Quartz crystal solute mass detector
阅读：104发布：2021-01-12
专利汇可以提供Quartz crystal solute mass detector专利检索，专利查询，专利分析的服务。并且A method and apparatus for detection of the mass of materials partitioned in a liquid chromatographic column by sampling a portion of the column effluent (eluate) and weighing the sample on a quartz crystal microbalance is disclosed. The solvent carrier is evaporated from the sample deposited on the crystal and its vibrational frequency measured. The change in frequency is proportional to the mass of material which remains after the solvent has been evaporated. Counting and recording equipment provide for continuous measurement and recording of the mass eluting from the chromatographic column.，下面是Quartz crystal solute mass detector专利的具体信息内容。
1. A method of measuring the mass of materials which have been separated in a liquid-liquid chromatographic column and subsequently eluted in a sequential manner by a carrier solvent according to their physical characteristics as an eluate stream comprising the following steps in combination: a. sampling an accurately reproducible amount of said eluate stream at uniform intervals during the elution of said materials, whereby the samples are representative of the separated material in said column; b. depositing each of said eluate samples on a first crystal; c. rapidly evaporating the carrier solvent from each of said eluate samples; and d. measuring the resonant frequency of said first crystal after said carrier solvent has been evaporated from each sample.
2. The method of claim 1 further comprising the steps of: e. comparing the frequency measured in (d) with a reference frequency; f. determining the difference between the resonant frequency of said first crystal and said reference frequency; g. determining the mass of the solids deposited on said first crystal by each eluate sample by means of a predetermined correlation between change of vibrational frequency and mass; and h. repeating the steps (a) through (g) until all of the separated material has eluted from the column.
3. The method of claim 1 wherein the sample is deposited on said first crystal by spraying.
4. The method of claim 3 wherein the amount of sample sprayed onto said first crystal is determined by the amount which the amplitude of vibration of said crystal is damped.
5. An apparatus for measuring the mass of materials which have been separated in a liquid-liquid chromatographic column and subsequently eluted by a carrier solvent in a sequential manner according to their physical characteristics as an eluate stream comprising: a. a first crystal adapted to receive a sample of the eluate; b. a first oscillator operably connected to said first crystal for measuring the resonant frequency thereof; c. a second reference crystal; d. a second oscillator operably connected to said second crystal for measuring the reference frequency thereof; e. means for depositing an accurately reproducible sample of said eluate on said first crystal at uniform intervals during the elution of said materials, whereby the samples are representative of the separated material in said column; f. means for comparing the resonant and reference frequencies of said first and second crystals; g. controller means for periodically activating said depositing means.
6. The apparatus of claim 5 wherein said depositing means is an adjustable spraying means characterized by its ability to deliver an accurately reproducible amount of spray each time it is actuated.
7. The apparatus of claim 6 wherein said spraying means is a spray gun operated by gaseous nitrogen under pressure and admitted to said spray gun by actuation of a valve by said controller means.
8. The apparatus of claim 7 wherein said eluate stream upon leaving said column passes through a tubing passageway connected to said spray gun near the outlet nozzle thereof and thereafter exits said nozzle through a tubing passageway to a measuring device.
9. The apparatus of claim 5 wherein nitrogen under pressure is admitted over said first crystal to assist evaporation of said carrier solvent by actuation of a valve by said controller means.
10. The apparatus of claim 9 wherein a heater is connected between said nitrogen valve and said first crystal whereby said nitrogen is warmed before reaching said crystal to speed the removal of said carrier solvent.
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