子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 221 | COPOLYMERS HAVING POLYISOBUTYLENE AND BIODEGRADABLE POLYMER SEGMENTS | US12650234 | 2009-12-30 | US20100166820A1 | 2010-07-01 | Mark Boden; Marlene C. Schwarz; Frederick H. Strickler; Rudolf Faust; Umaprasana Ojha; Tomoya Higashihara |
| The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages. | ||||||
| 222 | Thermoplastic and polymer foams and method of preparation thereof | US11131565 | 2005-05-18 | US07638560B2 | 2009-12-29 | Ramani Narayan; Yogaraj Nabar |
| A foamed starch-polyester graft copolymer and chemically modified starch-polyester graft copolymer composition comprising a chemically modified starch or chemically modified starch-nanoclay product is described. The composition can be produced continuously in a twin-screw co-rotating extruder in the presence of a blowing agent. The foams are biodegradable. | ||||||
| 223 | Starch-polyester biodegradable graft copolyers and a method of preparation thereof | US10993186 | 2004-11-19 | US07629405B2 | 2009-12-08 | Ramani Narayan; Sunder Balakrishnan; Yogaraj Nabar; Jean-Marie Raquez; Philippe Dubois |
| A starch-polyester graft copolymer and chemically modified starch-polyester graft copolymer composition comprising a chemically modified starch or chemically modified starch-nanoclay product is described. The composition can be produced continuously in a twin-screw co-rotating extruder. The starch-polyester graft copolymer can be solvent cast, melt cast and blown into clear transparent film particularly for use in single use disposable applications and can be biodegradable. | ||||||
| 224 | Bioabsorbable Surgical Composition | US12409642 | 2009-03-24 | US20090266467A1 | 2009-10-29 | Joshua B. Stopek; Ahmad Robert Hadba |
| Bioabsorbable macromer compositions are provided including a polymeric component possessing a lipid segment which enhances the affinity of the macromer composition to targeted tissue. In some embodiments, the polymeric component can be combined with a second component. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses. | ||||||
| 225 | One-pot, one-step in situ living polymerization from silicate anchored multifunctional initiator | US11665157 | 2005-11-09 | US20090030174A1 | 2009-01-29 | Dotsevi Y Sogah; Jianbo Di |
| Silicate anchored multifunctional initiator has moiety initiating ring opening living polymerization of lactone or ethylene oxide or cyclic siloxane monomer and other moiety for initiating living free radical polymerization of ethylenically unsaturated monomer. The monomers are reacted with the initiator in a one-pot, one-step reaction to cause living polymerization of both monomers and exfoliation of silicate layers to provide dispersed block copolymer silicate nanocomposite, with the junction of the two blocks being anchored to silicate layer and each block dangling therefrom. | ||||||
| 226 | POLYMERIC TISSUE SEALANT | US12102157 | 2008-04-14 | US20080253987A1 | 2008-10-16 | Annemie Rehor; Simona Cerritelli |
| Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein: i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is greater than or equal to 2 ii) the second precursor molecule is of the general formula: A-[(C3H6O)n—(C2H4O)m—B]i wherein m and n are integers from 1 to 200 i is greater than 2 A is a branch point B is a conjugated unsaturated group The precursors are selected based on the desired properties of the biomaterial. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to reduce, inhibit, or contain loss of a biological fluid or gas in a patient. | ||||||
| 227 | NOVEL SUSTAINED RELEASE POLYMER | US11469392 | 2006-08-31 | US20080194663A1 | 2008-08-14 | Richard L. Dunn |
| A polymer and a method for its preparation are provided. The polymer comprises poly(lactide), poly(lactide/glycolide) or poly(lactic acid/glycolic acid) segments bonded by ester linkages to both ends of an alkanediol core unit. The polymer is for use in a controlled release formulation for a medicament, preferably leuprolide acetate. The controlled release formulation is administered to a patient as a subcutaneous depot of a flowable composition comprising the polymer, a biocompatible solvent, and the medicament. Controlled release formulations comprising the polymer release leuprolide for treatment of prostate cancer patients over periods of 3-6 months. | ||||||
| 228 | Aliphatic copolyester resin, a preparation method, an aliphatic polyester resin composition, uses thereof, a coating composition, a particle-state composition for agriculture and gardening coated by degradable layer | US10992524 | 2004-11-18 | US07371444B2 | 2008-05-13 | Yasuteru Kajikawa |
| In the present invention, there are obtained aliphatic polyesters having a controlled thermal decomposing property, hydrolizability, and biodegradability, in which OH terminals and COOR terminals are decreased to 50% and 30%, respectively, through a ring-opening polymerization of a lactone and lactide by a mono alcohol having a high boiling point or a metal alkoxide, or by further decreasing both terminals through combining produced polymer terminals with a diisocyanate and, from a composition containing the polyesters, there is obtained a particle-state composition for agriculture and gardening in which a duration period of a fertilizing effect can be controlled, and which is not remained in soil by decomposition. From a resin primarily containing fatty acid cellulose ester derivatives, there are obtained a base film for a marking film which does not include a problem such as volatilization and migration of a plasticizer and a picture image formable heat-sensitve transfer recording material which is excellent in strippability, coloring concentration, and brightness, a conductive coating composition which is excellent in storage stability, adhesion, and conductivity, and single-liquid type coating an a moisture-curable graft copolymer, and a coating composition which have a non toxicity and nonirritating property and which are excellent in dryability. A copolymer in which average chain length in lactone and lactide units are controlled is excellent in heat resistance and impact resistance. | ||||||
| 229 | Polymer additives for powder coatings | US10737283 | 2003-12-16 | US07361715B2 | 2008-04-22 | William H. Retsch, Jr.; Michael J. Ziegler; Jackie L. Kulfan; Ronald R. Ambrose; Christopher P. Kurtz |
| Star polymers prepared by reacting a highly branched polymer and either a lactone or lactam are disclosed. These star polymers find particular application as additives for powder coating compositions, to improve various performance properties thereof. Powder coating composition comprising the described star polymers are also disclosed. | ||||||
| 230 | Multiblock biodegradable hydrogels for drug delivery and tissue treatment | US11158565 | 2005-06-22 | US07250177B2 | 2007-07-31 | Chandrashekhar P. Pathak; Shikha P. Barman; C. Michael Philbrook; Amarpreet S. Sawhney; Arthur J. Coury; Luis Z. Avila; Mark T. Kieras |
| Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating. | ||||||
| 231 | Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug | US10483826 | 2002-07-13 | US07226616B2 | 2007-06-05 | Min-Hyo Seo; In-Ja Choi; Young-Hoon Cho |
| The present invention provides a cationic group-containing amphiphilic block copolymer that is biocompatible and biodegradable, and when used as a drug carrier for an anionic drug, provides several advantages, such as increased blood concentration and improved stability of the drug. | ||||||
| 232 | Starch-polyester biodegradable graft copolyers and a method of preparation thereof | US10993186 | 2004-11-19 | US20060111511A1 | 2006-05-25 | Ramani Narayan; Sunder Balakrishnan; Yogaraj Nabar; Jean-Marie Raquez; Philippe Dubois |
| A starch-polyester graft copolymer and chemically modified starch-polyester graft copolymer composition comprising a chemically modified starch or chemically modified starch-nanoclay product is described. The composition can be produced continuously in a twin-screw co-rotating extruder. The starch-polyester graft copolymer can be solvent cast, melt cast and blown into clear transparent film particularly for use in single use disposable applications and can be biodegradable. | ||||||
| 233 | Process for the preparation of a block copolymer | US10522168 | 2003-07-14 | US20060100390A1 | 2006-05-11 | Andreas Heise; Ann Palmans; Paul Thomassen |
| The invention relates to a process for the preparation of a block copolymer, the process being carried out in the presence of a multifunctional initiator and comprising at least one enzymatically catalyzed homo- or copolymerization reaction and at least one non-enzymatically catalyzed controlled homo- or copolymerization reaction, wherein the non-enzymatically catalyzed controlled homo- or copolymerization reaction is chosen from the group comprising a free radical polymerization reaction, an ionic polymerization reaction, a polycondensation reaction, and a ring opening polymerization (ROP) reaction. The invention also relates to a chiral block copolymer wherein at least one block comprises at least one substituted ε-caprolactone derivative. | ||||||
| 234 | Transparent, electrically conductive, coated polyester film, process for its production, and its use | US11083767 | 2005-03-18 | US20050214526A1 | 2005-09-29 | Dagmar Klein; Holger Kliesch; Thorsten Kiehne; Bodo Kuhmann; Franz Hora; Gottfried Hilkert; Manfred Wiederhold |
| The invention relates to a transparent, electrically conductive, biaxially oriented, single- or multilayer polyester film which includes a coating composed of (a) conductive (ITO) indium tin oxide particles or (ATO) antimony tin oxide particles, or of a mixture of these. The film further include other conductive components (b). The other conductive components (b) may be present either in the coating including ITO particles and/or ATO particles or in a layer in contact therewith. The conductive component (b) may also be a metal layer in contact with the ITO and/or ATO. The film is only oriented or relaxed prior to application of the ITO and/or ATO coating. The invention further relates to a process for the production of the film, and its use. | ||||||
| 235 | Multiblock biodegradable hydrogels for drug delivery and tissue treatment | US10650163 | 2003-08-27 | US06923986B2 | 2005-08-02 | Chandrashekhar P. Pathak; Shikha P. Barman; C. Michael Philbrook; Amarpreet S. Sawhney; Arthur J. Coury; Luis Z. Avila; Mark T. Kieras |
| Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating. | ||||||
| 236 | Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers | US10727083 | 2003-12-02 | US20050119404A1 | 2005-06-02 | Laibin Luo; David Lessard; Sandra Gori; Maxime Ranger; Yuan Wang; Julie Lafreniere; Jean-Francois Meunier; Genevieve Bibeau; Frederic Lebrun; Lu Liu |
| The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery. | ||||||
| 237 | Compound and coating compositions for adhesion to olefinic substrates | US09907207 | 2001-07-17 | US06841619B2 | 2005-01-11 | John D. McGee; Daniel Blickberndt; Craig Schang; Walter H. Ohrbom; Keri Krueger |
| The present invention provides an olefin-based block copolymer that has an olefin block that is substantially saturated and at least one (poly)ester or (poly)ether block. The olefin-based block copolymer of the invention can be prepared by reacting a liquid hydroxyl-functional, saturated or substantially saturated olefin polymer with a chain-extension reagent that is reactive with hydroxyl groups and will polymerize in a head-to-tail arrangement of monomer units. The olefin-based block copolymer of the invention can be used to prepare an adhesion promoter that provides excellent adhesion of subsequent coating layers to olefinic substrates like TPO and superior properties as compared to previously used adhesion promoters containing chlorinated polyolefins. Alternatively, the olefin-based copolymers of the invention can be used as an additive in a curable coating composition to provide excellent adhesion to olefinic substrates like TPO, even when used in very minor amounts compared to the amounts required for previously known agents. | ||||||
| 238 | Biodegradable copolymers linked to segment with a plurality of functional groups | US10101408 | 2002-03-20 | US06830747B2 | 2004-12-14 | Meidong Lang; Chih-Chang Chu |
| Biocompatible biodegradable polymer or copolymer is capped at one end and has free hydroxyl at the other end. The free hydroxyl can be reacted to link a plurality of functional groups some or each of which can be reacted to attach directly or via a spacer molecule a moiety containing an aminoxyl-containing radical or to a moiety comprising other drug molecule residue or a moiety comprising other biologically active agent residue. | ||||||
| 239 | Aliphatic copolyester resin, a preparation method, an aliphatic polyester resin composition, uses thereof, a coating composition, a particle-state composition for agriculture and gardening coated by degradable layer | US10261422 | 2002-09-30 | US20030187181A1 | 2003-10-02 | Masanori Sakane; Masaaki Ito |
| In the present invention, there are obtained aliphatic polyesters having a controlled thermal decomposing property, hydrolizability, and biodegradability, in which OH terminals and COOH terminals are decreased to 50% and 30%, respectively, through a ring-opening polymerization of a lactone and lactide by a mono alcohol having a high boiling point or a metal alkoxide, or by further decreasing both terminals through combining produced polymer terminals with a diisocyanate and, from a composition containing the polyesters, there is obtained a particle-state composition for agriculture and gardening in which a duration period of a fertilizing effect can be controlled, and which is not remained in soil by decomposition. From a resin primarily containing fatty acid cellulose ester derivatives, there are obtained a base film for a marking film which does not include a problem such as volatilization and migration of a plasticizer and a picture image formable heat-sensitive transfer recording material which is excellent in strippability, coloring concentration, and brightness, a conductive coating composition which is excellent in storage stability, adhesion, and conductivity, a single-liquid type coating and a moisture-curable graft copolymer, and a coating composition which have a non toxicity and nonirritating property and which are excellent in dryability. A copolymer in which average chain length in lactone and lactide units are controlled is excellent in heat resistance and impact resistance. | ||||||
| 240 | ALIPHATIC COPOLYMER, PRODUCTION PROCESS, ALIPHATIC POLYESTER RESIN COMPOSITION, VARIOUS USES, COATING COMPOSITION, AND AGRICULTURAL OR HORTICULTURAL PARTICULATE COMPOSITION COMPRISING DEGRADABLE COATING FILM | US09600242 | 2000-09-14 | US06509440B1 | 2003-01-21 | Masanori Sakane; Michiyo Nakai; Kunio Shimizu; Yasuteru Kajikawa; Masaaki Ito |
| In the present invention, there are obtained aliphatic polyesters having a controlled thermal decomposing property, hydrolizability, and biodegradability, in which OH terminals and COOH terminals are decreased to 50% and 30%, respectively, through a ring-opening polymerization of a lactone and lactide by a mono alcohol having a high boiling point or a metal alkoxide, or by further decreasing both terminals through combining produced polymer terminals with a diisocyanate and, from a composition containing the polyesters, there is obtained a particle-state composition for agriculture and gardening in which a duration period of a fertilizing effect can be controlled, and which is not remained in soil by decomposition. From a resin primarily containing fatty acid cellulose ester derivatives, there are obtained a base film for a marking film which does not include a problem such as volatilization and migration of a plasticizer and a picture image formable heat-sensitive transfer recording material which is excellent in strippability, coloring concentration, and brightness, a conductive coating composition which is excellent in storage stability, adhesion, and conductivity, a single-liquid type coating and a moisture-curable graft copolymer, and a coating composition which have a non toxicity and nonirritating property and which are excellent in dryability. A copolymer in which average chain length in lactone and lactide units are controlled is excellent in heat resistance and impact resistance. | ||||||
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