子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | Method to provide for production of hair coloring pigments in hair follicles | US858970 | 1997-05-20 | US5965157A | 1999-10-12 | Lingna Li; Valeryi Lishko |
| The present invention provides a method to specifically target hair follicles with formulations which effect the production of hair coloring pigments in the follicle. Liposomal formulations for this purpose are disclosed. | ||||||
| 62 | Cosmetic composition comprising a dispersion of lipid vesicles as well as melanin pigments | US271990 | 1994-07-08 | US5874091A | 1999-02-23 | Jean-Fran.cedilla.ois Grollier |
| This composition based on lipid vesicles dispersed in an outer phase is characterized in that it contains at least one melanin pigment in the aqueous outer phase. The melanin pigments may be carried on mineral or polymeric fine particulate or lamellar fillers. The composition obtained can be used in the field of cosmetics where it makes it possible to obtain a highly homogeneous dispersion of the melanin pigment that can be distributed evenly over the skin or hair; it increases the period of protection of keratinous substances against the harmful effects of ultraviolet radiation; it promotes tanning of the skin and gives it an even color and better appearance; it colors grey hair; and it causes improved storage of the melanin pigment in the stratum corneum. | ||||||
| 63 | Synthesis of quarternary melanin compounds and their use as hair dyes or for skin treatment | US874154 | 1997-06-13 | US5827330A | 1998-10-27 | Gottfried Wenke; Giuseppe Prota |
| Water soluble, cationic products useful as hair colorants or for the treatment of skin which are esters or amides formed by reaction of melanin and a quaternary salt containing a reactive amino or hydroxyl group, as well as compositions containing them and methods of using such products to color hair or treat skin are described. | ||||||
| 64 | Compounds in the form of 5,6-dihydroxyindole polymers, their process of preparation and compositions comprising them | US976346 | 1997-11-21 | US5801169A | 1998-09-01 | Laurent Marrot |
| Novel 5,6-dihydroxyindole polymers, which are soluble in an aqueous or aqueous-alcoholic medium and a process for the preparation of these polymers and to compositions containing these polymers, especially cosmetic compositions. | ||||||
| 65 | Cosmetic melanins | US392589 | 1995-02-23 | US5744125A | 1998-04-28 | John M. Pawelek; James T. Platt |
| Disclosed are cosmetic melanins of different colors produced by procedures involving oxidative polymerization of monomeric precursors of melanin and/or co-monomers that enhance substantivity or adherence of the melanins to the skin and hair. Also disclosed are methods for preparing cosmetic melanins and methods for using these compositions topically to produce a natural-appearing tan and to prevent damage to skin caused by UV exposure. | ||||||
| 66 | Melanoquaternary compounds and their use as hair dyes and for skin treatment | US568056 | 1995-12-06 | US5702712A | 1997-12-30 | Gottfried Wenke; Giuseppe Prota |
| Water soluble, cationic products useful as hair colorants or for the treatment of skin which are esters or amides formed by reaction of melanin and a quaternary salt containing a reactive amino or hydroxyl group, as well as compositions containing them and methods of using such products to color hair or treat skin are described. | ||||||
| 67 | Preparation for topical use | US640116 | 1996-04-30 | US5641509A | 1997-06-24 | Udo Gross; Joachim Roding; Klaus Stanzl; Leonhard Zastrow |
| The invention relates to a preparation for topical use, having light protection properties and in a special application form. In the known light protection agents containing the naturally occurring active compound melanin, the problem is inadequate transport of the melanin to its site of action. According to the invention, this problem is solved by a preparation for topical use which is characterised in that it contains melanin, dissolved or dispersed in one or more fluorocarbons, which are present as asymmetric lamellar phospholipid aggregates in an aqueous system together with a phospholipid, with a particle size of the aggregates in the range from 200 to 3000 nm. | ||||||
| 68 | Anti-pollution cosmetic composition | US510077 | 1995-08-01 | US5571503A | 1996-11-05 | Jack Mausner |
| A cosmetic composition according to the present invention incorporates a new combination of ingredients particularly designed to provide significant protection of the skin from several damaging components of environmental pollution, while also providing significant protection against moisture loss and damage due to free radical activity and ultraviolet light, both UV-A and UV-B, and controlling oil. In general, a cosmetic composition according to the present invention comprises: water, and emulsified and dispersed in the water: (1) an anti-pollution complex comprising propylene glycol, hydrolyzed wheat protein, mannitol, glycogen, yeast extract, ginseng extract, linden extract, calcium pantothenate, horse chestnut extract, and biotin; (2) a micellar complex comprising: phospholipids, glycosphingolipids, panthenol, Crataegus extract, cholesterol, and sodium hyaluronate; (3) an anti-free radical complex comprising melanin, a short-chain fatty acid ester of tocopherol, a long-chain fatty acid ester of retinol, and a long-chain fatty acid ester of ascorbic acid; and (4) a sunscreen. Other cosmetic components, such as aloe extract, matricaria extract, apricot kernel extract, garden balsam leaf extract, hydrolyzed soy protein, and horsetail extract, and ancillary components can also be used. | ||||||
| 69 | Compositions and method for temporarily coloring hair using a complex of water soluble melanin and a cationic material | US214062 | 1994-03-15 | US5454841A | 1995-10-03 | L. Wolfram; G. Wenke |
| Compositions comprising chemically synthesized or biosynthetic water-soluble melanin and at least one water dispersible cationic material which, when combined with the melanin, forms a composition that is suitable for use as a temporary haircolor. A process for temporarily coloring hair using those compositions. | ||||||
| 70 | Synthetic melanin as a sunscreen and tanning agent | US16418 | 1993-03-25 | US5384116A | 1995-01-24 | John Pawelek; Michael P. Osber; Seth J. Orlow |
| A melanin that is soluble in an aqueous solution at a pH between 5 and 9 at a temperature of 0.degree. to 100.degree. C. Advantageously, the melanin is capable of being filtered through at least a 0.45 micron size filter, and has a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and an appropriate enzyme, or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone or with 5,6-dihydroxyindole, or with 3-amino-tyrosine. The melanin is also useful for providing a sun-screen to mammalian skin and hair, to treat post-inflammatory hypo- and hyperpigmentation, to tint glass and plastic, to protect industrial materials against ultraviolet damage, and as a coloring agent in foodstuffs such as coffee, tea, soda, whiskey and liquors. | ||||||
| 71 | Paste composition for skin barrier | US8477 | 1993-01-25 | US5369130A | 1994-11-29 | Satoru Numata |
| Skin barrier paste compositions free from organic solvents comprised of at least a rubber component and a filler component wherein the rubber component includes a liquid rubber having an average molecular weight of about 1,000 to about 80,000 and a viscosity of about 200 poise to about 6,000 poise at 40.degree. C., the rubber component being present in the paste composition in the range of about thirty percent to about seventy percent by weight. The present inventive paste compositions can be freely formed with the fingertips or a spatula; they are less irritating to the skin, mucosa and/or the injured area; and they are less susceptible to a viscosity change when exposed to the atmosphere, thus assuring an ease of application and a stable paste formulation when stored in a container. | ||||||
| 72 | Composition and method for protecting the skin from UV-rays | US638695 | 1991-01-08 | US5256403A | 1993-10-26 | Frances C. Gaskin |
| Solubilized melanin based compositions supply melanin to skin, scalp and/or hair. The compositions consist of melanin, as an active ingredient, and a substance to solubilize the melanin blended together in a vehicle suitable for topical application. A melanin-based composition applied to the skin provides photoprotection of the human epidermis from exposure to ultraviolet rays. A melanin-based composition applied to wounds in the skin accelerates healing of the wounds. A melanin-based composition applied to the hair and scalp strengthens the hair. | ||||||
| 73 | Soluble melanin | US603111 | 1990-10-25 | US5218079A | 1993-06-08 | John M. Pawelek; Seth J. Orlow |
| A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair. | ||||||
| 74 | Soluble melanin | US525944 | 1990-05-18 | US5216116A | 1993-06-01 | John M. Pawelek |
| A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. The melanin is also useful for providing a sun-screen to mammalian skin and hair. | ||||||
| 75 | Color modified melanins and methods for their preparation and use | US883226 | 1992-05-07 | US5188844A | 1993-02-23 | Ago B. Ahene; Miles Chedekel |
| Color modified melanin compositions are produced by exposure of a natural or synthetic melanin starting material to a color modifying agent under controlled conditions. By treating the melanin starting materials for a preselected time period, melanin products having a desired final color may be obtained. The color modified melanin may be employed in a variety of cosmetic and other topically applied formulations. Prior to incorporation in such formulations, the color modified melanins will be cleaned to remove the color modifying agent and low molecular weight degradation products of the melanin. | ||||||
| 76 | Synthetic melanin aggregates | US206542 | 1988-06-14 | US4855144A | 1989-08-08 | Helen Leong; Martin Katz; Ann Delk; Sergio Nacht; David Berliner |
| Melanin compositions include a melanin pigment incorporated within polymeric particles, usually within an internal pore network defined by a polymeric particle matrix. The melanin compositions may be produced by in situ oxidation of melanin precursors within the pore network, or by absorption of a melanin pigment in a suitable vehicle or carrier. The melanin compositions are found to display enhanced absorbance of ultraviolet radiation and better cosmetic attributes when compared to melanin pigments which are not incorporated in such a polymeric particle matrix. | ||||||
| 77 | Depilation method | US65094 | 1987-06-22 | US4830633A | 1989-05-16 | Yutaka Hori; Katsuo Matsumoto; Katsuhiro Yamamoto; Toshimitsu Sasaki; Masayuki Shida |
| A depilation method is disclosed, comprising coating a depilatory agent containing an aqueous solution or emulsion of a polymer compound having a film forming ability and a depilatory medicine, drying the resulting coating to form a film and peeling off the film. This method permits to remove hair without causing any pain and producing any unpleasant odor due to the decomposition of hair. | ||||||
| 78 | Anthracene derivatives | US90569 | 1987-08-28 | US4803221A | 1989-02-07 | Kenneth W. Bair |
| The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.1 (I)or a monomethyl or a monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is an anthracene or substituted anthracene ring system; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1;R.sup.5 is hydrogen;R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-3 alkyl optionally substituted by hydroxy;R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five- or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl;R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl;R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl. | ||||||
| 79 | Methods to deliver macromolecules to hair follicles | US858469 | 1997-05-20 | US5914126A | 1999-06-22 | Lingna Li; Valeryi Lishko |
| The invention provides methods to deliver macromolecules to hair follicles selectively using formulations of these macromolecules in liposomal separations. | ||||||
| 80 | Melanin enhanced hair coloration | US989452 | 1997-12-12 | US5906610A | 1999-05-25 | Thomas L. Mehl, Sr.; Nardo Zaias |
| A method of altering skin tissues by application of light energy. Hair coloring is altered by introduction of melanin to the hair and hair follicle. Delivery of melanin is enhance by encapsulation in a liposome. Liposomes are specifically selected for the ability to bind to the tissues of the epidermis. Light energy is applied to release the melanin and assist binding to the targeted tissues. Light energy is preferably provided by one of several laser light sources. The light energy is matched to the absorption of the melanin to reduce absorption and damage to surrounding untargeted skin tissues. | ||||||
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