| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | MEASUREMENT DEVICE, METHOD, AND RECORDING MEDIUM | US13860034 | 2013-04-10 | US20130284930A1 | 2013-10-31 | Eiji KATO |
| According to the present invention, a measurement device includes an electromagnetic wave detector, a phase measurement unit and a deriving unit. The electromagnetic wave detector detects an electromagnetic wave having a frequency equal to or more than 0.02 THz and equal to or less than 12 THz having traveled inside an object to be measured, which is an aggregation of particles. The phase measurement unit measures a change in phase of the electromagnetic wave generated by the travel inside the object to be measured based on a detection result by the electromagnetic wave detector. The deriving unit derives hardness or porosity of the object to be measured based on a measurement result by the phase measurement unit. | ||||||
| 182 | Spatial positioning of spectrally labeled beads | US12620475 | 2009-11-17 | US08405828B2 | 2013-03-26 | Stephen Empedocles; Andrew Watson; Jian Jin |
| Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser. | ||||||
| 183 | Device for Determining Particle Sizes | US13509465 | 2010-11-11 | US20120224166A1 | 2012-09-06 | Martin Heine; Stefan Manz |
| Method for measuring particle size distributions, in particular for the optical measurement of wide particle size distributions of bulk materials such as cereals, cereal milling products, cereal products and the like, which is intended to enable the measurement of particle size distributions which vary by orders of magnitude. To address this problem, a sample of isolated particles is optically detected in an arrangement by means of at least two measurement methods, wherein preferably detection of the contours of the particles and laser diffraction take place at the same time. | ||||||
| 184 | METHOD FOR THE TOXICITY ASSESSMENTS OF NANO-MATERIALS | US13278716 | 2011-10-21 | US20120219985A1 | 2012-08-30 | Tae-Hyun Yoon; Song-Hee Lee; Dong-Wook Kwon; Jong-Hoon Park; Hyun-Ju Yoo; Hyun-Woo Nho |
| The present invention relates to a method for the toxicity assessment of nano-materials, and more specifically, it is relates to an objective, reproducible and accurate assessment method for the unbiased toxicity testings of nano-materials, which minimize artifacts of the conventional methods for the toxicity assessment of the nano-materials by considering the dose characteristics of the nano-material itself using Selective multi-Plane Illumination Microcopy (SPIM); and the response characteristics of the nano-material using the improved or novel cellular responses assessment methods for nano-materials (e.g., modified MTT assay using image cytometric analysis, normal-inverted exposure apparatus, and modified flow cytometry), and a system and an apparatus thereof. | ||||||
| 185 | Image recognition and analysis system and software | US11970313 | 2008-01-07 | US08254657B2 | 2012-08-28 | Michael J. Pollack; Branson J. Darnell; Steven J. Mandrachia; Gary Reichl; Richard A. DiDomizio |
| A method of analyzing bubbles, cells, cell viability, or other particles or agglomerates in a process liquid contained in a vessel is provided. Images of bubbles, cells or other particles in the liquid are obtained in-situ with a vision probe extending through a wall of the vessel. The images are analyzed with image recognition software. The software measures at lease one of bubble, cell or particle size, mean diameter, surface area, flow rate, flow pattern, population distribution, viability, agglomerates or clumping, color change, viscosity, Sauter mean, ratio of surface area of bubbles relative to volume of bubbles, gas hold-up ratio of gas volume to volume of liquid, or interfacial area. The software distinguishes valid or viable bubbles, cells or particles that should be included in an analysis from invalid or non-viable bubbles, cells or particles that should not be included. The software can be configured to provide an analysis of the valid bubbles, cells or particles that fall within pre-set size and shape or viability parameters. | ||||||
| 186 | Detection system and user interface for a flow cytometer system | US12770341 | 2010-04-29 | US08229684B2 | 2012-07-24 | Clement James Goebel; Collin A. Rich |
| The detection system of the first preferred embodiment includes a detector, having a wide dynamic range, that receives photonic inputs from an interrogation zone and produces an analog signal; and an analog-to-digital converter (ADC), having a high bit resolution, that is coupled to the detector and converts an analog signal to a digital signal. The digital signal includes an initial data set of the full dynamic range of the input signals from the flow cytometer sample. The method of extracting and analyzing data from a flow cytometer system of the first preferred embodiment preferably includes the steps of: collecting a full dynamic range of input signals from a flow cytometer sample; recognizing and annotating aggregate particle events; and storing an initial data set and an annotated data set of the full dynamic range of the input signals from the flow cytometer sample. | ||||||
| 187 | Measuring agglutination parameters | US12518895 | 2007-12-18 | US08217647B2 | 2012-07-10 | Wendy Uyen Dittmer; Peggy De Kievit; Jeroen Hans Nieuwenhuis; Menno Willem Jose Prins; Leonardus Josephus Van Ijzendoorn; Xander Jozef Antoine Janssen |
| A method and system for measuring agglutination in a target-induced agglutination assay with one or more magnetic particles is performed in a reaction chamber. After the magnetic particles, which are capable of binding to a target are provided in the assay, an agglutination process is performed resulting in agglutinated particles. Further an alternating current magnetic field (HAC) is applied to the assay. The method further includes measuring an effect of the HAC on the one or more magnetic particles unattached to any surface. The measured effect is indicative of one or more agglutination parameters. | ||||||
| 188 | METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS | US13323438 | 2011-12-12 | US20120147357A1 | 2012-06-14 | Stephen C. Wardlaw; Robert A. Levine; Niten V. Lalpuria |
| A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into a sample container having an analysis chamber adapted to quiescently hold the sample for analysis, and an amount of colorant that platelets absorb and which fluoresces upon exposure to one or more predetermined first wavelengths of light; 2) imaging at least a portion of the sample disposed in the analysis chamber, including producing image signals indicative of fluorescent emissions from the platelets illuminated by first wavelengths of light; 3) identifying the platelets using the image signals; and 4) enumerating individual platelets and clumped platelets within the sample using one or more of fluorescent emissions, area, shape, and granularity. | ||||||
| 189 | Measurement system for the multidimensional aerosol characterization | US12366963 | 2009-02-06 | US08181505B2 | 2012-05-22 | Michael Mertler; Bernd Sachweh; Markus Linsenbühler; Michael Schäfer; David Y. H. Pui; Heinz Fissan; Jing Wang; Weon Gyu Shin |
| A method is proposed for characterizing a totality of particles. The method can be used in particular for characterizing microparticular or nanoparticular aerosols. The method comprises the following steps: a) in a classification step, a class of the totality is selected, wherein the particles of the selected class have a prespecified mobility dm; b) in a counting step, a number N of the particles of the selected class is determined; c) in a charge determination step, a charge Q of the particles of the selected class is determined; and d) in an evaluation step, at least one morphological parameter is determined from the charge Q, the number N and the mobility dm, wherein the morphological parameter comprises at least one item of information about an agglomerate state of the particles. | ||||||
| 190 | POLARIZATION SWITCHING LIDAR DEVICE AND METHOD | US13238263 | 2011-09-21 | US20120026497A1 | 2012-02-02 | Savyasachee Liptarag Mathur; Yunhui Zheng; Edward Lee Leventhal |
| A polarization switching lidar device, arranged for remote detection and characterization of airborne aggregations of particulates, includes a pulsed laser, a mirror, a polarizing beam splitter, an actively controlled retarder arranged to be controllably alternated between a zero retardation state and a quarter-wave retardation state such that the transmitted portion of the exiting laser light beam is linearly polarized in a predetermined direction when the actively controlled retarder is in the zero retardation state, while being circularly polarized in a predetermined rotational sense when the actively controlled retarder is in the quarter-wave retardation state. A directable telescoping assembly is arranged to collect photons backscattered by the airborne aggregations of particulates and to redirect the collected portion of depolarized backscattered photons onto the polarizing beam splitter. A photodetector is arranged to generate at least one electronic signal proportional to the collected portion of depolarized backscattered photons. | ||||||
| 191 | Method and apparatus for detecting and counting platelets individually and in aggregate clumps | US13088853 | 2011-04-18 | US08077296B2 | 2011-12-13 | Stephen C. Wardlaw; Robert A. Levine; Niten V. Lalpuria |
| A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; 2) admixing a colorant with the sample, which colorant is operative to cause the platelets to fluoresce upon exposure to one or more predetermined first wavelengths of light; 3) illuminating at least a portion of the sample containing the platelets at the first wavelengths; 4) imaging the sample, including producing image signals indicative of fluorescent emissions from the platelets, which fluorescent emissions have an intensity; 5) identifying the platelets by their fluorescent emissions, using the image signals; 6) determining an average fluorescent emission intensity value for the individual platelets identified within the sample; 7) identifying clumps of platelets within the sample using one or more of their fluorescent emissions, area, shape, and granularity; and 8) enumerating platelets within each platelet clump using the average fluorescent emission intensity value determined for the individual platelets within the sample. | ||||||
| 192 | Polarization switching lidar device and method | US12693172 | 2010-01-25 | US08054464B2 | 2011-11-08 | Savyasachee Liptarag Mathur; Yunhui Zheng; Edward Lee Leventhal |
| A polarization switching lidar device is arranged for remote detection and characterization of airborne aggregations of particulates. It includes a pulsed laser, a mirror, a polarizing beam splitter, an actively controlled retarder arranged to be controllably alternated between a zero retardation state and a quarter-wave retardation state such that the transmitted portion of the exiting laser light beam is linearly polarized in a predetermined direction when the actively controlled retarder is in the zero retardation state, while being circularly polarized in a predetermined rotational sense when the actively controlled retarder is in the quarter-wave retardation state. A directable telescoping assembly is arranged to collect photons backscattered by the airborne aggregations of particulates and to redirect the collected portion of depolarized backscattered photons onto the polarizing beam splitter. A photodetector is arranged to generate at least one electronic signal proportional to the collected portion of depolarized backscattered photons. | ||||||
| 193 | Simultaneous detection apparatus of raman and light scattering | US12442109 | 2007-08-30 | US08018582B2 | 2011-09-13 | Dae-Hong Jeong; Yoon-Sik Lee; Myung-Haing Cho; Yong-Kweon Kim |
| Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies. | ||||||
| 194 | POLARIZATION SWITCHING LIDAR DEVICE AND METHOD | US12693172 | 2010-01-25 | US20110181881A1 | 2011-07-28 | Savyasachee Liptarag Mathur; Yunhui Zheng; Edward Lee Leventhal |
| A polarization switching lidar device is arranged for remote detection and characterization of airborne aggregations of particulates. It includes a pulsed laser, a mirror, a polarizing beam splitter, an actively controlled retarder arranged to be controllably alternated between a zero retardation state and a quarter-wave retardation state such that the transmitted portion of the exiting laser light beam is linearly polarized in a predetermined direction when the actively controlled retarder is in the zero retardation state, while being circularly polarized in a predetermined rotational sense when the actively controlled retarder is in the quarter-wave retardation state. A directable telescoping assembly is arranged to collect photons backscattered by the airborne aggregations of particulates and to redirect the collected portion of depolarized backscattered photons onto the polarizing beam splitter. A photodetector is arranged to generate at least one electronic signal proportional to the collected portion of depolarized backscattered photons. | ||||||
| 195 | PROGRAMMABLE ELECTROMAGNETIC ARRAY FOR MOLECULE TRANSPORT | US12900826 | 2010-10-08 | US20110065140A1 | 2011-03-17 | Xing SU; Kenneth Swartz; Liming Wang; David Eric Schwartz; Mineo Yamakawa |
| An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid. | ||||||
| 196 | Systems and methods for measuring fluid properties | US12214544 | 2008-06-18 | US07906338B2 | 2011-03-15 | Sivaprasad Sukavaneshvar; Johnny Rhodes; Ramachandran Thekkedath |
| A fluid property measurement system for measuring free stream particulates includes a fluid movement device positioned within a fluid container which is configured to cause fluid flow within the fluid container along a fluid flow path when a fluid is present. A constricted region along the fluid flow path generates a region of concentrated streamlined flow within the constricted region and mixing of the fluid outside of the constricted region. A property measuring device is positioned with respect to the constricted region to measure fluid properties in the region of streamlined flow. | ||||||
| 197 | Particle size variation monitoring in a fluid | US12641264 | 2009-12-17 | US07830509B1 | 2010-11-09 | Thomas F. Haddock; Mark A. Dugan; Ali Said; Philippe Bado |
| A method continuously monitors variations in the size of particles present in a fluid on a real time basis. The method includes passing one or more optical signal through the fluid such as engine oil. The variation (attenuation or enhancement) in the intensity of the optical signal is continuously measured with respect to time. In an embodiment, the method enables monitoring of the amount, size and onset of particle agglomeration using single or multiple wavelengths as interrogating optical signal(s). An exemplary embodiment is provided for monitoring of the amount, size and onset of soot particle agglomeration in engine oil using single or multiple wavelengths as interrogating optical signal(s). | ||||||
| 198 | Detection system and user interface for a flow cytometer system | US12770341 | 2010-04-29 | US20100271620A1 | 2010-10-28 | Clement James Goebel; Collin A. Rich |
| The detection system of the first preferred embodiment includes a detector, having a wide dynamic range, that receives photonic inputs from the interrogation zone and produces an analog signal; and an analog-to-digital converter (ADC), having a high bit resolution, that is coupled to the detector and converts an analog signal to a digital signal. The digital signal includes an initial data set of the full dynamic range of the input signals from the flow cytometer sample. The method of extracting and analyzing data from a flow cytometer system of the first preferred embodiment preferably includes the steps of: collecting a full dynamic range of input signals from a flow cytometer sample; recognizing and annotating aggregate particle events; and storing an initial data set and an annotated data set of the full dynamic range of the input signals from the flow cytometer sample. | ||||||
| 199 | BLOOD FLUIDITY MEASUREMENT SYSTEM AND BLOOD FLUIDITY MEASUREMENT METHOD | US12744638 | 2008-10-28 | US20100260391A1 | 2010-10-14 | Shuji Ichitani; Masaaki Takama; Takanori Murayama |
| Blood fluidity is measured in a short time. A blood fluidity measurement system, which measures blood fluidity by flowing blood into a channel, is equipped with a TV camera which photographs the blood stream in the channel and an image processing part which detects the state of the blood stream in the channel as blood fluidity from the image taken by the TV camera. | ||||||
| 200 | PORTABLE CONTAMINANT SAMPLING SYSTEM | US12683990 | 2010-01-07 | US20100180699A1 | 2010-07-22 | BRUCE J. BRADLEY; JARED BRADLEY |
| The invention is a portable sampling system for sampling various media for contaminants. The media sample can include gases, liquids, and dry powders. The contaminant sample can include gaseous components, particulates of various kinds, and microorganisms. The system can be used to sample the surfaces of fruits and vegetables, meat carcasses, the interior of envelopes of other containers, gases in rooms or containers, and surfaces such as countertops, a vehicle exterior, skin, and clothing. | ||||||
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