Spectral imaging for measurement of nuclear pathology features in cancer cells prepared for in situ analysis专利检索- ..由结构辅助元件的弹性变形或折断而操作的专利检索查询-专利查询网

Spectral imaging for measurement of nuclear pathology features in cancer cells prepared for in situ analysis
申请号	US14115327	申请日	2012-05-07	公开(公告)号	US09951388B2	公开(公告)日	2018-04-24
申请人	Francesca Demichelis; Karl Garsha; Phillip C. Miller; Ray B. Nagle; Michael Otter; Gary Anthony Pestano; Mark Rubin;			发明人	Francesca Demichelis; Karl Garsha; Phillip C. Miller; Ray B. Nagle; Michael Otter; Gary Anthony Pestano; Mark Rubin;
摘要	In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
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