VIRAL VECTOR IMMUNOGENIC COMPOSITIONS |
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| 申请号 | PCT/GB2011051865 | 申请日 | 2011-09-30 | 公开(公告)号 | WO2012042279A3 | 公开(公告)日 | 2012-07-26 |
| 申请人 | ISIS INNOVATION; DE CASSAN SIMONE; DOUGLAS ALEXANDER; DRAPER SIMON; FORBES EMILY; GOODMAN ANNA; HILL ADRIAN; MILICIC ANITA; REYES-SANDOVAL ARTURO; | 发明人 | DE CASSAN SIMONE; DOUGLAS ALEXANDER; DRAPER SIMON; FORBES EMILY; GOODMAN ANNA; HILL ADRIAN; MILICIC ANITA; REYES-SANDOVAL ARTURO; | ||||
| 摘要 | There is provided a composition comprising: (a) a modified vaccinia virus ankara (MVA) vector, wherein said MVA vector comprises a nucleic acid sequence encoding an antigen; and (b) an adjuvant comprising a saponin, or an emulsion. There is also provided a composition comprising:(a) an adenovirus vector, wherein said adenovirus vector comprises a nucleic acid sequence encoding an antigen, and wherein the adenovirus is selected from: a group B adenovirus, a group C adenovirus, and a group E adenovirus; and (b) an adjuvant comprising a saponin, or an emulsion; wherein the group B adenovirus is not an adenovirus 35, the group C adenovirus is not Ad5 having an intact E3 gene region, and the group E adenovirus is not an adenovirus C7. Also provided are corresponding uses of the compositions in medicine. | ||||||
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