| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Pyrazolesulfonylurea derivative, production thereof and herbicide | JP16882986 | 1986-07-17 | JPS6327489A | 1988-02-05 | YAMAMOTO SUSUMU; TSUNODA TAKUYA; SATO TOSHIAKI; MORIMOTO KATSUYUKI; OYA EIICHI; IGAI TAKASHI; NAWAMAKI TSUTOMU; HATTORI KENJI |
| NEW MATERIAL:A compound expressed by formula I {Q represents formulae IIWIV [R 1WR 3 represent H, halogen atom, nitro, lower alkyl, etc.; R 4 and R 5 represent H, halogen atom, lower (halogenated) alkyl, etc.; R 6 and R 7 represent H, halogen atom, lower alkyl, etc.], etc.; B represents H, lower alkyl, lower alkoxy, halogen atom, etc.; D represents (cyclo)alkyl, (halo)alkenyl, etc.; G represents formula V [X and Y represent H, halogen atom, lower alkyl, etc.; Z represents N, C-R 16 (R 16 represents H, lower alkyl, etc.), etc.]}. EXAMPLE: 4-Bytoxycarbonyl-N-[( 4, 6-dimethoxypyrimidin-2-yl )aminocarbonyl ]-1-(2-pyridyl)pyrazole-5-sulfonamide. USE: A herbicide. PREPARATION: A pyrazolesulfonylisocyanate derivative expressed by formula VI is reacted with an aminopyrimidine, aminotriazine or aminotriazole derivative express by the formula NH 2-G in an inert solvent. COPYRIGHT: (C)1988,JPO&Japio | ||||||
| 162 | Benzothiazolone derivative, production thereof and herbicide containing said derivative as active ingredient | JP5903586 | 1986-03-17 | JPS62215589A | 1987-09-22 | HAGA TORU; NAGANO HIDEYOSHI; MORITA KOICHI; SATO MAKOTO |
| NEW MATERIAL:A compound expressed by formula I (R represents lower alkyl, lower alkenyl, lower alkenyl or lower alkoxy-lower alkyl; X represents O or S). EXAMPLE: 2-[ 3-( 2-Propenyl )-6-fluoro-2( 3H )-benzothiazolon-5-yl ]tetrahydro-1H- [1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione. USE: A herbicide exhibiting no phytotoxicity problems with rice plant. PREPARATION: A pyridazine derivative expressed by formula II (Y represents lower alkoxyl) {example; ethyl 2-[6-fluoro-3-(2-propenyl)-2(3H)-benzothiazolon-5- ylaminocarbonyl] hexahydropyridazine-1-carboxylate, etc.} is heated preferably at 40W100°C for 0.5W24hr in the presence of a base such as sodium methoxide, etc. COPYRIGHT: (C)1987,JPO&Japio | ||||||
| 163 | Novel heterocyclic compound | JP4862986 | 1986-03-07 | JPS62207266A | 1987-09-11 | SHIOKAWA KOZO; TSUBOI SHINICHI; TOSHIBE SHINZO; SASAKI AKITAKA; MORIIE KOICHI; HATTORI YUMI |
| NEW MATERIAL:A compound shown by formula I [R 1 is H or alkyl; A is ethylene or trimethylene which may be replaced with alkyl, respectively; X is O, S, NR 2 (R 2 is H, alkyl, alkenyl, etc.) or CHR 3 (R 3 is H or alkyl); Z is at least two hetero atoms (N, O or S)-containing 5-W6-membered heterocyclic group, 3- or 4-pyridyl]. EXAMPLE: 1-(2-Chloro-5-pyridylmethyl)-2-cyanoimidazolidine. USE: An insecticide having strongly insecticidal activity and showing excellently controlling effects on insect pests (especially stabbing, absorbing insect pests) having resistance to organic phosphorus insecticides and carbamate insecticides. PREPARATION: For example, a compound shown by formula II is reacted with a compound shown by formula III [M 1 is halogen, -OSO 2-M 2 (M 2 is alkyl or aryl) to give a compound shown by formula I. COPYRIGHT: (C)1987,JPO&Japio | ||||||
| 164 | Pyridazinone derivative, production thereof, insecticide, acaricide, nematocide and fungicide | JP5085986 | 1986-03-07 | JPS62207262A | 1987-09-11 | OGURA TOMOYUKI; KAWAMURA YASUO; BABA MASANORI; ISHII SHIGERU; HIRATA KIMINORI; KUDO MASAKI; OCHIAI YOSHINORI; HIROSE MASAYOSHI |
| NEW MATERIAL:A compound shown by formula I {R is alkyl; A is alkyl or halogen; X is O or S; R 1 and R 2 are H or alkyl; B is CH=CH, N=CH, N=N, S, O or NR 3 (R 3 is H or alkyl); Y is halogen, alkyl alkoxy, NO 2, CN, group shown by formula II (Z is halogen, alkyl, NO 2, etc.; l is 0W6), -O-W [W is group shown by formula III (R 4 R 6 are H or alkyl; R 7 is H, alkyl, etc.; R 3 is alkyl, alkenyl, etc.; E is O, S SO, etc.)], etc.; n is 1W3; at least one of Y is -O-W}. EXAMPLE: 2-t-Butyl-4-chloro-5-[4-(2-ethoxyethoxy)-benzyloxy]-3(2H)-pyridazinone. USE: An insecticide, an acaricide, a nematocide, a fungicide and an expellent of mites living on animals. PREPARATION: A compound shown by formula IV is reacted with a compound shown by formula V (one of X 1 and X 2 is halogen and the other is OH or SH) to give a compound shown by formula I. COPYRIGHT: (C)1987,JPO&Japio | ||||||
| 165 | Substituted pyrrole-1-yl-phenyl-dihydropyridadinone and use | JP30669886 | 1986-12-24 | JPS62164680A | 1987-07-21 | KAARU HAINTSU GAISU; BERUNHARUTO SHIYUMIIDO; RUDORUFU KUROTSUPU; FUERENA BARUDEINGAA; YOOZEFU GURIISU; HANSU DEIITAA REEMAN; KURAUSU RIYUUPUZAAMEN; MARUCHIN TORAUTO |
| 166 | 3(2h)-pyridazinone derivative, drug composition and manufacture | JP25713886 | 1986-10-30 | JPS62161768A | 1987-07-17 | ENDORE KAASUTOREINERU; JIYORUJI RABUROTSUKII; NAANDORU MATSUKU; RAASUROO YASURITSU; PEETERU MAACHIYUSHIYU; JIYORUJI CHIEFU; IRUDEIKOO PURIBUSU; KURAARA TSUAKOO; ESUTERU DEIESHIYURERU; ISHIYUTOBUAAN EREKESHIYU; RAASUROO KAUFUERU; MAARIA KUHAARU; YUDEITO KINCHIETSUSHII; YUDEITO KOSAARII; JIOENJII NAJII |
| 167 | Peroxidized lipid-formation inhibitor | JP29068785 | 1985-12-25 | JPS62149617A | 1987-07-03 | MORINAKA YASUHIRO; NISHI HIROYOSHI; WATANABE TOSHIAKI; YUKI TOSHIYUKI; SAKURAI YOKO |
| PURPOSE:The titled preparation that contains, as an active ingredient, a pyrazolone derivative or its salt, thus being used as a good preventive or remedy for a variety of ischemic diseases or other diseases caused by them, e.g., cerebral infarction or hemorrhage and other cerebrovascular diseases or cerebral hy pofunction caused by them. CONSTITUTION:The objective preparation contains, as an active ingredient, a pyrazolone derivative of formula I (R1 is H, aryl, 1-5C alkyl, 3-6C alkoxycarbonylalkyl; R2 is H, aryloxy, arylmercapto, 1-5C alkyl; or R1 and R2 incorporate to form 3-5C alkylene; R3 is residue of heterocyclic ring) or its pharmaceutically permissible salt. It is applied orally, intravenously or rectally. The active ingredient of formula I is synthesized by reaction of a beta-ketoacid derivative of formula II (R' is 1-5C alkyl) with a hydrazine derivative of formula III. | ||||||
| 168 | JPS6225661B2 - | JP11139078 | 1978-09-12 | JPS6225661B2 | 1987-06-04 | HORUSUTO MAIYAA; GERUHARUTO FURANKUKOBIAKU; FURIIDORITSUHI BOTSUZAATO; ARENTO HAIZE; SUTANISURAFU KATSUDA; KURUTO SUTETSUPERU; ROBAATOSON TOWAATO; EGUBAATO BEHINGAA |
| 169 | Pyridadinone derivative, its preparation and insecticide | JP15236486 | 1986-06-27 | JPS62123176A | 1987-06-04 | OGURA TOMOYUKI; KAWAMURA YASUO; HIROSE MASAYOSHI; HIRATA KIMINORI; KUDO MASAKI; MIYAKE TOSHIRO |
| NEW MATERIAL:A compound of formula I [X is halogen, alkyl, alkoxy, NO2; n is 1-4; A is halogen, alkyl, alkoxy, H; B is CX1 (X1 is H, halogen), N; R<1>, R<2> are H, alkyl; E is H, halogen, OH; Q is formula II - formula V (Y is halogen, alkyl, alkoxy, CN; m is 1-5)]. EXAMPLE:4-Chloro-5-(4-chlorobenzyloxy)-2-(4-chlorophenyl)-3(2H)-pyrida zinone. USE:Insecticide. It has very strong specificity against certain kinds of insect pests such as Hemiptera, Coleoptera and sanitarily harmful insects. Additionally, it exerts high residual effect. PREPARATION:The reaction of a compound of formula VI (X' is halogen, OM; M is H, alkali metal) with another compound of formula VII (X'' is OM, when X' is halogen, vice versa) gives the compound of formula I. | ||||||
| 170 | Condensed bicyclic imide having psychotropic drug activity | JP24646486 | 1986-10-15 | JPS62116577A | 1987-05-28 | MAGITSUDO ABUDERU MEGITSUDO AB |
| 171 | Piperidine derivative | JP13947486 | 1986-06-16 | JPS6289679A | 1987-04-24 | MURO TOMIO; SEKI TOSHIO; KAWAKAMI MINORU; INUI ATSUSHI; SATO HIROYUKI |
| NEW MATERIAL:The compound of formula I [R<1> is H, OH, lower alkoxy, lower alkanoyl, etc.; R<2> is H, lower alkyl, aralkyl, or di(lower alkyl)amino(lower alkyl); R<3> and R<4> are H, halogen, lower alkyl or alkyloxy; Z is O, S or H2; L is H, alkyl, tetrahydrofurfuryl, carbamoylalkyl, etc.; the dotted line in the formula II is single or double bond] and its acid addition salt. EXAMPLE:4-(2-Pyridylcarbamoyl)piperidine. USE:A medicine for circulatory organ. It has hypotensive and coronary and cere bral circulation improving activities. Dose: 5-500mg/kg daily in 1 - several divided doses. PREPARATION:The compound of formula I can be produced e.g. by reacting the compound of formula III with the compound of formula IV or its reactive derivative in an inert solvent under stirring and, if necessary, under heating. | ||||||
| 172 | JPS6214554B2 - | JP9828076 | 1976-08-19 | JPS6214554B2 | 1987-04-02 | RICHAADO ANSONII PARUCHIKA; MATSUKUSUIRU GOODON; KAMETANI TETSUJI; KIKAZAWA KAZUO |
| 173 | Indole derivative, its production and drug containing the same for preventing or treating heart and circulatory diseases | JP20811886 | 1986-09-05 | JPS6256486A | 1987-03-12 | ARUFUREETO MERUTENSU; BUORUFUGANGU FUON DERU ZAARU; BUARUTAA GUNAARU FURIIBE; BERUNTO MIYURAA BETSUKUMAN; GISUBERUTO SUPOONAA |
| 174 | Cardiac | JP12935585 | 1985-06-14 | JPS61289032A | 1986-12-19 | OKUJIMA HIROMI; NARIMATSU AKIHIRO; KOBAYASHI MAKIO; SHIMOODA RETSU; KITADA YOSHI |
| PURPOSE:A cardiac having high activity and durability of effects, comprising a specific pyridazinone derivative or its salt as an active ingredient. CONSTITUTION:A cardiac comprising a pyridazinone derivative shown by the formula I (A is 1-3N heterocyclic ring of 5-membered ring or 6-membered ring, containing optionally substituent group such as 1-6C alkyl, cyano, amino, etc., on the ring) or its salt as an active ingredient. To be concrete, a compound shown by the formula IV, etc., may be cited as the derivative. The compound shown by the formula I, for example, is obtained by heating a compound shown by the formula II and a compound shown by the formula III (X is halogen) in a polar solvent such as DMF, etc., at 50-200 deg.C for 0.5-10hr. The compound shown by the formula I has high activity as a cardiac and improved durability of effects. | ||||||
| 175 | JPS6153350B2 - | JP8519277 | 1977-07-15 | JPS6153350B2 | 1986-11-17 | NAKAO TATSU; SETOGUCHI NOBURO; YAOKA OSAMU |
| 176 | JPS61227582A - | JP6825586 | 1986-03-26 | JPS61227582A | 1986-10-09 | Haueru Noruberuto; Naa Berutorudo; Nooru Kurausu; Bomuharuto Andoreasu; Haidaa Yohahimu; Pushiorutsu Manfuretsudo; Deiederen Buirii; Jiyatsu |
| 177 | Production of thiazole derivative | JP6532085 | 1985-03-29 | JPS61225182A | 1986-10-06 | TAKASE MUNEAKI; YOSHIOKA KIMITOMO; YAMAZAKI HIROSUKE |
| PURPOSE:To obtain the titled substance useful as a cardiac inexpensively in high yield, by reacting a thiazole derivative with a compound such as pyridine and a compound such as 2,2,2-trichloroethyl chloroformate, etc., and reacting the reaction product with sulfur, etc. CONSTITUTION:A thiazole derivative shown by the formula I (R1 is H, hydroxyl group, lower alkyl, aryl, acyl, amino, lower alkylamino, arylamino, etc.; R2 is H, or lower alkyl) is reacted with a compound shown by the formula A-X<1> [A is group shown by the formula II (X is halogen; n is 1-3); X<1> is halogen] and a compound shown by the formula R3-H (R3 is nitrogen-containing hetero ring residue) at normal pressure under a temperature condition of environment by using preferably equimolar amounts of the compound shown by the formula I and the compound shown by the formula A-X' and >= an equimolar amount of the compound shown by the formula R3-H to give a compound shown by the formula III (R3' is dihydro derivative residue of nitrogen-containing hetero ring). Then, this compound is reacted with sulfur, or reacted with zinc and oxidized, to give the aimed compound including a novel compound shown by the formula IV. | ||||||
| 178 | Pyridylphenylpyridazinone cardiac stimulant | JP23089785 | 1985-10-15 | JPS6197284A | 1986-05-15 | DEIBITSUDO UEIN ROBAATOSON |
| 179 | Pyridazinone derivative and its preparation | JP21396884 | 1984-10-12 | JPS6193169A | 1986-05-12 | MORISAWA YASUHIRO; KATAOKA MITSURU; KUMAKURA SEIJI; KOIKE HIROYUKI; KOBAYASHI SHINSAKU |
| NEW MATERIAL:The compound of formula I [R1 and R2 are H or lower alkyl; R3 is group of formula II (R is O or S; A is alkylene; R7 is OH, lower alkoxy, etc.), etc.; R4 and R5 are H, lower alkyl, halogen, OH, etc.; R6 is H, lower alkyl, etc.; the bond containing dotted line is single or double] and its salt. EXAMPLE:6-{3-Chloro-4-[N-(2-morpholinoethyl)carbamoylmethoxy]p-henyl}- 4,5-di hydro-3-(2H)pyridazinone. USE:Cardiotonic, antihypertensive agent, and remedy for thrombotic diseases. PREPARATION:The compound of formula I wherein R3 is group of formula II, R4 is R10, R5 is R11, and R6 is H, can be prepared e.g. by converting the compound of formula III (R10 and R11 are R1, R2, halogen, lower alkoxy, etc.) to an alkali metal salt, and reacting the salt with the compound of formula IV (R12 is lower alkoxy, aryloxy, etc.; X is halogen). | ||||||
| 180 | Novel 1, 4-thiazine derivative and its preparation | JP20878184 | 1984-10-04 | JPS6185386A | 1986-04-30 | TAKASE MUNEAKI; YOSHIOKA KIMITOMO; YAMAZAKI HIROSUKE |
| NEW MATERIAL:The compound of formula I (R1 and R2 are H or lower alkyl; R3 is residue of nitrogen-containing hetero-ring) and its salt. EXAMPLE:5-Methyl-6-(4-quinolinyl)2-2H-1, 4-thiazin-3(4H)-one. USE:Remedy for cardiopathy. It increases the myocardial systole, and has low acute toxicity. PREPARATION:The objective compound can be prepared by reacting the compound of formula II [e.g. 5-methyl-2H-1, 4-thiazin-3(4H)-one, etc.] with the compound of formula AX' [A is CXnH3-nCH2OCO (X is halogen; n is 1-3); X' is halogen other than X] (e.g. 2,2,2-trichloroethyl chloroformate) and the compound of formula R3H (e.g. quinoline) preferably for 1-7hr, and reacting the resultant compound of formula III (R3' is dihydro residue of nitrogen-containing hetero-ring) with sulfur preferably at 140-180 deg.C for 1-5hr. | ||||||
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