| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Method for separation of chemically pure Os from metal mixtures | US14336767 | 2014-07-21 | US09528169B2 | 2016-12-27 | Hendrik P. Engelbrecht; Cathy S. Cutler; Leonard Manson; Stacy Lynn Wilder |
| A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided. | ||||||
| 2 | Adsorbents for radioisotopes, preparation method thereof, and radioisotope generators using the same | US13491221 | 2012-06-07 | US08758714B2 | 2014-06-24 | Jun Sig Lee; Hyon Soo Han; Ul Jae Park; Kwang Jae Son; Hyeon Young Shin; Soon Bog Hong; Kang Duk Jang; Jong Sub Lee |
| Disclosed is a novel adsorbent for use in a 99Mo/99mTc generator, which is a medical diagnostic radioisotope generator, and in a 188W/188Re generator, which is a therapeutic radioisotope generator. The adsorbent composed of sulfated alumina or alumina-sulfated zirconia exhibits adsorption capacity superior to that of conventional adsorbents, and is stable and is thus loaded in a dry state in an adsorption column so that the radioisotope 99Mo or 188W can be adsorbed. Thus, it is possible to miniaturize the column, and such a miniaturized column is small, convenient to use, and highly efficient, and extracts a radioisotope satisfying the requirements for pharmaceuticals, and thus can be useful for radioisotope generators extracting 99mTc or 188Re. | ||||||
| 3 | Adsorbents for Radioisotopes, Preparation Method Thereof, and Radioisotope Generators Using the Same | US13491221 | 2012-06-07 | US20120244055A1 | 2012-09-27 | Jun Sig LEE; Hyon Soo HAN; Ul Jae PARK; Kwang Jae SON; Hyeon Young SHIN; Soon Bog HONG; Kang Duk JANG; Jong Sub LEE |
| Disclosed is a novel adsorbent for use in a 99Mo/99mTc generator, which is a medical diagnostic radioisotope generator, and in a 188W/188Re generator, which is a therapeutic radioisotope generator. The adsorbent composed of sulfated alumina or alumina-sulfated zirconia exhibits adsorption capacity superior to that of conventional adsorbents, and is stable and is thus loaded in a dry state in an adsorption column so that the radioisotope 99Mo or 188W can be adsorbed. Thus, it is possible to miniaturize the column, and such a miniaturized column is small, convenient to use, and highly efficient, and extracts a radioisotope satisfying the requirements for pharmaceuticals, and thus can be useful for radioisotope generators extracting 99mTc or 188Re. | ||||||
| 4 | Generator for 188R | US10175515 | 2002-06-19 | US20030235530A1 | 2003-12-25 | Alan Cisar; Todd Adams |
| Radioisotope generators comprising inorganic layered hydroxide composition, such as magnesium aluminates and lithium aluminates. These inorganic layered hydroxides form anion exchange materials that exhibit surprisingly high selective affinities for certain radioisotopes. Inorganic layered hydroxides have been prepared and shown to have high affinity for tungstate anions, the anion form of tungsten-188, yet low affinity for perrhenate anions, the anion form of rhenium-188. | ||||||
| 5 | Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system | US692110 | 1991-04-26 | US5186913A | 1993-02-16 | Furn F. Knapp, Jr.; Edward C. Lisic; Saed Mirzadeh; Alvin P. Callahan |
| A generator system for providing a carrier-free radioisotope in the form of an acid comprises a chromatography column in tandem fluid connection with an ion exchange column, the chromatography column containing a charge of a radioactive parent isotope. The chromatography column, charged with a parent isotope, is eluted with an alkali metal salt solution to generate the radioisotope in the form of an intermediate solution, which is passed through the ion-exchange column to convert the radioisotope to a carrier-free acid form. | ||||||
| 6 | Process of producing rhenium for tungsten-rhenium alloys by the irradiation of tungsten | US41927264 | 1964-12-10 | US3324005A | 1967-06-06 | MILLER EDWARD F |
| 7 | Method for separation of chemically pure Os from metal mixtures | US15352304 | 2016-11-15 | US10087503B2 | 2018-10-02 | Hendrik P. Engelbrecht; Cathy S. Cutler; Leonard Manson; Stacy Lynn Wilder |
| A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided. | ||||||
| 8 | Adsorbents for Radioisotopes, Preparation Method Thereof, and Radioisotope Generators Using the Same | US12813661 | 2010-06-11 | US20100248955A1 | 2010-09-30 | Jun Sig LEE; Hyon Soo HAN; Ul Jae PARK; Kwang Jae SON; Hyeon Young SHIN; Soon Bog HONG; Kang Duk JANG; Jong Sub LEE |
| Disclosed is a novel adsorbent for use in a 99Mo/99mTc generator, which is a medical diagnostic radioisotope generator, and in a 188W/188Re generator, which is a therapeutic radioisotope generator. The adsorbent composed of sulfated alumina or alumina-sulfated zirconia exhibits adsorption capacity superior to that of conventional adsorbents, and is stable and is thus loaded in a dry state in an adsorption column so that the radioisotope 99Mo or 188W can be adsorbed. Thus, it is possible to miniaturize the column, and such a miniaturized column is small, convenient to use, and highly efficient, and extracts a radioisotope satisfying the requirements for pharmaceuticals, and thus can be useful for radioisotope generators extracting 99mTc or 188Re. | ||||||
| 9 | Adsorbents for Radioisotopes, Preparation Method Thereof, and Radioisotope Generators Using the Same | US12117353 | 2008-05-08 | US20090277828A1 | 2009-11-12 | Jun Sig LEE; Hyon Soo HAN; Ul Jae PARK; Kwang Jae SON; Hyeon Young SHIN; Soon Bog HONG; Kang Duk JANG; Jong Sub LEE |
| Disclosed is a novel adsorbent for use in a 99Mo/99mTc generator, which is a medical diagnostic radioisotope generator, and in a 188W/188Re generator, which is a therapeutic radioisotope generator. The adsorbent composed of sulfated alumina or alumina-sulfated zirconia exhibits adsorption capacity superior to that of conventional adsorbents, and is stable and is thus loaded in a dry state in an adsorption column so that the radioisotope 99Mo or 188W can be adsorbed. Thus, it is possible to miniaturize the column, and such a miniaturized column is small, convenient to use, and highly efficient, and extracts a radioisotope satisfying the requirements for pharmaceuticals, and thus can be useful for radioisotope generators extracting 99mTc or 188Re. | ||||||
| 10 | Generator for rhenium-188 | US10175515 | 2002-06-19 | US07329400B2 | 2008-02-12 | Alan Cisar; Todd Adams; Paul Sylvester |
| Radioisotope generators comprising inorganic layered hydroxide composition, such as magnesium aluminates and lithium aluminates. These inorganic layered hydroxides form anion exchange materials that exhibit surprisingly high selective affinities for certain radioisotopes. Inorganic layered hydroxides have been prepared and shown to have high affinity for tungstate anions, the anion form of tungsten-188, yet low affinity for perrhenate anions, the anion form of rhenium-188. | ||||||
| 11 | METHOD FOR SEPARATION OF CHEMICALLY PURE OS FROM METAL MIXTURES | US15352304 | 2016-11-15 | US20170058381A1 | 2017-03-02 | Hendrik P. Engelbrecht; Cathy S. Cutler; Leonard Manson; Stacy Lynn Wilder |
| A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided. | ||||||
| 12 | General radioisotope production method employing PET-style target systems | US13485885 | 2012-05-31 | US09269467B2 | 2016-02-23 | Nigel Raymond Stevenson |
| Methods for producing a radioisotope by a charged particle irradiation of a fluid target matrix are provided. A method of producing a radioisotope includes irradiating a fluid target matrix comprising a compound of a target isotope with a charged particle beam to transform at least a portion of the target isotope to the radioisotope, and isolating the radioisotope from the irradiated fluid target matrix. The target isotope may be an isotope of cadmium, an isotope of thallium, an isotope of zinc, an isotope of gallium, an isotope of tellurium, an isotope of molybdenum, an isotope of rhodium, an isotope of selenium, an isotope of nickel, an isotope of yttrium, an isotope of strontium, an isotope of bismuth, an isotope of tungsten, and an isotope of titanium, provided that the target isotope is not Mo-100. | ||||||
| 13 | METHOD FOR SEPARATION OF CHEMICALLY PURE OS FROM METAL MIXTURES | US14336767 | 2014-07-21 | US20140328736A1 | 2014-11-06 | Hendrik P. Engelbrecht; Cathy S. Cutler; Leonard Manson; Stacy Lynn Wilder |
| A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided. | ||||||
| 14 | METHOD OF PRE-TREATING AN ADSORBENT FOR A CHROMATOGRAPHIC SEPARATION | US13707824 | 2012-12-07 | US20130220928A1 | 2013-08-29 | Steve OELSNER |
| A method of treating an adsorbent for a chromatographic separation. The method involves sonicating particles of an inorganic metal oxide having fragile edges in the absence of any alkylating or acylating agent to form smoothened particles of the inorganic metal oxide and washing the smoothened particles of the inorganic metal oxide to remove fine particulate matter to produce a treated adsorbent. The treated adsorbent can be used in a method of isolating a daughter radioisotope from a daughter radioisotope that is produced from the parent radioisotope by radioactive decay. | ||||||
| 15 | General Radioisotope Production Method Employing PET-Style Target Systems | US13485885 | 2012-05-31 | US20120307953A1 | 2012-12-06 | Nigel Raymond Stevenson |
| Methods for producing a radioisotope by a charged particle irradiation of a fluid target matrix are provided. A method of producing a radioisotope includes irradiating a fluid target matrix comprising a compound of a target isotope with a charged particle beam to transform at least a portion of the target isotope to the radioisotope, and isolating the radioisotope from the irradiated fluid target matrix. The target isotope may be an isotope of cadmium, an isotope of thallium, an isotope of zinc, an isotope of gallium, an isotope of tellurium, an isotope of molybdenum, an isotope of rhodium, an isotope of selenium, an isotope of nickel, an isotope of yttrium, an isotope of strontium, an isotope of bismuth, an isotope of tungsten, and an isotope of titanium, provided that the target isotope is not Mo-100. | ||||||
| 16 | Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system | US898050 | 1992-06-12 | US5275802A | 1994-01-04 | Furn F. Knapp, Jr.; Edward C. Lisic; Saed Mirzadeh; Alvin P. Callahan |
| A generator system for providing a carrier-free radioisotope in the form of an acid comprises a chromatography column in tandem fluid connection with an ion exchange column, the chromatography column containing a charge of a radioactive parent isotope. The chromatography column, charged with a parent isotope, is eluted with an alkali metal salt solution to generate the radioisotope in the form of an intermediate solution, which is passed through the ion-exchange column to convert the radioisotope to a carrier-free acid form. | ||||||
| 17 | TUNGSTEN-188/CARRIER-FREE RHENIUM-188 PERRHENIC ACID GENERATOR SYSTEM | EP92912654.0 | 1992-04-23 | EP0606212A1 | 1994-07-20 | KNAPP, Furn, F., Jr.; LISIC, Edward, C.; MIRZADEH, Saed; CALLAHAN, Alvin, P. |
| Système de générateur servant à produire un radioisotope sans support sous forme d'un acide, ledit système comprenant une colonne de chromatographie (10) se trouvant en communication fluide tandem avec une colonne (22) échangeuse d'ions; la colonne de chromatographie (10) contenant une charge d'un isotope parent radioactif. La colonne de chromatographie (10) chargée avec un isotope parent est éluée avec une solution de sel de métal alcalin pour générer le radioisotope sous forme d'une solution intermédiaire, qui traverse la colonne (22) échangeuse d'ions pour transformer le radioisotope en une forme d'acide sans support. | ||||||
| 18 | RHENIUM GENERATOR SYSTEM AND METHOD FOR ITS PREPARATION AND USE | EP87907875.6 | 1987-10-30 | EP0288556B1 | 1992-05-13 | EHRHARDT, Gary, J.; VANDERHEYDEN, Jean-Luc, E.; SU, Fu-Min |
| A process for preparing a tungsten-188/rhenium-188 generator having a tungstate matrix containing W-188 produced by irradiating tungsten-186 in the tungstate compound. High activity, carrier-free rhenium-188 may be obtained by elution. Substrates for further purifying the rhenium-188 eluate are also described. | ||||||
| 19 | Radioisotope composite | JP27994696 | 1996-10-01 | JPH09211197A | 1997-08-15 | NATSUPU FUAAN EFU JIYUNIA; EDOWAADO SHII RISHITSUKU; SAEDO MAAZADEII; ARUBUIN PII KIYARAHAN |
| PROBLEM TO BE SOLVED: To provide a carrier-free radioisotope. SOLUTION: A producer consists of a chromatography column 10 communicating vertically with an ion exchange column 22 through a liquid. The chromatography column 10 houses the input of radioactive parent isotopes. The chromatography column 10 charged with the radioactive parent isotopes is eluted by an alkaline metal salt to produce radioactive parent isotope in the form of an intermediate solution, which is passed through the ion exchange column 22 to convert the isotopes into the form of a carrier-free acid. COPYRIGHT: (C)1997,JPO | ||||||
| 20 | JPH06507714A - | JP51192492 | 1992-04-23 | JPH06507714A | 1994-09-01 | |
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