alignment process, and after it is determined that the alignment process completes alignment, the power supply ECU performs the power transmission function check process. |
US11427091B1 |
Electric drive system for a mower
An example vehicle comprises: (i) at least one electric generator that can be electronically-commutated or passively rectified, (ii) at least one electronically-commutated electric motor configured to drive a wheel of the vehicle, (iii) a voltage bus connecting the electric generator with the electronically-commutated electric motor, and (iv) means of controlling voltage level of the voltage bus. |
US11427089B2 |
Electric axle with ring gear disconnect clutch
An electric axle is configured to selectively enable an electric motor to power a pair of drive shafts of a vehicle. The electric axle includes a planetary gearset configured to drivably couple an electric motor with first and second drive shafts coaxially arranged. The planetary gearset including a ring gear. A housing at least partially surrounds the planetary gearset and is configured to be grounded to the vehicle. A clutch is configured to selectively ground the ring gear with the housing to enable an electric motor to power the first and second drive shafts. The electric axle may include a second planetary gearset, namely a differential planetary gearset. The differential planetary gearset may include a carrier that is shared or common amongst the planetary gearset and the differential planetary gearset. |
US11427088B2 |
Movable structure driving unit
A movable structure driving unit is a movable structure driving unit used for a movable structure, including: an electric motor that is electrically connected to a power supply and that drives a front wheel; a rear-side motive power source that drives a rear wheel; a jump detector that detects a jump of the front wheel from ground; and a motor controller that controls driving of the electric motor. The motor controller stops supply of a driving current from the power supply to the electric motor when the jump of the front wheel from the ground is detected in a state in which driving of the front wheel and the rear wheel is instructed. |
US11427086B2 |
System and method for electrical power conversion suited for driving an electric motor
Electrical power conversion systems and methods suited for driving electric motors, and related systems such as propulsion systems, and vehicles employing same, are disclosed herein. In an example embodiment, the electrical power conversion system includes a plurality of series coupled inverters, each including respective first and second DC input terminals and also including respective AC output ports by which the inverters can respectively be coupled at least indirectly to motor winding sets. Additionally, the system includes a controller coupled to the inverters and configured to generate control signals that are respectively provided to the inverters. The control signals tend to cause respective AC output powers output from the respective AC output ports to be equal or substantially equal in a manner that tends to result in respective DC link voltage portions applied between the respective DC input terminals of the respective inverters being or becoming equal or substantially equal. |
US11427082B2 |
Accelerator device
An accelerator device includes a pad, a case having an internal accommodation space, an internal movable mechanism, and an arm configured to connect the pad and the internal movable mechanism. When the case is viewed from the side of the pad, a fully open stopper is provided on an outer wall surface of the case at a position in an outer circumference of an area that overlaps with the internal accommodation space. |
US11427080B2 |
Power transmission device for four-wheel drive vehicle
A power transmission device of a four-wheel drive electrically driven vehicle comprises a transverse engine that is supported on one right side surface of two side surfaces of the gear case, and a motor that is supported on the other left side surface of the two side surfaces of the gear case. The power transmission device includes a transfer case that is supported by a gear case and the distributes power from a power source between the left and right front wheels and the left and right rear wheels. The transfer case wraps around from the side surface to a rear surface of the gear case, as seen from above, and outputs power to the left and right rear wheels from the rear surface side of the gear case. |
US11427077B2 |
Support assembly type baffle
A support assembly type baffle is proposed. The baffle may include a baffle body provided in an inner space of a vehicle tank to reduce flow noise, and having a plurality of through holes spaced apart from each other and a fastening portion formed on the inner circumferential surface of the through holes, and a support having a columnar shape, being fitted into the through holes to penetrate the through holes, and having an engagement portion coupled with the fastening portion, formed on the outer circumferential surface thereof, so that the support is fastened to the baffle body in a state of penetrating the baffle body, each of both ends of the support being fixed to two opposite sides of the inner sides of the tank to maintain the shape of the inner space of the tank. |
US11427073B2 |
Diesel exhaust fluid cap assembly for vehicle and diesel exhaust fluid supply system including the same
A diesel exhaust fluid (DEF) cap assembly for a vehicle includes: a body having a first opening and a second opening arranged at an opposite side of the first opening, the second opening configured to be opened and closed; a flange portion protruding radially outward between the first opening and the second opening of the body, and having a plurality of through holes and a flange gasket configured to be sealably coupled to a mounting subject on which the flange portion is mounted; and a membrane member coupled to the flange portion, and configured to cover the plurality through holes and allow air flow. |
US11427071B2 |
Motor and carrier vehicle
A motor includes a shaft extending along a center axis, and a first groove that is recessed in a radial direction and extends in an axial direction, on an outer side surface of the shaft. The motor includes a stator core into which the shaft is inserted, and a rotation restrictor that is inserted into at least a portion of the first groove and restricts the stator core and the shaft in a circumferential direction. A carrier vehicle is equipped with the motor further including a lead wire extending from the stator. The shaft includes a shaft portion and a flange portion that overhangs to a radially outer side from one side of the shaft portion in the axial direction. The flange portion includes an opening through which the lead wire passes. The opening includes a notch connected to an outer side surface of the flange portion. The opening of the motor is positioned above the center axis. |
US11427068B2 |
Mount for vehicle
The present disclosure provides a mount for a vehicle that is provided at a portion at which damping performance is desired and that is fastened by a stud bolt. The mount for the vehicle includes a flange into which the stud bolt is inserted and that supports the stud bolt, an insulator configured to surround the flange, a housing coupled to the other one of the vibrating body or the supporting body and to which the insulator is fixed, a chamber formed inside the housing as a space surrounded by the housing and the insulator, and the chamber is filled with a fluid. In addition, the mount for the vehicle includes a damping part mounted on the housing to divide the chamber into two spaces and to be disposed in the chamber. The mount for the vehicle is configured to appropriately absorb vibrations and reduce noise. |
US11427065B2 |
Mounting structure for waterproof rubber strip of vehicle cover
A mounting structure for a waterproof rubber strip of a vehicle cover includes a vehicle cover and an edge rubber strip. A flat adhesive surface is provided on the edge rubber strip. The edge rubber strip is sealingly adhered and fixed with the vehicle cover through the flat adhesive surface. The mounting structure further includes a first joint. The edge rubber strip is provided with an L-shaped engaging portion. The first joint is fixedly mounted on the vehicle cover. An end of the engaging portion is embedded in the first joint, and the engaging portion is located between the first joint and the vehicle cover. In addition, the edge rubber strip is provided with the L-shaped engaging portion, and the first joint cooperates with the vehicle cover to clamp the engaging portion, so that the edge rubber strip is sealed and fixed on the vehicle cover. |
US11427063B2 |
Locking device having detent hooks and top having a locking device
A locking device for fixing a top of a convertible vehicle at a front header of a convertible vehicle, including an actuating portion and an engagement portion, said actuating portion having a locking hook that can be pivoted between a cleared position and a closed position in which it is engaged with the engagement portion. A securing element is provided that assumes a rest position during normal operation and is pretensioned in the direction of a blocked position using a spring and that is secured in the rest position using a retaining element that can be adjusted by way of a trigger element in such a manner that the securing element is released and that the spring shifts the securing element into its blocked position so that it secures the locking hook in the closed position thereof. |
US11427055B2 |
Compressible latch bracket
A multi-function bracket may include an elongated guide member that defines a slot that is configured to guide a window pane, a handle-chassis bracket extending from the elongated guide member, a slider including a first portion and a second portion, configured to receive a handle chassis, and a compressible member. The compressible member may be coupled to the second portion of the slider and have a compressed state and an uncompressed state. The slider may be configured to translate towards the handle chassis bracket when the compressible member changes from the uncompressed state to the compressed state. |
US11427054B2 |
Vehicle sunshade assembly
A sunshade assembly for a vehicle door includes a housing including a storage portion configured to support a retractor for a sunshade, and a guide portion configured to guide the sunshade into and out of the storage portion. The guide portion includes a first wall and a second wall extended from the storage portion. The first wall and the second wall together define an elongated first opening for extension of the sunshade from the retractor. A sunshade garnish includes a base wall having an elongated second opening aligned with the first opening. A mounting flange depending from the base wall flanks the first wall and is directly connected to an outer surface of the storage portion. A weather-strip support covered by the sunshade garnish includes a mounting tab flanking the second wall and directly connected to the outer surface of the storage portion. |
US11427052B2 |
Glass panel integrated heaters and applications thereof
A glass panel apparatus is provided. The glass panel apparatus includes an outer glass pane comprising a low-e coating on a side facing the inner glass pane, an inner glass pane comprising a low-e coating on a side facing the outer glass pane, a gap between the inner glass pane and the outer glass pane, the gap comprising a vacuum, and a heating element configured to heat the inner glass pane. |
US11427051B2 |
Ultra-low profile HVAC apparatus for a vehicle
A HVAC apparatus for a vehicle having a fan unit with at least one impeller driven by a motor; a heat exchanger unit forming an air duct receiving air from the fan unit, wherein the heat exchanger unit comprises a heat exchanger having at least two different cooling regions with different working temperatures through which received air flows consecutively; and wherein the different working temperatures are controlled by a temperature control unit; and a plate-shaped housing accommodating the fan unit and the heat exchanger unit. |
US11427035B2 |
Pneumatic tire
A pneumatic tire is provided with four or more circumferential main grooves extending in a tire circumferential direction and five or more land portions defined by the circumferential main grooves. Additionally, second land portions are each provided with first through lug grooves and second through lug grooves that extend through the second land portion in a tire lateral direction and are adjacently arranged in the tire circumferential direction. Crossing angles of the first through lug grooves and the second through lug grooves with respect to the outermost circumferential main grooves are mutually different. |
US11427034B2 |
Tire
A tire includes a tread portion including a tire equator, a tread edge located axially outwardly of the tire equator, and at least one block. The at least one block includes a ground contact top surface having an axially extending first edge, and a first sidewall surface extending radially inwardly from the first edge. The first sidewall surface includes an axially inner portion located on the tire equator side and an axially outer portion located on the tread edge side. A maximum inclined angle of the inner portion with respect to a tire normal is greater than a maximum inclined angle of the outer portion with respect to a tire normal. |
US11427033B2 |
Tire
A tire having an outer middle land portion demarcated between an outer shoulder circumferential groove and an outer crown circumferential groove and located at an outer side of a vehicle when the tire is mounted on the vehicle, and an inner middle land portion demarcated between an inner shoulder circumferential groove and an inner crown circumferential groove and located at an inner side of the vehicle when the tire is mounted on the vehicle formed in a tread portion. The outer middle land portion has first outer middle sipes extending from the outer crown circumferential groove toward the outer shoulder circumferential groove and terminating within the outer middle land portion. The inner middle land portion has first inner middle sipes extending from the inner shoulder circumferential groove toward the inner crown circumferential groove and terminating within the inner middle land portion. An angle θ1 of each first outer middle sipe with respect to a tire axial direction is smaller than an angle θ2 of each first inner middle sipe with respect to the tire axial direction. |
US11427032B2 |
Tire tread and a tire comprising a tread
The present invention relates to a tire tread comprising a tread cap comprising at least one tread cap rubber compound, at least three circumferential grooves, wherein at least portions of the sidewalls and the bottom of each of said grooves are formed by a circumferential groove reinforcement, and wherein a first groove reinforcement of a groove laterally next to the equatorial plane of the tire comprises a first reinforcement rubber compound which has a higher hardness than the tread cap rubber compound, and wherein a second groove reinforcement of a groove with a larger lateral distance to the equatorial plane of the tire than the first groove, comprises a second reinforcement rubber compound which has a higher hardness than the tread cap rubber compound and a lower hardness than the second reinforcement rubber compound. |
US11427029B2 |
Pneumatic tire and crosslinked rubber composition
A pneumatic tire includes bead cores, a carcass ply, an inner liner, and a tread having a volume of the low density region of 35% or more at elongation by an applied stress of 1.5 MPa, a volume of the void portion of 7.5% or less at elongation by an applied stress of 3.0 MPa and a hardness of 65 or more and the crosslinked rubber composition of the present invention having a volume of the low density region of 35% or more at elongation by an applied stress of 1.5 MPa, a volume of the void portion of 7.5 or less at elongation by an applied stress of 3.0 MPa and a hardness of 65 or more are excellent in abrasion resistance. |
US11427024B2 |
Method and dryer system for drying a fluid mixture
Thermal energy is supplied to a fluid mixture on a substrate that has a first component, for example water, and a second component, for example cosolvent, such that the proportion of the second component in the fluid mixture is increased at relatively high temperatures of the fluid mixture. It may thus be reliably produced that an optimally small quantity of the second component is located on the surface of the substrate following the drying process. |
US11427020B2 |
Method and system for improved sheet running control in a sheet-fed printing machine
A method for computer-aided sheet running control in a sheet-fed printing machine includes, during a printing operation, using a measuring sensor to detect a printed sheet in the printing machine and using an activation sensor to initiate measuring performed by the measuring sensor by emitting an activation signal. The activation sensor is mechanically fixedly installed without adjustment, and temporal deviations of the activation signal are determined and compensated. A system for computer-aided sheet running control in a sheet-fed printing machine is also provided. |
US11427018B2 |
Printing apparatus and printing method
A printing apparatus and a printing method, including a first irradiation unit provided at one side in a main scanning direction with respect to a reference region in which the nozzle row is provided, and a second irradiation unit provided at another side, wherein at least one of the first irradiation unit and the second irradiation unit irradiates and changes an irradiation position different from a directly-below irradiation position. |
US11427015B2 |
Printer for marking strips
A printer is provided for printing marking strips having a plurality of marking elements for marking electric devices which can be arranged next to one another. Each of the marking elements has a marking plate with at least one writing field which can be printed with information such as writing. The printer has a rotatably mounted feed shaft which can be driven by a motor and a printing head. The rotatably mounted feed shaft has at least one section which is provided with protrusions and which rests directly against the marking strip while the feed shaft is rotated such that the advancing speed of the marking strip is synchronized with the circumferential speed of the feed shaft. |
US11427010B2 |
Logic circuitry
A logic circuitry package for a replaceable print apparatus component comprises an interface to communicate with a print apparatus logic circuit, and at least one logic circuit. The logic circuit may be configured to identify, from a command stream received from the print apparatus, parameters including a class parameter, and/or identify, from the command stream, a read request, and output, via the interface, a count value in response to a read request, the count value based on identified received parameters. |
US11427009B2 |
Image formation device
The image formation device includes a tank, a hollow member, and a sensor. The tank is configured to store ink. The hollow member is disposed inside the tank, and extends in an up-down direction. The sensor is disposed outside the tank and above the hollow member, and is configured to detect a pressure inside the hollow member. |
US11427008B2 |
Liquid discharge apparatus
A liquid discharge apparatus includes a head configured to discharge a liquid, and a discharge receptacle configured to receive the liquid discharged from the head at an installation position. The discharge receptacle includes a liquid holder configured to receive the liquid discharged from the head, and a support configured to detachably support the liquid holder. At least a part of the support is displaceable to a detachment position at which the liquid holder is detachable from the support, and the detachment position is lower than the installation position. |
US11427001B2 |
Head maintenance device, liquid discharge apparatus, and printer
A head maintenance device includes a cap configured to cap a nozzle surface of a head configured to discharge a liquid, a wiper configured to wipe the nozzle surface of the head, a holder configured to vertically movably hold the cap and the wiper to a height at which the cap and the wiper bite into the absorbing member, and a cleaner configured to move relative to the cap and the wiper, the cleaner comprising an absorbing member configured to contact the cap and the wiper. |
US11426993B2 |
Three-dimensional printing system
A three-dimensional printing system includes a build device and an optical projection engine. The build device includes a curing tank, a photocurable material and a build platform, and the photocurable material and the build platform is disposed in the curing tank. The optical projection engine has a zoom lens for projecting image beams with at least a first pixel size and a second pixel size on the build platform to cure the photocurable material, and the first pixel size is different to the second pixel size. |
US11426987B2 |
Fabric for unidirectional liquid transport
A fabric having a base layer with an inside and a face side. The base layer may be hydrophobic and/or omniphobic. The fabric also has a hydrophilic transport layer, a portion of which passes through one or more ducts in the side of the base layer for absorbing liquids. The inner portion may have a shape configured to better absorb and move liquids. The liquids are transported to the face side of the base layer. A covering layer may be disposed on the face side of the base layer such that the outer portion of the transport layer is between the base and covering layers. In some embodiments, an inner layer is disposed on the inside of the base layer such that the inner portion of the transport layer is between the inner layer and the base layer. |
US11426971B2 |
Composite structure and method for barely visible impact damage detection
A composite structure including a composite body having an outer surface, wherein the composite body is elongated along a span axis, and a detection layer connected to the outer surface of the composite body, the detection layer including a plurality of strips, wherein each strip comprises a plurality of glass fibers embedded in a matrix material, is elongated along a detection axis, the detection axis being substantially aligned with the span axis, and is spaced a non-zero distance apart from adjacent strips such that a discontinuity is defined between adjacent strips. |
US11426969B2 |
Insulated radiant barriers in apparel
Fabrics made for apparel, tents, sleeping bags and the like, in various composites, constructed such that a combination of substrate layers and insulation layers is configured to provide improved thermal insulation. The fabric composites are constructed to form a radiant barrier against heat loss via radiation and via conduction from a body. |
US11426966B2 |
Bendable panel
A bendable panel comprising a substrate layer, wherein the panel is provided with a mechanism enabling the panel to bend. The mechanism enabling the panel to bend is at least one groove or cut, and the depth of the groove or cut is no longer than the panel thickness. The substrate layer is prepared by the following materials with the following mass ratio: 100 parts of PVC resin or PVC powder, 30-55 parts of a styrene based elastomer, 150-300 parts of stone powder, sawdust or rock, 1-10 parts of an additive, and 1-4 parts of an elastomer coupling agent. The panel may be bent during the installation, and several panels can be seamlessly installed. |
US11426965B2 |
Box erecting apparatus and method
An apparatus and method for expanding a box blank into a box, the apparatus comprising an arm assembly, a controller, a camera and a box blank conveyor. The arm assembly includes a folding arm having a position in a first direction and a rotational angle controlled by the controller based on a position of a feature of the box blank in the field of view of the camera. The camera captures images of the box blank which are used to position the arm assembly and to evaluate the need to reject a box blank. |
US11426964B2 |
Device for rupturing attachment zones on folding boxes and production unit comprising such a rupture device
This severing device (1) includes an upper pressing member (2), a pile support part (4) having a plurality of conveying members (10) for conveying the pile in a conveying direction (X), a lower pressing member (6) arranged under the conveying members (10). The conveying members (10) are juxtaposed in a transverse direction. Two juxtaposed conveying members can be parted. The lower pressing member (6) has: i) two adjacent lower plates (6.1, 6.2) that can be moved apart, and ii) a lower translation actuator (6.3) for moving the lower plates (6.1, 6.2) so as to cause the severance slot (2.0) between juxtaposed conveying members to coincide with a frangible line in the plate. |
US11426963B2 |
Composite blade and method of forming composite blade
A composite blade made of prepreg obtained by impregnating reinforcement fibers with resin and curing the resin-impregnated reinforcement fibers, the composite blade including: a blade root provided on a base end and fitted into a blade groove; an airfoil provided extending from the blade root toward a tip end; and a metal patch provided between the blade groove and the blade root and placed on the blade root. The metal patch includes a plurality of projections protruding toward the blade root. |
US11426953B2 |
Fiber composite laying device and fiber composite laying method for producing a fiber composite scrim for forming a fiber composite component
A fiber composite laying device for producing a fiber composite scrim for forming a fiber composite component has a laying head which is designed or configured to continuously supply a reinforcement fiber band, a compaction roller which is designed or configured to receive the supplied reinforcement fiber band, lay the band on a laying surface and press the band onto the laying surface at an average compaction pressure, and pressure sensors which are arranged on the compaction roller and are designed or configured to detect a local compaction pressure on the laid reinforcement fiber band. |
US11426952B2 |
Lay-up head
There is provided a lay-up head for applying elongate fibre reinforcement material to an application surface. The lay-up head comprises a support head having a transverse axis, a dispensing mechanism carried by the support head for dispensing elongate fibre reinforcement material, and a roller for pressing elongate fibre composite material against the application surface. The roller is tiltable with respect to the support head such that the roller axis can be angled with respect to the transverse axis of support head. The lay-up head also comprises a holding mechanism operable to hold the roller in a central position in which the roller axis is parallel to the transverse axis of the support head. |
US11426950B2 |
Electromagnetic energy absorbing three dimensional flocked carbon fiber composite materials
This disclosure relates to electromagnetic absorbing materials, and, more particularly, to a flocked carbon fiber composite material and methods for forming thereof. The flocked carbon fiber material comprises electrostatically applied carbon fibers, having a Z-plane component; electromagnetic modifiers; a substrate; a bonding agent; and an encapsulation agent. The method for forming said flocked carbon fiber composite material comprises preparing carbon fiber strands; separating carbon fiber strand clumps into carbon fiber strands; separating carbon fiber strands into carbon fibers; applying a bonding agent to a substrate; and electrostatically applying the carbon fibers to the substrate. The flocking device used to perform this method comprises an insulative section; a high voltage power source; a container attached to the insulative section; and a filtering section attached to the container. |
US11426945B2 |
Three-dimensional printing of hydrophobic materials in fumed silica suspension
A three-dimensional (3D) printing methodology is disclosed for freeform fabrication of hydrophobic structures without the use of printed support structures. The build material is directly printed in and supported by a fumed silica-containing yield-stress support bath to form an intermediate article in the support bath material. The intermediate article may be liquid or only partially solidified after being printed into the support bath material. The intermediate article is then heated or irradiated with ultraviolet radiation to initiate cross-linking to solidify the printed intermediate article, forming a finished article. |
US11426944B2 |
Supervision of an additive manufacturing process
Disclosed is a method for supervision of an additive manufacturing process for producing a manufacturing product by selectively solidifying build-up material in a process chamber. The build-up material is irradiated according to predefinable irradiation control data; and a process chamber supervisory data set is generated based on the irradiation control data, supervisory data being encoded process chamber point by process chamber point in said data set. Quality data concerning the manufacturing process are determined based on the process chamber supervisory data set. A description is further given of a supervisory device suitable therefor a control device for an apparatus for additive manufacturing of manufacturing products, and an apparatus for additive manufacturing of manufacturing products comprising such a control device. |
US11426935B2 |
Method and apparatus for 3D printing
A printing head assembly for 3D printing and methods of using the same are provided. The printing head incorporates a backing means that can be shaped and positioned by use of an attractive force. This creates the possibility of embodiments in which the head can move in three dimensions, without the need to print each successive layer on the layer below. Methods of ensuring the security and integrity of the 3D printing process are also provided. |
US11426933B2 |
Molten material supplying apparatus, three-dimensional modeling apparatus, and method for producing composite material
A molten material supplying apparatus includes: a first introduction unit introducing fiber material; a melting unit melting a thermoplastic resin into a molten material; a first flow path in which the molten material and the fiber material are distributed; and a nozzle communicating with the first flow path to feed a composite of the molten material and the fiber material. The melting unit includes: a facing section in which a communication hole communicating with the first flow path is formed, the facing section having a heater, and a flat screw which has a groove at a position facing the facing section, the flat screw being rotated to melt the thermoplastic resin into the molten material and supply the molten material into the communication hole. The first introduction unit introduces the fiber material into at least one of the communication hole and the first flow path. |
US11426930B2 |
Calibration method for powder fusion system
A manufacturing system for fabricating a three-dimensional article includes a housing, a sensor within the housing, a coater, a removable powder module (RPM) with a platen, a laser system, and a controller. A method of operating the manufacturing system includes installing the RPM into the housing, forming pillars onto the platen, positioning the top surfaces of the pillars a distance D below a build plane, installing a calibration plate onto the top surfaces of the pillars, and then calibrating the laser system using the sensor. The sensor can include one or more of an optical sensor and an acoustic sensor. |
US11426926B2 |
Method and device for the lithography-based additive manufacture of three-dimensional molded bodies
A method for the lithography-based additive manufacture of three-dimensional molded bodies, in which a build platform is positioned at a distance from a material support, which is permeable to the radiation of a radiation source at least in some areas, for a material solidifiable by exposure to said radiation, wherein the material support is translationally moved between a first position and a second position, characterized in that material is applied with a defined layer thickness during the movement of the material support from the first position to the second position, after this the applied material, between the build platform and the material support, is location- and/or time-selectively irradiated by the radiation source and solidified, and subsequently material is removed from the material support during the movement of the material support from the second position to the first position. |
US11426925B2 |
3D printer calibration
Apparatuses and methods for calibrating a 3D printer are disclosed. A 3D printer toolhead may include mechanisms for detecting when a portion of the toolhead comes into contact with a build surface. A process for detecting the distance from the toolhead to the build surface is disclosed using these mechanisms. A further method of calibrating a 3D printer by measuring a plurality of points on a build surface is also disclosed. |
US11426924B2 |
Thermoset additive manufactured articles incorporating a phase change material and method to make them
An additive manufactured article is comprised of at least two adhered layers of extrudates (120) comprised of a thermoset material having therein a phase change material, wherein the phase change material undergoes a phase change at a temperature less than where the thermoset material decomposes. The article may be made by dispensing a mixture comprised of an organic reactive material and phase change material forming extrudates that are 3D printed into an article having multiple layers of extrudates bound together and then allowing the organic reactive material to react forming a thermoset material having therein the phase change material to form the additive manufactured article. The shape of the article may be changed by heating to a temperature above the temperature where the phase change material undergoes a phase change while applying a force and then cooling below the phase change temperature. Likewise, the original shape may be returned by merely heating above the phase change temperature and then cooling in the absence of a force being applied. |
US11426922B2 |
Method of blow molding
Systems and methods for simultaneously forming and filling a container are provided where a pressure source is accelerated from an initial state to attain a predefined process speed while applying pressure to a volume of fluid. The volume of fluid is fluidly coupled to a preform upon attaining the predefined process speed, the pressure source directs at least a portion of the volume of fluid into the preform and stretching the preform to form the container, where the container includes at least the portion of the volume of fluid. The volume of fluid is fluidly decoupled from the container and the pressure source is then decelerated from the predefined process speed toward the initial state. |
US11426915B2 |
Method and apparatus for die coating a substrate with high viscosity materials
A method is disclosed for die coating a moving substrate with a high viscosity material such as a polymer. The method includes heating and mixing ingredients to form a homogenous mixture, pumping the mixture around a circulation loop with a first pump, maintaining a predetermined pressure of the mixture within the circulation loop, drawing mixture from the circulation loop with a second pump, delivering the mixture using the second pump to an extrusion die adjacent the moving substrate to coat the substrate, and controlling the second pump as a function of at least the speed of the moving substrate to maintain predetermined characteristics of the coating mixture applied to the moving substrate. An apparatus for carrying out the method also is disclosed. |
US11426914B2 |
Resin film manufacturing device and resin film manufacturing method
In a resin film manufacturing device according to an embodiment, a current state and a reward for a previously selected action are determined for each heat bolt based on a control error calculated from a thickness distribution of a resin film acquired from a thickness sensor. Then, control conditions, which are a combination of states and actions, are updated based on the reward, and a most appropriate action corresponding to the current state is selected from the updated control conditions. Then, the heater is controlled based on the most appropriate action. |
US11426908B2 |
Mould equipment for pipeline section coating and methods for coating of pipeline sections with moulds
A mold for coating a pipeline section with molten coating material from an injection molding machine, wherein the mold comprises a shell of impervious material reinforced by an exoskeleton of non-distensible material. An assembly for supporting a mold comprising a plurality of mutually separable shell bodies for coating a pipeline section, wherein the assembly comprises motorized opening and closing of the shell bodies in a straight line. An assembly for supporting a bent pipeline section wherein the assembly comprises a base and a pair of arms extending from the base, wherein each arm comprises a respective clamping collar for clamping a bent pipe section between the arms. A vehicle for induction heating a bent pipeline section, wherein the vehicle comprises: a helical induction coil; and wheels arranged to guide movement of both ends of the induction coil through a tubular inside face of a bent pipeline section. |
US11426907B2 |
Mold assembly for injection molding
Disclosed is a mold assembly comprising: a cavity forming an inner space to be filled with resin containing metallic particles, and having a protruding part corresponding to a hole of a molded object; a first gate disposed at any one side of the cavity so as to inject the resin into the inner space; and a second gate disposed at another side of the cavity, and injecting the resin, which flows in a second direction intersecting with a first direction, into the inner space so as to change the arrangement of the metallic particles such that a weld line, formed according to the orientation of metallic particle in the first direction, is blurred in an area at which the flow of the resin is separated by the protruding part and then comes back together. |
US11426906B2 |
Imprint apparatus, imprint method, and article manufacturing method
An imprint apparatus cures an imprint material by irradiating the imprint material with light while the imprint material on a substrate is in contact with a pattern region of a mold. The imprint apparatus includes a first supply unit configured to supply a first gas to a gap between the substrate and the mold, the first gas accelerating filling of recessed portions of the pattern region with the imprint material, and a second supply unit configured to supply a second gas to the gap, the second gas inhibiting curing of the imprint material. |
US11426900B2 |
Molding a fluid flow structure
In one example, a process for making a micro device structure includes molding a micro device in a monolithic body of material and forming a fluid flow passage in the body through which fluid can pass directly to the micro device. |
US11426898B2 |
Process for fabrication of fiber composites using dual-cure free-form 3D-printed tailored fiber placement preform
A method for generating a thermoset Fiber-Reinforced Polymer (FRP) composite preform includes: dispensing, from a print head of a 3D-printer, a dual-cure resin coated fiber including a dual-cure resin with a ultra-violet (UV)-curable component and a thermally-curable component; curing, during the dispensing of the dual-cure resin coated fiber, the UV-curable component with a UV light source such that the dual-cure resin coated fiber is partially cured and contacting lengths of the partially-cured dual-cure resin coated fiber bond together; and positioning the print head during the dispensing and curing of the dual-cure resin coated fiber to three-dimensionally print the thermoset FRP composite preform. |
US11426895B2 |
Integral composite shuttering panel and monolithic wall building system
A composite wall panel having a front surface, a rear surface, and side surfaces extending therebetween is provided. The panel includes a cured composition of pieces of cellulose and/or chaff and at least one binder. A wall assembly is also provided. The assembly includes: a frame including a plurality of linearly arranged elongated studs having a top end, a bottom end, and a first longitudinal side and a second longitudinal side extending between the respective ends; a plurality of interconnected wall panels mounted to the first side of the elongated studs of the frame to form a first wall portion; a plurality of interconnected panels mounted to the second side of the elongated studs to form a second wall portion; and an insulating layer inserted within a cavity between the first wall portion and the second wall portion. |
US11426890B2 |
Razor cartridge and razor assembly using the same
At least one embodiment of the present disclosure provides a razor assembly including at least one shaving blade having a cutting edge, a blade housing, and an aid supplying member. The blade housing is configured to accommodate at least one shaving blade such that a width direction of the blade housing is in parallel with a longitudinal direction of the cutting edge and includes an inlet portion, a discharge portion, and a communication portion configured to communicate the inlet portion to the discharge portion. The aid supplying member is configured to deliver a shaving aid to the inlet portion. The shaving aid that is delivered from the aid supplying member is introduced into the inlet portion, passes through the communication portion, and is discharged from the discharge portion. |
US11426887B2 |
Easily disassembled folding knife
A folding knife includes a handle and a blade. The handle includes a first side portion and a second side portion. The blade is pivotably coupled to the handle and pivotable relative to the handle about a pivot axis between a closed position and an open position. The first side portion of the handle comprises a first portion and a second portion, the second portion slidable relative to the first portion in a longitudinal direction that is perpendicular to the pivot axis and parallel to a longitudinal axis of the first portion, between a first position and a second position. When the second portion is in the first position, the first portion is prevented from rotating relative to the second portion and the second side portion, and when the second portion is in the second position, the first portion is rotatable relative to the second portion and the second side portion. |
US11426886B1 |
Protective robot wrap
The present disclosure relates generally to protective covers, for example, suitable for protecting parts of a robot. The present disclosure relates more particularly to a protective wrap for a robot component. The protective wrap includes a continuous strip of a material sheet configured to wrap around the robot component in a plurality of loops so as to form a tubular body that surrounds a portion of the robot component. |
US11426882B2 |
Gripping tool, gripping system, and method for manufacturing resin member
According to one embodiment, a gripping tool includes a gripper. The gripper is flexible and includes a first portion contacting a workpiece, a second portion opposing the first portion, and a granular material provided between the first portion and the second portion. The first portion includes a concave portion and a convex portion. The concave portion is recessed in a first direction. The first direction is from the first portion toward the second portion. The convex portion is provided around the concave portion and protrudes in a second direction. The second direction is the reverse of the first direction. The concave portion has a groove having a ring configuration recessed outward from a center of the gripper. |
US11426880B2 |
Soft gripper with multizone control to allow individual joint articulation
A gripper assembly is disclosed. The gripper assembly includes a stage, a mounting platform, and a plurality of the flexible gripper elements. The flexible gripper element is configured to grip an object. The flexible gripper elements are supported by a first end piece, where the first end piece is attached to the mounting platform. The mounting platform is connected to the stage, where the stage is moveable. The flexible gripper element includes a hollow section that is selectively pressurizable. The hollow section includes one or more zones, where each zone includes chambers which are pressurizable by a fluid input. The selective pressurization of the hollow section allows the flexible gripper element to grip the object. |
US11426879B2 |
Device, method, and program
A device communicates with a human through voice recognition of voice of the human. The device includes: a drive mechanism that drives the device; and a processor. The processor controls the drive mechanism to drive the device to a waiting place for the device to contact the human, and the waiting place is determined based on contact information that is history of contact between the device and the human. |
US11426877B2 |
Robotic drummer
Robotic drummers include voice coil actuators that are coupled to linear-to-rotary motion convertors to produce drumstick rotations so as to strike a drum head. Such rotations can be triggered via a microprocessor using stored performance data, by a user with a mouse, trackpad, joystick, or other user input device. Performances are enhanced by driving the VCA with drive signals have random variations associated with strike timing, amplitude, location, and speed. Multiple strikes are provided by reducing, eliminating, or reversing drumstick rotation with a corresponding drive signal upon detection of drumstick contact with the drum head. |
US11426874B2 |
Robot-based insertion mounting of workpieces
Methods and systems for insertion mounting workpieces are provided. In one embodiment, a method is provided that includes acquiring a position of the second fitting part of the receiving component, moving the first fitting part of the workpiece towards the second fitting part of the receiving component until the workpiece is in contact with the receiving component, and rotating the workpiece while pressing the workpiece towards the receiving component. The implementation of the present disclosure may be applied for various types of workpieces and receiving components and may overcome minor deviations of positions between the workpiece and the receiving component during the insertion operation, thereby improving the efficiency of the insertion operation. |
US11426871B1 |
Automated robotic floor map generation
A system can be configured to generate and analyze one or more candidate logistics maps based on a set of input parameters and a baseline map of a logistics facility. The system can identify modifications strategies, resource limits, regions of interest, mapping constraints through analysis of the input parameters and the baseline map. The generated candidate maps and the baseline map can be implemented in virtual environments that are configured to replicate one or more operations associated with the baseline map, such as item distribution, item retrieval, and reorganization operations. The virtual environment can further simulate the resource limits associated with the baseline map and compare performance indicators from simulation of the baseline map to performance indicators from simulation of the candidate maps to identify viable improvements over existing logistics solutions. |
US11426868B2 |
Operation device, control system, control method, and non-transitory computer-readable storage medium
An operation device includes operation input circuitry that receives instructions for operating robot having leading end and arm that changes position and posture of the end, and processing circuitry that outputs, to the input circuitry, operation image by which instruction for motion command for the end is input, detects posture of the input circuitry in first coordinate system, rotates second coordinate system relative to the first system based on the posture of the input circuitry, converts the command into first-coordinate-system command, and outputs the first-coordinate-system command based on the first-coordinate-system command. Upon execution of operation of specifying point on the image, the processing circuitry determines motion direction of the end in the second system correlated with positional relationship between the point and reference point in the image, determines motion scalar quantity of the end correlated with distance between the points, and generates the motion command including the direction and quantity. |
US11426867B2 |
Robot simulation engine architecture
A virtualization system implemented within a cloud server enables the simulation of robot structure and behavior in a virtual environment. The simulated robots are controlled by clients remote from the cloud server, enabling human operators or autonomous robot control programs running on the clients to control the movement and behavior of the simulated robots within the virtual environment. Data describing interactions between robots, the virtual environment, and objects can be recorded for use in future robot design. The virtualization system can include robot templates, enabling users to quickly select and customize a robot to be simulated, and further enabling users to update and re-customize the robot in real-time during the simulation. The virtualization system can re-simulate a portion of the robot simulation when an intervention by a human operator is detected, positioning robots, people, and objects within the virtual environment based on the detected intervention. |
US11426863B2 |
Four-chain six-degree-of-freedom hybrid mechanism
The present invention provides a four-chain six-degree-of-freedom hybrid mechanism. The four-chain six-degree-of-freedom hybrid mechanism comprises a fixed platform, a sliding rail mounted on the fixed platform, two sliding blocks, a mobile platform and four linear actuator chains connecting the mobile platform with a first sliding block and a second sliding block. The mobile platform is square-shaped. In the four linear actuator chains, the first linear actuator chain and the third linear actuator chain have the same structure while the second linear actuator chain and the fourth linear actuator chain have the same structure. The mobile platform can achieve six degrees of freedom. The four linear actuator chains coordinate to drive so as to achieve two translational degrees of freedom and two rotational degrees of freedom; the first sliding block and the second sliding block coordinate to drive so as to achieve the other translational and rotational degrees of freedom. |
US11426862B2 |
Guiderail for underslung robot, underslung robot and operating system thereof
Disclosed are a guiderail of an underslung robot, an underslung robot and an operating system thereof. The guiderail of an underslung robot includes: a main guiderail, suspended in the air by a support frame; and an auxiliary guiderail, communicating with the main guiderail and suspended in the air by a support frame. An intersection of the main guiderail and the auxiliary guiderail is provided with a gap through which a traveling underslung robot can pass. The guiderail further includes path indicators mounted on the main guiderail and the auxiliary guiderail. An underslung robot, comprising: wheels for bearing the underslung robot, wherein at least one of the wheels is a power wheel; and two booms, wherein the top of the booms is connected to the wheels, the bottom of the booms is connected to a frame of the underslung robot. |
US11426858B2 |
High-capacity self-locking toolbox with three opening modes
A high-capacity self-locking toolbox with three opening modes, which includes a box frame, a box cover, and a clamping base. The box frame includes an upper box frame and a lower box frame which are folded in the middle to make two pieces. The box cover includes an upper box cover and a lower box cover. The two box covers are respectively provided on an upper surface and a lower surface of the box frame. A reinforced rib surface is provided inside an inner wall of the box frame. The reinforced rib surface is provided with self-locking clamping members in pairs, and the clamping base is installed in the self-locking clamping members. The three opening modes enable the toolbox to be opened from the upper side, the lower side, or the middle, so as to have access to the tools from any side of the toolbox. The interior of the toolbox is designed in modular, the clamping base has a self-locking function, and the tools have a compact arrangement. |
US11426857B2 |
Truss jigging system and method
A truss-jig-positioning system that includes a truss-assembly table having a support plane, a plurality of slots in the support plane, and a plurality of puck assemblies automatically movable along the slots. Each puck is self-powered and self-locks at selected locations. A controller controls the pucks. Images of the truss-assembly table and pucks allow the controller to locate pucks, and transmit location-correction information as needed to move pucks to desired locations for building various trusses, wall assemblies, etc. Pucks are self-powered, self-moving, motorized jigging members. Each operates from controller commands to unlock from one location, move along their slot and lock to a new location. Optionally location-measuring (machine-vision) subsystem(s) communicate wirelessly with the pucks to readjust positions and re-lock at the adjusted position. Optionally, the jigging pucks can automatically move along slots to connect to a recharging station to self-recharge on-puck batteries or supercapacitors. |
US11426856B2 |
Convertible sawhorse and worktable
A convertible sawhorse and worktable including a sawhorse assembly having first and second outer-facing side surfaces and a worktable top assembly arranged for selectable positioning relative to the sawhorse assembly, the worktable top assembly including a worktable surface defining element and a worktable auxiliary support assembly, the worktable top assembly having at least two operative orientations including a storage operative orientation wherein the worktable surface defining element is located adjacent the first outer-facing side surface of the sawhorse assembly and the worktable auxiliary support assembly is located adjacent the second outer-facing side surface of the sawhorse assembly and a worktable usage operative orientation wherein the worktable surface defining element is located above the sawhorse assembly and the worktable auxiliary support assembly is located adjacent the second outer-facing side surface of the sawhorse assembly. |
US11426854B2 |
Work tool with motor and fan
Described herein is a work tool (100) comprising: a motor (125) provided with a drive shaft (130), a casing (195) containing the motor (125) and provided with at least one inlet opening (235) and with at least one outlet opening (240), an implement (135) positioned outside the casing (195) and kinematically connected with the drive shaft (130), and a fan (245) kinematically connected to the drive shaft (130) and able to generate a flow of air from the inlet opening (235) towards the outlet opening (240) of the casing (195) passing in heat exchange relationship with the motor (125), wherein said fan (245) is contained inside the casing (195) in a space located between the motor (125) and the implement (135). |
US11426853B2 |
Power tool having improved air exhaust ports
A power tool, such as an impact driver, includes a motor having a rotor that rotates relative to a stator, and a centrifugal fan that rotates together with the rotor. A motor housing and a rear housing house the motor. Overlapping parts of the motor housing and the rear housing radially surround an outer circumference of the centrifugal fan. Air exhaust ports are defined in each of the overlapping parts and are offset in an axial direction of the rotor. Fluid communication paths are defined between the air exhaust ports in the overlapping parts. The fluid communication paths have an opening area or width in the axial direction that is smaller than an opening area or width in the axial direction of the air exhaust ports. |
US11426851B2 |
Fastener driving tool
Various embodiments of the present disclosure provide a combustion powered fastener driving tool including a fuel cell receiver configured to receive and engage a fuel cell metering valve of a fuel cell, the fuel cell metering valve configured to dispense a dose of fuel from the fuel cell. |
US11426848B2 |
Setting method for threading connection by means of impact wrench
A control method for tightening a threaded connection executes, in response to actuation of a pushbutton key, a sequence with consecutive phases. In a first phase, an impact mechanism of an impact wrench exerts a predefined number of rotary impacts on the threaded connection. During the first phase, a profile of a rotational angle over time is estimated. A pattern is adapted to the profile and on the basis of the pattern a setpoint torque is determined for a second phase and a final rotational angle or a final number of impacts is determined for a third phase. During the second phase, rotary impacts are exerted until an estimated torque reaches the setpoint torque. During the third phase, rotary impacts are exerted on the threaded connection until a number of rotary impacts corresponds to the final number or a rotational angle corresponds to the final rotational angle. |
US11426843B2 |
Crimp tool force monitoring device
A crimp tool includes a frame, a lead screw and a nut assembly connected to the lead screw. A spring member is connected to the frame and movable with rotation of the lead screw. A first transducer is connected to the nut assembly to measure a first force applied on the nut assembly. A second transducer is connected to the spring member to measure a second force applied thereon by the spring member. |
US11426841B2 |
Internal gear retention mechanism
A retaining structure for a drive gear of a ratchet wrench. The drive gear has a partial internal bore that receives a gear retainer that is coupled to the tool housing via screws. The gear retainer can further be rotatably coupled to the drive gear to retain the drive gear within the head of the tool without requiring a cover plate. By potentially avoiding the cover plate, the ratchet wrench head can be thinner compared to conventional ratchet wrenches and the ratchet wrench seal can be improved. |
US11426836B2 |
Roller burnishing tool
The invention relates to a roller burnishing tool 10 with a base body 12 extending along a longitudinal center axis 11, at least one roller holder 14 arranged radially adjustably on the base body 12, which holds a roller 15 rotatably, and an adjusting device 16 arranged in the base body 12 for adjusting the roller holder 14 cooperates in the radial direction with the roller holder 14. According to the invention, the roller holder 14 has a holder arm 18b holding the roller 15, which can be pivoted out in a radial direction by the adjusting device 16 relative to the base body 12 in a radial direction. |
US11426824B2 |
Aluminum-containing welding electrode
The disclosed technology generally relates to consumable electrode wires and more particularly to consumable electrode wires having a core-shell structure, where the core comprises aluminum. In one aspect, a welding wire comprises a sheath having a steel composition and a core surrounded by the sheath. The core comprises aluminum (Al) at a concentration between about 3 weight % and about 20 weight % on the basis of the total weight of the welding wire, where Al is in an elemental form or is alloyed with a different metal element. The disclosed technology also relates to welding methods and systems adapted for using the aluminum-comprising electrode wires. |
US11426822B2 |
Braze composition and process of using
A composition includes the constituents, in approximate weight percentages: Chromium 15-17; Silicon 2.5-3.5; Cobalt 6.0-8.0; Aluminum 1.0-2.0; Tantalum 1.5-2.5; Boron 1.5-2.5; Yttrium 0.015-0.025; Nickel balance; and incidental impurities. |
US11426818B2 |
Additive manufacturing processes and additively manufactured products
A technique to additively print onto a dissimilar material, especially ceramics and glasses (e.g., semiconductors, graphite, diamond, other metals) is disclosed herein. The technique enables manufacture of heat removal devices and other deposited structures, especially on heat sensitive substrates. It also enables novel composites through additive manufacturing. The process enables rapid bonding, orders-of-magnitude faster than conventional techniques. |
US11426817B2 |
Lock and fail-safe for laser welding lens
A locking and fail-safe system can ensure proper installation of a lens assembly in a laser welding machine. The laser welding machine includes a laser head, a lens assembly, and an alignment tab operatively connected to the lens assembly. A device can be operatively positioned relative to the laser welding machine. The device can include a spring pin member with a movable slide pin. In a locked condition, the spring pin member can be positioned such that the slide pin is received in an aperture in the alignment tab, indicating that the lens assembly is properly installed and locking the lens assembly in place. A sensor can be used to determine whether the spring pin assembly is in a correct position, location, and/or orientation. The laser welding machine can be disabled if the spring pin member is not in a correct position, location, and/or orientation. |
US11426814B2 |
Systems and methods for providing location services for a welding power supply
Embodiments described herein include wireless control of a welding power supply via portable electronic devices, such as dedicated original equipment manufacturer (OEM) welding remote devices, cellular radio telephones, satellite radio telephones, laptops computers, tablet computers, and so forth. In particular, operating parameters and statuses of the welding power supply may be modified by the portable electronic device, as well as be displayed on the portable electronic device. A pairing procedure may be used to pair the welding power supply and the portable electronic device in a wireless communication network. Furthermore, in certain embodiments, a method of providing location services for the welding power supply includes utilizing location data for the portable electronic device controlling the welding power supply as an approximation for the location of the welding power supply. |
US11426813B2 |
Welding or additive manufacturing dual wire drive system
A welding or additive manufacturing wire drive system includes a first spindle for a first welding wire spool, a second spindle for a second welding wire spool, a first drive roll, and a second drive roll. One or both of the drive rolls has a circumferential groove. A first welding wire and a second welding wire are located between the first drive roll and the second drive roll in the circumferential groove. The first welding wire contacts the second welding wire between the first drive roll and the second drive roll. The first welding wire further contacts a first sidewall portion of the circumferential groove. The second welding wire further contacts a second sidewall portion of the circumferential groove. Both of the first welding wire and the second welding wire are radially offset from a central portion of the circumferential groove. |
US11426812B2 |
Machining apparatus and machining system
A machining apparatus includes a curved outer conduit, a curved rotary electrode and a driving motor. The outer conduit has a cavity and a fluid inlet in fluid communication with the cavity. The electrode includes a flexible shaft positioned in the cavity and having a first end and a second end, and a machining head having a fluid outlet in fluid communication with the cavity and electrically connected with the first end of the flexible shaft to be powered via the flexible shaft. The motor is mechanically coupled to the second end of the flexible shaft for driving the flexible shaft to rotate. A machining system includes the machining apparatus, a power supply for powering the flexible shaft, an electrolyte supply for providing electrolyte to the fluid inlet and a machine tool onto which the outer conduit and the motor are positioned. |
US11426811B2 |
Hollow gear hob
A hob for a cutting apparatus including a hollow body of a sintered hard metal composition and a cavity located within the body, the cavity having a volume in the range of about 10% to about 90% of the volume of the body. |
US11426807B2 |
Mobile machine tool
A mobile machine tool (10), namely a manually-operated machine tool or semi-stationary machine tool, for machining a workpiece (W), wherein the machine tool has a plate-like guide element (30) with a guide surface (32) for guiding the machine tool on the workpiece (W) or the workpiece (W) on the machine tool, wherein the machine tool has a drive unit (11) with a drive motor (13) for driving a tool holder (14) arranged on the drive unit (11), wherein the drive unit (11) is, by means of a bearing arrangement (35), mounted adjustably on the guide element (30) in order to adjust at least two adjustment positions (S0, S1, S2) of the tool holder (14) relative to the guide surface (32), wherein at least one adjustment position (S0, S1, S2) corresponds to a workpiece machining position in which the work tool (15) arranged on the tool holder (14). |
US11426805B2 |
Surface precision defect shaver
An apparatus for precision shaving is provided. In one embodiment, the apparatus includes an endmill cutter, a base frame, and a motor adjacent to the base frame and having a shaft on one end. A coupler is positioned between the shaft and the endmill cutter. A positioning slide is housed within the base frame and a coupler frame and a first gear are fastened to the positioning slide. A second gear is adjacent to the first gear, the second gear having a set of first teeth and a set of second teeth positioned opposite the set of first teeth. The set of first teeth and the set of second teeth are separated by a gap. |
US11426796B2 |
Metal shaped article production method
A metal shaped article production method includes a shaping data input step, a step of forming a constituent material layer using a constituent material, a step of forming a support material layer using a support material, a step of cutting a cut face in the constituent material layer of a stacked body formed by performing the constituent material layer forming step and the support material layer forming step, a step of degreasing a thermoplastic resin contained in the stacked body for which the cut face cutting step was performed, and a step of sintering metal particles by heating the stacked body, wherein in the support material layer forming step, the support material layer is formed so that a support face comes into contact with a face to be supported at an opposite side to the cut face at a position of the constituent material layer based on the shaping data. |
US11426790B2 |
Printing-enhanced casting cores
Aspects of the disclosure are directed to treating a substrate, the substrate including at least one of a refractory metal or a ceramic material, and depositing a media onto the treated substrate to generate a casting core. Embodiments include a fixture, a substrate located on the fixture, the substrate including at least one of a refractory metal or a ceramic material, and a delivery head that deposits media onto the substrate to generate a casting core. Aspects are directed to a core configured for casting a component, the core comprising: a substrate that includes at least one of a refractory metal or a ceramic material, and media deposited on the substrate, the media having a dimension within a range of between 0.5 and 100 micrometers. |
US11426788B2 |
Method for joining at least one component to a second component without preformed hole(s)
A joining method for connecting a first component to a second component without pre-punching. The first component and the second component are positioned relative to one another prior to the connection by an auxiliary joining element, which is joined via a joining device to the components positioned relative to one another. The auxiliary joining element firstly passes through the first component without pre-punching and is then connected to the second component without pre-punching. Before the components are connected by the auxiliary joining element, the first component is thermally pre-treated at the joining area via an electric arc formed between the first component and an electrode of the joining device. A heat-affected zone is formed on the first component in the joining area, and the first component in is weakened or melted in the heat-affected zone. |
US11426787B2 |
Robotic weight machine
A robotic press assembly configured to apply force to a wheel, may include a selectively moveable arm that is operatively connected to a body portion at a first end thereof; and a press tool operatively connected to a second end of the moveable arm; wherein the press tool includes at least one mounting bracket maintaining a press tool thereon, the mounting bracket arranged on a platform, and a base operatively connected to the second end of the arm, the platform being slidably fixed to the base in order to adjust the lateral displacement of the press tool, and wherein the press tool is configured to apply force at the wheel. |
US11426784B2 |
Method and device for producing components having an adjusted bottom reagion
The invention relates to a method for producing a component, said method comprising: preforming a workpiece to a preformed component having a base region, a side-plate region, and optionally a flange region, such that the preformed component has a material surplus for the side-plate region and/or the base region and/or optionally the flange region; and calibrating the preformed component to an at least in regions finally formed component having a base region, a side-plate region, and optionally a flange region; wherein the base region of the preformed component has substantially the geometry and/or the local cross sections of the base region of the at least in regions finally formed component. The invention moreover relates to a device for producing a component, in particular for carrying out the method. |
US11426780B2 |
Support arm—tool cradle module
A unitary forward mounting assembly for a bodymaker includes a unitary forward mounting body with a cradle portion, a first support arm portion and a second support arm portion. The cradle portion has a forward side, a rear side, a right side, and a left side. The first support arm portion is disposed at the cradle portion right side. The second support arm portion is disposed at the cradle portion left side. |
US11426777B2 |
Systems and methods for controlling surface texturing of a metal substrate with low pressure rolling
Systems and methods of applying a texture on a substrate include applying a texture to the substrate with a work stand of a coil-to-coil process. The work stand includes an upper work roll and a lower work roll vertically aligned with the upper work roll. At least one of the upper work roll and the lower work roll includes the texture. Applying the texture includes applying, by the upper work roll and a lower work roll, a work roll pressure on an upper surface and a lower surface of the substrate. The method further includes adjusting a contact pressure parameter of the work stand such that the work stand provides a desired contact pressure distribution across the width of the substrate and a desired thickness profile of the edges of the substrate while an overall thickness of the substrate remains substantially constant. |
US11426774B1 |
Dust removal method and system in rollable display device
In a method for dust removal in a rollable display device, a control module activates rolling mechanisms and a dust removal mechanism of the rollable display device. The control module determines a first amount of dust particles on a display surface of the rollable display device using data from a dust detection mechanisms. When the first amount of dust particles is determined to exceed a threshold, the control module engages magnetic locks to lock the rolling mechanisms, and the dust removal mechanism continues to remove the dust from the display surface. The control module determines a second amount of dust particles on the display surface. When the second amount of dust particles is determined to fall below the threshold, the control module disengages the magnetic locks to release the rolling mechanisms. Dust removal mechanism may include piezoelectric strips or an ultrasound haptic effect generation module. |
US11426773B2 |
Load port and control method
A load port includes a dock plate on which a container storing a substrate is placed, a port plate, a moving mechanism configured to move the dock plate between a dock position and an undock position, a gas supply nozzle unit provided in the dock plate and configured to contact a bottom surface of the container placed on the dock plate and supply a gas into the container, and a pressing unit provided above the dock plate and configured to press the container placed on the dock plate downward. The pressing unit includes a contact member brought into contact with the container placed on the dock plate, and a driving mechanism configured to move the contact member between a first position apart from the container and a second position in contact with the container. |
US11426768B2 |
Sorting apparatus
A method for sorting products and sorting apparatus with a flow of granular products moving in an inspection zone, in which a light beam is moved over the product flow to generate a reflected stream of light. At least one detector unit is provided to detect light reflected by the products to generate detection signals. This detector unit cooperates with a control unit to sort the products by these detection signals. The detector unit contains at least two sensors that are provided one after the other in the reflected stream of light so that a sensor is placed upstream of a downstream sensor. Each sensor detects a different part of the reflected stream of light. |
US11426767B2 |
Shaker screens for shale shakers
This disclosure discloses a shaker screen. The shaker screen comprises a frame and at least one screen layer supported by the frame for sieving materials. The frame comprises a rectangular outer support structure, at least one lateral inner support member, and at least one longitudinal inner support member. The lateral inner support member comprises an aperture, and the longitudinal inner support member comprises a groove on a side of the longitudinal inner support member. The lateral inner support member is engaged with the longitudinal inner support member by engaging the aperture on the lateral inner support member and the groove on the longitudinal inner support member. |
US11426766B2 |
Injection molded screening apparatuses and methods
Screening members, screening assemblies, methods for fabricating screening members and assemblies and methods for screening materials are provided for vibratory screening machines that incorporate the use of injection molded materials. Use of injection molded screen elements provide, inter alia, for: varying screening surface configurations; fast and relatively simple screen assembly fabrication; and a combination of outstanding screen assembly mechanical and electrical properties, including toughness, wear and chemical resistance. Embodiments of the present invention use a thermoplastic injection molded material. |
US11426753B2 |
Method and device for applying coating layers to a coating material
Subject matter of the present invention is a method of applying coating layers (9) to a substrate (1, 11, 21, 31), wherein the substrate (1, 11, 21, 31) is drawn through a coating chamber (2) containing a pressurized coating agent (3) being liquefied or softened by means of a thermal exposure, wherein the substrate (1, 11, 21, 31) is drawn through a drawing tool (8), wherein the coating agent (3) serves as a lubricant between the drawing tool (8) and a surface of the substrate (8) and wherein at the same time the coating layer (9) is applied to the surface of the substrate (8). Subject matter of the invention is also a corresponding apparatus for applying a coating layer (9) to a substrate (1, 11, 21, 31). By means of the invention coating layers can be applied to a substrate in an efficient and economical way. |
US11426749B2 |
Valve block assembly for a bottle attachment apparatus
A valve block assembly for a bottle attachment apparatus for handling liquids has a valve block, an intake valve insert and/or an exhaust valve insert, and a valve receptacle assigned to the respective valve insert. The valve insert is inserted in a replaceable and sealing manner in the valve receptacle. The valve insert has a stop portion, a fastening portion distinct therefrom and a sealing portion distinct from both. The associated valve receptacle has stop, fastening, and sealing portions matching the equivalent portions of the valve insert. When the valve insert is installed correctly both the stop portions and the sealing portions bear on one another in a planar manner. |
US11426747B2 |
Hand-held battery operated sprayer with rotatable spray lance
A hand-held battery operated sprayer with a rotatable spray lance includes a spray lance assembly and a spray chamber. A motor, a pump, a shutoff valve, a suction hose assembly, a pump inlet hose, a pump outlet hose, a battery pack, and a conductor are disposed in the spray chamber. Water sequentially passes the suction hose assembly, the shutoff valve, the pump inlet hose, the pump, and the pump outlet hose, and flows out of the spray chamber. A rotary axle base is disposed at the front end of the spray chamber. A right-angled rotating shaft is movably connected in the rotary axle base. The rotating shaft is connected to the spray lance assembly. The pump outlet hose can reach a nozzle of the spray lance assembly through the rotating shaft. |
US11426744B2 |
Spool valve for polyurethane foam dispenser
A foam dispenser having a metal housing has a spool valve socket therein. A metal handle extends from the housing. A spool valve is disposable within the spool valve socket. A trigger couplable to the spool valve enables the spool valve to be rotated between open and closed orientations within the housing. The spool valve has internal channels for selectively passing liquids through the spool valve in the open orientation and not in the closed orientation. The spool valve also has a channel for selectively passing a gas through the spool valve in both the open and closed orientations. |
US11426741B2 |
Water output device
A shower apparatus includes a pivotable member and a main body having a receiving space, an inlet communicating with the receiving space, and a first outlet. A first communicating hole is located at a connection site between the receiving space and the inlet in the main body. The pivotable member is pivotally connected to the main body and is manipulated to pivot relative to the main body and includes a pivotal axle disposed in the receiving space and a second outlet. When the pivotable member is pivoted relative to the main body, the pivotal axle is simultaneously pivoted in the same direction in the receiving space. The pivotal axle has a tube body, an isolating member, a second communicating hole, and a third communicating hole. The isolating member is fixed in the tube body to divide an inner space of the tube body separately into a first flow channel and a second flow channel. When the first communicating hole communicates with either the second communicating hole or the third communicating hole, water flows through one of the first flow channel or the second flow channel, thereby the water is outputted through one of the first outlet and the second outlet. |
US11426740B2 |
Adhesive splitter systems and methods of using the same
Disclosed herein are adhesive splitter systems and methods for using the same. The adhesive splitter systems comprise a multi-nozzle adapter configured to dispense multiple streams of adhesive onto a substrate. The splitter system can also include an attached adhesive dispenser for providing adhesive to the multi-nozzle adapter. |
US11426732B2 |
Flow cell device and use thereof
Flow cell devices, cartridges, and systems are described that provide reduced manufacturing complexity, lowered consumable costs, and flexible system throughput for nucleic acid sequencing and other chemical or biological analysis applications. The flow cell device can include a capillary flow cell device or a microfluidic flow cell device. |
US11426731B2 |
Cartridge for digital real-time PCR
A cartridge for digital real-time Polymerase chain reaction (PCR) includes a microfluidic chamber, a well array, a CMOS photo sensor array and a PCB. The microfluidic chamber includes an inlet formed for injection of a liquid sample, the microfluidic chamber being capable of injection molding. The well array includes a plurality of microwells through which upper and lower portions are perforated and being attached to a lower surface of the microfluidic chamber. The CMOS photo sensor array is disposed below the well array to capture a response image of a sample filled in microwells of the well array. The PCB has a vent formed for vacuum processing of micro flow path formed in the microfluidic chamber, a space formed between the well array and the microfluidic chamber, and a microwell formed in the well array as the liquid sample is injected through the inlet. |
US11426728B2 |
Apparatus for high throughput continuous droplet electroporation for delivery of a material, and a method for droplet electroporation using the same
An electroporation device is disclosed, which includes a first tubular electrode including a first inlet and a first outlet; an aqueous solution supply connected to the first tubular electrode and configured for supplying an aqueous solution to the first tubular electrode and for allowing a droplet of the aqueous solution to be discharged from the first outlet of the first tubular electrode, the aqueous solution contains a cell and a delivery target substance; a second tubular electrode including a second inlet and a second outlet, wherein the second inlet is spaced away from the first outlet at a spacing corresponding to a size of a portion of the droplet; a power supply for applying a voltage to the electrodes for electroporation of the cell in the droplet; and a droplet sucking unit connected to the second electrode and configured for allowing the droplet to be sucked into the second electrode. |
US11426726B2 |
Systems and methods for serial flow emulsion processes
Disclosed herein are systems and methods for serial flow emulsion processes. Systems and methods as described herein can result in reduced cross-contamination, greater accuracy and precision, less expensive materials and processes, decreased run times, and/or other advantages, e.g., through use of improved injectors, partitioners, detectors, and/or other elements useful in serial flow emulsion systems and processes. |
US11426723B2 |
System and method for sequestered wash buffered reuse
A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device. |
US11426719B2 |
Preparation method of catalyst with white carbon black modified by Zr—Nd—O
The present invention discloses a preparation method of a catalyst with white carbon black modified by Zr—Nd—O and use thereof, and belongs to the field of catalyst technologies. In the present invention, an organic solvent evaporation induced self-assembly method is used to load Zr—Nd—O onto white carbon black to obtain a mesoporous Zr—Nd—O/white carbon black catalyst. The mesoporous Zr—Nd—O/white carbon black catalyst in the present invention has high catalytic activity, contains uniformly distributed mesopores with a relatively large average aperture, and has a simple preparation process, etc. |
US11426718B2 |
Cerium oxide particles and method for production thereof
The present invention relates to cerium oxide particles that have excellent heat resistance and/or pore volume especially useful for catalysts, functional ceramics, solid electrolyte for fuel cells, polishing, ultraviolet absorbers and the like, and particularly suitable for use as a catalyst or cocatalyst material, for instance in catalysis for purifying vehicle exhaust gas. The present invention also relates to a method for preparing such cerium oxide particles, and a catalyst, such as for purifying exhaust gas, utilizing these cerium oxide particles. |
US11426717B2 |
Catalyst, structures, reactors, and methods of forming same
Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous support structures using atomic layer deposition techniques. |
US11426716B2 |
Plugged honeycomb segment, and plugged honeycomb structure
A plugged honeycomb segment includes a honeycomb segment having a quadrangular prism shape which includes porous partition walls arranged to surround a plurality of cells and an outermost circumferential wall, and a plugging portion, wherein a porosity of the partition walls is 30 to 70%, in a cross section orthogonal to the cell extending direction, an inflow cell surrounded by the partition walls is a hexagon, and an outflow cell is a square, one outflow cell is surrounded by four inflow cells, the cell located at the outermost circumference includes a complete cell and an incomplete cell, and a thickness of the outermost circumferential wall in contact with the incomplete cell (T1), a thickness of the outermost circumferential wall in contact with the complete cell (T2), and a thickness of the partition walls (WT), satisfy 0.200 mm |
US11426711B2 |
Method of making highly active metal oxide and metal sulfide materials
A method of making highly an active mixed transition metal oxide material has been developed. The method may include sulfiding the metal oxide material to generate metal sulfides which are used as catalyst in a conversion process such as hydroprocessing. The hydroprocessing may include hydrodenitrification, hydrodesulfurization, hydrodemetallation, hydrodesilication, hydrodearomatization, hydroisomerization, hydrotreating, hydrofining, and hydrocracking. |
US11426708B2 |
Potassium-promoted red mud as a catalyst for forming hydrocarbons from carbon dioxide
A method and catalyst for forming higher carbon number products from carbon dioxide is provided. An exemplary catalyst includes red mud including iron and aluminum, and impregnated potassium. |
US11426707B2 |
Composite materials containing nanoparticles and their use in chromatography
Novel porous materials comprising nanoparticles, use in chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material are described by the instant invention. In particular, the disclosure describes porous inorganic/organic hybrid particles embedded with nanoparticles selected from oxides or nitrides of the following: silicon carbide, aluminum, diamond, cerium, carbon black, carbon nanotubes, zirconium, barium, cerium, cobalt, copper, europium, gadolinium, iron, nickel, samarium, silicon, silver, titanium, zinc, boron, and mixtures thereof. |
US11426705B2 |
Reduced polymer content and bonding in polymer particulate composite
Disclosed is a composite of a particulate and polymer, the composite characterized by less than enough polymer to fully occupy the available excluded volume of the particulate of the composite. The resulting composite is characterized by the particulate partially covered by the polymer leaving a substantial surface area uncovered. |
US11426703B2 |
Gas processing device and method
A methane conversion device comprises a reaction chamber; a sensor for detecting the presence of methane; blowing means for directing external gasses Into the reaction chamber when the sensor detects the presence of methane above a predetermined threshold; conversion means that are configured to oxidise methane; and positioning means for positioning the device on an animal. |
US11426692B2 |
Radial seal air filter
Various example embodiments relate to a filtration system. The filtration system comprises a housing having a first housing end and a second housing end. The housing defines a central compartment therein. The housing comprises a first alignment portion disposed on the first housing end. The filtration system further comprises a filter element positioned within the central compartment of the housing. The filter element has a first filter end and a second filter end. The filter element comprises filter media and a second alignment portion disposed on the first filter end. The second alignment portion is complementary to the first alignment portion. The installation of the filter element within the housing causes the first alignment surface and the second alignment surface to align to provide for engagement of a radial seal between the filter element and the housing. |
US11426691B2 |
Filter elements, air cleaner assemblies, and methods of use and assembly
Air cleaner assemblies, components, and features are described. The features can be used to provide that the air cleaner assembly includes a housing and cover within which primary and secondary filter cartridges, having a media pack and a seal arrangement surrounding the media pack, can be installed. The filter cartridges can include an open end cap with an axially deviating seal arrangement and a plurality of axially extending channels for engaging with ribs on the housing. The filter cartridges can also include extension members extending from the open end cap that include the axially extending channels, entirely or partially. The filter cartridges can also include a guide member extending from the extension members for providing a low friction surface against the housing during installation that allows axial force exerted by the installer to be translated into a rotational force that rotates the filter cartridge during installation. |
US11426688B2 |
Honeycomb structure and method for producing honeycomb structure
A honeycomb structure including a plurality of porous honeycomb block bodies bound via joining material layers A. Each of the porous honeycomb block bodies includes a plurality of porous honeycomb segments bound via joining material layers B, each of the porous honeycomb segment includes: partition walls that defines a plurality of cells to form flow paths for a fluid, each of cells extending from an inflow end face that is an end face on a fluid inflow side to an outflow end face that is an end face on a fluid outflow side; and an outer peripheral wall located at the outermost periphery. At least a part of the joining material layers A has higher toughness than that of the joining material layers B. |
US11426686B1 |
Fluid filter with under-cap metered fluid shut off assembly
A cap for a filter system includes a housing, a turbine, at least one gear, and a valve. The housing defines an interior of the cap configured for receiving a fluid flow. The turbine is supported on the housing in the interior of the cap and configured for being driven by the fluid flow. The at least one gear is supported on the housing and meshed with the turbine for being driven by the turbine. The valve is supported on the housing and meshed with the at least one gear for being driven by the at least one gear. The valve closes the interior of the cap from receiving the fluid flow after a predetermined number of rotations driven by the at least one gear. |
US11426683B2 |
Negative pressure filtration apparatus, method, and system
Disclosed herein is a method, system, and apparatus, for filtering liquid, which uses negative air pressure to draw liquid stream through a filter screen and which cleans that filter screen by periodically modulating the negative air pressure to allow the liquid stream to wash any contaminants from the surface of the filter screen. |
US11426677B2 |
Plant and process for separating sulfur-containing components from laden methanol
Plant and process for separation of sulfur-containing components, H2S, COS and mercaptans from methanol which is used as absorbent within the Rectisol process by hot regeneration of the methanol laden in the absorption and an additional step for separation of the mercaptans from the methanol by stripping. |
US11426669B2 |
Method of manufacturing a model car body
The present disclosure relates to a method of manufacturing a model car body, including preparing a steel mold comprising a core plate with an inner core, a top plate and at least two side plates; attaching at least one pre-fabricated plastic block to a side of the inner core of the core plate; combining the core plate, the top plate and the at least two side plates with each other, wherein a cavity is formed among the top plate, the side plates, the inner core of the core plate and the at least one pre-fabricated plastic block; injecting melted plastic material into the cavity, wherein the melted plastic material is filled with the cavity and the at least one pre-fabricated plastic block is encased by the melted plastic material; solidifying the melted plastic so as to form the model car body, wherein the at least one pre-fabricated plastic block is integrated with the plastic model car body; separating the core plate, the top plate and the at least two side plates from each other; and releasing the model car body with the at least one pre-fabricated plastic block from the mold. |
US11426660B2 |
Gaming object with orientation sensor for interacting with a display and methods for use therewith
A gaming object includes an orientation sensor that generates orientation data in response to the orientation of the gaming object. An actuator that generates interaction data in response to an action of a user. A transceiver sends an RF signal to a game device that indicates the orientation data and the interaction data. The game device generates display data for display on a display device that contains at least one interactive item, and wherein the at least one interactive item is interactive in response to the orientation data and the interaction data. |
US11426635B2 |
Golf ball
An object of the present invention is to provide a golf ball having excellent durability and good shot feeling. The present invention provides a golf ball comprising a core, wherein a difference (crosslinking density at surface of core−crosslinking density at center of core) between a crosslinking density at a surface of the core and a crosslinking density at a center of the core is more than 1.0×102 mol/m3 and less than 9.0×102 mol/m3, and a hardness difference (Hs−Ho) between Hs and Ho is 13.0 or more and 30.0 or less, and the core satisfies H50−Ho>Hs−H50, wherein Hs (Shore C hardness) is a hardness at the surface of the core, Ho (Shore C hardness) is a hardness at the center of the core, and H50 (Shore C hardness) is a hardness at a midpoint between the center of the core and the surface of the core. |
US11426634B2 |
Golf ball
A golf ball according to an aspect of the present invention is a golf ball having a large number of dimples, a surface of the golf ball is covered with a plurality of virtual flat surfaces each having a triangular shape, one or more dimples are arranged so as to correspond to each of the virtual flat surfaces, and an edge of each dimple is formed in a linear shape. Each dimple may have a triangular pyramid shape or a triangular frustum shape. |
US11426623B2 |
Climbing exercise machine
An exercise machine creates a simulated continuous resisted climbing motion. The machine includes a floor- or ground-contacting base frame and two or more substantially vertically oriented uprights, wherein at least one upright is rigidly connected to the base frame. The machine further includes two handles and two foot pedals, each handle and each foot pedal being movably engaged with an upright for linear reciprocating motion along the upright. The handles and foot pedals are interconnected so that they move concurrently. An adjustable resistance mechanism may be operatively connected to the interconnection of the handles and foot pedals to provide adjustable resistance for the simulated continuous climbing motion. |
US11426622B2 |
Climbing exercise machine
An exercise machine creates a simulated continuous resisted climbing motion. The machine includes a floor- or ground-contacting base frame and two or more substantially vertically oriented uprights, wherein at least one upright is rigidly connected to the base frame. The machine further includes two handles and two foot pedals, each handle and each foot pedal being movably engaged with an upright for linear reciprocating motion along the upright. The handles and foot pedals are interconnected so that they move concurrently. An adjustable resistance mechanism may be operatively connected to the interconnection of the handles and foot pedals to provide adjustable resistance for the simulated continuous climbing motion. |
US11426620B2 |
Inflatable plyometric box
An inflatable plyometric box having a first inflatable member adapted to be inflated to a pressure, a second inflatable member on top of the first inflatable member and adapted to be inflated to a pressure, and a connecting member connected to the first inflatable member and the second inflatable member which secures the first inflatable member to the second inflatable member. The first and second inflatable members incorporate drop stitch technology which provides substantial rigidity to first and second inflatable members when the first and second inflatable members are inflated to the pressures. Thus the inflatable plyometric box is substantially rigid to support a user landing on the top of the inflatable plyometric box. The inflatable plyometric box may include a stabilizing member which may be connected to the bottom of the inflatable plyometric box, wherein the stabilizing member is adapted to increase the stability of the inflatable plyometric box. |
US11426613B2 |
Personal protection suit
A personal protection suit has a selectively sealable hood (1) for protection against CBRN threats. In one series of embodiments, the hood (1) is separable from a jacket body (5) by a releasable attachment means (11), and has a mask hood seal (2) for sealing with a mask. In one series of embodiments the hood (1A) has a deployable face mask (60) stored within the hood (1A). The hood (1) can be removed without breaking the seal between the mask and mask hood seal (2) to minimise contamination during donning and doffing. |
US11426611B2 |
Ultrasound therapeutic and scanning apparatus
The present disclosure is directed to a precision ultrasound scanner for imaging, for example, the prostate in a way that produces a superior image of the prostate while removing the iatrogenic risk and patient discomfort associated with other methods of providing an ultrasound image of the prostate. The present disclosure describes an apparatus and method for forming a high precision image of the prostate from outside the patient's body wherein the resolution in sufficient to image, for example, cancerous lesions on the surface of the prostate. To achieve such images, coded excitation, tissue harmonic imaging, advanced transducers operating in the 10 MHz to 40 MHz range is used to achieve a useable signal-to-noise reflection while being able to position the imaging transducer as close as possible to the prostate without risk or discomfort to the patient. The present disclosure further discloses an imaging transducer and an irradiating therapeutic transducer can be mounted such that they are movable between a plurality of positions. The irradiating transducer is, for example, about a 12 MHz transducer with a focal length of about 20 mm to about 40 mm that would produce a strong second harmonic at about 24 MHz that could be used for imaging. The imaging transducer has, for example, a focal length of about 10 mm to about 20 mm and typically operates in the range of about 25 MHz to about 40 MHz. |
US11426610B2 |
Neuromodulation techniques for perturbation of physiological systems
Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject. |
US11426602B2 |
System and method for manufacturing bolus for radiotherapy using a three-dimensional printer
Disclosed herein are systems, methods, and computer-readable storage devices for manufacturing patient-specific bolus for use in targeted radiotherapy treatment. Based on dose calculations without a bolus and based on three-dimensional scan data of a patient, the example system generates a model of a bolus for targeting radiotherapy treatment to a planning target volume or target region within the patient. The system can perform several iterations to generate a resulting model for the bolus. Then, the system can generate instructions for controlling a three-dimensional printer to generate the bolus that conforms to the patient's skin surface while also specifically targeting the planning target volume for the radiotherapy treatment. In this way, the amount of radiotherapy treatment administered to other tissue is reduced, while the costs, time, and human involvement in creating the bolus are significantly reduced. |
US11426600B2 |
Photobiomodulation therapy to delay dystrophy progression
Photobiomodulation therapy (PBMT) can be applied to a dystrophic muscle to delay dystrophy progression. A light source device can be contacted to a subject's skin proximal to a dystrophic muscle or muscle group. A light signal (with wavelengths from the red to infrared part of the spectrum) can be applied in at least one of a pulsed operating mode, a continuous operating mode, and a super-pulsed operating mode through the light source device to the dystrophic muscle or muscle group. The light signal is applied for a time sufficient to stimulate a phototherapeutic response in the dystrophic muscle or muscle group. |
US11426599B2 |
Three-dimensional coil set used for neuromodulation
A neuromodulator includes one or more coil sets. Each of the coil sets has three coils aligned to produce magnetic and electric fields in three different directions. A plurality of conductors couple the coils of the one or more coil sets to one or more input signals such that each of the coils is independently activated via an individually selectable current applied through the conductors. The individual activation creates a resultant field that is a combination of the magnetic and electric fields in three different directions for each of the coil sets. |
US11426598B2 |
Reusable adhesive pad with embedded magnets
A reusable adhesive pad with embedded magnets consists of a layer of fibrous cloth with elasticity, a layer of silicone gel padding, and permanent magnets. The fibrous cloth with elasticity is made from fiber materials with a stretchable characteristic. The silicone gel padding is spread out fully and glued on one surface of the fibrous cloth with elasticity. In addition, the silicone gel padding is provided with holes that the permanent magnets with cylindrical or conical outers can be filled in and glued to the adhesive surface of the fibrous cloth with elasticity. Since the other sides of the permanent magnets protrude outwards the surface of the silicone gel padding, applying the invention to the human skin can perform the acupuncture and moxibustion treatment and the magneto-therapy to lessen painful discomfort. |
US11426596B2 |
Embedment of medical lead coil electrodes
In some examples, a coil electrode assembly includes a coil electrode including a plurality of windings and extending from an electrode proximal end to an electrode distal end, the coil electrode defining an electrode lumen from the electrode proximal end to the electrode distal end. The coil electrode assembly further includes an insulative tube extending within the lumen of the coil electrode such that the coil electrode extends along an outer surface of the insulative tube. The coil electrode is partially embedded within the insulative tube when the insulative tube is in an expanded state to maintain a spacing between the windings. |
US11426595B2 |
Optical stimulation system with on-demand monitoring and methods of making and using
An adapter to add optical stimulation to a stimulation system includes an adapter body and a connector disposed on the distal end of the adapter body. The connector includes a connector body defining a port and a connector lumen; connector contacts disposed in the connector body and arranged along the connector lumen; and a light source disposed in the connector body. The adapter also includes terminals disposed along the proximal end of the adapter body and conductors extending along the adapter body and electrically coupling the connector contacts and the light source to the terminals. The adapter may be used with an optical stylet that fits into a stimulation lead which is, in turn, coupled to the connector of the adapter. Alternatively, the adapter can include a fiber optic coupled to the light source and configured to extend into the stimulation lead. |
US11426594B2 |
Intracardiac pacemaker device, particularly for VDD or VDDR pacing
An intracardiac pacemaker device, comprising a housing that is configured to be implanted entirely within a ventricle (V) of a heart (H), an electronic module for generating pacing pulses, a battery for supplying energy to the electronic module, an elongated lead extension protruding from the housing, at least a first electrode arranged on the elongated lead extension, and a pacing electrode and a return electrode for applying the pacing pulses to cardiac tissue, wherein the pacing electrode is arranged on the housing. The electronic module is electrically coupled to the pacing electrode via the housing, and wherein the electronic module is configured to carry out measurements of electrical activity via the at least one first electrode of the elongated lead extension. |
US11426590B2 |
Leadless cardiac pacemaker device configured to provide intra-cardiac pacing
A leadless pacemaker device for providing an intra-cardiac pacing includes processing circuitry configured to generate ventricular pacing signals for stimulating ventricular activity at a ventricular pacing rate, a first sensor configuration receiving a first sense signal, and a second sensor configuration receiving a second sense signal. The processing circuitry derives, in a first sensing state, atrial events from the first sense signal for controlling the ventricular pacing rate based on the atrial events. The processing circuitry switches, based on at least one switching criterion, from the first sensing state to a second sensing state in which the processing circuitry derives atrial events from the second sense signal. The second sense signal is received by the second sensor configuration for detection of atrial events and the second sensor configuration is a motion sensor or a sound sensor. A method for operating the pacemaker device is also provided. |
US11426588B2 |
Systems and methods for arbitrary current waveform generation
The present disclosure provides systems and methods for generating waveforms for an implantable pulse generator of a neurostimulation system. A waveform generation system includes a computing device, at least one buffer memory, and at least one programmable current regulator. The at least one buffer memory is coupled between the computing device and the at least one programmable current regulator. The computing device is configured to load a string of output current values into the at least one buffer memory, and the at least one buffer memory is configured to sequentially feed each output current value to the at least one programmable current regulator. Further, the at least one programmable current regulator is configured to control current supplied to a plurality of electrodes based on the received output current values. |
US11426587B2 |
Method and apparatus for application of a neural stimulus
A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked. |
US11426585B2 |
Slurry electrodes for direct current nerve conduction block
The present disclose relates to slurry electrodes that can deliver direct current (DC) nerve conduction block to neural tissue. Such slurry electrodes can include an ionically conductive membrane having a first side and a second side. Slurry electrodes can also include a mechanism that is configured to encapsulate a slurry against the first side of the ionically conductive membrane. The slurry can include an ionically conductive material and a plurality of electrically conducting high surface area particles. The mechanism and the first side of the ionically conductive membrane make up a housing for the slurry. Slurry electrodes can also include a connector configured to establish an electrical connection between the slurry and the DC generator. |
US11426584B2 |
Devices and methods for treating craniofacial pain
Some implementations provide a method for treating craniofacial pain in a patient, the method including: placing a wirelessly powered passive device through an opening into a target site in a head or neck region of the patient's body, the wirelessly powered passive device configured to receive an input signal non-inductively from an external antenna; positioning the wirelessly powered passive device adjacent to or near a nerve at the target site; and causing neural modulation to the nerve through one or more electrodes on the wirelessly powered passive device. |
US11426583B2 |
Method and apparatus for multimodal electrical modulation of pain
Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic. |
US11426576B2 |
Securing an implanted medical device in a patient
An apparatus and method for implanting and securing an implanted medical device in a recipient. The implantable medical device of the generally includes an electrode assembly that comprises an elongate carrier member having at least one stimulating electrode positioned thereon. The carrier member further has a fixation structure positioned thereon configured to interact with a portion of the rigid structure to longitudinally secure the carrier member in the recipient. |
US11426572B2 |
Implant injection device provided with frictional retaining means
An implant injection device, includes an injection needle, a receiver housing for receiving at least one implant, injection device, including a pushing rod, arranged upstream from the implant housed in the receiver housing, and configured to push the implant through the injection needle between an initial position and a final position, a pushing member for pushing the pushing rod between the initial position and the final position, a retaining member for retaining the pushing rod by friction relative to the injection needle, opposing the displacement of the pushing rod to its final position, it being possible for a user to actuate the retaining member. |
US11426570B2 |
Core-shell microneedle platform for transdermal and pulsatile drug/vaccine delivery and method of manufacturing the same
A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections. |
US11426569B2 |
Fluid product applicator
A fluid applicator including a skin contact detector device. The contact detector device includes a flexible outer substrate (S1) that defines an outer contact surface (S11), the flexible outer substrate (S1) covering a detection zone (Z) that has a plurality of conductive pellets (P1, P2, P3, P4, P5) separate from one another, the conductive pellets (P1, P2, P3, P4, P5) being arranged above a common conductive plate (D). The conductive pellets (P1, P2, P3, P4, P5), in the absence of stress, are spaced apart from the common conductive plate (D) by insulating spacers (C), so that pressure exerted on the flexible outer substrate (S1) causes at least one of the conductive pellets (P1, P2, P3, P4, P5) to come into contact with the common conductive plate (D), thereby creating at least one short-circuit signal. |
US11426564B2 |
Method and apparatus for forming drug coating layer
A method and apparatus are disclosed for forming a drug coating layer capable of preventing breakage of elongated drug crystals on a surface of a balloon and maintaining the drug crystals in an appropriate shape in order to act on a living body. The method includes supplying a coating solution which contains the water-insoluble drug, a water-soluble additive, an organic solvent, and water to the surface of the balloon and evaporating the organic solvent and the water to form an additive layer containing the water-soluble additive and a protruding crystal having a tip end protruding from the additive layer, cutting a surplus portion protruding from the additive layer of the protruding crystal from a part surrounded by the additive layer and forming the part surrounded by the additive layer as the elongated body, and removing the cut-out surplus portion from the drug coating layer. |
US11426559B2 |
Body cavity irrigation and drainage system and method
A body cavity irrigation and drainage system and a related method. The body cavity irrigation and drainage system may include two pigtail catheters that are coupled together so that when in a use state the tail portions of the two pigtail catheters curl in opposite directions. The two pigtail catheters may be coupled together so that they are maintained in a fixed relative orientation. The system may also include a sheath having a cavity within which both of the two pigtail catheters are positioned during an insertion process. The sheath may be a peel-away type sheath such that the sheath can be torn and removed from the body cavity while the two pigtail catheters remain in the body cavity. |
US11426556B2 |
Catheter securement device
A device for securing a catheter, or similar flexible medical tube or medical device to the skin of a patient. The device comprises a planar body (1) at least a lock retainer (5) and a passive retainer (6), both spaced-apart from each other. Furthermore a method of securing a catheter to a patient using a device as described. |
US11426554B2 |
Humidifier system
A blower unit for use as part of an integrated blower/humidification system is described. The blower unit has an outer casing, which encloses and forms part of the blower unit, the casing including an air inlet vent. The blower unit further includes a humidifier compartment for receiving a humidifier unit with a separate gases inlet and outlet, the compartment having a heater base for heating the contents of the humidifier unit. The compartment also has a blower inlet port which aligns with the humidifier unit inlet in use, the blower providing a gases path through the casing between the inlet vent and the inlet port. The blower unit also includes a fan for providing a pressurised gases stream along the gases path, and a power supply unit for powering the fan. The gases path is routed over the power supply unit in order to provide a cooling air flow. |
US11426550B2 |
Micro bi-directional valves and systems
Disclosed is a bi-directional exhalation valve useful for many applications such as in CPAP devices. The exhalation valve includes a valve body having a center chamber, side chambers, and bidirectional ports coupled to the center chamber via passages and a mechanism that provides fluid ingress into the bi-directional valve in a first mode of operation or fluid egress from the bi-directional valve in a second mode of operation. Unidirectional ports are coupled to the plurality of bidirectional ports to provide providing fluid egress from the valve in the second mode of operation, and a unidirectional port provides fluid ingress into the bi-directional valve in the first mode of operation. A mechanism including a center paddle, side paddles, and a shaft are arranged in an elongated compartment of the valve body, such that the shaft is pivots and the central and side paddles open and close corresponding ones of the input and output ports. |
US11426540B2 |
Methods for measuring dose content uniformity performance of inhaler and nasal devices
The methods described herein provide improvements to the measurement of dose content uniformity of inhaler and nasal devices. The methods involve analyzing and measuring a spray pattern of an emitted spray from an inhaler or nasal device. The spray pattern may be used to determine the dose content uniformity of an inhaler or nasal device. |
US11426535B2 |
Intravenous fluid warmer using uniform thermal field
A heating cabinet for IV bags provides a uniform thermal field promoted by circulated heated air passing through air permeable shelves. Temperatures of the IV bags are modeled through a knowledge of a temperature of the uniform thermal field and arrival time of the IV bags eliminating a need for separate temperature sensors and control loops. Bag status may be signaled through modulated light distinguishable by individuals with limited color sensitivity. Signals are associated with particular IV bags by projecting the light of the signals into the IV bags themselves. |
US11426532B2 |
Needle guard with dual hinge functionality
A needle guard for protecting a human or animal from accidental contact with a needle connected to said needle guard is disclosed. The needle guard comprises a mounting base for the needle, a hinge structure connecting the mounting base to a needle shield, and a needle shield hinge adjacent to the hinge structure and needle shield. The hinge structure is adapted to pivot the needle shield relative to the mounting base from an open position in which the needle shield is separated from the needle, to a closed position in which the needle shield encloses the needle. The needle shield hinge is adapted to pivot the needle shield relative to the hinge structure. A method of manufacturing the needle guard is also disclosed. |
US11426531B2 |
Medical injector cap remover
A cap remover for removing a cap covering a needle of a medical injector includes a body having an insertion portion at its proximal end configured to at least partially accommodate the cap, and a grabbing portion at its distal end having an internal cavity which includes an extraction member having a series of laminas extending radially and inwardly from a ring. |
US11426529B2 |
Auto-injector with active agent container latching
In an elongated casing, an active agent container connected to an injection needle can be shifted axially by a spring force. Auto-injectors distributed pre-filled and with the springs tensed may be provided with a needle protecting cap to ensure sterility of the needle. When the needle protecting cap is removed as preparation for using the auto-injector, a tensile force can be exerted on the active agent container. Therefore, the active agent container and needle must be prevented from being undesirably pulled forwards. At least one latching tongue prevents the active agent container from being prematurely shifted with respect to the casing, by abutting a flange arranged on a sliding sleeve accommodating the active agent container. When the auto-injector is placed onto the skin, a needle protecting tube is shifted into the casing, forcing the latching tongue away from the flange, thereby freeing the travel path for needle movement. |
US11426527B2 |
Dose detection for a medication delivery device
The present disclosure relates to a dose detection system in combination with a medication delivery device. In one aspect, the system includes a module body adapted to be removably attached to the actuator of a medication delivery device, and one or more magnetic sensing elements attached to said module body. The system detects the amount of rotation of a magnetic ring of said one or more dipoles of a medication delivery device relative to the magnetic sensing elements during dose delivery when the module is attached to the device. |
US11426525B2 |
Assembly for a drug delivery device and drug delivery device
An assembly for a drug delivery device comprises a housing, a dose member which is displaceable in a proximal direction with respect to the housing for setting of a dose of a drug, a clutch member which is displaced in the proximal direction with respect to the housing when setting the dose, and a stop member configured to define a clutch stop position. The clutch member and the dose member are configured to mechanically cooperate with one another when the clutch member is in the clutch stop position, thereby preventing further displacement of the dose member in the proximal direction with respect to the housing during setting of the dose. |
US11426524B2 |
Dose setting device for an injection device
A dosing device for an injection device, the dosing device including an actuating element for adjusting and/or dispensing a dose from the injection device, a thrust element for generating a forward movement for discharging a dose and a coupling to which the actuating element and the thrust element are coupled such that a rotational movement of the actuating element is transmitted directly to the thrust element and an axial movement of the actuating element is different than an axial movement of the thrust element. |
US11426522B2 |
Drug container
The present invention relates to an assembly comprising an injection device comprising a container for a product, wherein the container includes a distal tip encompassing a channel providing a passageway for transferring the product, and an adaptor mounted onto the distal tip. The assembly further includes a heat-shrinkable film covering at least part of the container and at least part of the adaptor, wherein the heat-shrinkable film maintains the adaptor blocked in rotation and in translation relative to the container when the heat-shrinkable film is in heat-shrunk condition. |
US11426516B2 |
Port-flushing control valve
A valve is disclosed that has a body with an inlet, an outlet, and a needleless access port coupled to the body. The access port has an interior space and is configured to be actuated by a needleless connector. The inlet is selectively coupled to the outlet through the interior space such that fluid entering the inlet entirely flows through the interior space to the outlet. |
US11426511B2 |
Microflow restrictor assembly and methods of making the same
A medical fluid microflow assembly having an assembly fluid inlet and an assembly fluid outlet, and a mandrel having a curved exterior surface, the mandrel being positioned within an cavity of a housing so that the exterior surface of the mandrel is substantially parallel to an interior surface of the cavity, and at least one protrusion positioned helically around and extending from the interior surface of the cavity, each protrusion abutting the exterior surface of the mandrel to form a sealed fluid channel which has a channel inlet positioned proximate to the assembly fluid inlet and a channel outlet positioned proximate to the assembly fluid outlet, the exterior surface of the mandrel and the interior surface of the cavity having a minimal or neutral triboelectric value with respect to a fluid. |
US11426510B2 |
Medical device for constipation prevention, coprostasis removal and good bowel movement
A medical device includes: a hollow body part formed in a predetermined bent shape; a head part provided at a tip portion thereof with a discharge port for discharging cleaning water and detachably coupled to a front end of the body part; a connection part connected to a shower hose and a rear end of the body part and provided with a control valve for controlling water supply, a water flow rate and a water pressure; a water purification tube built in the body part and provided with leakage preventing grilles at both ends thereof; and a purified water discharge part provided inside the head part and configured to remove foreign substances in the water by using a filter. |
US11426507B2 |
Arthroscopic devices and methods
A fluid management system includes a pump connectable to a fluid source. An inflow line removably connects to a cannula for delivering a fluid flow from the pump into a surgical site, such as a joint cavity. A flow pressure sensor is coupled to measure flow pressure in the inflow line and produce a measured pressure value, A controller is connected to the pump and the flow pressure sensor, and the controller maintains a pressure set point by controlling a pump speed based on a backpressure-adjusted pressure value calculated by subtracting a backpressure value selected from a backpressure table from the measured pressure value. The BAPV is monitored to determine whether the BAPV deviates outside an initial BAPV range, and corrective measure are taken should such deviations occur. |
US11426506B2 |
Wound therapy system with wound volume estimation
A wound therapy system includes a negative pressure circuit, a pump, a pressure sensor, and a controller. The negative pressure circuit applies negative pressure to a wound. The pump is fluidly coupled to the negative pressure circuit and produces a negative pressure at the wound or within the negative pressure circuit. The pressure sensor measures the negative pressure within the negative pressure circuit or the wound. The controller performs a testing procedure including a first drawdown period, a leak rate determination period, a vent period, and a second drawdown period. The controller is configured to receive one or more pressure measurements of the pressure sensor over the leak rate determination period to determine a leak rate parameter, monitor an amount of elapsed time over the second drawdown period to determine a drawdown parameter, and estimate a volume of the wound based on the leak rate parameter and the drawdown parameter. |
US11426505B2 |
Apparatus and method for contacting blood with ozone
An apparatus, system, and method for contacting blood with ozone to kill microorganisms in the blood are described. The method involves injecting microbubbles of ozone containing gas into a flow of blood, preferably at a temperature of less than 12° C. The apparatus includes a blood flow conduit including a blood ozone contacting portion including a porous ozone injector. |
US11426501B2 |
Apparatus for extracorporeal blood treatment
An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant. |
US11426492B2 |
Collagen and collagen like peptide based hyrdogels, corneal implants, filler glue and uses thereof
The present invention provides for collagen and collagen like peptide based hydrogels, corneal implants, filler glue and uses thereof. The invention represents an advancement in the field of hydrogels, corneal implants, filler glue based on collagen and collagen like peptides. The invention discloses collagen and novel collagen like peptides crosslinked with DMTMM and their use in preparation of hydrogel, corneal implant and filler glue which are highly efficacious and robust as compared to existing corneal implants. Further, the invention relates to method of treating corneal defects and diseases. |
US11426488B2 |
Bioactive micro-nano pore gradient oxide ceramic film
The invention discloses micron-nano pore gradient oxide ceramic films with biological activity, which are prepared by the following methods: The surface structures are biomedical engineering materials; Inorganic precursor coating solutions or the organic precursor coating solutions are prepared with or without micron and nanopore additives; The surface structures of the substrate are treated in the following steps: (1) The surfaces of the substrate are coated by the inorganic precursor coating solutions or the organic precursor coating solutions with or without micron and nanopore additives; (2) The substrate with coatings are dried, sintered, naturally cooled, and cleaned. (3) The biomedical engineering materials with the micron-nanopore gradient oxide ceramic films, especially biomimetic micro-nanoporous gradient alumina film, yttrium partially stabilized zirconia film, and alumina doped yttrium partially stabilized zirconia films in this invention greatly improve biocompatibility and biological activity. |
US11426479B2 |
Device and method for sterilization of instruments and surfaces
A device for decontaminating a medical device, the device including a compartment adapted to contain a medical device and a solution, the solution comprising a photoactivatable substance; and a light system providing 360 degrees of exposure to the compartment. Also, a method for decontaminating a medical device, the method including placing a medical device in a compartment with a solution, the solution comprising a photoactivatable substance; incubating the medical device in the solution to allow the photoactivatable substance to attach to pathogens; and exposing the compartment to 360 degrees of light exposure to activate the photoactivatable substance. |
US11426476B2 |
Internal ultraviolet LED antifouling
An internal ultraviolet-C light emitting diode antifouling system and method that include a waterproof, light transmissible potted enclosure; an object disposed within the waterproof, light transmissible potted enclosure; and at least one ultraviolet-C light emitting diode disposed within the waterproof, light transmissible enclosure, wherein the at least one ultraviolet-C light emitting diode is configured to emit light on the object, wherein the light is configured to prevent biofouling on the object. |
US11426475B2 |
UV sterilization device for container
A UV sterilization device for a container includes a housing, a base, a receiving room formed between the housing and the base, a transmission member symmetrically and rotatably mounted on the base and including a clamp for clamping the container, an extension rod symmetrically mounted on the base and inserting into the container to stretch out and draw back relative to the container along the axial direction of the extension member, a UV sterilization member mounted on the extension member to move with the extension member, and a driving member fixed with the base and including a motor therein. The motor is fixed with the transmission member and the extension member. The motor can drive the transmission member and the container to rotate, and drive the extension member to stretch out and draw back relative to the container along the axial direction of the extension member to further drive the UV sterilization member to disinfect the container. |
US11426472B2 |
Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis
Excessive deposition of extracellular matrix is a hallmark of Idiopathic pulmonary fibrosis (IPF), it is advantageous to target the cells and the mechanisms associated with this process. By targeting myofibroblasts (specialized contractile fibroblasts) that are key for the development of IPF with drugs conjugated with fibroblast activation protein (FAP), this technology helps minimize the production of extracellular matrix in the lungs and provides a new treatment option for patients diagnosed with IPF. |
US11426467B2 |
Dosage regimes for the administration of an anti-CD25 ADC
The present disclosure relates to novel dosage regimes for the treatment of pathological conditions, such as cancer, with Antibody Drug Conjugates (ADCs). In particular, the present disclosure relates to novel dosage regimes for the administration of ADCs which bind to CD25 (CD25-ADCS). |
US11426466B2 |
Toxin-derived delivery constructs for pulmonary delivery
The present disclosure relates to isolated non-naturally occurring delivery constructs comprising a bacterial toxin-derived delivery construct coupled to a biologically active therapeutic cargo; wherein the delivery construct is capable of delivering the biologically active cargo via transcytosis transport across an epithelial cell; and wherein the delivery construct does not comprise a bacterial toxin-derived translocation domain or a bacterial toxin-derived catalytic (cytotoxic) domain. |
US11426465B2 |
Hydrazinyl-indole compounds and methods for producing a conjugate
The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same. |
US11426464B2 |
Engineered primate cystine/cysteine degrading enzymes as antineogenic agents
Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with L-cyst(e)ine using the disclosed proteins or nucleic acids. |
US11426462B2 |
Monovalent anti-CD3 adjuvants
This document provides methods and materials related to using monovalent anti-CD3 antibodies (e.g., monovalent anti-CD3 Fab fragments) as adjuvants to increase the immune response produced against an antigen (e.g., a tumor associated antigen). For example, vaccine compositions containing monovalent anti-CD3γε Fab fragments in combination with tumor associated antigens (e.g., tumor associated antigens having little or no immunogenicity in the absence of monovalent anti-CD3γε Fab fragments) alone or in combination with adjuvants for signals two and/or three required for full activation of T cell immune function, as well as methods and materials for using monovalent anti-CD3γε Fab fragments to increase the immune response produced against an antigen (e.g., a tumor associated antigen) within a mammal (e.g., a human) are provided. |
US11426459B2 |
Mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof
The disclosure relates to a mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof. In addition, the disclosure also relates to a pharmaceutical composition (e.g., a vaccine) comprising the mutant, a method for preparing the mutant, and a method of using the mutant for prevention and/or treatment of an infection of influenza virus and/or a disease (e.g., an influenza) caused by the infection. |
US11426458B2 |
Formulation of a peptide vaccine
The invention relates to a novel reconstitution composition, a pharmaceutical composition and kit of parts comprising said reconstitution composition. The invention further relates to a method of treatment using said pharmaceutical composition and/or the pharmaceutical composition for use as a medicament. Also provided is a method for reconstituting dried peptides and a method for preparing a pharmaceutical composition using the reconstitution composition of the invention. |
US11426457B2 |
MHC class I associated peptides for prevention and treatment of zika virus
The invention provides a vaccine composition comprising a flavivirus peptide comprising one or more CD8+ T cell C1 epitopes, wherein the peptide is attached to a nanoparticle. |
US11426455B2 |
Immunogenic composition comprising staphylococcal antigens
The invention provides an immunogenic composition comprising staphylococcal antigens, containing protein antigens and conjugates of capsular polysaccharides, n particular Hla, ClfA, SpA and conjugates of capsular polysaccharides. Adjuvanted formulations are also provided. The invention may find use in the prevention and treatment of staphylococcal infections, in particular S. aureus infection and disease. |
US11426452B2 |
Vaccine
The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients. |
US11426450B2 |
Shear-thinning compositions as an intravascular embolic agent
This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas. |
US11426448B2 |
Methods for treatment of erectile dysfunction with sonic hedgehog compounds
Provided herein is technology relating to compositions comprising sonic hedgehog protein and therapeutic uses thereof. In particular, the technology relates to compositions comprising a hedgehog protein and one or more peptide amphiphiles for use in methods of treating or preventing stress urinary incontinence and/or erectile dysfunction in a subject. |
US11426442B2 |
Compositions and methods for invasive and non-invasive procedural skincare
Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing. |
US11426440B2 |
Collagen peptide-based medicament compositions and devices and methods of production and use thereof
The present invention is in the fields of medicinal chemistry, biotechnology and pharmaceuticals. The invention provides compositions comprising one or more collagen mimetic peptides, optionally attached to one or more therapeutic compounds or one or more imaging compounds, for use in methods of treating, preventing, ameliorating, curing and diagnosing certain diseases and physical disorders in humans and veterinary animals, as well as methods of manufacturing such composition. The invention also provides medical devices comprising one or more such compositions of the invention. The invention also provides methods of use of such compositions and devices in treating and diagnosing certain diseases and physical disorders in humans and veterinary animals, including ocular diseases or disorders, skin diseases or disorders, certain cancers, particularly intraluminal cancers, gastrointestinal diseases or disorders, genitourinary tract diseases or disorders, fibrotic diseases/disorders and rheumatic diseases/disorders. |
US11426439B2 |
Nutritional product and method of using it
A nutritional product for improving performance during physical activity and a method of using the nutritional product to improve performance during activity. The nutritional product contains Rhodiola root extract, French pine extract, Pulsatilla vulgaris extract, ginger extract, yohimbe extract, Ginseng extract, Coleus forskohlii extract, vitamin B12, red beet extract, L-Arginine NO3, tongkat ali, a combination of Fenugreek fenugreek A and Fenugreek fenugreek B, and Tribulus terrestris extract. Also described are methods for improving a user's physical activity performance employing the nutritional products. |
US11426430B2 |
Method for generating T cells progenitors
The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment. |
US11426426B2 |
Pharmaceutical composition for preventing or treating inflammatory diseases, containing nitrogen monoxide-sensitive acrylamide-based polymer
The invention relates to a nitric oxide-responsive acrylamide-based polymer, and more particularly, to an acrylamide-based polymer that is produced using an acrylamide-based monomer and a nitric oxide-sensitive crosslinking agent and allows prevention or treatment of a disease or illness caused by overexpression of nitric oxide. |
US11426423B2 |
Methods relating to lung cancer
The methods and assays described herein relate to detection, diagnosis, and treatment of lung cancer, e.g., by detecting the level of expression of certain miRNAs described herein and/or by therapeutically increasing the level of those miRNAs. |
US11426420B2 |
Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor. |
US11426417B2 |
Neuroactive steroid formulations and methods of treating CNS disorders
Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders. |
US11426414B2 |
Pharmaceutical compositions comprising meloxicam
Disclosed herein are compositions comprising an NSAID such as meloxicam and/or rizatriptan in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less. |
US11426411B2 |
Cycloalkyl-diamines for the treatment of inflammation
The invention is directed to a method of treatment for inflammation in mammals including inflammation caused by bacterial or viral infection, the method comprising administering to a mammal, including a human, in need of such treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. |
US11426404B2 |
Dosing of KRAS inhibitor for treatment of cancers
Provided herein are methods of administering a KRAS G12C inhibitor to a cancer subject. |
US11426403B2 |
Formulations of 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione, and methods of making and using same
This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions. |
US11426402B2 |
IRE1 activating compounds for use in therapy
Disclosed herein are compounds, their pharmaceutical salts, and pharmaceutical compositions that selectively activate the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1s) signaling pathway of the unfolded protein response (UPR), but that do not target the IRE1 kinase domain. The compounds are useful in treating diseases or conditions characterized by imbalances in proteostasis within the endoplasmic reticulum (ER) or secretory pathway, including those not associated with ER stress or activation of UPR. |
US11426400B2 |
Methods of increasing satellite cell proliferation with vorinostat or bosutinib
The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject. |
US11426398B2 |
Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders
Compositions containing a combination of nicotinamide riboside and pterostilbene for treating skin disorders, and methods of treating skin disorders using these compositions and their equivalents are described. The skin disorders that are treated using these compositions or methods include sun exposure-related skin disorders, inflammatory skin disorders, autoimmune disease-related skin disorders and cancer-related skin disorders. In one embodiment, the compositions containing a combination of nicotinamide riboside and pterostilbene are prepared as oral formulations. |
US11426393B2 |
Prolyl hydroxylase inhibitors and methods of use
The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. |
US11426392B1 |
Antiviral and virucidal lung nebulizer compositions and related treatment methods
Compositions for treatment or prevention of viral infections, such as influenza A and B, coronaviruses, including but not limited to COVID-19 and any variant thereof, and rhinoviruses, along with related treatment methods. Certain compositions according to preferred embodiments may comprise chlorpheniramine and albuterol administered by inhalation in nebulized form. |
US11426390B2 |
Methods of treating gastrointestinal stromal tumors
The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof. |
US11426388B2 |
Controlled release pharmaceutical formulations of nitazoxanide
Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided. |
US11426387B2 |
2-iminobiotin for use in the treatment of brain cell injury
The present disclosure relates to the use of 2-iminobiotin for treating brain cell injury, in particular in adults. The treatment may be used for the treatment of cerebral hypoxia-ischemia and/or reperfusion injury, including one or more symptoms thereof. Provided are methods of treatment comprising administering a therapeutically effective dose of 2-iminobiotin to an individual in need thereof. |
US11426380B2 |
Urolithins as immune response enhancers
Disclosed are compounds for use in raising an immune response to an antigen and/or enhancing, modulating or augmenting an immune response to an antigen. Particularly the use of urolithins. The invention also relates to immune enhancers comprising urolithins, methods of using such immune enhancers and processes for the preparation of such immune enhancers. The invention also relates to the use of urolithins in methods for modulating stem cell function, for example, enhancing stem cell numbers, promoting stem cell regeneration and promoting stem cell differentiation. |
US11426378B2 |
Method for long-term treatment of rosacea
A regimen for the long-term therapeutic treatment of rosacea. The regimen includes topically applying a pharmaceutical composition to the skin of a subject. The pharmaceutical composition includes about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient. The benzoyl peroxide is the only active ingredient in the pharmaceutical composition, and the pharmaceutical composition is applied once daily for a period of about 52 weeks, to achieve, in a group of such subjects, a success rate of about 75%. |
US11426366B2 |
Compositions and methods for treating motor disorders
This invention provides methods utilizing ketamine for the treatment of motor disorders and/or side effects associated with certain medications used in the treatment of motor disorders. For example, in some embodiments, methods are provided for treating side effects associated with the administration of levodopa to a subject having Parkinson's disease, by administering a dose of ketamine or a pharmaceutically acceptable salt thereof. In particular, the invention provides methods for reducing dyskinesia associated with motor disorder (e.g., Parkinson's disease) treatments, and effective doses of ketamine or a pharmaceutically acceptable salt thereof. |
US11426362B2 |
Oral cannabinoid formulations
The present invention relates to an oral formulation containing one or more cannabinoids. Preferably one or more cannabinoids dissolved in a solvent system consisting essentially of: a non-ionic surfactant and water together with other components which ensure the cannabinoids stability and the formulations palatability. Furthermore, the cannabinoid may be selected from one or more of cannabichromene (CBC), cannabichromenic acid (CBCV), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabigerol (CBG), cannabigerol propyl variant (CBGV), cannabicyclol (CBL), cannabinol (CBN), cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV) and tetrahydrocannabivarinic acid (THCVA). |