Method for producing 2-amino-substituted benzaldehyde compound |
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| 申请号 | US15504499 | 申请日 | 2015-08-25 | 公开(公告)号 | US10047037B2 | 公开(公告)日 | 2018-08-14 |
| 申请人 | Nippon Soda Co., Ltd.; | 发明人 | Shinichi Kobayashi; | ||||
| 摘要 | The present invention provides a method for producing a benzaldehyde in which an amino group is bonded in the 2 position, a halogeno group or an alkoxy group is bonded in the 3 position, and a hydrogen atom, an alkyl group, a halogeno group, an alkoxy group, or a cyano group is bonded independently in each of the 4, 5, and 6 positions, the method including: preparing a benzaldehyde in which a halogeno group or an alkoxy group is bonded in the 3 position, a hydrogen atom is bonded in the 2 position, and a hydrogen atom, an alkyl group, a halogeno group, an alkoxy group, or a cyano group is bonded independently in each of the 4, 5, and 6 positions so that a lithiation reaction is most active at the 2 position; acetal-protecting a formyl group in the benzaldehyde; sequentially performing lithiation, azidation, and amination of the 2 position; and the performing acetal deportection. | ||||||
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| 说明书全文 | |||||||
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