序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
41 THERAPEUTIC ANGIOGENESIS FOR TREATING ERECTILE CONDITIONS US15962978 2018-04-25 US20190029589A1 2019-01-31 Vance Gardner; Mickael Flaa; Laurence R. Meyerson; John Jacobs
Disclosed are devices, methods and surgical procedures for detecting, imaging, analyzing, diagnosing and/or treating vascular disorders and related conditions of the human and mammalian body in males and/or females. In particular embodiments, treatments include methods for imaging, analyzing and improving erectile dysfunction and related conditions and potentially increasing angiogenesis in response to specifically diagnosed conditions.
42 COMPOSITIONS AND METHODS FOR HEMOSTASIS US16057652 2018-08-07 US20180344893A1 2018-12-06 David Knaack; John Pacifico; Marci Wirtz; Richard L. Kronenthal; Frank Do; Aniq Darr
The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.
43 MATERIALS AND TREATMENTS USING PIEZOELECTRIC EMBOLIC MATERIALS US15912187 2018-03-05 US20180250058A1 2018-09-06 Bharathi Jagadeesan; Sean Lester Moen; George R. Greene, JR.
An embolic agent and a piezoelectric substance are mixed together. The mixture can be delivered to a tumor or other object by a non-invasive method. The embolic agent prevents movement of the piezoelectric substance from the target location. Subsequent impulses applied to the target location cause ablation of the surrounding area due to the piezoelectric effect of the particles, promoting highly accurate and precise ablation without the need for more invasive procedures.
44 PACKAGING FOR ADHESIVE COMPOSITIONS US15426734 2017-02-07 US20180222618A1 2018-08-09 Sheng ZHANG; Rafael RUIZ, SR.; Amanda GUIDO
A package system suitable for sterilizing cyanoacrylate compositions and providing the sterile cyanoacrylate compositions a shelf life of at least 24 months, wherein the package system comprises: an ampoule comprising a chamber comprising a cyanoacrylate monomer, wherein the chamber is defined by an opening and sidewalls, wherein the ampoule comprises a material comprising a cyclic olefin copolymer; a multilayer foil seal sealing the opening of the ampoule; and a secondary package housing the ampoule.
45 THERAPEUTIC ANGIOGENESIS FOR TREATING ERECTILE CONDITIONS US15675595 2017-08-11 US20170340266A1 2017-11-30 Vance GARDNER; Kenneth THOMAS; John JACOBS
Disclosed are devices, methods and surgical procedures for detecting, imaging, analyzing, diagnosing and/or treating vascular disorders and related conditions of the human and mammalian body in males and/or females. In particular embodiments, treatments include methods for imaging, analyzing and improving erectile dysfunction and related conditions and potentially increasing angiogenesis in response to specifically diagnosed conditions.
46 CARTILAGE GEL FOR CARTILAGE REPAIR, COMPRISING CHITOSAN AND CHONDROCYTES US15532020 2015-12-01 US20170306295A1 2017-10-26 Pascale HAZOT; Frédéric MALLEIN GERIN
The present invention concerns a method for obtaining an implantable cartilage gel for tissue repair of hyaline cartilage, comprising particles of chitosan hydrogel and cells that are capable of forming hyaline cartilage, said method comprising a step for amplification of primary cells in a three-dimensional structure comprising particles of physical hydrogel of chitosan or a chitosan derivative, then a step for re-differentiation and induction of the synthesis of extracellular matrix by said amplified cells, in the same three-dimensional structure, wherein said cells are primary articular chondrocytes and/or mesenchymal stem cells differentiated into chondrocytes. The present invention also concerns the cartilage gel obtained thereby, and its various uses for cartilage repair following a traumatic lesion or an osteoarticular disease such as osteoarthritis. The invention also concerns a three-dimensional matrix comprising particles of physical hydrogel of chitosan or of chitosan derivative, optionally supplemented with an anionic molecule such as hyaluronic acid or a derivative of hyaluronic acid or a complex of hyaluronic acid.
47 Temperature controlled hypoallergenic garments or pads US14756689 2015-09-30 US20170087010A1 2017-03-30 Kanita Anjanette Howard
A hypoallergenic garment is provided that offers relief by achieving a desirable cooling or heating effect in an individual experiencing pain or discomfort. It can be used for treatment of conditions such as itching, burning, yeast or bacterial infection, urethral pain, inflammation, urinary tract infections, dermatitis, vaginal varicosity, menopausal perspiration, post-surgery swelling, edema due to a sports injury, swelling due to trauma, damage to the perineum, menopausal pain and combinations thereof.
48 Nerve repair with a hydrogel and adhesive US12922725 2009-03-19 US09386990B2 2016-07-12 David F. Muir; James B. Graham; Debbie Neubauer
The subject invention provides materials and methods for effective nerve repair. In a preferred embodiment, the subject invention provides nerve repair methods comprising the steps of applying a fibrin glue between severed nerve stumps, coapting the nerve stumps, and applying a polyethylene glycol (PEG) hydrogel to encase the coapted nerve stumps.
49 VASCULAR CLOSURE DEVICE HAVING A FLOWABLE SEALING MATERIAL US14979317 2015-12-22 US20160113636A1 2016-04-28 Catherine A. Pipenhagen; Melissa K. Gardner; Jyue Boon Lim; William R. Fiehler; Gary J. Schorr; Janet L. Jacobsen
Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids.
50 Vascular closure device having a flowable sealing material US13609115 2012-09-10 US09254346B2 2016-02-09 Catherine A. Pipenhagen; Melissa K. Gardner; Jyue Boon Lim; William R. Fiehler; Gary J. Schorr; Janet L. Jacobsen
Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids.
51 Biodegradable bone plates and bonding systems US14505601 2014-10-03 US09173970B2 2015-11-03 Stephen McCarthy; Jeffrey Weinzweig
The invention relates to novel internal fixation devices, such as bone plates, generally and novel craniomaxillofacial bone plates more specifically and systems for bonding the same. More specifically, the invention relates to bone plates made of a polymer blend of (poly)lactic acid and Ecoflex as well as a novel hot-melt adhesive polymer blend of the same material.
52 Drainable ostomy pouch US13255802 2010-03-16 US08821463B2 2014-09-02 Christen Grum-Schwensen
The present invention concerns a drainable ostomy pouch comprising first proximal pouch wall and second distal pouch wall joined together along the outer periphery to form a cavity for accommodating waste material and to form an outlet portion with an outlet for draining the content of the pouch; an inlet provided in the first pouch wall for receiving waste into the pouch; a comfort layer provided at least on the distal side wall; a closure system with first and second fastener strips provided on at least one, preferably both exterior sides of the pouch walls for in cooperation to close the outlet by folding the outlet portion upon itself, wherein the second fastener strip is provided between the comfort layer and the distal side wall such that the outlet portion when folded up may be releasably secured to the comfort layer between the comfort layer and the distal side wall.
53 Sterilized liquid compositions of cyanoacrylate monomer mixtures US13953011 2013-07-29 US08652510B2 2014-02-18 Sheng Zhang; Rafael Ruiz, Sr.
Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.
54 STERILIZED LIQUID COMPOSITIONS OF CYANOACRYLATE MONOMER MIXTURES US13953011 2013-07-29 US20130310755A1 2013-11-21 Sheng Zhang; Rafael Ruiz, SR.
Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.
55 VASCULAR CLOSURE DEVICE HAVING A FLOWABLE SEALING MATERIAL US13609115 2012-09-10 US20130006299A1 2013-01-03 Catherine A. Pipenhagen; Melissa K. Gardner; Jyue Boon Lim; William R. Fiehler; Gary J. Schorr; Janet L. Jacobsen
Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids.
56 HIP JOINT METHOD US13383332 2010-07-12 US20120116526A1 2012-05-10 Peter Forsell
The present invention relates to a method of treating a hip joint of a human patient by providing at least one hip joint surface, said hip joint comprising a caput femur and an acetabulum, said method comprising the steps of: cutting the skin of said human patient, dissecting an area of the pelvic bone on the opposite side from said acetabulum, creating a hole in said dissected area, said hole passing through said pelvic bone and into said hip joint of said human patient, and providing at least one hip joint surface to said hip joint, through said hole in said pelvic bone of said human patient. The method further relates to a laparoscopic/arthroscopic method of treating a hip joint of a human patient by providing at least one hip joint surface, said hip joint comprising a caput femur and an acetabulum, said method comprising the steps of: inserting a needle or a tube like instrument into the patient's body, using the needle or tube like instrument to fill a part of the patient's body with gas and thereby expanding a cavity within said body, placing at least two laparoscopic/arthroscopic trocars in said cavity, inserting a camera through one of the laparoscopic/arthroscopic trocars into said cavity, inserting at least one dissecting tool through one of said at least two laparoscopic/arthroscopictrocars, dissecting an area of the pelvic bone on the opposite side from said acetabulum, creating a hole in said dissected area, said hole passing through said pelvic bone and into said hip joint of said human patient, and providing at least one hip joint surface to said hip joint, through said hole in said pelvic bone of said human patient.
57 Nerve Repair with a Hydrogel and Optional Adhesive US12922725 2009-03-19 US20110137328A1 2011-06-09 David F. Muir; James B. Graham; Debbie Neubauer
The subject invention provides materials and methods for effective nerve repair. In a preferred embodiment, the subject invention provides nerve repair methods comprising the use of a fibrin glue and a polyethylene glycol (PEG) hydrogel to coapt severed nerve stumps or nerve grafts.
58 VASCUAR CLOSURE DEVICE HAVING A FLOWABLE SEALING MATERIAL US11968020 2007-12-31 US20090171282A1 2009-07-02 Catherine A. Pipenhagen; Melissa K. Gardner; Jyue Boon Lim; William R. Fiehler; Gary J. Schorr; Janet L. Jacobsen
Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids.
59 Novel biodegradable bone plates and bonding systems US11787076 2007-04-13 US20080234754A1 2008-09-25 Stephen McCarthy; Jeffrey Weinzweig
The invention relates to novel internal fixation devices, such as bone plates, generally and novel craniomaxillofacial bone plates more specifically and systems for bonding the same. More specifically, the invention relates to bone plates made of a polymer blend of (poly)lactic acid and Ecoflex as well as a novel hot-melt adhesive polymer blend of the same material.
60 Method of removing medical adhesive US11216701 2005-08-31 US20070054821A1 2007-03-08 Ian Askill
Medical adhesive may be removed by applying a solution including tetrahydrofurfuryl acetate (THFA) to the surface upon which is located the adhesive and rubbing the surface to facilitate removal of the adhesive. The solution may be applied to a wipe before application to the surface and the wipe may be used to rub the surface. The surface may be living or dead human or animal skin, hard surfaces and medical instruments. Various additional ingredients may be added to the solution, like perfumes, emollients and other commonly known skin products and polymer diluents.
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