POLYAMIDE CHAINS OF PRECISE LENGTH, METHODS TO MANUFACTURE THEM AND THEIR CONJUGATES WITH PROTEINS |
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| 申请号 | PCT/US9919280 | 申请日 | 1999-08-23 | 公开(公告)号 | WO0012587A3 | 公开(公告)日 | 2000-06-02 |
| 申请人 | GRYPHON SCIENCES; ROSE KEITH; | 发明人 | ROSE KEITH; | ||||
| 摘要 | Provided are chains of precise length and methods for their preparation. These chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water soluble oligomer, preferably polyethylene glycol. These chains are then used to chemically modify target macromolecules such as biologically important polypeptides. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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