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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	METHOD OF DETECTION OF VOLATILE ORGANIC COMPOUNDS USING LIQUID CRYSTALS THAT FORM A BLUE PHASE; AND DEVICE FOR STABILIZATION AND THICKNESS CONTROL OF LIQUID CRYSTAL FILMS	US14971014	2015-12-16	US20160178588A1	2016-06-23	Nicholas L. Abbott; Marco Antonio Bedolla Pantoja; Xiaoguang Wang
Methods and compositions for detecting a targeted analyte, such as volatile organic compound (VOCs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. The phase transition can be readily detected with the naked eye. The disclosed methods and compositions may be used in, for example, dosimeters for detecting analyte (e.g., VOC) exposure. Methods and compositions for producing arrays of liquid crystal thin films are also disclosed. The surface between the microwells in a microwell array is coated with a liquid-crystal-phobic material, such as a fluorinated polymer or a fluorinated silane, creating isolated micowell domains that are preferentially wetted by liquid crystal. Liquid crystal can be added to the microwell domains by simple techniques such as spin coating.
2	Method of Detection of Volatile Organic Compounds Using Liquid Crystals that Form a Blue Phase; and Device for Stabilization and Thickness Control of Liquid Crystal Films	US15825290	2017-11-29	US20180080912A1	2018-03-22	Nicholas L. Abbott; Marco Antonio Bedolla Pantoja; Xiaoguang Wang
Methods and compositions for detecting a targeted analyte, such as volatile organic compound (VOCs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. The phase transition can be readily detected with the naked eye. The disclosed methods and compositions may be used in, for example, dosimeters for detecting analyte (e.g., VOC) exposure. Methods and compositions for producing arrays of liquid crystal thin films are also disclosed. The surface between the microwells in a microwell array is coated with a liquid-crystal-phobic material, such as a fluorinated polymer or a fluorinated silane, creating isolated microwell domains that are preferentially wetted by liquid crystal. Liquid crystal can be added to the microwell domains by simple techniques such as spin coating.
3	Analytic separation arrangement and method for the analysis of chemical samples	US990213	1992-12-14	US5290520A	1994-03-01	Francois Maystre; Alfredo E. Bruno
An analytic separation arrangement includes a system of tubes including a separation zone, preferably a separation column, which tubes upstream the separation zone are connected with reservoirs for a carrier and a chemical sample to be seperated and analyzed, and downstream the separation zone are connected with a waste container for the carrier containing the sample and also are connected with transporting means for the carrier and the sample. The tube system is associated with an optical detector for monitoring changes in the absorption, in the fluorescence or in the optical activity of the carrier when it is transported through the tube system and past the optical detector, which is arranged in the path of the carrier behind the separation zone but in front of the waste container. Between the separation zone and the optical detector there is arranged in the path of the carrier a refractive index equalizing unit. Prior to being transported past the optical detector the carrier, which is comming from the separation zone, is directed through the refractive index equalizing unit, where its refractive index is preferably constantly monitored and where upon detection of changes of the refractive index of the carrier the deviation is compensated by adding to the carrier a compensating agent.
4	Method and apparatus for detecting x-ray radiation using a cholesteric detector	US3657538D	1968-08-22	US3657538A	1972-04-18	FERGASON JAMES L; GOLDBERG NEWTON N
Increasing dosages of X-ray radiation progressively lower the color-play range of cholesteric-phase liquid-crystal materials. The effect is enhanced when an effective amount of an iodinecontaining compound is used in the liquid-crystal material. Novel iodine-containing compounds are described, and articles are disclosed that give direct-reading indication of the dosages of X-ray radiation that they have received, without need for a separate development operation.
5	Analyzing-separating apparatus and method for analyzing chemical sample	JP35581392	1992-12-18	JPH05249094A	1993-09-28	FURANSOWA MAISUTORE; ARUFUREEDO EMIRIO BURUUNO
PURPOSE: To eliminate harmful actions caused by a change of an index of refraction of a carrier during a separation, by adding a correction agent when the change is detected and correcting the change of the index of refraction of the carrier. CONSTITUTION: A chemical sample S is transferred together with a carrier E through a separation column 6 as a separation area. The carrier E and sample S separated through the column 6 are passed through an optical detector 15 which is always tracking the carrier E to a change of an absorption, a fluorescent or an optical activity. A refraction index uniformity unit 16 is set in front of the detector 15. When a refraction index detector 19 of the unit 16 detects a change of an index of refraction of the carrier E, a controller unit 20 adjusts the amount of a correction agent C added to the carrier E through a mixing chamber 17 arranged at the upstream of the detector 19 until the carrier E is returned to the original index of refraction. COPYRIGHT: (C)1993,JPO
6	Analytic separation arrangement and method for the analysis of chemical samples	EP91810991.9	1991-12-19	EP0547282A1	1993-06-23	Maystre,Francois,Dr.; Bruno,Alfredo Emilio,Dr.
An analytic separation arrangement (1) comprises a system of tubes (2 - 9) including a separation zone (6), preferably a separation column, which tubes upstream the separation zone (6) are connected with reservoirs (10, 11) for an carrier (E) and a chemical sample (S) to be seperated and analyzed, and downstream the separation zone (6) are connected with a waste container (12) for the carrier containing the sample (W) and also are connected with transporting means (13, 14)for the carrier and the sample. The tube system is associated with an optical detector (15) for monitoring changes in the absorption, in the fluorescence or in the optical activity of the carrier (E) when it is transported through the tube system and past the optical detector, which is arranged in the path of the carrier behind the separation zone (6) but in front of the waste container (12). Between the separation zone (6) and the optical detector (15) there is arranged in the path of the carrier (E) a refractive index equalizing unit (16). According to the invention prior to being transported past the optical detector (15) the carrier (E), which is comming from the separation zone (6), is directed through the refractive index equalizing unit (16), where its refractive index is preferably constantly monitored and where upon detection of changes of the refractive index of the carrier the deviation is compensated by adding to the carrier a compensating agent.
7	Analytic separation arrangement and method for the analysis of chemical samples	EP91810991.9	1991-12-19	EP0547282B1	1996-05-01	Maystre,Francois,Dr.; Bruno,Alfredo Emilio,Dr.

8	LIQUID CRYSTAL COMPOSITION, AND PH SENSING DEVICE USING THE SAME	US15644051	2017-07-07	US20180156764A1	2018-06-07	Chih-Hsin Chen; Wei-Long Chen; Tsung-Yang Ho
A liquid crystal composition includes a nematic liquid crystal, and a compound of Formula (I) where R is an alkyl, aryl, aralkyl or heteroaryl having 6 to 30 carbon atoms, wherein the compound accounts for 0.3 to 0.6% of the liquid crystal composition. Further, a sensing device includes a substrate, a frame, an alignment film, the liquid crystal composition as described above, and two polarizers. The frame is connected to the substrate and forms an accommodation space having an opening, and the alignment film and the liquid crystal composition are both located inside the accommodation space. One of the polarizers is arranged in correspondence with the opening such that a channel exists between the polarizer and the frame, the other polarizer is located at a lateral side of the substrate, and the polarization directions of the two polarizers intersect with each other.
9	Method of detection of volatile organic compounds using liquid crystals that form a blue phase; and device for stabilization and thickness control of liquid crystal films	US14971014	2015-12-16	US09863923B2	2018-01-09	Nicholas L. Abbott; Marco Antonio Bedolla Pantoja; Xiaoguang Wang
Methods and compositions for detecting a targeted analyte, such as volatile organic compound (VOCs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. The phase transition can be readily detected with the naked eye. The disclosed methods and compositions may be used in, for example, dosimeters for detecting analyte (e.g., VOC) exposure. Methods and compositions for producing arrays of liquid crystal thin films are also disclosed. The surface between the microwells in a microwell array is coated with a liquid-crystal-phobic material, such as a fluorinated polymer or a fluorinated silane, creating isolated microwell domains that are preferentially wetted by liquid crystal. Liquid crystal can be added to the microwell domains by simple techniques such as spin coating.
10	Liquid crystal device and method for screening protein stabilizing agents or optimal protein concentrations to prevent unfolding	US13778564	2013-02-27	US09372142B2	2016-06-21	Nicholas L. Abbott; Lie Na Tan
Methods and devices for assaying the effectiveness of a cleaning composition in removing a protein or a biofilm from a surface are disclosed. Such methods include the steps of providing one or more proteins at an interface between an aqueous phase and a liquid crystal phase or at the surface of a liquid crystal, contacting the interface or liquid crystal surface with a cleaning composition, and observing the orientational ordering of the liquid crystal at the interface or liquid crystal surface. A continuous change in the orientational ordering of the liquid crystal at the interface or liquid crystal surface indicates that the proteins are being removed from the interface, and the rate of change in orientational ordering, the extent of the change in orientational ordering, or both, are correlated with the effectiveness of the cleaning composition. Because the ability of cleaning agents to remove proteins from the interface or liquid crystal surface is correlated with the state and concentration of the protein that is being removed, similar methods and devices can be used to assay the effectiveness of a putative protein stabilizing agent or to assay the optimal concentration of a protein for preventing the unfolding of the protein.
11	LIQUID CRYSTAL DEVICE FOR SCREENING CLEANERS OF BIOFOULING OR FOR VALIDATING CLEANING PROCESSES	US13778564	2013-02-27	US20130224780A1	2013-08-29	Nicholas L. Abbott; Lie Na Tan
Methods and devices for assaying the effectiveness of a cleaning composition in removing a protein or a biofilm from a surface are disclosed. Such methods include the steps of providing one or more proteins at an interface between an aqueous phase and a liquid crystal phase or at the surface of a liquid crystal, contacting the interface or liquid crystal surface with a cleaning composition, and observing the orientational ordering of the liquid crystal at the interface or liquid crystal surface. A continuous change in the orientational ordering of the liquid crystal at the interface or liquid crystal surface indicates that the proteins are being removed from the interface, and the rate of change in orientational ordering, the extent of the change in orientational ordering, or both, are correlated with the effectiveness of the cleaning composition. Because the ability of cleaning agents to remove proteins from the interface or liquid crystal surface is correlated with the state and concentration of the protein that is being removed, similar methods and devices can be used to assay the effectiveness of a putative protein stabilizing agent or to assay the optimal concentration of a protein for preventing the unfolding of the protein.
12	Ferroelectric chiral smectic liquid crystal composition and liquid crystal element containing same	JP14799589	1989-06-09	JPH0312490A	1991-01-21	SHINJO KENJI; TERADA MASAHIRO; TOKANOU GOUJI; YAMASHITA MASATAKA; TAKIGUCHI TAKAO; ASAOKA MASANOBU
PURPOSE: To obtain the subject composition, containing plural compounds expressed by specific structural formulas and a liquid crystal compound with a negative dielectric anisotropy, having a high response speed and reduced temperature dependence thereof and useful as optical shutters, etc. CONSTITUTION: The objective composition, containing (A) at least one compound expressed by formula I (R ₁ is 1-18C alkyl which may have a substituent group; X ₁ is single bond, -O- or formula II; Z is single bond or formula II; formula III is formula IV or V; n is 1-12), (B) at least one compound expressed by formula VI (R ₂ and R ₃ are 1-18C alkyl which may have a substituent group, provided that at least either thereof is optically active group; X ₂ and X ₃ are single bond, -O-, formula II, etc.) and further (C) at least one liquid crystal compound having a negative dielectric anisotropy (▵ω) (preferably ▵ω<-2). COPYRIGHT: (C)1991,JPO&Japio
13	JPS505068B1 -	JP6508169	1969-08-19	JPS505068B1	1975-02-27

14	METHOD OF DETECTION OF VOLATILE ORGANIC COMPOUNDS USING LIQUID CRYSTALS THAT FORM A BLUE PHASE: AND DEVICE FOR STABILIZATION AND THICKNESS CONTROL OF LIQUID CRYSTAL FILMS	PCT/US2015065992	2015-12-16	WO2016100446A3	2016-08-11	ABBOTT NICHOLAS L; BEDOLLA PANTOJA MARCO ANTONIO; WANG XIAOGUANG
Methods and compositions for detecting a targeted analyte, such as volatile organic compound (VOCs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. The phase transition can be readily detected with the naked eye. The disclosed methods and compositions may be used in, for example, dosimeters for detecting analyte (e.g., VOC) exposure. Methods and compositions for producing arrays of liquid crystal thin films are also disclosed. The surface between the microwells in a microwell array is coated with a liquid- crystal-phobic material, such as a fluorinated polymer or a fluorinated silane, creating isolated micowell domains that are preferentially wetted by liquid crystal. Liquid crystal can be added to the microwell domains by simple techniques such as spin coating.

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