| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 141 | VERFAHREN ZUR HERSTELLUNG VON 7-DEHYDROCHOLESTEROL UND/ODER DESSEN BIOSYNTHETISCHEN ZWISCHEN- UND/ODER FOLGEPRODUKTEN IN TRANSGENEN ORGANISMEN | EP03701537.7 | 2003-01-22 | EP1472354A1 | 2004-11-03 | LANG, Christine; VEEN, Markus |
| The invention relates to a method for the production of 7-dehydrocholesterol and/or the biosynthetic intermediate or subsequent products thereof by the cultivation of organisms, in particular, yeasts which show an increased activity of at least one activity, selected from delta-8/delta-7 isomerisation activity, delta-5 desaturase activity or delta-24 reductase activity. The invention further relates to the nucleic acid constructs necessary for production of the genetically-modified organisms and the genetically-modified organisms, in particular, the yeasts themselves. | ||||||
| 142 | INDUCIBLE TRANSPOSITION IN TRANSGENIC ORGANISM USING TRANSPOSON VECTOR | EP03700348.0 | 2003-01-09 | EP1465993A2 | 2004-10-13 | Craig, Roger; Savakis, Charalambos; GROSVELD, Frank |
| A method of inducing transposition in a transgenic embryo is described, comprising the steps of (a) generating a first adult transgenic organism comprising within its genome one or more copies of a transposon; (b) generating a second adult transgenic organism comprising within its genome one or more copies of a gene encoding a transposase cognate for said transposon and/or a sequence capable of regulating expression of said gene encoding the transposase; (c) crossing the first adult transgenic organism with the second transgenic adult organism to provide a progeny which comprises, in the genome of one or more of its cells, both (i) one or more copies of the transposon and (ii) a gene encoding a transposase cognate for said transposon, wherein the gene encoding the transposase is under the control of one or more inducible regulatory sequences which permit expression of the transposase, and (d) inducing expression of said gene encoding the transposase in said embryo to cause mobilisation of said transposon within at least a portion of the tissues or cells of the progeny. Using the method, mobilisation of a transposon can advantageously be induced at predetermined stages of development of an embryo and the mutated gene of a single cell may be replicated in subsequent cell divisions, resulting in groups of cells which are essentially homogeneous for the transposed gene. | ||||||
| 143 | TRANSGENIC ORGANISM EXPRESSING FUNGAL MRP-LIKE ABC TRANSPORTERS | EP02781949.9 | 2002-10-16 | EP1446486A1 | 2004-08-18 | SONG, Won YongPostech Foundation; YANG, Young YeulDepartment of Biological Science; LEE, Youngsook; HWANG, Inhwhan; NO, Eun Won; CHOI, Young Im; JEONG, Eun HwaPostech Foundation; MARTINOIA, E.Lab. of Molecular Plant Physiology |
| The present invention relates to an isolated DNA encoding fungal MRP (multidrug resistance associated protein) subfamily of ATP-binding cassette (ABC) transporter protein which confers organisms with resistance to and/or accumulation of toxic materials such as heavy metals and herbicides, vectors containing the isolated DNA, and organisms transformed with the isolated DNA. Organisms transformed with the fungal MRP subfamily of ABC transporters of the present invention can be used for remediation of environment polluted with toxic materials. For example, the transformed plants can be used for cleaning polluted soil or water, and thereby providing an environmentally-friendly way to remediate polluted resources with low cost. | ||||||
| 144 | VERFAHREN ZUR HERSTELLUNG VON ARACHIDONSÄURE IN TRANSGENEN ORGANISMEN | EP02764826.0 | 2002-07-31 | EP1412488A1 | 2004-04-28 | FEUSSNER, Ivo; HORNUNG, Ellen; PERNSTICH, Christian; KORFEI, Martina; KINDL, Helmut |
| The invention relates to a method for the production of arachidonic acid in transgenic organisms, especially in transgenic plants and yeasts. The invention also relates to DNA sequences coding for a protein with enzymatic activity of a Δ5-desaturase from Phytophthera megasperma. The invention further relates to transgenic plants and plant cell and transgenic yeasts containing a nucleic acid molecule comprising a DNA sequence according to the present invention and having, on the basis thereof, an enhanced arachidonic acid synthesis in comparison with wild-type cells. The invention also relates to harvest products and propagating material of transgenic plants. | ||||||
| 145 | EXPRESSION OF THE GLUCOSE OXIDASE GENE IN TRANSGENIC ORGANISMS | EP95908174 | 1995-02-10 | EP0746616A4 | 1997-05-21 | MURRAY FIONA RUTH; LLEWELLYN DANNY JAMES; DENNIS ELIZABETH SALISBURY; PEACOCK WILLIAM JAMES |
| A genetic construct for use in production of transgenic plants and other organisms with reduced susceptibility or increased resistance to pests or diseases comprises an isolated nucleotide sequence encoding, or complementary to a sequence encoding, the glucose oxidase enzyme or a functional derivative thereof, the nucleotide being operably linked to a promoter capable of expression in the host organism. | ||||||
| 146 | EXPRESSION OF THE GLUCOSE OXIDASE GENE IN TRANSGENIC ORGANISMS | EP95908174.0 | 1995-02-10 | EP0746616A1 | 1996-12-11 | MURRAY, Fiona Ruth; LLEWELLYN, Danny James; DENNIS, Elizabeth Salisbury; PEACOCK, William James |
| A genetic construct for use in production of transgenic plants and other organisms with reduced susceptibility or increased resistance to pests or diseases comprises an isolated nucleotide sequence encoding, or complementary to a sequence encoding, the glucose oxidase enzyme or a functional derivative thereof, the nucleotide being operably linked to a promoter capable of expression in the host organism. | ||||||
| 147 | Transfer foil having reflecting layer with surface relief pattern recorded thereon | EP95201359.7 | 1992-01-28 | EP0677400A1 | 1995-10-18 | Tahara, Shigehiko |
A transfer foil has a base film (31), a release layer (32), thermoplastic resin layer (33), reflecting layer (34) of a metal transparent film having a finely dimpled pattern (interference fringe relief) and a heat-sensitive adhesive layer (35). The foil can transfer precisely a pattern by breaking portions of the material released from the base film by action of a hot stamper (37), which then adheres to a substrate. The dimpled pattern can be formed by press-embossing a hard dimpled roller onto a reflecting layer (34) of thickness 100-600 Å. |
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| 148 | INCREASED EXPRESSION BY A SECOND TRANSFERRED SEQUENCE IN TRANSGENIC ORGANISMS | EP92901696.0 | 1991-12-24 | EP0566596A1 | 1993-10-27 | CLARK, Anthony, John 29 Broomieknowe |
| On produit des animaux et des plantes transgéniques pouvant exprimer une protéine désirée en introduisant conjointement dans une cellule d'un oeuf ou d'un embryon d'un animal, ou dans des cellules réceptrices appropriées d'une plante, une première séquence codant la protéine désirée et une seconde séquence d'ADN plus efficacement exprimée. L'efficacité d'expression est ainsi conférée à la première séquence, ce qui permet d'obtenir un rendement ou un ciblage amélioré, ou les deux. L'introduction simultanée peut être effectuée lorsqu'on injecte conjointement un mélange des deux séquences d'ADN dans un oeuf fertilisé, dans le cas d'un animal. L'invention peut être utilisée pour améliorer l'efficacité d'expression de protéines choisies, telles que celles présentant une activité biologique dans les glandes mammaires d'un animal transgénique femelle. | ||||||
| 149 | Helicopter rotor flexbeam | EP88106606.2 | 1988-04-25 | EP0288957A2 | 1988-11-02 | Olsen, Eric G.; Campbell, Thomas G. |
An improved helicopter rotor flexbeam (20) comprises a pair of generally parallel outwardly open, cross-sectionally C-shaped beams (25) of a geometry which defines therein a first inboard region (A) of enhanced out-of-plane flexibility and a second outboard region (B) of enhanced in-plane and torsional flexibility. |
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| 150 | Use of genetically modified organisms to generate biomass degrading enzymes | US13269414 | 2011-10-07 | US08318436B2 | 2012-11-27 | Stephen Mayfield; Bryan O'Neill; Michael Mendez; Yan Poon |
| The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol. | ||||||
| 151 | TRANSGENIC RABBITS PRODUCING HUMAN FACTOR VII | US12934124 | 2008-03-25 | US20110059510A1 | 2011-03-10 | Pierre-Jean Ripoll |
| The invention relates to transgenic rabbits that produce human factor VII in their mammary glands. The milk of said transgenic rabbits can be used as a raw material for the production of recombinant human factor VII. | ||||||
| 152 | TRANSGENIC MOLLUSK AND METHOD FOR PRODUCING THE SAME | US12775904 | 2010-05-07 | US20100218263A1 | 2010-08-26 | Keizaburo Miki; Johji Miwa; Nozomu Isowa |
| A transgenic mollusk which can express a desired foreign gene, and a method for producing the same are disclosed. The mollusk is a transgenic mollusk into which a desired foreign gene (excluding a gene giving resistance to a virus) is introduced, which expresses the foreign gene. This transgenic mollusk can be produced by microinjecting into gonad of male and/or female of mollusk a recombinant vector into which a desired foreign gene to be introduced or a nucleic acid containing the foreign gene is inserted; crossing the male and female to produce individuals of first generation; and selecting therefrom (an) individual(s) which express(es) the desired gene. | ||||||
| 153 | Use of genetically modified organisms to generate biomass degrading enzymes | US12156450 | 2008-05-30 | US20090253169A1 | 2009-10-08 | Stephen Mayfield; Bryan O'Neill; Michael Mendez; Yan Poon |
| The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol. | ||||||
| 154 | Method of generating transgenic organisms using transposons | US11809579 | 2007-05-31 | US20080193933A1 | 2008-08-14 | Charalambos Savakis; Frank Grosveld |
| The invention relates to a method for generating a transgenic organism. The invention also relates to a method for detecting and characterizing a genetic mutation in a transgenic organism. The invention further relates to a method for isolating a gene which is correlated with a phenotypic characteristic in a transgenic animal. The invention further relates to a method for isolating an exon in a transgenic animal. The invention also relates to a method for modulating the expression of a gene in an organism. | ||||||
| 155 | Transgenic organism epressing fungal mrp-like abc transporters | US10492880 | 2002-10-16 | US20050091709A1 | 2005-04-28 | Won Yong Song; Young Yang; YoungSook Lee; InWhan Hwang; Eun Noh; Young Choi; Eun Jeong; Enrico Martinoia |
| The present invention relates to an isolated DNA encoding fungal MRP (multidrug resistance associated protein) subfamily of ATP-binding cassette (ABC) transporter protein which confers organisms with resistance to and/or accumulation of toxic materials such as heavy metals and herbicides, vectors containing the isolated DNA, and organisms transformed with the isolated DNA. Organisms transformed with the fungal MRP subfamily of ABC transporters of the present invention can be used for remediation of environment polluted with toxic materials. For example, the transformed plants can be used for cleaning polluted soil or water, and thereby providing an environmentally-friendly way to remediate polluted resources with low cost. | ||||||
| 156 | Beta secretase transgenic organisms and methods of use thereof | US10656624 | 2003-09-04 | US20040132680A1 | 2004-07-08 | Philip C. Wong; Huaibin Cai; Donald L. Price |
| The invention provides transgenic non-human animals, such as transgenic rodents and transgenic non-human mammalian cells harboring a transgene which eliminates the expression of a null-secretase BACE1. Also provided are methods of diagnosing neurodegenerative diseases including Alzheimer's Disease as well as methods of identifying agents which modulate or treat Alzheimer's Disease and related pathology. | ||||||
| 157 | Method for increasing transgenic biomass | US09973122 | 2001-10-09 | US20020062494A1 | 2002-05-23 | Phillippe Bournat |
| The present invention relates to a method for rapidly increasing the amount and the quality of a transgenic biomass, in particular in the production of transgenic plants which produce a recombinant protein for therapeutic use, and applies more particularly to maize. | ||||||
| 158 | Genetically modified organisms for the production of lipids | EP13075003.7 | 2010-08-04 | EP2586859B1 | 2018-04-18 | Lang, Christine, Dr.; Raab, Andreas, Dr. |
| The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism. | ||||||
| 159 | PRODUCTION OF COMMERCIAL BIODIESEL FROM GENETICALLY MODIFIED MICROORGANISMS | EP10762558 | 2010-04-10 | EP2417244A4 | 2015-10-14 | SANCHEZ-RIERA FERNANDO; HUANG WEI; SHASTRY VINEET |
| 160 | PRODUCTION OF COMMERCIAL BIODIESEL FROM GENETICALLY MODIFIED MICROORGANISMS | EP10762558.4 | 2010-04-10 | EP2417244A1 | 2012-02-15 | SANCHEZ-RIERA, Fernando; HUANG, Wei; SHASTRY, Vineet |
| The invention provides a fermentation and recovery process for the production of biodiesel of commercial grade quality according to commercial and environmental standards (e.g., ASTM ANP, or EPA trace elements and emissions standards), by fermentation of carbohydrates using a genetically modified microorganism. The process provides a direct route for the production of fatty esters, without the need for producing oils which are later chemically transesterified with the concomitant production of large quantities of glycerin and other undesirable side -products. | ||||||
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