专利汇可以提供2-Methyl-3-phenyl-1,2,3,7,8,8a-hexahydro-1H-cyclopent[i,j]-isoquinoline hydrobromide专利检索,专利查询,专利分析的服务。并且A compound 2-methyl-3-phenyl-1,2,3,7,8,8a-hexahydro-1H-cyclopent[i,j]-isoquinoline hydrobromide of the formula: ##SPC1##Possesses pharmacological activity as an antidepressant.,下面是2-Methyl-3-phenyl-1,2,3,7,8,8a-hexahydro-1H-cyclopent[i,j]-isoquinoline hydrobromide专利的具体信息内容。
What is claimed is:1. A compound of the formula: ##SPC3##
This invention relates to a chemical compound. In particular it is concerned with a compound of the formula: ##SPC2##
This compound possesses pharmacological activity affecting the central nervous system. When administered perorally to animals it exhibits antidepressant action. Its antidepressant property is evidienced in the control of tetrabenazine-induced ptosis in mice. An oral dose of 50 mg/kg of this compound mice intraperitoneally receiving 35 mg/kg of tetrabenazine counteracts the ptosis producing property of tetrabenazine.
In order that this invention be readily available to and understood by those skilled in the art the following illustration is included:
A. 2-(1-Indanylamino)-1-phenylpropanol hydrochloride
A mixture of 50 g (0.378 mole) of 1-indanone, 57.0 g (0.378 mole) of 2-amino-1-phenylpropanol, 2.0 g p-toluenesulfonic acid monohydrate and 250 ml. toluene was stirred and refluxed using a Dean-Stark apparatus until the theoretical amount of water was collected. The solvents were removed in vacuo and the residue was dissolved in 750 ml. CH3 OH. The solution was stirred at 15°-20° while sodium borohydride (15.2 g, 0.40 mole) was added over 10 minutes. The mixture was stirred at 10°-20° for 3.0 hours, diluted with 750 ml. H2 O and extracted with 2 × 300 ml. chloroform. The combined chloroform extracts were dried (MgSO4) and concentrated to dryness in vacuo. Treatment of an ethanolic solution of the residue with ethanolic hydrogen chloride gave in two crops 62.0 g (54%) of the product.
B. 2-Methyl-3-phenyl-1,2,3,7,8,8a-hexahydro-1H-cyclopent[i,j]isoquinoline hydrobromide
A mixture of 31.6g(0.104 mole) of A and 400 ml 48HBr was stirred and refluxed for 6.0 hours. The mixture was cooled and stirred in an ice bath for 30 minutes and the solid was filtered through a medium sintered glass funnel. The solid was air dried and then recrystallized from 600 ml. CH3 CN to give 13.40 g (40%) of the product, m.p. 190°-200°. Further recrystallization from acetonitrile gave the analytical sample, m.p. 207°-210°.
Anal. Calcd. for C18 H19 N.HBr: C, 65.46; H, 6.10; N, 4.24. Found: C, 65.19; H, 6.28; N, 4.18.
标题 | 发布/更新时间 | 阅读量 |
---|---|---|
一种环境友好的氟化物纳米材料规模化制备方法 | 2020-05-08 | 702 |
一种用于去除强酸性废水中重金属阳离子的吡啶胺类螯合树脂及其制备方法 | 2020-05-08 | 587 |
三氮唑醇类衍生物及其制备方法和应用 | 2020-05-08 | 319 |
一种构建基于壳聚糖的聚电解质复合材料的方法 | 2020-05-11 | 414 |
氧化石墨烯/咪唑聚苯醚复合阴离子交换膜的制备方法 | 2020-05-11 | 578 |
一种温和条件下高收率制备赛乐西帕中间体化合物的方法 | 2020-05-08 | 261 |
一种制备尼古丁的方法 | 2020-05-11 | 377 |
一种纯化长链氨基酸的工艺 | 2020-05-08 | 670 |
酰基膦(氧)化合物及其制备方法和应用 | 2020-05-11 | 991 |
一种4-溴-2-氯-6-甲氧基吡啶的合成方法 | 2020-05-08 | 705 |
高效检索全球专利专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台,是提供专利分析,专利查询,专利检索等数据服务功能的知识产权数据服务商。
我们的产品包含105个国家的1.26亿组数据,免费查、免费专利分析。
专利汇分析报告产品可以对行业情报数据进行梳理分析,涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度,系统通过AI智能系统对图表进行解读,只需1分钟,一键生成行业专利分析报告。