首页 / 专利库 / 酸,碱,盐,酸酐和碱 / 氢溴酸 / Method of producing racemic estradiol-3,17{62

Method of producing racemic estradiol-3,17{62

阅读:113发布:2023-07-06

专利汇可以提供Method of producing racemic estradiol-3,17{62专利检索,专利查询,专利分析的服务。并且A method of producing racemic estradiol-3,17 Beta wherein 6methoxytetralone is demethylated by hydrobromic acid in the medium of acetic acid while boiling, the resultant 6hydroxytetralone is reacted with vinylmagnesiumbromide to form into 1-vinyl-1,2,3,4-tetrahydronaphthalene-1,6-diol which is condensed with 2-methylcyclopentane-1,3-dione; the thus-obtained Delta 1,3,5(10),9(11)-8,14-seco-estratetraen-3-o1-14,17-dione is subjected to cyclization, the resulting Delta 1,3,5(10),8(9), 14(15)-estrapentaen-3-o1-17-one is hydrogenated into Delta 1,3,5(10),8(9)-estratetraen-3-o1-17-one then reduced by sodiumborohydride and the thus-produced Delta 1,3,5(10),8(9)estratetraene-3,17 Beta -diol is subjected to ionic reduction by triethylsilane and trifluoroacetic acid in the medium of an organic solvent followed by the isolation of the final product. The thus-obtained racemic estradiol-3,17 Beta finds application in medical practice as a pharmaceutical preparation in the treatment of genital disorders, and therapy of hormone-dependent tumors, as well as a component in contraceptive prescriptions.,下面是Method of producing racemic estradiol-3,17{62专利的具体信息内容。

  • 2. A method according to claim 1 wherein the organic solvent in step (7) is benzene.
  • 3. A method according to claim 1 wherein the molar ratio of Delta 1,3,5(10),8(9)-estratetraene-3,17 Beta -diol to triethylsilane to trifluoroacetic acid is 1:20:20.
  • 4. A method according to claim 1 wherein step (2) is carried out at 18*-20*C.
  • 5. A method according to claim 1 wherein step (8) comprises extracting said estradiol-3,17 Beta from the reaction mixture with benzene, evaporating the benzene extract to form a residue, treating said residue with sodium borohydride in methanol at 40*-45* C. and then with acetic acid with cooling, and separating the crystallized estradiol-3,17 Beta .
  • 说明书全文
    高效检索全球专利

    专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台,是提供专利分析,专利查询,专利检索等数据服务功能的知识产权数据服务商。

    我们的产品包含105个国家的1.26亿组数据,免费查、免费专利分析。

    申请试用

    分析报告

    专利汇分析报告产品可以对行业情报数据进行梳理分析,涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度,系统通过AI智能系统对图表进行解读,只需1分钟,一键生成行业专利分析报告。

    申请试用

    QQ群二维码
    意见反馈