| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Method for production of multiple-unsaturated fatty acid in transgenic organism | JP2010232883 | 2010-10-15 | JP2011087578A | 2011-05-06 | ZANK THORSTEN; BAUER JOERG; CIRPUS PETRA; ABBADI AMINE; HEINZ ERNST; QIU XIAO; VRINTEN PATRICIA; SPERLING PETRA; DOMERGUE FREDERIC; MEYER ASTRID; KIRSCH JELENA |
| <P>PROBLEM TO BE SOLVED: To provide a method for producing a multiple-unsaturated fatty acid in an organism, into which a nucleic acid coding for a polypeptide having Δ-5 elongase activity is introduced. <P>SOLUTION: There are provided a nucleic acid sequence coding for Δ-6 desaturase, Δ-5 desaturase, Δ-4 desaturase and/or Δ-6 elongase activity and derived from Thalassiosira, Euglena or Ostreococcus, and a genetic construction containing the nucleic acid sequence. <P>COPYRIGHT: (C)2011,JPO&INPIT | ||||||
| 122 | 유전자 변형체의 검정을 위한 프라이머 세트，검정방법 및이에 사용되는 표준 플라스미드 | KR1020050023190 | 2005-03-21 | KR100664992B1 | 2007-01-04 | 이성훈 |
| 본 발명은 유전자 변형체의 검정을 위한 프라이머 세트, 검정방법 및 이에 사용되는 표준 플라스미드에 관한 것으로, 보다 상세하게는 Cry3Bb1:tahsp17 유전자를 함유한 유전체의 검정에 매우 유용하여 종래 검정이 불가능하여 왔던 옥수수 MON863과 같은 계통에 대하여 특이적인 프라이머 세트, 검정방법 및 이에 사용되는 표준 플라스미드에 관한 것이다. MON863, 프라이머 | ||||||
| 123 | 담배에서 개화-리프레싱 특성을 제공하는 FT 패밀리의 핵산 서열 및 펩티드/단백질 및 이들로 형질전환된 트랜스제닉 식물 | KR1020147031014 | 2013-03-28 | KR1020150005587A | 2015-01-14 | 하리크,레나; 프뤼퍼,디르크; 피셔,라이너 |
| 본 발명은 (1) 각각의 프로모터 하에서 식물의 개화를 서프레스(suppress)하거나, 리프레스(repress)하거나, 지연시킬 수 있고, (2) 유전자 StSP5G의 핵산 또는 이의 일부를 제외하고 모티브 "NAPDIIDS" 또는 일부 경우에 "VNAPDIIDS"를 포함하는 단백질을 코딩하는 핵산 서열에 관한 것이다. 바람직하게는, 핵산 서열은 계통발생학적으로 PEBP 유전자 패밀리의 FT-클레이드에 속하며, 여기서 모티브 "(V)NAPDIIDS"가 개화 촉진 단백질 AtFT 및 BvFT2의 "(V)YAPGW" 모티브 대신에 존재한다. 본 발명은 추가로 본원에 기재된 청구항 중 임의의 청구항의 핵산의 발현에 의해 수득가능한 펩티드 또는 단백질, 상기 정의된 핵산 서열을 포함하는 벡터, 및 상기 핵산 서열을 포함하는 식물, 식물의 일부 또는 식물의 종자에 관한 것이다.
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| 124 | トランスジェニック生物における多不飽和脂肪酸の製造方法 | JP2016110891 | 2016-06-02 | JP2016220683A | 2016-12-28 | ザンク,トルステン; バウア,ヨーグ; シルプス,ペトラ; アッバディ,アミネ; ハインツ,エルンスト; キウ,シャオ; ヴリンテン,パトリシア; スペルリング,ペトラ; ドメルグー,フレデリック; マイアー,アストリド; キルシェ,イェレーナ |
| 【課題】Δ5−エロンガーゼ活性を有するポリペプチドをコードする核酸を導入した生物において多不飽和脂肪酸を製造する方法の提供。 【解決手段】特定の配列を有する核酸配列、遺伝暗号の縮重の結果として、特定のアミノ酸配列をコードする核酸配列、または、特定の核酸配列に対してアミノ酸レベルで少なくとも40%の同一性を有し、かつΔ5−エロンガーゼ活性を有するポリペプチドをコードする核酸配列の誘導体よりなる群から選ばれる、Δ5-エロンガーゼ活性を有するポリペプチドをコードする単離された核酸配列。 【選択図】なし |
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| 125 | Method for production of multiply-unsaturated fatty acids in transgenic organisms | JP2013270709 | 2013-12-27 | JP2014128269A | 2014-07-10 | ZANK THORSTEN; BAUER JOERG; CIRPUS PETRA; ABBADI AMINE; HEINZ ERNST; QIU XIAO; VRINTEN PATRICIA; SPERLING PETRA; DOMERGUE FREDERIC; MEYER ASTRID; KIRSCH JELENA |
| PROBLEM TO BE SOLVED: To provide a method for producing multiply-unsaturated fatty acids in an organism into which nucleic acids have been introduced, the nucleic acids encoding polypeptides with Δ-5 elongase activity.SOLUTION: The method for the production of an oil and/or triacylglyceride which has increased content of long chain multiply-unsaturated fatty acids employs a vector with an isolated nucleic acid sequence encoding a polypeptide having Δ-6 desaturase, a Δ-5 desaturase, Δ-4 desaturase and/or Δ-6 elongase activity derived from Thalassiosira, Euglena, or Ostreococcus, and enzymes of an introduced transgenic organism: a microorganism, a nonhuman animal or a plant. | ||||||
| 126 | 标贴（转基因生物图形标识） | CN03315972.6 | 2003-04-17 | CN3352904D | 2004-02-11 | 周曙东 |
| 平面设计，省略其它视图。 | ||||||
| 127 | トランスジェニック生物における多不飽和脂肪酸の製造方法 | JP2013270709 | 2013-12-27 | JP5985464B2 | 2016-09-06 | ザンク,トルステン; バウア,ヨーグ; シルプス,ペトラ; アッバディ,アミネ; ハインツ,エルンスト; キウ,シャオ; ヴリンテン,パトリシア; スペルリング,ペトラ; ドメルグー,フレデリック; マイアー,アストリド; キルシェ,イェレーナ |
| 128 | Mutagenesis, mutagenic gene, transgenic organism and its production | JP17455896 | 1996-07-04 | JPH1014571A | 1998-01-20 | OGATA NORIO; MIURA TAKANORI |
| PROBLEM TO BE SOLVED: To obtain an organism to which mutation is induced by introducing a mutator gene obtained by polymerizing deoxyribonucleoside in the presence of a protein with no template nor primer into cells so as to provide the organism with diversity of mutation while suppressing damage to the organism. SOLUTION: This mutation-induced transgenic organism having diversity of mutation is obtained by introducing into a mutator gene a DNA obtained by polymerizing a deoxylibonucleoside in a reaction system in which no template nor primer is present at approximately 20-70 deg.C in the presence of a protein composed of thermostable DNA polymerase originating from cells which belong to Cellumococcus or Cellumus bacteria, transplanting the mutator gene- introduced cells into an oviduct or uterus of an adaptive mother being in pseudopregnant condition, or otherwise into an uterus after the cells are cultured in vitro so as to grow to a morula or blastocyst, thereby increasing the size of the genome DNA in condition where the damage to the objective organism is suppressed. | ||||||
| 129 | Production of (-)-trans-kumausyne and its novel intermediate | JP12057195 | 1995-04-21 | JPH08291160A | 1996-11-05 | SUGIMURA HIDEYUKI; OSUMI KENJI |
| PURPOSE: To obtain optically active (-)-trans-kumausyne. CONSTITUTION: The compound of formula I is treated with peracetic acid and mercury acetate in acetic acid, then allowed to react with tert.- butylchlorodiphenylsilane in the presence of imidazole in an organic solvent to give the compound of formula II. The product is reduced with diisobutylaluminum hydride to form the compound of formula III, which is treated with (3-trimethylsilyl-2-propyl) triphenylphosphorane, then with acetic anhydride in pyridine to give a new intermediate of formula IV. Then, the intermediate is allowed to react with tetrabutylammonium fluoride in an organic solvent and with oxalyl chloride in the presence of dimethyl sulfoxide and triethylamine to produce the compound of formula V. Finally, the product of formula V is treated with 3-trimethylsilyl-1-pentene followed by reaction with triphenylphosphine and carbon tetrabromide in the presence of 2,6-tert.- butylpyridine in an organic solvent to give the objective compound of formula VI. COPYRIGHT: (C)1996,JPO | ||||||
| 130 | TRANSGENIC FICUS, METHOD FOR PRODUCING SAME AND USE THEREOF | PCT/IL2005000532 | 2005-05-24 | WO2005115130A3 | 2006-06-22 | FLAISHMAN MOSHE; PEARL AVI; GOLOBOWICZ SARA |
| The present invention relates to transgenic Ficus plants, particularly Ficus carica (fig tree), to a method for producing same, and to Ficus plants, plant materials and plant products produced by or from such genetically modified plant material. More specifically, the present invention relates to transgenic Ficus carica plants and use thereof for producing trees having improved agricultural traits and for the production of foreign proteins and edible vaccines. | ||||||
| 131 | TRANSGENIC FICUS, METHOD FOR PRODUCING SAME AND USE THEREOF | PCT/IL2005/000532 | 2005-05-24 | WO2005115130A2 | 2005-12-08 | FLEISHMAN, Moshe; PEARL, Avi; GOLOBOWICZ, Sara |
The present invention relates to transgenic Ficus plants, particularly Ficus carica (fig tree), to a method for producing same, and to Ficus plants, plant materials and plant products produced by or from such genetically modified plant material. More specifically, the present invention relates to transgenic Ficus carica plants and use thereof for producing trees having improved agricultural traits and for the production of foreign proteins and edible vaccines. |
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| 132 | トランスジェニック生物を作製する方法およびシステム | PCT/JP2003/008681 | 2003-07-08 | WO2005003359A1 | 2005-01-13 | 竹田 潤二; 堀江 恭二 |
本発明は、トランスポゾンを用いて外来遺伝子を効率よく細胞に導入する技術に関する。より詳細には、本発明は、トランスポゾンを含む配列をメチル化することによって、トランスポゾンの転位活性を飛躍的に向上させ、効率よくトランスジェニック生物を作製する技術に関する。メチル化は、ゲノムに組み込まれた後も保持されており、実際のゲノムへの遺伝子の組み込みにも利用することが可能になった。本発明を用いれば、従来のトランスポゾンを用いたトランスジェニック生物の作製方法よりも、格段に効率よく遺伝子を形質転換することができる。 |
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| 133 | PRODUCTION OF TRANSGENIC BIRDS USING STAGE X PRIMORDIAL GERM CELLS | PCT/US0230195 | 2002-09-23 | WO03024200A8 | 2004-05-06 | SUTRAVE PRAMOD |
| The present invention relates to methods for isolating primordial germ cells (PGCs) from the blastoderm of a stage X avian embryo. The present invention further relates to methods for producing a transgenic bird by modifying the isolated PGCs, such that the cells incorporate at least one transgene into their genetic material; transferring the modified PGCs into a suitable recipient, such as a blastoderm of an avian embryo, hatching the embryo; and testing for the presence of the transgene or expression of the protein encoded by the transgene. | ||||||
| 134 | PRODUCTION OF A TRANSGENIC AVIAN BY CYTOPLASMIC INJECTION | PCT/US2002/029878 | 2002-09-18 | WO2003025146A2 | 2003-03-27 | RAPP, Jeffrey, C.; CHRISTMANN, Leandro |
This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred methods for introducing a transgene into the cytoplasm of avian embryonic cells by cytoplasmic microinjection. The embryo then develops into a transgenic adult capable of expressing a heterologous protein and/or capable of generating a line of transgenic birds through breeding. Synthetic vectors and gene promoters useful in the methods are also provided by the present invention, as are transgenic birds that express heterologous protein and avian eggs containing heterologous protein. |
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| 135 | PRODUCTION OF TRANSGENIC BIRDS USING STAGE X PRIMORDIAL GERM CELLS | PCT/US2002/030195 | 2002-09-23 | WO2003024200A2 | 2003-03-27 | SUTRAVE, Pramod |
The present invention relates to methods for isolating primordial germ cells (PGCs) from the blastoderm of a stage X avian embryo. The present invention further relates to methods for producing a transgenic bird by modifying the isolated PGCs, such that the cells incorporate at least one transgene into their genetic material; transferring the modified PGCs into a suitable recipient, such as a blastoderm of an avian embryo, hatching the embryo; and testing for the presence of the transgene or expression of the protein encoded by the transgene. |
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| 136 | TRANSGENIC IMMUNODEFICIENT MOUSE EXPRESSING HUMAN SIRPalpha | EP13712769.2 | 2013-03-26 | EP2830417A1 | 2015-02-04 | GARCIA, Sylvie; SERRA-HASSOUN, Malika |
| The present invention provides a transgenic mouse which comprises a deficiency for murine T lymphocytes, B lymphocytes and NK cells, a deficiency for murine MHC class I and MHC class II molecules, and a functional xenogenic SIRP± transgene. This mouse is useful for in vivo screening of various compounds, including immuno-therapeutic agents and vaccines. The said mouse is also useful for testing the in vivo metabolism of xenobiotic compounds. | ||||||
| 137 | USE OF GENETICALLY MODIFIED ORGANISMS TO GENERATE BIOMASS DEGRADING ENZYMES | EP08767983.3 | 2008-05-30 | EP2162537B1 | 2012-01-04 | MAYFIELD, Stephen; O'NEILL, Bryan; MENDEZ, Michael; POON, Yan |
| The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol. | ||||||
| 138 | Inducible transposition in transgenic organism using transposon vector | EP09010211.2 | 2003-01-09 | EP2147974A2 | 2010-01-27 | Craig, Roger; Savakis, Charalambos; Grosveld, Frank |
A method of inducing transposition in a transgenic embryo is described, comprising the steps of: (a) generating a first adult transgenic organism comprising within its genome one or more copies of a transposon; (b) generating a second adult transgenic organism comprising within its genome one or more copies of a gene encoding a transposase cognate for said transposon and/or a sequence capable of regulating expression of said gene encoding the transposase; (c) crossing the first adult transgenic organism with the second transgenic adult organism to provide a progeny which comprises, in the genome of one or more of its cells, both (i) one or more copies of the transposon and (ii) a gene encoding a transposase cognate for said transposon, wherein the gene encoding the transposase is under the control of one or more inducible regulatory sequences which permit expression of the transposase, and (d) inducing expression of said gene encoding-the transposase in said embryo to cause mobilisation of said transposon within at least a portion of the tissues or cells of the progeny. Using the method, mobilisation of a transposon can advantageously be induced at predetermined stages of development of an embryo and the mutated gene of a single cell may be replicated in subsequent cell divisions, resulting in groups of cells which are essentially homogeneous for the transposed gene. |
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| 139 | TRANSGENIC ORGANISMS WITH LOWER GROWTH TEMPERATURE | EP04804497.8 | 2004-10-11 | EP1673442B1 | 2008-07-09 | FERRER, Manuel; TIMMIS, Kenneth, N.; CHERNIKOVA, Tatjana; GOLYSHIN, Peter; YAKIMOV, Michail Compl. Linea Verde |
| The present invention in general relates to the growth temperature of organisms, especially plants and microorganisms and the manipulation of the tolerable cultivation temperature. More specifically, the present invention relates to the expression of heterologous proteins in microorganisms, and especially to the heterologous expression of heat sensitive proteins in bacteria, either gram-negative or gram-positive. In a first aspect, the present invention provides a method for manipulation of cells and the resultant cells, characterized in that at least one gene from a psychrophilic micro organism coding for at least one chaperone or chaperonin is expressed. Such cells are selected among cultivated eukaryotic cells, i.e. animal and plant cells and entire plants, gram-negative and gram-positive bacteria, fungi and yeasts. | ||||||
| 140 | VERFAHREN ZUR HERSTELLUNG MEHRFACH UNGESÄTTIGTER FETTSÄUREN IN TRANSGENEN ORGANISMEN | EP05819684.1 | 2005-12-21 | EP1831377A1 | 2007-09-12 | CIRPUS, Petra; BAUER, Jörg; HEINZ, Ernst; DOMERGUE, Frederic |
| The invention relates to a method for producing polyunsaturated fatty acids in an organism by introducing into the organism nucleic acids which encode polypeptides having Δ-5-elongase, Δ-6-desaturase, Δ-5-desaturase, Δ-4-desaturase, Δ-12-desaturase and/or Δ-6-elongase activity. Preferably, these desaturases and elongases are derived from Ostreococcus. The invention also relates to a method for producing oils and/or triacylglycerides having an increased content in long-chain polyunsaturated fatty acids. The invention further relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising the inventive nucleic acid sequences, to vectors comprising the nucleic acid sequences and/or to the nucleic acid constructs and to transgenic organisms comprising the aforementioned nucleic acid sequences, nucleic acid constructs and/or vectors. Another part of the invention relates to oils, lipids and/or fatty acids produced according to the inventive method and to the use thereof. The invention finally relates to fatty acids and triglycerides having an increased content in unsaturated fatty acids and to the use thereof. | ||||||
