PREVENTION AND REVERSAL OF INFLAMMATION INDUCED DNA DAMAGE |
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| 申请号 | PCT/US2018/027786 | 申请日 | 2018-04-16 | 公开(公告)号 | WO2018194976A1 | 公开(公告)日 | 2018-10-25 |
| 申请人 | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; | 发明人 | KELLEY, Mark R.; FEHRENBACHER, Jill; | ||||
| 摘要 | Methods of reducing neuronal sensitivity, thereby reducing inflammation and chronic pain, are disclosed herein. Particularly disclosed are methods of administrating the apurinic/apyrimidinic endonuclease 1 redox factor 1 (APE1/Ref-1) inhibitor, APX3330, to enhance the DNA base excision repair (BER) pathway, thereby reducing neuronal sensitivity to inflammatory mediators and alleviating inflammatory or chronic pain. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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