MONO-ACYLATED O-PHENYLENDIAMINES DERIVATIVES AND THEIR USE AGAINST CANCER
| 专利类型 | 发明申请 | 法律事件 | |
| 专利有效性 | 公开 | 当前状态 | |
| 申请号 | PCT/EP2004001044 | 申请日 | 2004-02-05 |
| 公开(公告)号 | WO2004069803A3 | 公开(公告)日 | 2004-11-18 |
| 申请人 | HOFFMANN LA ROCHE; | 申请人类型 | 其他 |
| 发明人 | FERTIG GEORG; HERTING FRANK; KUBBIES MANFRED; LIMBERG ANJA; REIFF ULRIKE; WEIDNER MICHAEL; | 第一发明人 | FERTIG GEORG |
| 权利人 | HOFFMANN LA ROCHE | 权利人类型 | 其他 |
| 当前权利人 | HOFFMANN LA ROCHE | 当前权利人类型 | 其他 |
| 省份 | 当前专利权人所在省份： | 城市 | 当前专利权人所在城市： |
| 具体地址 | 当前专利权人所在详细地址： | 邮编 | 当前专利权人邮编： |
| 主IPC国际分类 | A61K31/381 | 所有IPC国际分类 | A61K31/381 ; A61K31/44 ; C07C233/80 ; C07D213/82 ; C07D213/90 ; C07D333/38 |
| 专利引用数量 | 3 | 专利被引用数量 | 0 |
| 专利权利要求数量 | 0 | 专利文献类型 | A3 |
| 专利代理机构 | 专利代理人 | ||
| 摘要 | Objects of the present invention are new mono-acylated o-phenylendiamines derivatives of formula (A) wherein Ar is thiophen-2,5-diyl, pyridine-2,5-diyl, pyridine-5,2-diyl, pyridine-2,6-diyl, pyridine-2,4-diyl or 1,4-phenylene, R , R independently from each other represent hydrogen, C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, C3-12-cycloalkyl, the alkyl, alkenyl, alkynyl and cycloalkyl groups being optionally mono or multiple substituted by hydroxy, halogen, C3-12-cycloalkyl, alkoxy, alkylsulfanyl, acyloxy, alkoxycarbonyl, acyl, C1-6-alkyl-NH-C(O)-, C1-6-alkyl-C(O)NH- or -NR R , or alternatively R is hydrogen, and R is hydroxyl, alkoxy, C2-C12-alkenyloxy or phenoxy, which phenoxy group is optionally substituted with methyl, methoxy, halogen, nitro, cyano, trifluoromethyl, ethenyl or -C(O)-O-CH3, provided that if R is hydroxy, Ar is not thiophen-2,5-diyl; and R and R independently from each other represent hydrogen or C1-6-alkyl, or wherein R and R together with the nitrogen-atom to which they are attached form a ring, which ring is monosubstituted by oxo and which ring may contain a further heteroatom, and pharmaceutically acceptable salts thereof, as well as processes for the manufacturing of these compounds, pharmaceutical compositions containing such compounds and their use in the manufacture of drugs for the treatment of diseases such as cancer. | ||
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