DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM |
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| 申请号 | US15561285 | 申请日 | 2016-07-18 | 公开(公告)号 | US20180118737A1 | 公开(公告)日 | 2018-05-03 |
| 申请人 | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.; | 发明人 | Elena BRASOLA; Filippo TOMASI; Loris PERUZZI; | ||||
| 摘要 | Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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