子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | PROTEIN-POLYMER-DRUG CONJUGATES | US14834159 | 2015-08-24 | US20160067353A1 | 2016-03-10 | Aleksandr Yurkovetskiy; Mao Yin; Timothy B. Lowinger; Joshua D. Thomas; Charles E. Hammond; Cheri A. Stevenson; Natalya D. Bodyak; Patrick R. Conlon; Dmitry R. Gumerov |
| A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. | ||||||
| 82 | PROTEIN-POLYMER-DRUG CONJUGATES | US14457961 | 2014-08-12 | US20150044160A1 | 2015-02-12 | Aleksandr Yurkovetskiy; Mao Yin; Timothy B. Lowinger; Joshua D. Thomas; Charles E. Hammond; Cheri A. Stevenson; Natalya D. Bodyak; Patrick R. Conlon; Dmitry R. Gumerov |
| A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. | ||||||
| 83 | Low emission polyoxymethylene | US13832502 | 2013-03-15 | US08816015B2 | 2014-08-26 | Rong Luo; Xinyu Zhao; Robert Gronner; Nicolai Papke |
| Low VOC emission polyoxymethylene and compositions and products that incorporate the polyoxymethylene are described. The polyoxymethylene is end capped with compound that can prevent degradation of the polymer and subsequent emission of VOC degradation products such as formaldehyde. The end-capped polyoxymethylene can include an inorganic linkage within the polymer backbone that is the reaction product of a terminal hydroxyl group of the polyoxymethylene and a hydrolyzable group of the compound. Also disclosed are products as may be formed from the low VOC emission polyoxymethylene. | ||||||
| 84 | Processes for preparing diacids, dialdehydes and polymers | US13950401 | 2013-07-25 | US08785667B2 | 2014-07-22 | Vladimir Grushin; Leo Ernest Manzer; Walter Partenheimer |
| Alcohols are catalytically oxidized to aldehydes, in particular to benzaldehyde and diformylfuran, which are useful as intermediates for a multiplicity of purposes. The invention also relates to the polymerization of the dialdehyde and to the decarbonylation of the dialdehyde to furan. | ||||||
| 85 | Photo-Responsive Microencapsulation Materials, Compositions and Methods of Use Thereof | US13590857 | 2012-08-21 | US20130137625A1 | 2013-05-30 | Michael H.B. Stowell |
| Photoactivatable prepolymers and methods of use thereof are disclosed for microencapsulation of a substantially water-insoluble material within a nonporous shell. As provided herein, the microencapsulated material is released with no more than a slow release rate. Upon exposure of the nonporous shell to light, the nonporous shell is converted into a porous shell having an increased release rate for the microencapsulated material. | ||||||
| 86 | OXIDATION OF 5-(HYDROXYMETHYL) FURFURAL TO 2,5 DIFORMYLFURAN AND SUBSEQUENT DECARBONYLATION TO UNSUBSTITUTED FURAN | US13102436 | 2011-05-06 | US20110213112A1 | 2011-09-01 | Vladimir Grushin; WALTER PARTENHEIMER; LEO E. MANZER |
| Alcohols are catalytically oxidized to aldehydes, in particular to benzaldehyde and diformylfuran, which are useful as intermediates for a multiplicity of purposes. The invention also relates to the polymerization of the dialdehyde and to the decarbonylation of the dialdehyde to furan. | ||||||
| 87 | Manufacture of polyketones | US09913044 | 2001-08-08 | US06538098B1 | 2003-03-25 | Marc Bruce Goldfinger |
| Polyketones are manufactured by reacting an aromatic carboxylic acid with a biractive aromatic compound, using as a catalyst a combination of a carboxylic acid anhydride and phosphoric acid, or equivalent thereof. The product polymers are useful as molding resins. | ||||||
| 88 | Acrolein-releasing copolymers | US804698 | 1997-02-21 | US6060571A | 2000-05-09 | Peter Werle; Hans-Peter Krimmer; Martin Trageser; Franz-Rudolf Kunz |
| Acrolein polymer from acrolein and one or more polyhydric alcohols, characterized by release of monomeric acrolein in aqueous systems and hence by a prolonged effect on microorganisms, is prepared by adding acrolein to a reaction medium containing catalyst in dissolved form, and not allowing the temperature of the reaction medium to rise about 50.degree. C. The acrolein polymer may be used in aqueous systems as a biocide. | ||||||
| 89 | Process for producing branched or crosslinked polyacetal resin | US115625 | 1998-07-14 | US5929195A | 1999-07-27 | Kuniaki Kawaguchi; Kaoru Yamamoto; Hajime Serizawa |
| A branched or crosslinked polyacetal resin is excellent in blow moldability, has impact resistances such as plane impact resistance, and the smoothness of the inner surfaces of moldings produced therefrom, and is suitable for molding, particularly blow molding. It can be produced by the bulk polymerization of (A) trioxane with (B) a cyclic ether and/or cyclic formal and (C) a polyfunctional glycidyl ether compound in the presence of (D) a cationic polymerization catalyst, a mixture prepared by mixing the cyclic ether and/or cyclic formal (B) with the polyfunctional glycidyl ether compound (C) and the cationic polymerization catalyst (D) is added to trioxane (A) to conduct the polymerization. | ||||||
| 90 | Aldehyde resins with reduced and stabilized free-formaldehyde content | US213288 | 1994-03-15 | US5627261A | 1997-05-06 | Norman G. Albrecht; Michael T. Foran |
| A ketone/formaldehyde crosslinking additive having reduced and stabilized free-formaldehyde content and which are useful in starch based alkaline corrugating adhesive compositions are provided by a process wherein the ketone/aldehyde additives are treated with hydrogen peroxide and further with an urea compound. | ||||||
| 91 | Novel initiators for cationic polymerization | US478939 | 1990-02-12 | US5084586A | 1992-01-28 | Omar Farooq |
| Disclosed are novel compounds which are useful as initiators for cationically polymerizable monomers. The novel compounds comprise a carbon containing cation (e.g., trimethyloxonium) which is capable of initiating cationic polymerization and a non-nucleophilic counterion which is an at least partially fluorinated hydrocarbylsulfonato metallate (e.g. perfluoroethylsulfonato-aluminate). The disclosed initiators are capable of initiating the cationic polymerization of a wide variety of monomers such as epoxides, tetrahydrofuans, oxazolines, vinyls, lactones, and the like. | ||||||
| 92 | Process for the preparaton of low molecular weight polyhydroxyl compounds | US934650 | 1978-08-17 | US4326086A | 1982-04-20 | Edgar Mohring; Hanns P. Muller; Kuno Wagner |
| This invention relates to an improved process for the preparation of formose by the condensation of aqueous formaldehyde. In the process according to this invention, tertiary amines which contain an electrophilic hetero atom in the .beta.-position to the tertiary nitrogen atom are used for controlling the pH instead of the inorganic bases which have previously been used for this purpose. | ||||||
| 93 | Polyglutaraldehyde microspheres | US21988 | 1979-03-19 | US4267235A | 1981-05-12 | Alan Rembaum; Shlomo Margel |
| Suspension polymerization of aqueous glutaraldehyde in basic conditions in presence of surfactants such as isobutoxy acrylamide copolymers and/or cross-linking agents yield cross-linked, water insoluble glutaraldehyde polymer microspheres ranging in size from 200 A to 10.mu.. Addition of fluorochromes, e.g., FITC, during polymerization yields microspheres of high fluorescent intensity and addition of a suspension of metal containing particles such as Fe.sub.3 O.sub.4 during polymerization yields magnetic microspheres. Immunopolyglutaraldehyde microspheres can be obtained by interacting the polyglutaraldehyde microspheres with antibodies. The immunomicrospheres were used to label and separate cell subpopulations. The labeling specificity is considerably improved by increasing the amount of isobutoxy polyacrylamide incorporated in the microspheres. | ||||||
| 94 | Process for the preparation of low molecular weight polyhydroxyl compounds | US829167 | 1977-08-30 | US4247653A | 1981-01-27 | Kuno Wagner |
| A process is disclosed for preparing mixtures of low molecular weight polyhydroxyl compounds and hydroxyaldehydes and hydroxyketones by condensing formaldehyde hydrate with itself in the presence of (I) as catalyst a soluble or insoluble compound of a metal of the first to eighth sub-group or second to fourth main group of the Periodic System of Elements, optionally bound to a high molecular weight carrier, and (II) more than 10% by weight, based on formaldehyde, of one or more dihydric or higher hydric low molecular weight alcohols and/or higher molecular weight polyhydroxyl compounds. The pH of the reaction mixture is held at 5.5 to 9.0 until 5-40% conversion has occurred and is then lowered to between 4.5 and 8.0 (0.5-2.0 pH units lower). The reaction is then stopped by inactivating the catalyst. | ||||||
| 95 | Rapid curing resin compositions employing aminoplast condensation polymer modified with a di-substituted bis-aryl amine | US40840973 | 1973-10-23 | US3896081A | 1975-07-22 | BAXTER GENE F; FREEMAN HARLAN G; TIEDEMAN GEORGE T |
| Described herein are resin products having particular utility as rapid curing adhesives for wood and other materials, and processes for making the resin compositions. The products are made by reacting aldehude condensation polymer containing reactive alkylol groups, such as a phenol-formaldehyde condensation polymer, with di-substitued bis-aryl amine having the formula:
WHERE R and R'' are alkoxy, amino, hydrogen, hydroxyl, nitro, carboxyl or C1 to C4 alkyl AND X is to obtain an amine-modified polymer. When the resulting reaction product is blended with an appropriate curing agent, such as an aldehyde, the compositions cure very rapidly at ambient temperature. When pieces of wood or other materials are spread with the preferred adhesives employing the resin compositions of this invention and brought into contact with another wood surface the bond strength develops within minutes. The durability, strength and flexibility of the adhesives of this invention under adverse weathering conditions are excellent. |
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| 96 | Rapid curing resin compositions comprising a phenol-aldehyde condensation polymer modified with an acyl hydrazide | US3755258D | 1971-05-25 | US3755258A | 1973-08-28 | TIEDEMAN G |
| Described herein are resin products having particular utility as rapid curing adhesives for wood and other materials, and processes fo making the resin compositions. These products are made by reacting an aldehyde condensation polymer containing reactive alkylol groups, such as a phenol-formaldehyde condensation polymer, with an acyl hydrazide. When the resulting acyl hydrazide-modified polymers are blended with an appropriate curing agent, such as an aldehyde, the compositions cure very rapidly at ambient temperatures. When pieces of wood or other materials are spread with the preferred resin compositions of this invention and brought into contact with another wood surface the bond strength develops within minutes. The durability, strength and flexibility of the adhesives of this invention under adverse weathering conditions are excellent.
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| 97 | Novel resinous polyquinoxaline polymers and process for preparing the same | US3509097D | 1966-12-28 | US3509097A | 1970-04-28 | HOYT JOHN M; KOCH KARL |
| 98 | Polymerization of aldehydes in the presence of anhydrous polar solvents and alkali metal alkoxide catalysts | US3422072D | 1966-01-26 | US3422072A | 1969-01-14 | SANDLER STANLEY ROBERT; LEONARD EDWARD CHARLES |
| 99 | Benzoin-type homopolymers and glass fabric laminates thereof | US32809963 | 1963-12-04 | US3414466A | 1968-12-03 | RUDOLF WEHR |
| 100 | Grain-oriented iron and steel and method of making same | US46722865 | 1965-06-28 | US3392063A | 1968-07-09 | KOHLER DALE M |
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