| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 141 | DEVICE FOR GENERATING BEAMS OF CONVERGING X-PHOTONS AND ELECTRONS | PCT/IB2012051983 | 2012-04-19 | WO2012143893A3 | 2013-01-17 | FIGUEROA SAAVEDRA RODOLFO; VALENTE MAURO |
| The invention relates to scientific/technological equipment intended for the generation of a beam of converging photons for use in radiotherapy or other applications. The equipment is used for suitably forming, by means of the application of magnetic and/or electric fields, a beam of electrons originating from a linear accelerator (LINAC), which electrons perpendicularly intercept the surface of a curved material of a particular radius of curvature (anode), thereby generating X-rays. The interaction between the electrons and the atoms of the anode material generates X-rays with a non-isotropic angular distribution having a greater concentration in the focal direction and being defined by the geometry of the anode. A curved collimator is located at the rear part of the anode, said collimator having a suitable radius of curvature and being formed by an arrangement of a large number of small holes pointing towards the focal point. The device allows the transmission of X-rays only in the focal direction. A typical diagram of the invention is provided in the figure. | ||||||
| 142 | ELECTRONIC APPARATUS | PCT/GB2005002878 | 2005-07-22 | WO2006008541A3 | 2006-06-01 | MILLER RODNEY |
| The invention provides a device for producing and focussing an electron beam; the device comprising an evacuated chamber (4), a source of electrons (2), a target (6), means for creating an electric field to accelerate a stream of the electrons constituting the electron beam through the chamber towards the target, and means (12) for providing a magnetic field crossing the electron beam; characterised in that the magnetic flux of the magnetic field progressively reduces in the direction of the target. | ||||||
| 143 | METHOD AND DEVICE FOR CONTROLLING A BEAM EXTRACTION RASTER SCAN IRRADIATION DEVICE FOR HEAVY IONS OR PROTONS | PCT/EP0214256 | 2002-12-13 | WO03069634A3 | 2003-10-09 | HABERER THOMAS |
| The invention relates to a method and a device for controlling a beam extraction raster scan irradiation device for heavy ions or protons, wherein the beam energy, beam focusing and beam intensity are adjusted for every accelerator cycle. Adjustment of the beam extraction duration for every accelerator cycle allows to substantially save time. | ||||||
| 144 | Dual rotation charged particle imaging / treatment apparatus and method of use thereof | US15260763 | 2016-09-09 | US10143854B2 | 2018-12-04 | Susan L. Michaud; Daniel J. Raymond; W. Davis Lee |
| The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as: (1) using a rotatable gantry support to support and rotate a section of a positively charged particle beam transport line about a rotation axis and a tumor of a patient; (2) using a rotatable and optionally extendable secondary support to support, circumferentially position, and laterally position a primary and optional secondary imaging system about the tumor; (3) image the tumor using the primary and optional secondary imaging system as a function of rotation and/or translation of the secondary support; and (4) treat, optionally concurrently with imaging, the tumor using the positively charged particles as a function of circumferential position of the section of the charged particle beam about the tumor. | ||||||
| 145 | Ion beam extraction apparatus and method of use thereof | US15847772 | 2017-12-19 | US10112060B2 | 2018-10-30 | W. Davis Lee; Mark R. Amato; James P. Bennett |
| The invention comprises an apparatus and method of use thereof for extracting ions from an ion source, such as for use in cancer treatment or tomographic imaging. The extraction apparatus uses a triode extraction system, with the ion source and/or first electrode held at a first potential; an extraction electrode held at a second potential; and a gating electrode, positioned between the ion source and the extraction electrode, oscillating and/or alternating between a first suppression potential proximate that of the ion source potential and a second extraction potential between the ion source potential and the extraction electrode potential. Optionally, the ion source comprises an electron cyclotron resonance ion source. | ||||||
| 146 | CANCER THERAPY SYSTEM TREATMENT BEAM PROGRESSION AND METHOD OF USE THEREOF | US15823070 | 2017-11-27 | US20180264289A1 | 2018-09-20 | Susan L. Michaud; W. Davis Lee |
| The invention comprises a method and apparatus for treating a tumor with positively charged particles, comprising the steps of: (1) transporting the positively charged particles sequentially from an accelerator, along a beam transport path, through a nozzle system, and along a treatment beam path and (2) while scanning the treatment beam path along each of a set of vectors for treating the tumor, on average for the set of vectors, intentionally deviating the treatment beam path from a current vector of the set of vectors off of the current vector by at least one-eighth of a treatment beam diameter at least once for every twenty movements of the treatment beam. | ||||||
| 147 | MULTIPLE TREATMENT BEAM TYPE CANCER THERAPY APPARATUS AND METHOD OF USE THEREOF | US15919090 | 2018-03-12 | US20180200539A1 | 2018-07-19 | Mark R. Amato; Scott Penfold; W. Davis Lee |
| The invention comprises a method and apparatus for treating a tumor of a patient, comprising the steps of: (1) using a first treatment beam comprising electrons in a cancer therapy system used to treat the tumor, the electrons passing along a beam transport path from a synchrotron, through a beam transport system, through an exit nozzle, and toward the tumor and (2) using a second treatment beam to treat the tumor, the second treatment beam both generated using the synchrotron and penetrating into the tumor, where the second treatment beam comprises at least one of: (1) cations and (2) secondary X-rays emitted resultant from energy transfer from the electrons, where the cations are optionally used to image the tumor of the patient. | ||||||
| 148 | MULTIPLE CATION CANCER THERAPY APPARATUS AND METHOD OF USE THEREOF | US15907076 | 2018-02-27 | US20180185673A1 | 2018-07-05 | W. Davis Lee; Mark R. Amato; Scott Penfold; Stephen L. Spotts |
| The invention comprises a method and apparatus for imaging and/or treating a tumor of a patient using multiple ion types, such as a cations with one, two, or more mass-to-charge ratios and/or electrons, where the multiple ion types are accelerated, at separate times, using a single accelerator, and the multiple ion types are used to treat different depths into a tumor of a patient, where the patient is optionally maintained in a single treatment position relative to a patient positioning system during treatment. | ||||||
| 149 | ION BEAM EXTRACTION APPARATUS AND METHOD OF USE THEREOF | US15847772 | 2017-12-19 | US20180117362A1 | 2018-05-03 | W. Davis Lee; Mark R. Amato; James P. Bennett |
| The invention comprises an apparatus and method of use thereof for extracting ions from an ion source, such as for use in cancer treatment or tomographic imaging. The extraction apparatus uses a triode extraction system, with the ion source and/or first electrode held at a first potential; an extraction electrode held at a second potential; and a gating electrode, positioned between the ion source and the extraction electrode, oscillating and/or alternating between a first suppression potential proximate that of the ion source potential and a second extraction potential between the ion source potential and the extraction electrode potential. Optionally, the ion source comprises an electron cyclotron resonance ion source. | ||||||
| 150 | DOUBLE DIPOLE CANCER THERAPY TREATMENT BEAM SCANNING APPARATUS AND METHOD OF USE THEREOF | US15838072 | 2017-12-11 | US20180099156A1 | 2018-04-12 | Faye Hendley Elgart; Nick Ruebel; Mark R. Amato; Nandish Desai; W. Davis Lee |
| The invention comprises a method and apparatus for steering/scanning charged particles, comprising: a double dipole scanning system, comprising: (1) a beam path chamber comprising an entrance side and an exit side, the entrance side comprising a smaller area than the exit side; (2) a first dipole magnet, the first dipole magnet comprising a first coil and a third coil on first opposite sides of the beam path chamber; and (3) a second dipole magnet, the second dipole magnet comprising a second coil and a fourth coil on second opposite sides of the beam path chamber, the beam path chamber further comprising a truncated square/rectangle pyramid shape, the smaller entrance side of the charged particles comprising a top of the truncated pyramid shape, the exit side of the charged particles comprising a larger bottom of the truncated pyramid shape. | ||||||
| 151 | Dynamic energy control of a charged particle imaging/treatment apparatus and method of use thereof | US15334122 | 2016-10-25 | US09937362B2 | 2018-04-10 | W. Davis Lee; Mark R. Amato; Scott Penfold |
| The invention comprises a beam adjustment method and apparatus used to perform energy adjustments on circulating charged particles in a synchrotron previously accelerated to a starting energy with a traditional accelerator of the synchrotron. The beam adjustment system uses a radio-frequency modulated potential difference applied along a longitudinal path of the circulating charged particles to accelerate or decelerate the circulating charged particles. Optionally, the beam adjustment system phase shifts the applied radio-frequency field to accelerate or decelerate the circulating charged particles while tightening spatial distribution of a grouped bunch of the circulating charged particles. Optionally, the beam adjustment system simultaneously radially focuses the circulating charged particles using two or more gaps with focusing and/or defocusing edges. The beam adjustment system facilitates treating multiple layers or depths of the tumor without hysteresis and/or between the repeating slow steps of reloading the synchrotron. | ||||||
| 152 | CHARGED PARTICLE CANCER THERAPY BEAM STATE DETERMINATION SYSTEM AND METHOD OF USE THEREOF | US15823148 | 2017-11-27 | US20180078790A1 | 2018-03-22 | W. Davis Lee; Scott Penfold; Mark R. Amato; Lou Wainwright |
| The invention comprises a method and apparatus for determining state of a positively charged particle, such as a proton, for use in imaging a tumor of a patient prior to and/or concurrent with cancer therapy. The imaging system comprises: (1) a beam transport path of the positively charged particle sequentially passing through a patient, through a first time of flight detector, and, after traversing a pathlength, at least into a second time of flight detector and (2) a beam state determination system configured to: use elapsed time between detection at the first and second time of flight detectors and the pathlength to determine a residual beam energy, which, when compared to a known incident beam energy, is used in generation of an image of the tumor. An optional beam energy degrading element increases time differences between the time of flight detectors. | ||||||
| 153 | X-ray detector for proton transit detection apparatus and method of use thereof | US15348625 | 2016-11-10 | US09855444B2 | 2018-01-02 | Scott Penfold; W. Davis Lee; Mark R. Amato |
| The invention comprises a method and apparatus for probing a tumor of a patient using positively charged particles, comprising the steps of: (1) sequentially delivering sets of varied and known positively charged particles to a patient; (2) after transmission through the patient, sequentially detecting a residual energy of each of the sets of positively charged particles; and (3) determining a water equivalent thickness of a probed path of the patient using a plot of the detector response as a function of residual energy that is fit with a curve. The analyzer relates a half maximum of the fit curve, such as a Gaussian curve, to the water equivalent thickness of the sampled beam path. Repeated measurements as a function of incident angle and/or position of the incident charged particles allows generation of an image of the sample, such as a computed tomography image. | ||||||
| 154 | Hybrid charged particle / X-ray-imaging / treatment apparatus and method of use thereof | US15257686 | 2016-09-06 | US09782140B2 | 2017-10-10 | Susan L. Michaud; Daniel J. Raymond; W. Davis Lee |
| The invention comprises a method and apparatus for imaging and treating a tumor of a patient using positively charged particles and X-rays. A mounting rail, supporting a scintillation detection system element and an X-ray detection system element, is alternatingly extended/retracted to position the required detection system element opposite a patient tumor position from an exit nozzle of a beam transport system connected to an accelerator of the positively charged particles, where the positively charged particles are alternatingly used to treat the tumor via irradiation. The mounting rail optionally rotates with rotation of the exit nozzle about the patient, such as with rotation of a support gantry. | ||||||
| 155 | Charged particle beam system | US14524495 | 2014-10-27 | US09757590B2 | 2017-09-12 | Kazuo Hiramoto; Masumi Umezawa; Shinichiro Fujitaka; Hiroki Shirato; Shinichi Shimizu; Kikuo Umegaki |
| First ions and second ions that are heavier than first ions are generated in an ion source. One kind of ions of the first ions and second ions is injected into an accelerator by action of a switching magnet and accelerated in the accelerator. An ion beam including the one kind of ions is extracted from the accelerator to a beam transport system and a tumor volume of a patient is irradiated with the ion beam from an irradiation nozzle. In the irradiation of the ion beam, a tumor volume depth and the largest underwater range of each ion species are compared, and an ion species in which the tumor volume depth becomes the longest underwater range or lower is injected into the accelerator, and accelerated by the accelerator. The tumor volume is irradiated with the ion species. | ||||||
| 156 | Charged particle cancer therapy beam state determination apparatus and method of use thereof | US15207309 | 2016-07-11 | US09737272B2 | 2017-08-22 | W. Davis Lee; Susan L. Michaud; Daniel J. Raymond; Mark R. Amato |
| The invention comprises an apparatus and method of use thereof for determining a charged particle beam state after passage through a final beam modification insert and prior to entering a patient, such as in cancer treatment or tomographic imaging. The insert comprises a range shifter, a known energy absorber, a ridge filter, a focal length altering insert, an aperture defining element, a compensator, and/or a patient specific beam modifier. The monitoring element comprises one or more sheets, configured to emit photons upon passage therethrough of the charged particle beam, where the emitted photons are detected, tested, such as against a predetermined cancer treatment plan, and/or used to aid in three dimensional tomographic image generation. | ||||||
| 157 | TREATMENT BEAM PATH VERIFICATION IN A CANCER THERAPY APPARATUS AND METHOD OF USE THEREOF | US15467915 | 2017-03-23 | US20170197097A1 | 2017-07-13 | Susan L. Michaud; Jillian Reno; Nick Ruebel; Mark R. Amato; W. Davis Lee; James P. Bennett |
| The invention comprises a method and apparatus for treating a tumor of a patient using positively charged particles, comprising the steps of: (1) providing an approved current version of a radiation treatment plan for treatment of the tumor using the positively charged particles; (2) implementing the current version of the radiation treatment plan using a cancer therapy system comprising a controller linked to a synchrotron; (3) upon identifying an object, using a set of fiducial indicators, in a treatment vector of the radiation treatment plan: generating a modified version of radiation treatment plan and receiving medical doctor approval of the modified version of the radiation treatment plan, the modified version of the radiation plan becoming the current version of the radiation treatment plan; and (4) repeating the steps of implementing and identifying until completion of treatment of the tumor using the positively charged particles. | ||||||
| 158 | PROTON - X-RAY DUAL/DOUBLE EXPOSURE IMAGING APPARATUS AND METHOD OF USE THEREOF | US15413066 | 2017-01-23 | US20170128747A1 | 2017-05-11 | James P. Bennett; Kyle Schmanke; Lauri Reichert; Stephen Sledge; Nick Ruebel; Jillian Reno; Edward Ivanov; Mark R. Amato; Scott Penfold; W. Davis Lee |
| The invention comprises an X-ray—positively charged particle double/dual exposure imaging apparatus and method of use thereof. Double exposure imaging of a tumor of a patient is performed using detector hardware responsive to both X-rays and positively charged particles. A near-simultaneous double exposure yields enhanced resolution due to the imaging rate versus patient movement, no requirement of a software overlay step of the X-ray based image and the positively charged particle based image, and enhancement of an X-ray image, the enhancement resultant from a differing physical interaction of the positively charged particles with the patient compared to interactions of X-rays and the patient. Further, resolution enhancements utilize individual particle tracking, as measured using detection screens, to determine a probable intra-patient path. Residual energy positively charged particles are optionally used to generate a second or dual image at a secondary detector, such as a detector detecting scintillation resultant from proton absorbance. | ||||||
| 159 | TREATMENT ROOM FIDUCIAL MARKER / CANCER THERAPY APPARATUS AND METHOD OF USE THEREOF | US15391494 | 2016-12-27 | US20170106213A1 | 2017-04-20 | W. Davis Lee; Mark R. Amato; Nick Ruebel; Jillian Reno |
| The invention comprises a fiducial marker-fiducial detector based treatment room position determination/positioning system apparatus and method of use thereof. Generally, a set of fiducial marker detectors detect photons emitted from and/or reflected off of a set of fiducial markers positioned on one or more objects in a treatment room and resultant determined distances and/or calculated angles are used to determine relative positions of multiple objects or elements in the treatment room. Position of the mapped objects is used in: (1) imaging, such as X-ray, positron emission tomogram, and/or proton beam imaging and/or (2) beam targeting and treatment, such as proton based cancer treatment. As relative positions of objects in the treatment room are dynamically determined using the fiducial marking system, engineering and/or mathematical constraints of a treatment beamline isocenter are removed. | ||||||
| 160 | DETACHABLE / MOVABLE NOZZLE OF A CHARGED PARTICLE IMAGING/TREATMENT APPARATUS AND METHOD OF USE THEREOF | US15334206 | 2016-10-25 | US20170036041A1 | 2017-02-09 | Lauri Reichert; Stephen Sledge; Edward Ivanov; W. Davis Lee |
| The invention comprises a method and apparatus for directing charged particles into a patient from several directions. A delivery system is described that uses a primary beam line from an accelerator to a path switching magnet used to dynamically direct bunches of the positively charged particles down a selected pathway of a plurality of physically separated beam transport lines to a single patient treatment position, where the selected pathways enter the patient from two or more sides. Optionally, a repositionable treatment nozzle is repositioned to interface with each beam transport line, which allows the charged particle delivery system to use a single scanning capable nozzle in combination with delivery of the charged particles to the two or more sides of the patient to implement a tumor irradiation plan without a necessity of a moveable beamline in, at, or near a treatment room. | ||||||
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