| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | A33抗原以及JAM－IT的用途 | CN200380105090.0 | 2003-10-01 | CN1720336A | 2006-01-11 | 阿维·J·阿什克纳齐; 舍曼·方; 奥德丽·戈达德; 奥斯汀·L·格尼; 玛丽·A·内皮尔; 丹尼尔·塔马斯; 门诺·范洛克伦; 威廉·I·伍德 |
| 本发明涉及治疗和诊断疾病的组合物和方法，所述疾病的特征在于存在与炎性疾病和/或癌症相关的抗原。 | ||||||
| 2 | 烟曲霉Aspf4的线性抗原表位最小基序肽Aspf4136-141及其扩展短肽 | CN201610366592.8 | 2016-05-30 | CN105859849A | 2016-08-17 | 顾少华; 霍克克; 徐万祥; 石晶; 高岩; 季朝能; 谢毅 |
| 本发明属于生物检测技术领域，具体为烟曲霉Asp f 4的线性抗原表位最小基序肽及其扩展短肽。本发明的烟曲霉Asp f 4的线性抗原表位最小基序肽为Asp f 4136?141，最小基序肽的扩展短肽为Asp f 4133?141、Asp f 4134?142、Asp f 4135?143和Asp f 4136?144，其氨基酸序列如SEQ ID No. 1~SEQ ID No. 5所示。它们可作为抗原单独或组合用于特异检测烟曲霉感染患者血清。 | ||||||
| 3 | 烟曲霉Aspf4的线性抗原表位最小基序肽Aspf4219-226及其扩展短肽 | CN201610366591.3 | 2016-05-30 | CN105859848A | 2016-08-17 | 顾少华; 霍克克; 徐万祥; 高岩; 石晶; 季朝能; 谢毅 |
| 本发明属于生物检测技术领域，具体为烟曲霉Asp f 4的线性抗原表位最小基序肽及其扩展短肽。本发明的烟曲霉Asp f 4的线性抗原表位最小基序肽为Asp f 4219?226，最小基序肽的扩展短肽为Asp f 4218?226和Asp f 4219?227，其氨基酸序列如SEQ ID No.1~SEQ ID No.3所示。它们可作为抗原单独或组合用于特异检测烟曲霉感染患者血清。 | ||||||
| 4 | 烟曲霉Aspf4的线性抗原表位最小基序肽Aspf4130-134及其扩展短肽 | CN201610366594.7 | 2016-05-30 | CN105859850A | 2016-08-17 | 顾少华; 霍克克; 徐万祥; 高岩; 石晶; 季朝能; 谢毅 |
| 本发明属于生物检测技术领域，具体为烟曲霉Asp f 4的线性抗原表位最小基序肽及其扩展短肽。本发明的烟曲霉Asp f 4的线性抗原表位最小基序肽为Asp f 4130?134，最小基序肽的扩展短肽为Asp f 4126?134、Asp f 4127?135、Asp f 4128?136 、Asp f 4129?137和Asp f 4130?138，其氨基酸序列如SEQ ID No. 1~SEQ ID No. 6所示。它们可作为抗原单独或组合用于特异检测烟曲霉感染患者血清。 | ||||||
| 5 | 基于萘的抗凋亡蛋白抑制剂 | CN201080016840.7 | 2010-04-14 | CN102395268A | 2012-03-28 | 毛里西奥·佩莱基亚 |
| 本发明揭示使用阿朴棉子酚和其衍生物治疗炎症的方法。还描述一组具有结构A的化合物，或其医药学上可接受的盐、水合物、N-氧化物或溶剂化物，其中各R独立地为H、C(O)X、C(O)NHX、NH(CO)X、SO2NHX或NHSO2X，其中X是氢、烷基、取代的烷基、芳基、取代的芳基、烷基芳基、取代的烷基芳基、杂环基或取代的杂环基。组A的化合物可用于治疗各种疾病或病症，例如癌症。 | ||||||
| 6 | Naphthalene-based inhibitor of anti-apoptotic proteins | JP2012506187 | 2010-04-14 | JP2012524101A | 2012-10-11 | ペレッキア，マウリツィオ |
| 炎症を処置するためのアポゴシポールおよびその誘導体を使用する方法が開示される。 また、構造Ａを有する化合物の群が記載され、またはその薬学的に許容可能な塩、水化物、Ｎ−オキシド、または溶媒和物が提供される：ここで、各Ｒは、独立して、Ｈ、Ｃ（Ｏ）Ｘ、Ｃ（Ｏ）ＮＨＸ、ＮＨ（ＣＯ）Ｘ、ＳＯ
２ ＮＨＸ、またはＨＮＳＯ
２ Ｘであり、ここで、Ｘは、水素、アルキル、置換されたアルキル、アリール、置換されたアリール、アルキルアリール、置換されたアルキルアリール、ヘテロ環、または置換されたヘテロ環である。 化合物Ａの群は、癌などの様々な疾患または障害のために使用され得る。
【選択図】 図１Ａ |
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| 7 | Use of A33 antigens and JAM-IT | EP11179901.1 | 2003-10-01 | EP2434022A2 | 2012-03-28 | Ashkenzai, Avi, J.; Fong, Sherman; Goddard, Audrey; Gurney, Austin, L.; Napier, Mary, A.; Tumas, Daniel; Van Lookeren, Menno; Wood, William, I. |
The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
|
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| 8 | Poultry viral materials and methods related thereto | US12951352 | 2010-11-22 | US08679504B2 | 2014-03-25 | Holly S. Sellers; Mark Jackwood |
| The present invention provides materials and methods for researching poultry viruses, particularly for researching infectious bronchitis viruses in poultry. Also provided are materials and methods useful for reducing the economic impact that infectious bronchitis disease has on poultry production. In one aspect of the invention, there are provided nucleic acids, amino acids and related materials and compositions useful for combating infectious bronchitis virus in poultry. | ||||||
| 9 | Naphthalene-based inhibitors of anti-apoptotic proteins | US13238910 | 2011-09-21 | US08436207B2 | 2013-05-07 | Maurizio Pellecchia |
| Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer. | ||||||
| 10 | POULTRY VIRAL MATERIALS AND METHODS RELATED THERETO | US12951352 | 2010-11-22 | US20120039921A9 | 2012-02-16 | HOLLY S. SELLERS; MARK JACKWOOD |
| The present invention provides materials and methods for researching poultry viruses, particularly for researching infectious bronchitis viruses in poultry. Also provided are materials and methods useful for reducing the economic impact that infectious bronchitis disease has on poultry production. In one aspect of the invention, there are provided nucleic acids, amino acids and related materials and compositions useful for combating infectious bronchitis virus in poultry. | ||||||
| 11 | OPTICALLY PURE APOGOSSYPOL DERIVATIVE AS PAN-ACTIVE INHIBITOR OF ANTI-APOPTOTIC B-CELL LYMPHOMA/LEUKEMIA-2 (BCL-2) | US12960349 | 2010-12-03 | US20120004311A1 | 2012-01-05 | Maurizio Pellecchia |
| A compound of Formula I: or a pharmaceutically acceptable salt thereof is disclosed. In addition, pharmaceutical compositions thereof, methods for preparing and methods for using this compound or composition for treating a variety of diseases, including cancer and inflammation are also provided. | ||||||
| 12 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS | US12760380 | 2010-04-14 | US20100267781A1 | 2010-10-21 | Maurizio Pellechia |
| Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer. | ||||||
| 13 | Use of A33 antigens and jam-it | US11725063 | 2007-03-15 | US20090275738A1 | 2009-11-05 | Avi Ashkenazi; Sherman Fong; Audrey Goddard; Austin L. Gurney; Mary A. Napier; Daniel Tumas; Menno Van Lookeren; William I. Wood |
| The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer. | ||||||
| 14 | Use of A33 antigens JAM-it | US10633008 | 2003-07-31 | US20040120957A1 | 2004-06-24 | Avi Ashkenazi; Sherman Fong; Audrey Goddard; Austin L. Gurney; Mary A. Napier; Daniel Tumas; Menno Van Lookeren; William I. Wood |
| The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer. | ||||||
| 15 | POULTRY VIRAL MATERIALS AND METHODS RELATED THERETO | US12951352 | 2010-11-22 | US20110097353A1 | 2011-04-28 | HOLLY S. SELLERS; MARK JACKWOOD |
| The present invention provides materials and methods for researching poultry viruses, particularly for researching infectious bronchitis viruses in poultry. Also provided are materials and methods useful for reducing the economic impact that infectious bronchitis disease has on poultry production. In one aspect of the invention, there are provided nucleic acids, amino acids and related materials and compositions useful for combating infectious bronchitis virus in poultry. | ||||||
| 16 | Use of A33 antigens and jam-it | US11542578 | 2006-10-02 | US20070031405A1 | 2007-02-08 | Avi Ashkenazi; Sherman Fong; Audrey Goddard; Austin Gurney; Mary Napier; Daniel Tumas; William Wood |
| The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer. | ||||||
| 17 | Use of A33 antigens and JAM-IT | US10265542 | 2002-10-03 | US20030171568A1 | 2003-09-11 | Avi Ashkenazi; Sherman Fong; Audrey Goddard; Austin L. Gurney; Mary A. Napier; Daniel Tumas; William I. Wood |
| The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer. | ||||||
| 18 | A33 use of an antigen and jam-it | JP2005500358 | 2003-10-01 | JP5319051B2 | 2013-10-16 | アビ ジェイ． アシュケナジ，; シャーマン フォン，; オードリー ゴッダード，; オースティン エル． ガーニー，; マリー エー． ナピアー，; ダニエル トゥマス，; ロッケレン， メノ バン; ウィリアム アイ． ウッド， |
| The present invention relates to compositions and methods of treating and diagnosing disorders characterized by the presence of antigens associated with inflammatory diseases and/or cancer. | ||||||
| 19 | Use of a33 antigen and jam-it | JP2009201133 | 2009-08-31 | JP2010017187A | 2010-01-28 | ASHKENAZI AVI J; FONG SHERMAN; GODDARD AUDREY; GURNEY AUSTIN L; NAPIER MARY A; TUMAS DANIEL; VAN LOOKEREN MENNO; WOOD WILLIAM I |
| <P>PROBLEM TO BE SOLVED: To provide a composition and a method for the treatment and diagnosis of disorders characterized by the presence of an antigen associated with inflammatory diseases and/or cancers. <P>SOLUTION: Provided are a composition and a method for the treatment and diagnosis of disorders characterized by the presence of an antigen associated with inflammatory diseases and/or cancers. In one aspect, it relates to a composition and a method useful generally for the diagnosis and treatment of immune-relating diseases (including inflammatory diseases of mammals (including human)). It is based on the identification of compounds (polypeptides and antibodies) participating in the immune response of mammals. In another aspect, it relates to a method for the treatment of inflammatory disorder of mammals and contains a step to administer a mammal with therapeutically active amount of antagonist of native sequence STIgMA polypeptide, PRO301 polypeptide, PRO362 polypeptide or PRO245 polypeptide. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 20 | Use of a33 antigen and jam-it | JP2013032846 | 2013-02-22 | JP2013126418A | 2013-06-27 | ASHKENAZI AVI J; FONG SHERMAN; GODDARD AUDREY; GURNEY AUSTIN L; NAPIER MARY A; TUMAS DANIEL; VAN LOOKEREN MENNO; WOOD WILLIAM I |
| PROBLEM TO BE SOLVED: To provide compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.SOLUTION: The invention relates to compositions and methods for treating and diagnosing disorders characterized by the presence of antigens associated with inflammatory diseases and/or cancer. In one aspect, the invention generally concerns compositions and methods useful in the diagnosis and treatment of immune related diseases, including inflammatory diseases in mammals, including humans. The invention is based, in part, on the identification of compounds (including polypeptides and antibodies) which are involved in the immune response in mammals. In one aspect, the invention concerns a method of treating an inflammatory disorder in a mammal, comprising administering to the mammal a therapeutically effective amount of an antagonist of a native sequence STIgMA polypeptide, PRO301, PRO362 polypeptide, or PRO245 polypeptide. | ||||||
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