Document Document Title
US09556485B2 Methods and compositions for detecting non-hematopoietic cells from a blood sample
The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.
US09556484B2 Epigenetic marker for the identification of IL17 positive T cells in complex samples
The present invention relates to a method, in particular an in vitro method for identifying IL-17 expressing T cells in a blood and/or tissue sample derived from a mammal, comprising analysing the methylation status of at least one CpG position in the gene IL-17A, wherein a demethylation of said at least one CpG position in said sample when compared to an analogous position in a non IL-17 blood cell is indicative for a IL-17 positive CD4 positive T cell. The analyses according to the invention can identify IL-17 positive T cells and distinguish them from all other cells in complex samples, such as, for example, other blood cells. The present invention furthermore provides an improved method for quantifying IL-17 positive T cells in complex samples based on a comparison of the IL-17A methylation with a methylation of at least one marker selected from the group of CD3, FOXP3, and/or GAPDH. The method can be performed without a step of purifying and/or enriching cells, preferably in whole blood and/or non-trypsinized tissue.
US09556476B2 Method for active hybridization in microarrays with denaturing function
A method for active hybridization in microarrays includes pumping an already prepared sample through a denaturing unit with a microarray and then through a reaction region which is spatially separate from the denaturing unit. The denatured reactive sample components are hybridized in the reaction region.
US09556475B2 Amplification reporter with base-pairing oligomers
System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
US09556472B2 Methods for performing dry chemistry, lateral flow-reconstituted chromatographic enzyme-driven assays
Methods for performing dry chemistry, lateral flow-reconstituted chromatographic enzyme-driven assays are described. A combination of components necessary to elicit a specific enzyme reaction are predeposited as substrate in dry form together with ingredients necessary to produce a desired color upon occurrence of the desired reaction. The strip is equipped with a sample pad placed ahead of the substrate deposit in the flowstream, to which liquid sample is applied. The sample flows from the sample pad into the substrate zone where it immediately reconstitutes the dried ingredients while also intimately mixing with them and reacting with them at the fluid front. The fluid front moves rapidly into the final “read zone” wherein the color developed is read against predetermined color standards for the desired reaction. The assay in the format of the invention is faster and easier to perform than analogous wet chemistry assays.
US09556468B2 Production of lutein in mixotrophic mode by scenedesmus
Novel strains of microalgae belonging to the Scenedesmus genus enable the production of lipids, in particular lutein, in mixotrophic mode, as well as a method for selecting and culturing the strains using a variable and/or discontinuous supply of light, in particular in the form of flashes.
US09556464B2 Method for producing Haemophilus influenzae type B antigens
The invention concerns a method for producing, on an industrial scale, capsular polysaccharide of Haemophilus influenzae type b (PRP) intended for vaccine purposes, according to which a strain of Haemophilus influenzae type b (Hib) is cultured in a culture medium, the culture supernatant is harvested and treated in order to extract the capsular polysaccharide therefrom, said culture medium comprising at least: —one source of carbon, —protoporphyrin, —salts, —amino acids, —NAD or NADH, —vitamins, —means for regulating the pH, characterised in that said culture medium is chemically defined.
US09556461B2 Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene.
US09556457B2 Protein complex having activity catalyzing asymmetric oxidation reaction and process for producing the same
A process for producing a cross-linked crystallized protein complex, which comprises: a first step of concentrating a crude protein derived from an animal or plant; a second step of encapsulating the protein in a gel, to thereby allow the protein to undergo air oxidation, and then extracting a protein complex from the gel; a third step of allowing the extracted protein complex to undergo crystallization and precipitation; and a fourth step of cross-linking the precipitated protein complex. Alternatively, by use of a fifth step of drying (FD) the obtained crosslinked crystallized protein complex, to thereby form a powder. As a result, there is provided an enzyme which is stable at room temperature storage, and has an activity in catalyzing an asymmetric oxidation reaction. That is, there is provided a useful material which enables an efficient enzyme-mimetic reaction under a mild condition.
US09556450B2 Drought tolerant plants and related constructs and methods involving genes encoding DTP21 polypeptides
Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a DTP21 polypeptide.
US09556447B2 Soybean HRP1 promoter and its use in tissue-specific expression of transgenic genes in plants
The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean hypersensitive-induced response protein gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a tissue-specific manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same.
US09556446B2 Rice comprising an RC responsive promoter driving expression of a heterologous nucleic acid molecule
The present invention relates to rice plants, seeds, and cells that include a promoter responsive to a basic helix-turn-helix red anthocyanin transcription factor operably linked to a heterologous nucleic acid molecule.
US09556441B2 Methods of transforming a Listeria
Site-specific Listeria integration vectors and methods for their use are provided. The subject vectors include a bacteriophage integrase gene and a bacteriophage attachment site, where in many embodiments the bacteriophage that is the source 0 of these elements is a listeriophage. In certain embodiments, the subject vectors further include a multiple cloning site, where the multiple cloning site may further include a polypeptide coding sequence, e.g., for a heterologous antigen. The subject vectors and methods find use in a variety of different applications, including the study of Listeria species and the preparation of Listeria vaccines.
US09556440B2 Enhanced expression from the Pm promoter
The present invention concerns a method of producing a desired gene product in a recombinant gene expression system, said method comprising expressing said gene from a Pm promoter-based expression system using at least two mutant elements selected from: (i) a mutant Pm promoter; (ii) a mutant mRNA leader; and (iii) a mutant XyIS; wherein said mutant elements each comprise one or more mutations which enhance expression of said desired gene. Particularly combinations of a mutant Pm promoter and a mutant mRNA leader are concerned. Isolated nucleic acid molecules, vectors, host cells, libraries, expression systems, methods of enhancing expression, obtaining nucleic acid molecules and identifying combination mutants which enhance expression, artificially constructed operons and their uses are also encompassed.
US09556439B2 Agonists and antagonists of toll-like receptor (TLR) 13
The present invention relates to the field of immunology. The present invention provides agonists and antagonists of Toll-like receptor (TLR) 13. In particular, the present invention provides TLR13 activating and inhibiting nucleic acids, and provides such nucleic acids for use as pharmaceutical agents. The present invention further provides in vitro methods using such nucleic acids.
US09556436B2 Method of treating influenza A
A method of treating Influenza A is disclosed. The method includes the step of administering a pharmaceutical composition including an oligonucleotide complementary to a corresponding segment of the nucleotide sequence of microRNA-1290 (miR-1290) (SEQ ID NO: 1) to a subject suffering from Influenza A, wherein at least one of the nucleotides in the oligonucleotide is Thymidine phosphate.
US09556431B2 ShRNA molecules and methods of use thereof
The present invention relates to certain novel shRNA molecules and methods of use thereof. According to certain embodiments of the present invention, methods for reducing the expression level of a target gene are provided. Such methods generally comprise providing a cell with one or more precursor nucleic acid sequences that encode two or more RNA molecules. A first RNA molecule comprises a double stranded sequence, which includes a guide strand sequence that is complementary to a portion of an mRNA transcript encoded by the target gene. In addition, a second RNA molecule comprises a second double stranded sequence, which includes a second guide strand sequence that is partially complementary to a portion of the mRNA transcript encoded by the target gene. Preferably, the second guide strand sequence comprises one or more bases that are mismatched with a nucleic acid sequence of the mRNA transcript encoded by the target gene.
US09556429B2 Arrays and methods of use
Methods are provided for producing a molecular array comprising a plurality of molecules immobilized to a solid substrate at a density which allows individual immobilized molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.
US09556428B2 Multi-chain eukaryotic display vectors and uses thereof
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is exhibited at the surface of the host cell. Such a vector allows for the display of complex biologically active polypeptides, e.g., biologically active multi-chain polypeptides such as immunoglobulin Fab fragments. The present invention describes and enables the successful display of a multi-chain polypeptide on the surface of a eukaryotic host cell. Preferred vectors are described for expressing the chains of a multi-chain polypeptide in a host cell separately and independently (e.g., under separate vector control elements, and/or on separate expression vectors, thus forming a matched vector set). The use of such matched vector sets provides flexibility and versatility in the generation of eukaryotic display libraries, for example the ability to generate and to display multi-chain polypeptides by combining and recombining vectors that express variegations of the individual chains of a multi-chain polypeptide. Entire repertoires of novel chain combinations can be devised using such vector sets.
US09556408B2 Pedal-powered brewing system
A brewing system that includes bicycle-driven generators to offset, or supply, the electricity used in the brewing process. The brewing system includes at least one bicycle, a bicycle generator associated with each bicycle, and electrical components to store the electricity generators and/or feed the electricity back into a power grid. The electricity is then drawn on during the brewing process. There is also provided a data collector for receiving the electricity generated by each bicycle, a computer for monitoring and recording the electricity generated by each bicycle, and a video monitor that displays real-time statistics of the electricity produced by each bicycle.
US09556403B2 Method for preparing polyols and products obtained
The present invention relates to a method for preparing polyols of formula (I″) R′1 being H or an alkyl group, R″ being especially an alkyl group, A1, being an alkylene radical and R3, are being especially a group -A2-O—Y′, A2 being an alkylene radical and Y′ being especially H, said method especially comprising a step of epoxidation of a compound of formula R″1 being H or an alkyl group, At being defined as above in formula (I″) and R4 being especially a group -A2-O—Y1′, A2 being defined as above in formula (I″) and Y′1 being especially H, in order to obtain a compound of formula A1 being defined as above, R′″1 being H or an alkyl group and R5 being especially a group of formula -A2-O—Y2′, A2 being as defined above in formula (I″) and Y′2 being especially H.
US09556402B2 Hydroformylation of triglycerides in a self-emulsifying medium
The invention relates to a method for the hydroformnylation of triglycerides by homogeneous catalysis in the presence of at least one substituted cyclodextrin, said method comprising a step a) of combining, under agitation, at least one catalyst, waiter, at least one unsaturated triglyceride and said substituted cyclodextrin, in the presence of gaseous hydrogen and carbon monoxide, said step being carried out in reactive conditions allowing the formation of an emulsion during the agitation and a decanting of the products once the agitation has stopped.
US09556400B2 5,5-dimethyl-2-propyl-hexahydro-2,4a-methano-naphthalen-1-one as a fragrance agent
The invention relates to a compound of general formula (I) shown hereafter: as well as a composition comprising at least said compound of general formula (I), and its uses in perfumery.
US09556395B2 Use of polyalkoxylates in lubricant compositions
Provided are polyalkoxylates that are prepared by alkoxylating polytetrahydrofurane with butylene oxide for use in lubricant compositions and/or for reducing friction in a driveline.
US09556394B2 Natural and synthetic ester-containing lubricants having enhanced hydrolytic stability
A lubricant composition comprising (a) from 0.1 to 10 percent by weight of one or more polyalkylene glycols (PAG); and (2) one or more ester base oils selected from the group of natural esters, synthetic esters and combinations thereof; wherein the one or more PAG has a molecular weight in the range 1500 to 5000 g/mole, comprises from 10 to 40 percent by weight of units derived from ethylene oxide and from 90 to 60 percent by weight of units derived from propylene oxide; and wherein the one or more PAGs are in the form of block copolymer, reverse block copolymer or combinations thereof is provided. Also provided is a method of enhancing the hydrolytic stability of an ester base oil.
US09556391B2 Method for producing renewable hydrogen from biomass derivatives using steam reforming technology
A process of decomposing a biomass derivative to produce a gaseous product and then introducing the gaseous product into a steam reformer.
US09556387B2 Process for the hydrotreatment of a gas-oil feedstock, reactor for implementing said process, and corresponding hydrorefining unit
The invention relates to a process for the catalytic hydrotreating of a feed of oil origin, of diesel fuel type, in at least one fixed-bed hydrotreating reactor, for manufacturing diesel fuel, characterized in that incorporated into said feed are vegetable oils and/or animal fats up to a level of around 30% by weight, the mixture of said feed and vegetable oils and/or animal fats being introduced into the reactor operating in a single pass, without recycling liquid effluent at the top of the reactor.It also relates to a hydrotreating reactor for implementing said process, and to a corresponding hydrorefining unit.
US09556386B2 Separation of hydrocarbon families or of individual components by consecutive extractive distillations performed in a single column
A column for consecutive extractive distillations, in particular of crude hydrocarbon mixes comprising aromatic, naphthene and paraffin hydrocarbons. The invention also relates to methods for separating and recovering the components of a crude hydrocarbon mix comprising aromatic, naphthene and paraffin hydrocarbons by consecutive extractive distillations provided by means of the column for consecutive extractive distillations, to which the invention also relates.
US09556382B2 Polymerisable mixtures and the use thereof in liquid crystal displays
The present invention relates to polymerizable mixtures and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
US09556373B2 Gel comprising a phase-change material, method of preparing the gel, and thermal exchange implement comprising the gel
Gel including a phase-change material and a gelling agent. In one embodiment, the phase-change material may be n-tetradecane, and the gelling agent may be a styrene-ethylene-butylene-styrene (SEBS) triblock copolymer. In particular, the SEBS copolymer may be a high molecular weight SEBS copolymer with a styrene:rubber ratio of about 30:70 to 33:67% by weight. The SEBS copolymer may constitute up to about 10%, by weight, of the gel, preferably less than 6%, by weight, of the gel, with n-tetradecane constituting the remainder. To form the gel, the phase-change material and the gelling agent are mixed together at an elevated temperature relative to room temperature to partially, but not completely, dissolve the gelling agent, i.e., a homogeneous solution is not formed. The mixture is then allowed to cool to room temperature. The invention is also directed at a method of preparing the gel and a thermal exchange implement including the gel.
US09556372B2 Refrigerant compositions
Refrigerant compositions are described, which can be used for example, in refrigeration, air conditioning, and/or heat pump systems which for example, can be incorporated into a heating, ventilation and air conditioning (HVAC) system or unit. The refrigerant composition includes an amount of a R125 refrigerant, an amount of a R32 refrigerant, and an amount of a R1234yf refrigerant, where the R32 refrigerant has higher flammability than the R125 refrigerant, and the R1234yf refrigerant has higher flammability than the R125 refrigerant.
US09556371B2 Homogeneous blending
A method of forming a colloidal dispersion includes providing a first continuous material flow, providing a second continuous material flow, combining the first and second continuous material flows, and moving a continuous flow of a colloidal dispersion in a direction downstream of the first and second continuous flows. The first continuous material flow includes one or more of a diluent (e.g., deionized water), a base, and an acid, and the second continuous material flow includes an abrasive particle solution. The first and second material flows are combined with a Reynolds number greater than about 4400 and less than about 25000 (e.g., about 7400 to about 25000). The colloidal dispersion includes the diluent, the base, the acid, and abrasive particles from the abrasive particle solution.
US09556367B2 Blends of block copolymer and acrylic adhesives
Pressure sensitive adhesive compositions containing 92 to 99.9 parts of a block copolymer adhesive composition and 0.1 to less than 8 parts of an acrylic adhesive composition are described. Tapes including such adhesives, and methods of making such tapes are also described.
US09556366B2 Hot melt adhesive
A hot melt adhesive material and articles made using the hot melt adhesive to assemble structures in an article. The adhesive material typically is manufactured by blending amorphous polymer with a heterophase polymer having crystallinity into an adhesive composition.
US09556360B2 Silane mixtures
Silanation compositions containing a mixture of two or more silanation reagents, where at least one silanation reagent includes a functional group capable of supporting polymer synthesis and at least one silanation reagent includes no functional group capable of supporting polymer synthesis are useful in modulating the active site density and hydrolytic stability of a surface. These compositions are particularly useful in silanating a surface prior to preparation of a polymer array and provide for increased hybridization results.
US09556359B2 Method of producing member for electrophotography
Provided is a method of producing a member for electrophotography capable of providing a high-quality electrophotographic image. The method of producing a member for electrophotography is a method of producing a member for electrophotography having an electro-conductive support, an elastic layer, and a surface layer, the method comprising: a first step of forming, on a surface of the elastic layer, a coat of a surface-layer coating liquid containing a hydrolyzed condensate of a hydrolyzable silane compound and a chelate titanium compound represented by the following general formula (2); and a second step of crosslinking the hydrolyzed condensate in the coat through cleavage of an epoxy group in the hydrolyzed condensate to form the surface layer:
US09556358B2 Coated metallic article
A method for coating of a metallic article is provided. According to the method, the metal surface is coated with a composition which comprises a polymer or comprises a two-component system that reacts to form a polymer following application to the metal surface. The composition comprises 70-2700 meq/kg olefinic double bonds which leads to stronger adhesion and to increased corrosion resistance.
US09556356B2 Glass fiber structure designed to reinforce bonded abrasive articles
The invention relates to a structure based on glass fiber coated with a resin composition designed to reinforce bonded abrasive articles, the resin composition including the following constituents in the proportions indicated, expressed in percentage by weight of solid matter: 75 to 98% of a mixture of at least one novolac having a glass transition temperature lower than or equal to 60° C. and at least one novolac having a glass transition temperature above 60° C., 0.5 to 10% of at least one wax, 0 to 3.5% of at least one plasticizing agent.
US09556354B2 Method for fabricating a semicrystalline polymer / graphene oxide composite film
The present invention discloses a semicrystalline polymer/graphene oxide composite film, comprising: a first semicrystalline-typed polymer, distributed in structural space of the composite film and having a porous structure; and graphene oxide, having a layered structure and distributed in the composite film wherein gas passage exist between adjacent layered structures, the first semicrystalline-typed polymer existing between part of adjacent layered structures forms into a second semicrystalline-typed polymer by further heat treatment after the first semicrystalline-typed polymer and graphene oxide are blended uniformly to be distributed in the composite film so as to fill and seal a portion of the porous structure to block gas from flowing to extend path length(s) of gas passage; wherein graphene oxide existing between the first semicrystalline-typed polymers induces formation of the second semicrystalline-typed polymer.
US09556345B2 Defoaming wetting agents for aqueous coating systems
The disclosure relates to the use of compounds of specific structure as defoaming wetting agents for aqueous coating systems, for example paints and varnishes. The disclosure is more particularly related to methods of reducing the surface tension and/or increasing the density of an aqueous coating system, which methods include adding alcohol propoxylates to an aqueous coating system. The alcohol propoxylates have the general structure R—O—(PO)xH, in which R is a saturated alkyl radical having 7 to 10 C atoms, PO is a propylene oxide unit, and x is a number in the range from 4 to 6. The resulting aqueous coating composition has good wetting properties, but is low in foam, so it does not disrupt processing operations of the coating system.
US09556340B2 Polyoxazoline copolymers
A copolymer derived from a monomer mixture that includes monomers having the formulas: (A) and (B) wherein: Q is O or N; R10 is H or CH3; R11 is an organic group comprising a hydrolyzable silyl group; R12 is H or CH3; P is: (I); R1 is selected from H, an alkyl group, an aryl group, and a combination thereof; R2 is selected from an alkyl group, an aryl group, a combination thereof, and a Rf—Y—(CH2)x— group; Rf is a perfluorinated alkyl group; Y is selected from a bond, —S(O)2—N(CH3)—, —S(O)2—N(CH2CH3)—, —S(O)2—O—, —S(O)2—, —C(O)—, —C(O)—S—, —C(O)—O—, —C(O)—NH—, —C(O)—N(CH3)—, —C(O)—N(CH2CH3)—, —(CH2CH2O)y—, —O—, and —O—C(O)—CH═CH—C(O)—O—; n is an integer of greater than 2; x is an integer of at least 2; and y is an integer of at least 1.
US09556334B2 Flame-retardant thermoplastic resin composition and a molded product thereof
Provided herein is a flame-retardant thermoplastic resin composition and a molded product thereof, the composition including polycarbonate resin, rubber modified aromatic vinyl copolymer, aromatic phosphate ester compound, glass fiber, and carbon fiber, wherein the composition includes a weight ratio of the glass fiber to the carbon fiber of about 1:0.3 to about 1:2.
US09556328B2 Biodegradable hydrophobic composite materials and process for the preparation thereof
The present invention relates to biodegradable hydrophobic composite materials and a process for the preparation of said hydrophobic biodegradable materials from the seaweed polysaccharides through grafting reaction with vinylated monomers e.g. vinyl acetate. The said composites can be used as a substitute for synthetic ropes for varied applications including seaweed cultivation in the open sea. The results of cultivation experiments showed that ropes are suitable for cultivation of seaweeds in the sea environment, and exhibit higher biomass yield as compared to synthetic ropes. The prepared composites are very flexible and can be used for making handles for carry bags and for the preparation of biodegradable designs, bowls, pots, jars, gift items, stud caps and bracelets.
US09556325B2 NFC stabilized foam
A hydrophobized nanofibrillated cellulose foam comprising a charged hydrophobic amine, a method for providing such foam and its use.
US09556323B2 Ink for display device manufacturing and method for manufacturing of the same, method for manufacturing using the same
An ink for display device manufacturing, including a solid, a first solvent having a solubility for the solid of 2% or more and a second solvent having a solubility for the solid of 0.5% or less.
US09556322B2 Liquid pigment dispersions
The present invention provides fluid compositions comprising at least one hydrophobic liquid, at least one inorganic pigment, and at least one compatibilization agent comprising at least one phosphate monoester.
US09556313B2 Vinyl carbosiloxane resins
This invention is a vinylcarbosiloxane resin that is the hydrosilation reaction product of 1,3,5,7 -tetravinyl-1,3,5,7-tetramethylcyclotetrasiloxane and a hydride-terminated linear polysiloxane, siloxane, or silane, having two terminal Si—H hydrogens reactive with vinyl groups in a hydrosilation reaction, in the presence of a platinum catalyst. Suitable hydride-terminated linear polysiloxanes, siloxances, and silanes include those having the structures: In another embodiment, the vinylcarbosiloxane resin can be reacted with one or more other hydrido-silanes and hydrido-polysiloxanes in the presence of a platinum catalyst to form a curable composition.
US09556309B2 Alkylene oxide polymerization using a double metal cyanide catalyst complex and a magnesium, group 3-group 15 metal or lanthanide series metal compound
Alkylene oxide polymerizations are performed in the presence of a double metal cyanide polymerization catalyst and certain magnesium, Group 3-Group 15 metal or lanthanide series metal compounds. The presence of the magnesium, Group 3-Group 15 metal or lanthanide series metal compound provides several benefits including more rapid catalyst activation, faster polymerization rates and the reduction in the amount of ultra high molecular weight polymers that are formed. The catalyst mixture is unexpectedly useful in making polyethers having low equivalent weights.
US09556308B1 Dithiolane carbonate monomers and polymers thereof
1,2-Diothiolane monomers are disclosed, as are polymers and hydrogels comprising the polymers. Processes for preparing the monomers, polymers and compositions are also disclosed. The monomers have the formula: The polymers may include the following repeating units:
US09556305B2 Non-cytotoxic urethane elastomer
A non-cytotoxic polyether polyurethane elastomer is made by reacting a polyether triol, polyether diol, and polyether prepolymer terminated with toluene diisocyanate. The reaction is catalyzed with a zinc based catalyst, such as zinc neodecanoate. Silicone oil is also added to the reactants. The polyurethane elastomer is a solid, soft elastomer having a hardness of from 15 Shore 00 to 50 Shore A. The elastomer is particularly suited for use as padding in sleeves, splints and braces where it is in contact with human skin.
US09556303B2 Catalysts for polyurethane foam polyol premixes containing halogenated olefin blowing agents
The invention provides polyurethane and polyisocyanurate foams and methods for the preparation thereof. More particularly, the invention relates to closed-celled, polyurethane and polyisocyanurate foams and methods for their preparation. The foams are characterized by a fine uniform cell structure and little or no foam collapse. The foams are produced with a polyol premix composition which comprises a combination of a hydrohaloolefin blowing agent, a polyol, a silicone surfactant, and a non-amine catalyst used alone or in combination with an amine catalyst.
US09556301B1 Cyclopolymer containing residues of methionine and synthesis and uses thereof
Cyclopolymers and N,N-diallyl methionine-based monomers or salts, solvates, tautomers or stereoisomers as corrosion inhibitors. A process for producing the cyclopolymers by Butler cyclopolymerization of the monomers in the presence of sulfur dioxide. In addition, a method for determining a percent inhibition efficiency of metal corrosion for the cyclopolymers and monomers as well as applications and methods for the cyclopolymers as coatings, compositions, and formulations for preventing metal corrosion.
US09556300B2 Method for manufacturing resin particles and method for manufacturing toner particles
A method for manufacturing resin particles, including the step of producing the resin particles by using a liquid which is prepared with a resin having an ionic functional group and a pKa of 6.0 to 9.0, an organic solvent, which can dissolve the resin and which has a solubility parameter of 12.0 or less, water, and a neutralizer, wherein the neutralizer contains an acid having a pKa of 3.0 or less or a base having a pKb of 3.0 or less.
US09556299B2 Surface-active comb copolymers
The invention relates to a copolymer whose overall structure as such and/or an optionally present segment A having at least 10 bivalent structural units in the overall structure contains surface-active bivalent structural units present in the form of long hydrocarbon chains among other forms. The copolymer is effective as a universal surface-active additive, especially also in conjunction with nonpolar media.
US09556297B2 Functionalized polymer
A method for providing a polymer having terminal functionality involves reacting a terminally active polymer with an α,β-ethylenically unsaturated compound that includes a group 2-13 element so as to provide a functionalized polymer. The resulting polymer exhibits enhanced interactivity with particulate fillers and can be used in the manufacture of vulcanizates.
US09556293B2 Polyisocyanates from fused bicyclic polyols and polyurethanes therefrom
The present invention is directed to polyisocyanates and polyurethanes derived therefrom. In various embodiments, the present invention provides polyisocyanates, methods of making the polyisocyanates from fused bicyclic alcohols, polyurethanes, and methods of making the polyurethanes from the polyisocyanates.
US09556292B2 Optical composition
The present invention aims to reduce excess scattering in light emitting arrangements. A composition comprising a transparent matrix comprising an anionic organic moiety, and metal cations dispersed in the matrix is disclosed. The anionic organic moiety and the metal cations form an organometallic complex, and wherein the metal cations are capable of forming transparent nano-crystals upon contact with an agent comprising at least one element selected from the group consisting of sulfur and selenium. Also an optical composition comprising a transparent matrix comprising an organic moiety residue, and unmodified nanocrystals is disclosed. Further, a method of preparing an optical composition comprising the steps of: providing a transparent matrix comprising an anionic organic moiety; dispersing metal cations into the matrix; and contacting the organometallic complex with an agent in order to in situ convert at least part of the metal cations into transparent nanocrystals.Preferably the matrix is a silicone or a polysiloxane and silicone rubber mixture.
US09556289B2 Supported hybrid catalyst and method for preparing olefin-based polymer using the same
The present invention relates to a supported hybrid catalyst and a method for preparing an olefin based polymer using the same. The supported hybrid catalyst according to the present invention can be used in the preparation of an olefin-based polymer, and the olefin-based polymer prepared using the supported hybrid catalyst has excellent processability and mechanical properties and thus can be effectively used for the application of films or the like.
US09556287B2 Vinyl terminated macromonomers
Polymers produced by a process comprising contacting one or more olefins with a catalyst system comprising an activator and a Salan catalyst disposed on a support.
US09556277B2 Method of treating a TL1A-associated disease or disorder with human antibodies to TL1A
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human TNF-like ligand 1A (hTL1A) is provided. The human anti-hTL1A antibodies are useful in treating diseases or disorders associated with TL1A, such as inflammatory diseases or disorders, e.g., inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, rheumatoid arthritis, and the like; autoimmune diseases or disorders, such as multiple sclerosis, diabetes, and the like; and allergic reactions, such as asthma and allergic lung inflammation.
US09556274B2 Monospecific and bispecific anti-IGF-1R and anti-ERBB3 antibodies
Provided are monospecific and bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-1R and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-1R binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. AntiErbB3 and anti-IGF-1R antibodies (e.g., monoclonal antibodies) are also provided.
US09556270B2 Anti-TIM-3 antibody
Disclosed are an anti-human TIM-3 antibody having high ADCC activity or antibody fragment thereof by screening a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; and a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient.
US09556268B2 Therapeutic agent
The present invention relates to agents which modulate the effect of a RAMP (Receptor Activity Modifying Protein) protein on a Calcitonin Receptor Like Receptor (CRLR). Also included in the present invention are methods and uses of such agents and assays for identifying such agents. The agents of the present disclosure may be used in the treatment of, for example, cancer, obesity and other disorders.
US09556267B2 Anti-LRP6 antibodies
The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
US09556265B2 Solubility optimization of immunobinders
The invention provides methods of using sequence based analysis and rational strategies to improve the solubility of immunobinders, and in particular of single chain antibodies (scFvs). The invention provides methods of engineering immunobinders, and in particular scFvs, by performing one or more substitutions with hydrophilic residues identified by analysis of a database of selected, stable scFv sequences. The invention also provides immunobinders with optimized solubility prepared according to the engineering methods of the invention.
US09556262B2 Anti-polyubiquitin antibodies and methods of use
The invention provides anti-polyubiquitin antibodies and methods of using the same.
US09556258B2 Purification of fusion proteins
The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode.
US09556257B2 Antigen associated with rheumatoid arthritis
The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the detection and treatment of rheumatoid arthritis.
US09556254B2 Cross-reactive antibodies against dengue virus and uses thereof
The invention relates to a human anti-dengue virus antibody (an anti-DENV antibody) that binds to a DENV envelope protein and is cross-reactive with DENV serotype 1, DENV serotype 2, DENV serotype 3, and DENV serotype 4. The disclosure provides an anti-DENV antibody that cross-reacts with and neutralizes all four DENV serotypes. Also provided is a nucleic acid molecule that encodes such an anti-DENV antibody. Also provided is a method to produce and use such an antibody or nucleic acid molecule encoding such an antibody.
US09556251B2 Methods and compositions to regulate hepcidin expression
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.
US09556248B2 Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists
The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently linked NK1 variant polypeptides. Many of the disclosed variant polypeptides possess improved stability characteristics.
US09556245B2 CA125 gene and its use for diagnostic and therapeutic interventions
The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.
US09556238B2 Magnetosome gene expression in eukaryotic cells
The invention is the production of magnetosome-like structures in cells. The invention provides in vitro and in vivo diagnostic and therapeutic methods using eukaryotic cells expressing magnetosome-like structures that act as contrast agents.
US09556237B2 Antiviral rift valley fever virus peptides and methods of use
The invention entails synthetic short peptides based on Rift Valley Fever Virus (RVFV) fusion protein. The peptides are broad-spectrum antivirals, and are useful for prophylactic treatment against or therapeutic treatment of infection by hemorrhagic fever viruses, such as RVFV, Ebola Virus, and Andes Virus, as well as vesicular stomatitis virus.
US09556236B1 Compositions and methods for treating respiratory syncytial virus infection
Briefly described, embodiments of the present disclosure relate to isolated polypeptides useful for treatment of respiratory syncytial virus, and to methods and compositions for treating respiratory syncytial virus.
US09556233B2 Cyclohexapeptide
The present invention relates to a novel cyclohexapeptide, to a method for the preparation of said cyclohexapeptide and to the use of said cyclohexapeptide.
US09556230B2 TFPI inhibitors and methods of use
The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.
US09556226B2 Peptides with antifungal activity and methods of using the peptides
Compositions with antifungal activity and methods of using such compositions are provided herein. In particular the compositions are peptides of SEQ ID NO: 1 and variations thereof. The peptides may contain L or D amino acids and may be circularized, dimerized or otherwise modified to make the compositions resistant to proteolysis. The compositions may be used to inhibit microbial growth and in particular fungal growth.
US09556219B2 Procedure for the preparation of abiraterone acetate and intermediates thereof
Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for implementation on an industrial scale. There is also provided a process for the production of abiraterone acetate by acetylation of abiraterone in the absence of bases or acetylation catalysts.
US09556218B2 Process for the preparation of abiraterone and intermediates thereof
The present invention provides intermediates for preparing abiraterone, and processes for preparing abiraterone and intermediates thereof. The intermediates include a compound of formula (IV): wherein R represents a hydroxy-protecting group.
US09556213B2 Phosphorescent meso-unsubstituted metallo-tetrabenzoporphyrin probe molecules for measuring oxygen and imaging methods
Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as a dendritic oxygen probes, with controllable quenching parameters and defined biodistributions. Provided are a “next generation” of oxygen sensors with substantially improved phosphorescence emission for better imaging capabilities, ease of use, increasing the quantum efficiency (phosphorescence intensity) and extending their range of applicability including constructing a class of oxygen sensors for making measurements in organic media. In addition, provided are methods for synthesizing new porphyrin constructs in which the porphyrin is made less flexible and more planar, changing with decrease internal quenching, and thereby increasing the phosphorescence emission used for oxygen sensing. Additional methods are provided for structurally modifying the dendrimer used to encapsulate the porphyrin phosphor to provide internal quenching of singlet oxygen molecules formed during oxygen measurements.
US09556212B2 Chemical deposition raw material formed of ruthenium complex and method for producing the same, and chemical deposition method
The present invention provides a raw material, formed of a ruthenium complex, for producing a ruthenium thin film or a ruthenium compound thin film by a chemical deposition method, wherein the ruthenium complex is a ruthenium complex represented by the following formula, in which carbonyl groups and a fluoroalkyl derivative of a polyene are coordinated to ruthenium. The present invention provides a raw material for chemical deposition having a preferable decomposition temperature, and the production cost therefor is low: (nR-L)Ru(CO)3  [Chemical Formula 1] wherein L is a polyene having a carbon number of from 4 to 8 and 2 to 4 double bonds, wherein the polyene L has n (n≧1) pieces of substituents Rs, wherein the substituents Rs are each a fluoroalkyl group having a carbon number of from 1 to 6 and a fluorine number of from 1 to 13, and in the case when the polyene L has two or more (n≧2) of the substituents Rs, the carbon numbers and the fluorine numbers of the substituents Rs may be different in the same molecule.
US09556208B2 Hydrosilylation synthesis of haloalkylorganosilanes using peroxide promoters
This invention is directed to a process for producing a haloorganoalkoxysilane product comprising reacting an olefinic halide, an alkoxysilane, a catalytically effective amount of ruthenium-containing catalyst; and a reaction-promoting effective amount of a peroxy compound, optionally in the presence of an electron-deficient aromatic compound.
US09556205B2 Fungicide N-[(trisubstitutedsilyl)methyl]-carboxamide derivatives
The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
US09556201B2 Bicyclic pyridines and analogs as sirtuin modulators
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
US09556196B2 Anti-platelet compound addition salt
The present invention relates to a use of haloid acid salt and sulfonate of a compound of formula I and a salt of the compound of formula I in preparation of medicament for preventing or treating diseases caused by thrombosis or embolism. The present invention provides acid addition salts, especially haloid acid and sulfonic acid addition salts of a compound of formula I having high inhibition effect on platelet aggregation, and preparation method of the same, a medicament comprising the same, and a use and/or method for preventing or treating diseases caused by thrombosis or embolism.
US09556195B2 Compositions and methods for quadricyclane modification of biomolecules
The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.
US09556193B2 Benzimidazole hexahydrofuro[3,2-b]furan derivatives
The novel benzimidazole hexahydrofuro[3,2-B]furan derivatives of the present invention are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
US09556192B2 Functionalized 9-bromo-camptothecin derivatives
The present disclosure is directed to a compound of formula (I) wherein L is null or a conditionally-cleavable moiety; W is null or a self-immolative system, comprising one or more self-immolative groups; Z is null or a peptidic, non peptidic or hybrid —peptidic and non peptidic—linker; RM is null or a reactive moiety that can be attached to one or more of L, W or Z groups, or RM is attached to oxygen when L, W and Z are all null; provided that at least one of L, W, Z and RM is not null; or a pharmaceutically acceptable salt thereof.
US09556191B2 Aminoquinazoline derivatives and their salts and methods of use thereof
Provided herein are aminoquinazoline compounds, salts and uses thereof. The compounds have Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Also provided herein are pharmaceutical compositions containing the compounds disclosed herein, and uses of the compounds or the compositions for preventing, managing, treating or lessening the severity of a proliferative disorder in a patient and for modulating the protein tyrosine kinase activity.
US09556190B2 Piperidinyloxy lactone orexin receptor antagonists
The present invention is directed to piperidinyloxy lactone compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the piperidinyloxy lactone compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
US09556189B2 Polymorphic forms of naltrexone
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.
US09556188B2 Substituted imidazo[1,2-b]pyrazoles as bruton'S tyrosine kinase modulators
The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
US09556187B2 Substituted pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the same
This disclosure relates to novel tricyclic pyrimidine compounds and tricyclic pyridine compounds having JAK inhibitory activities. A tricyclic heterocyclic compound represented by the formula (Ib), wherein the rings Ab and Bb, Xb, Yb, R1b, R2b, R3b, L1b, L2b, L3b and nb are as defined in the specification.
US09556180B2 Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
US09556178B2 Imidazotriazinecarbonitriles useful as kinase inhibitors
The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
US09556177B2 Substituted 1,3-thiazoles as synthetic intermediates for preparation of Raf kinase inhibitors
The present disclosure provides compounds having Formula II-vi-a: wherein Cy1, Cy2, and A− are defined as set forth in the specification. These compounds are synthetic intermediates used to prepare inhibitors of Raf protein kinase.
US09556176B2 Purine derivatives for the treatment of viral infections
The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
US09556173B2 Method for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
This invention relates to methods for preparation of chemical compound 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid, which comprise addition of heterocyclic amine containing protecting group, to ethyl-3-oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propanoate, followed by interaction with triethyl orthoformate, addition of cyclic amine, subsequent cyclization and formation of target product. The method for preparation claimed is technologically simple in comparison with analog and requires no special complex technical operations, which in its turn simplifies method for preparation of this chemical compound, and reduces cost of the final product, while the commercial production utilizing the method claimed has low degree of environmental threat.
US09556165B2 Amidine substituted β-lactam compounds, their preparation and use as antibacterial agents
The present invention relates to novel β-lactam compounds, their preparation and use. In particular, this invention relates to novel β-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.
US09556164B2 Salts of Dasatinib in crystalline form
The present invention primarily relates to molecular crystalline substances, preferably salts of Dasatinib in crystalline form, comprising a compound of formula 1, preferably a cation of a compound of formula 1, and a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin, preferably an anion thereof. The invention is further related to pharmaceutical compositions comprising such a substance. Furthermore, the invention relates to processes for preparing said substances. The invention also relates to several aspects of using said substances or pharmaceutical compositions to treat a disease.
US09556159B2 Renin inhibitor
The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. wherein R1 is a cycloalkyl group or an alkyl, R22 is an optionally substituted aryl and the like, R is a lower alkyl group, R3, R4, R5 and R6 are the same or different, and are a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl, or a pharmaceutically acceptable salt thereof.
US09556152B2 Heterocyclic amides as kinase inhibitors
Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A, L, and B are as defined herein, and methods of making and using the same.
US09556150B2 Inhibitors of bruton's tyrosine kinase
This application discloses compounds according to generic Formula (I) wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
US09556149B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor
The present invention relates to processes for preparing pyrazole derivatives of Formula (I) and salts and pharmaceutical compositions of the salts thereof, useful as modulators of 5-HT2A serotonin receptor activity. The present invention also relates to intermediates used in the processes, and their preparation. The present invention also relates to salts of compounds of Formula (I) and pharmaceutical compositions thereof.
US09556148B2 N-cyanomethylamides as inhibitors of janus kinase
The present invention relates to compounds of general formula (1) that are inhibitors of Janus Kinase (JAK), a family of tyrosine kinases that are involved in inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. In particular, the compound of the invention inhibits JAK1 and/or JAK2 and/or JAK3 sub families. The present invention also provides methods for the production of the compounds of the invention, pharmaceutical compositions comprising the compounds of the invention, their tautomeric forms, and their pharmaceutically acceptable salts
US09556147B2 Inhibitors of bruton's tyrosine kinase
This application discloses compounds according to generic Formula I: (I) wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
US09556143B2 Metalloenzyme inhibitor compounds
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
US09556142B2 Process for the preparation of (R,S)-nicotine
A method of preparing (R,S)-nicotine, comprising reacting a nicotinate ester with N-vinyl-2-pyrrolidinone in the presence of a base and a solvent to form a first mixture, combining the first mixture with an acid to form a second mixture comprising an aqueous layer, separating the aqueous layer from second mixture, combining the separated aqueous layer with an acid to form a third mixture, combining the third mixture with a base to form a fourth mixture comprising myosamine, reducing myosamine to nornicotine using a reducing agent, and methylating the nornicotine to yield R,S-nicotine.
US09556140B2 Approach for synthesis of catechins
A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.
US09556134B2 Humic acid derivatives and methods of preparation and use
Disclosed are antioxidative natural compounds, their salts, chelates and cleavage derivatives that exhibit a superior combination of properties. The compounds can be used for a variety of purposes, including the stabilization of polymers. The compounds can be prepared by substantially cleaving a humic acid of formula I followed by esterification to provide at least one antioxidant compounds of formula V, formula VI, formula VII, formula VIII, salts thereof, or chelates thereof.
US09556128B2 Preparation method for acrylate compound
The present invention relates to a method for preparing an acrylate compound. The acrylate compound has a structure as shown in formula (I). The method includes: subjecting a compound with a structure of formula (II) or a mixture of compounds with structures of formula (I) and formula (II), and a catalyst to a contact reaction in the absence of an anhydride, and removing the resulting methanol by pressure reduced distillation during the contact reaction process. In the formulas (I) and (II), R is selected from one of: an alkoxy with a carbon number of 1-5, a substituent-containing phenoxyl with a carbon number of 6-20, a substituent-containing heteroaryloxy with a carbon number of 4-20, a substituent-containing heteroaryloxymethyl with a carbon number of 4-20, a substituent-containing phenoxymethyl with a carbon number of 5-20, and a substituent-containing alkyl with a carbon number of 2-20. According to the method for preparing an acrylate compound provided in the invention, the conversion rate and selectivity of the reaction can be substantially improved.
US09556125B2 Process for preparing a pyrimidine intermediate
The invention relates to a process for preparing a pyrimidine intermediate, namely the compound of formula I-2 or a salt thereof, which involves the use of a liquid-liquid extraction using methyl iso-butyl ketone. Said compound of formula I-2 or its salt can be used to prepare macitentan.
US09556124B2 Methods for removing triazine from N-methylimidazole for synthesis of oligonucleotide
Methods for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a N-methylimidazole and methods for making oligonucleotides using N-methylimidazole are provided. In one embodiment, a method for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a feedstock containing N-methylimidazole includes contacting the feedstock with small or medium pore molecular sieves. The small or medium pore molecular sieves adsorb 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from the feedstock. The method further includes separating the small or medium pore molecular sieves from the feedstock.
US09556118B2 Allosteric modulators of CB1 cannabinoid receptors
The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.
US09556117B2 Indole carboxamide derivatives as P2X7 receptor antagonists
The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
US09556112B2 Carboxylic acid ester prodrug inhibitors of MEK
The invention generally relates to compounds having structure I: wherein x represents alkyl, aryl or het-aryl, each of y independently represents hydrogen or halogen and z represents hydrogen or alkyl. Further, said compounds are inhibitors of MEK 1, 2 and 5. Furthermore, the invention includes methods of making said compounds, compositions including said compounds and uses for inhibiting MEK 1, 2 and 5.
US09556111B2 Tertiary amines for use in the treatment of cardiac disorders
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure.
US09556110B2 Aminoalcohol lipidoids and uses thereof
Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
US09556109B1 Triscationic amphiphile derivative compounds having a pendent alcohol group, compositions thereof, and methods for making same
The inventive subject matter relates to compounds of Formula I, compositions thereof, and processes for making such compounds as further described herein. The inventive compounds and compositions have antimicrobial properties and are useful as environmental disinfectants, topical cleansers such as topical personal care compositions, sanitizers, preservatives, in water treatment, as permanent or erodible coatings for medical devices and appliances, and in therapeutics. Additionally, the compounds of Formula I will serve as synthetic intermediates for making additional novel derivatives of triscationic amphiphile compounds.
US09556108B2 Process for preparing substituted phenylalkanes
The invention provides methods for preparing substituted phenylalkanes. In particular, the processes comprise reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction. The processes may be useful in the synthesis of tapentadol.
US09556107B2 Intermediate used for preparing tapentadol or analogues thereof
The invention discloses a novel intermediate for preparing tapentadol and analogs thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogs thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.
US09556105B2 Curcumin analogues as zinc chelators and their uses
This invention provides a compound having the structure wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.
US09556104B2 Process for hydrogenation of esters of aromatic carboxylic acids to yield saturated homologues thereof
A process for the hydrogenation of substituted aromatic compounds, with particular reference to esters of aromatic carboxylic acids, for example of aromatic esters used commonly as plasticizers in polymers having wide commercial application (see, in particular, esters of phthalic acid and trimellitic acid).
US09556091B2 Integrated process for the production of 1-chloro-3,3,3-trifluoropropene
The present invention is directed to processes for the production of 1233zd from 240fa and HF, with or without a catalyst, at a commercial scale. The 240fa and HF are fed to a reactor operating at high pressure. The resulting product stream comprising 1233zd, HCl, HF, and other byproducts is treated to one or more purification techniques including phase separation and one or more distillations to provide purified 1233zd, which meets commercial product specifications, i.e., having a GC purity of 99.5% or greater.
US09556089B2 Purification method and purification system for propane
[PROBLEM] To provide an industrially advantageous method and system that are simple and have superior energy efficiency for obtaining high-purity propane from low-purity propane.[SOLUTION] Water, carbon dioxide, at least one of ethane and propylene, and at least one of isobutane and normal butane present in low-purity propane in a gaseous phase are adsorbed by means of a zeolite molecular sieve that preferentially adsorbs water and carbon dioxide over propane, an activated carbon molecular sieve that preferentially adsorbs ethane and propylene over propane, and activated carbon that preferentially adsorbs isobutane and normal butane over propane. Propane is condensed in a state in which nitrogen and oxygen are maintained in a gaseous state by introducing the low-purity propane in a gaseous phase into a partial condenser. Nitrogen and oxygen in the gaseous phase are extracted from the partial condenser.
US09556088B2 Adsorbent catalytic nanoparticles and methods of using the same
The present invention provides an adsorbent catalytic nanoparticle including a mesoporous silica nanoparticle having at least one adsorbent functional group bound thereto. The adsorbent catalytic nanoparticle also includes at least one catalytic material. In various embodiments, the present invention provides methods of using and making the adsorbent catalytic nanoparticles. In some examples, the adsorbent catalytic nanoparticles can be used to selectively remove fatty acids from feedstocks for biodiesel, and to hydrotreat the separated fatty acids.
US09556087B2 Methyl-substituted biphenyl compounds, their production and their use in the manufacture of plasticizers
In a process for producing methyl-substituted biphenyl compounds, a feed comprising at least one aromatic hydrocarbon selected from the group consisting of toluene, xylene and mixtures thereof is contacted with hydrogen in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluenes and/or (dimethylcyclohexyl)xylenes together with dialkylated C21+ compounds. At least part of the dialkylated C21+ compounds is then removed from the hydroalkylation reaction product to produce a dehydrogenation feed; and at least part of the dehydrogenation feed is dehydrogenated in the presence of a dehydrogenation catalyst under conditions effective to produce a dehydrogenation reaction product comprising a mixture of methyl-substituted biphenyl compounds.
US09556083B2 Processes for the reduction of alkylation catalyst deactivation utilizing low silica to alumina ratio catalyst
Alkylation systems and methods of minimizing alkylation catalyst regeneration are described herein. The alkylation systems generally include a preliminary alkylation system adapted to receive an input stream including an alkyl aromatic hydrocarbon and contact the input stream with a preliminary alkylation catalyst disposed therein to form a first output stream. The preliminary alkylation catalyst generally includes a zeolite catalyst having a SiO2/Al2O3 ratio of less than about 25. The alkylation systems further include a first alkylation system adapted to receive the first output stream and contact the first output stream with a first alkylation catalyst disposed therein and an alkylating agent to form a second output stream.
US09556081B2 Device and method for the production of radiochemical compounds
The invention relates to a method for the preparation of radiochemical compounds using a device having at least a reaction module, a dosing module, and a storage module, wherein the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module. Substances needed for the preparation of the respective radiochemical compound are introduced into the reaction vessel of the reaction module by means of dosing units, wherein the dosing units can be moved via a pipetting head in x, y directions or in x, y, and z directions.
US09556080B2 Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts
The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates, said system consisting essentially of a mixture of (a) at least one organodisilane and (b) at least alkoxide base, preferably a potassium alkoxide base, and said methods comprising contacting a quantity of the organic substrate with a mixture consisting essentially of (a) at least one organodisilane and (b) at least one alkoxide base, preferably a potassium alkoxide, under conditions sufficient to silylate the heteroaromatic substrate.
US09556079B2 Catalyst and process using the catalyst
A new chromium-containing fluorination catalyst is described. The catalyst comprises an amount of zinc that promotes activity. The zinc is contained in aggregates which have a size across their largest dimension of up to 1 micron. The aggregates are distributed throughout at least the surface region of the catalyst and greater than 40 weight % of the aggregates contain a concentration of zinc that is within ±1 weight % of the modal concentration of zinc in those aggregates.
US09556077B2 Removal of urea and ammonia from exhaust gases
The invention relates to a method for recovery of urea dust and ammonia from a gas stream by contacting said gas stream with an aqueous sulphuric acid solution, thus forming an acid solution of ammonium sulphate and urea, characterized in that the acid solution is concentrated to a melt comprising less than 5 wt % of water, which melt is subsequently transferred into solid particles comprising urea and ammonium sulphate.
US09556073B2 Process for sintering silicon carbide
A process for sintering silicon carbide is provided which includes the steps of providing a silicon carbide powder of silicon carbide granules; purifying the silicon carbide powder; subjecting the purified silicon carbide powder to a gel-casting process; removing the gel-cast part from the mold; drying the gel-cast part; obtaining a dried cast ceramic part (a green body) which is capable of green machining into a final desired shape; firing the green body in an oven at temperatures ranging from about 100° C. to about 1900° C. to remove or burn out any polymer remaining in the ceramic; and sintering the green body at temperatures ranging from about 1600° C. to less than about 2200° C.
US09556055B2 Method for reducing glass-ceramic surface adhesion, and pre-form for the same
Provided herein is a method for producing glass-ceramic sheets. The method includes texturing at least one surface of a first glass sheet, and stacking the first glass sheet and a second glass sheet. The first glass sheet and the second glass sheet are stacked so that the textured surface of the first glass sheet contacts a surface of the second glass sheet. The first and second glass sheets are cerammed. After cooling, the cerammed first and second glass sheets are separated. Also provided is a pre-form for producing glass-ceramic sheets. The pre-form includes a first glass sheet having a textured surface, and a second glass sheet contacting the first glass sheet. The textured surface of the first glass sheet is in contact with a surface of the second glass sheet.
US09556052B2 Laminate fusion draw apparatus and method of use thereof
A laminate fusion draw apparatus including: a core isopipe having a first core melter; a clad isopipe having a clad melter; a first core down comer between the core melter and the core isopipe; and a second clad down comer between the clad melter and the clad isopipe, the second clad down comer having an independently adjustable linear and horizontal position with respect to a fixed horizontal position of the first down comer, and the core melter and the clad melter are linearly moveable for relative movement in the same or opposite horizontal direction, as described herein. Also disclosed is a method of using the apparatus where the first core down comer remains substantially centered or concentric on the first inlet tube, and the second clad down comer remains substantially centered or concentric on the second inlet tube.
US09556050B2 Process for cullet beneficiation
A process for cullet beneficiation by precipitation. A mass of cullet is melted to form a body of molten glass having a heavy metal con ration of greater than 100 ppm. A precipitate agent is introduced into the body of molten glass to form a heavy metal-containing precipitate phase and a liquid beneficiated glass phase within the body of molten glass. The precipitate phase may have a density greater than that of the liquid beneficiated glass phase. Thereafter, the liquid beneficiated glass phase is physically separated from the precipitate phase. The separated liquid beneficiated glass phase has a reduced concentration of heavy metals, as compared to the concentration of heavy metals in the body of molten glass.
US09556048B1 Chain filter system of micro wetland cells and method of forming same
A chain filter system established generally across a slope such as an agricultural field, residential area, reclamation site, industrial area, or municipal park, etc. The system comprises a series of basins oriented such that their upstream borders are aligned to capture variously directed stormwater runoff from the drainage area. Along each basin border opposite to the upstream border is extended a generally continuous berm to direct and contain stormwater movement, so as to avoid loss of runoff from and around the basins. The berm may include gates or scuppers for controlled release of captured stormwater runoff. This chain filter system serves to capture runoff for purposes of reducing pollution movement into state waters, flood control, creating wildlife habitats, enhancing aquifer levels in rural and urban settings, and avoiding downstream pollution.
US09556046B2 Membrane supported biofilm apparatus
A membrane supported biofilm apparatus has a plurality of hollow fiber gas permeable membranes in a tank containing water to be treated. A biofilm supported on the membranes occupies between about 40% and 80% of the volume of water to be treated in a reactor. Wastewater treatment processes are described. A process to denitrify water or treat oxidized contaminants comprises introducing hydrogen into an inner volume of the membranes to grow autotrophic organisms in the biofilm near the membrane and heterotrophic organism near the water. Another process is operated as a biomass concentration of at least 10 g/L and up to about 40 g/L to maintain a biofilm having a surface area of over 1000 square meters per cubic meter of tank volume. A hybrid process has suspended biomass and a membrane supported biofilm.
US09556041B2 Selective scaling in desalination water treatment systems and associated methods
Selective scaling in water treatment systems in which desalination is performed is generally described. According to certain embodiments, the location of the formation of solid scale within a water treatment system is controlled by adjusting one or more system parameters, such as the temperature and/or flow velocity of a saline stream within the water treatment system.
US09556038B2 Wastewater treatment system and methods
A system is disclosed for the treatment of wastewater as to reduce the biological oxygen demand, total nitrogen, total suspended solids, and phosphorous, as well as the reduction of liquid water discharged. A wastewater inlet allows the wastewater to enter a first vessel where wastewater is separated based on density. The wastewater is then transferred to a second vessel attached with a pump that sprays the water onto a media. Various other embodiments are also disclosed.
US09556037B2 Process for producing fluorine-containing combined salt
Disclosed is a process for producing a fluorine-containing complex salt, characterized by that, on a reaction mother liquor containing a plurality of cation species and a fluoroanion in a state that they have been dissolved in a solvent, a trigger for accelerating decomposition of the fluoroanion is allowed to act, thereby precipitating a complex salt containing a plurality of cation species and fluorine, as a solid, from the reaction mother liquor. According to this process, it is possible to produce a monodispersed fluorine-containing complex salt with uniform particle size and shape.
US09556034B2 System for producing graphene in a magnetic field
An improved system for generating graphene involves a liquid reaction chamber configured to receive a working liquid source, a carbon atom source, and a catalyst to cause a chemical reaction in the reaction chamber and a resulting reactant liquid comprising ring structures having starved carbon atoms. The ring structures are provided to a graphene generation chamber having a magnetic structure that includes a two-dimensional array of alternating polarity magnetic sources that produce a magnetic field having a gradient sufficient to float graphene over the magnetic structure. The graphene generation chamber generates graphene from said ring structures over the magnetic structure such that the graphene floats over the magnetic structure due to said graphene being diamagnetic. The rate at which the ring structures are produced is controlled to control the rate of graphene generation. The magnetic field of the magnetic structure can be controlled to control the rate at which the generated graphene moves through the graphene generation chamber until it exits as a recovered graphene product.
US09556033B2 Expanded graphite sheet and method of manufacturing same
An expanded graphite sheet is provided that can remarkably improve the quality and yield rate by preventing chipping and cracks in the surface in molding the sheet into a desired shape by inhibiting degradation in the flexibility while reducing the ash content to a certain degree. An expanded graphite sheet (3) has a flexibility of 25 times or greater, as determined in a flexibility test in which the flexibility is defined as the number of times the expanded graphite sheet (3) can be bent using a flexibility testing device having a rotator (2) to which one end of a plate-shaped expanded graphite sheet (3) is fixed, a weight (7) fixed to the other end of the expanded graphite sheet (3), and a bending position determining member (5) for determining a bending position of the expanded graphite sheet (3) when the rotator (2) is rotated.
US09556029B2 Liquid oxygen production device and method
A method for controlling an oxygen liquefaction device includes measuring a flow rate from an oxygen concentration subsystem to a liquefaction subsystem, comparing the flow rate to a flow rate setpoint, and adjusting a cycle timing of the oxygen concentration subsystem in accordance with the comparing. A device for producing liquid oxygen, includes an oxygen concentrator, a liquefaction system, that receives oxygen enriched gas from the concentrator, and condenses it to produce a liquid product. The device further includes a liquid product storage tank, a sensor, that measures a flow rate from the oxygen concentrator to the liquefaction system and a controller that adjusts an oxygen concentrating cycle time in response to the measured flow rate.
US09556028B2 Method and arrangement for generating oxygen
The present invention relates to a method of generating oxygen. The method addresses the objects of reducing the servicing work and improving the purity of the generated oxygen. According to the invention, the method comprises the steps of: providing an oxygen comprising gas at a primary side of a dense voltage drivable membrane (12); applying a voltage between a conductive element at the primary side of the membrane (12) and a conductive element at a secondary side of the membrane (12), the conductive elements being electrically connected to the membrane (12), wherein a plasma (18, 20) is generated at at least one of the primary side and the secondary side of the membrane (12), the plasma (18, 20) being used as conductive element.
US09556027B2 Method and system for producing hydrogen using an oxygen transport membrane based reforming system with secondary reforming
A method and system for producing hydrogen using an oxygen transport membrane based reforming system is disclosed that carries out a primary reforming process within a reforming reactor, and a secondary reforming process within a reactively driven and catalyst containing oxygen transport membrane reactor with or without an auxiliary source of heat to support primary reforming process within the reforming reactor to first form a synthesis gas product. The auxiliary source of heat is disposed within the oxygen transport membrane based reforming system proximate to the reforming reactors and comprises an auxiliary oxygen transport membrane reactor or a ceramic burner. The synthesis gas product is further treated in a separate high temperature water gas shift reactor and optionally in a separate low temperature water gas shift reactor. Hydrogen is produced from the resulting hydrogen-enriched gas using hydrogen PSA.
US09556025B2 Catalyst-containing reactor system with helically wound tubular assemblies
In accordance with one or more embodiments, a tubular catalyst-containing reactor system is provided. The system includes a housing and a vaporizer unit in the housing comprising a helically wound tubular assembly for receiving and at least partially vaporizing a liquid chemical reactant stream. A reformer unit in the housing receives a vaporized chemical reactant stream from the vaporizer unit. The reformer unit comprises a helically wound tubular assembly connected to and positioned coaxially relative to the helically wound tubular assembly of the vaporizer unit. The helically wound tubular assembly of the reformer unit contains a catalyst for catalyzing formation of gas product stream from the vaporized chemical reactant stream. A burner unit heats the vaporizer unit and the reformer unit. The burner unit receives a fuel stream and an air stream and produces a flame generally inside the helically wound tubular assemblies of the vaporizer unit and the reformer unit.
US09556023B2 Porous composite metal oxide, catalyst using the same, and methods for producing the porous composite metal oxide and the catalyst
A porous composite metal oxide, including a mixture of first ultrafine particles containing alumina and second ultrafine particles containing zirconia, wherein the first ultrafine particles and the second ultrafine particles are uniformly dispersed in such a way as to satisfy a condition that standard deviations of content ratios (% by mass) of all metal elements contained in the porous composite metal oxide at 0.1% by mass or more are each 10 or less, the standard deviations being obtained by measuring content ratios of the metal elements at 100 measurement points within a minute analysis region of 20 nm square by energy dispersive X-ray spectroscopy using a scanning transmission electron microscope equipped with a spherical aberration correction function.
US09556021B2 Method of manufacturing a MEMS structure and use of the method
A method creates MEMS structures by selectively etching a silicon wafer that is patterned by using a masking layer. The method comprises depositing and patterning a first mask on a silicon wafer to define desired first areas on the wafer to be etched. First trenches are etched on parts of the wafer not covered by the first mask. The first trenches are filled with a deposit layer. A part of the deposit layer is removed on desired second areas to be etched and a remainder is left on areas to function as a second mask to define final structures. Parts of the wafer on the desired second areas is etched, and the second mask is removed. A gyroscope or accelerator can be manufactured by dimensioning the structures.
US09556014B2 Seat support device for a riding animal or a pack animal
A seat support device for a riding animal or a pack animal, a saddle tree, and a saddle with such a saddle tree are disclosed. The seat support device comprises a right multi-linked lug arrangement with a first link section and at least a second link section and a left multi-linked lug arrangement with a first link section and at least a second link section. A pivoting device with a pivot axis is each formed case between two adjacent link sections, so that two adjacent link sections are pivotable towards one other around a pivot axis substantially within a pivot plane which penetrates the pivot axis substantially perpendicular.
US09556011B2 Apparatuses and methods for a refrigerator having liquid conditioning and enhancement components for enhanced beverage dispensing
Apparatuses and methods for conditioning a liquid stream with a liquid dispensing system associated with a refrigerator, preparing an enhanced beverage using one or more of the individually conditioned liquid streams and a liquid enhancement device and minimizing the potential for back contamination of the liquid dispensing system are provided.
US09556007B2 System for rearranging the counterweight of a crane operation
A system (19; 19, 35) for reducing an amount of a counterweight for a crane comprises a crane (2) having a founding structure (3) being disposed on a base (20), a coupling unit (4), and a superstructure (5) being coupled to the founding structure (3) via the coupling unit (4). The system (19; 19, 35) further comprises a suspension device (21; 21, 36) for suspending the crane (2) at the base (20), said suspension device (21; 21, 36) having a guiding structure (22; 22, 37) defining a guiding direction (23; 23, 38), said guiding structure (22; 22, 37) being attached to the base (20), a displacement device (24) being displaceably attached to the guiding structure (22; 22, 37) along the guiding direction (23; 23, 38), and at least one suspension element (29) being connected with a first end to the crane (2) and being connected with a second end to the displacement device (24).
US09556006B2 Method for controlling the orientation of a crane load and a boom crane
The present disclosure relates to a method for controlling the orientation of a crane load, wherein a manipulator for manipulating the load is connected by a rotator unit to a hook suspended on ropes and the skew angle ηL of the load is controlled by a control unit of the crane, characterized in that the control unit is an adaptive control unit wherein an estimated system state of the crane system is determined by use of a nonlinear model describing the skew dynamics during operation.
US09556005B2 Self-clamping handrail drive
A self-clamping handrail device includes a belt-handrail compound comprising a first belt, a second belt coupled to the first belt, and a handrail coupled to the second belt, a counter bar and a clamping frame configured to support the belt-handrail compound as the belt-handrail compound passes between the counter bar and the clamping frame, the clamping frame configured to move about a clamping curve based on a tension force applied to the handrail, and the first belt and the second belt applying a normal force to the handrail based at least in part on the tension force.
US09556004B2 Apparatus, system, and method for controlling a handrail of an escalator
A handrail drive inverter for an escalator can include a memory configured to store instructions, a processor coupled to the memory, an input configured to receive a main speed control signal that corresponds to the speed of a main drive motor of the escalator, and an output configured to provide a handrail speed control signal for a handrail drive motor based on the instructions in the memory. The processor is configured to calculate a torque output of the handrail drive motor and determine the handrail speed control signal as a function of the torque output and a feedback of the handrail speed control signal constrained by at least one of an upper limit and a lower limit, the upper limit and the lower limit being determined from the main speed control signal.
US09556001B2 Allocation of calls in a lift installation
A method of allocating calls of a lift installation with at least one lift and at least one car per lift to move passengers in a journey from at least one input floor to at least one destination floor, a system for executing the method and a computer readable memory with instructions for executing the method. The method includes receiving input calls from passengers travelling from an input floor to a destination floor, each call identifying at least one floor as an input floor or a destination floor. A start zone with identified input floors and a destination zone with identified destination floors are determined from the input calls and destination calls. Each identified floor within a corresponding zone is considered using at least one selection criterion and a stopping floor is selected which satisfies the criterion. The car is caused to stop at fewer than all the identified input floors and identified destination floors during the journey.
US09555999B2 Cable spool assembly
A spool assembly includes a drum having a first axial end and an oppositely disposed second axial end. The drum includes an inner surface that defines a bore that extends through the first and second axial ends. A drum support is disposed in the bore of the drum. The drum support includes a first end and an oppositely disposed second end. The drum support has an exterior surface. The exterior surface of the drum support and the inner surface of the drum define a plurality of channels. A first flange is engaged to the first end of the drum support. A second flange is engaged to the second end of the drum support.
US09555998B2 Sheet processing device, image forming system, and sheet processing method
A sheet processing device includes: a folder that forms a plurality of folds on a sheet such that a fold part and a part with no fold of the sheet overlap with each other; a conveyance unit that conveys the sheen on which the folds are formed by the folder; and a pressing part that presses the fold part of the conveyed sheet in which the fold part and the part with no fold overlap with each other, from a side on which the fold part is located.
US09555995B2 Sheet material take-in apparatus, sheet material conveying apparatus, image reading apparatus, and image forming apparatus
User labor relating to determining on an alignment condition is reduced and a stable conveying operation is realized by aligning a sheet bundle also when a sheet bundle is added. A sheet bundle composed of multiple sheet materials is placed on a loading platform. An encoder pulse unit detects the amount of the sheet bundle placed on the loading platform based on the opening amount of a pressure plate. A control unit determines on an alignment condition according to the amount of the sheet bundle. Rotating members align the sheet bundle in accordance with the alignment condition. When it is determined that another sheet bundle has been added to the loading platform, the control unit updates the alignment condition according to the total amount of the other sheet bundle and the sheet bundle remaining on the loading platform.
US09555992B2 Sheet transport device and image forming apparatus
A sheet transport device includes a transport path along which a sheet is transported in one direction; a sheet butting portion against which a side edge of the sheet on the transport path is butted, the sheet butting portion being provided at one side of the transport path; a butting section that moves the sheet toward the one side to butt the side edge against the sheet butting portion; and a sheet rotating section located on the upstream side of the butting section in a sheet transport direction, the sheet rotating section having two sheet transport parts provided so as to be shifted from each other in a direction intersecting the one direction, at least one of the sheet transport parts being configured to have a variable sheet transport speed, the sheet rotating section rotating the sheet by utilizing a difference in transport speed between the two sheet transport parts.
US09555987B2 Sheet conveyer and image reading apparatus
A sheet conveyer including a sheet support, a pickup roller, a separator roller, a holder, a guide, an urging member, and a contact section is provided. The holder is swingable and supports the pickup roller rotatably. The guide is attached to the holder and movable to swing relatively to the holder along with a swing movement of the holder. Urging force from the urging member acts on the guide to move toward a first position with respect to the holder. The contact section contacts a contacting part in the guide to restrict, the contacting part from being moved along with the swing movement of the holder. The guide is movable relatively to the holder from a position closer to the first position toward a position closer to a second position against the urging force from the urging member and allows the holder to further move toward the uppermost position.
US09555985B2 Sheet conveyance device, image processing apparatus, sheet conveyance method
A sheet conveyance device includes a sheet placing portion, a guide member, a signal obtaining portion, and a notification portion. On the sheet placing portion, a sheet to be conveyed is placed. The guide member is disposed on the sheet placing portion so as to move in a width direction vertical to a sheet conveyance direction, and restricts, in the width direction, a position of the sheet on the sheet placing portion. The signal obtaining portion obtains an electric signal with a value corresponding to a position of the guide member. The notification portion, when a difference between the value and any of thresholds that are set in advance based on each sheet size in the width direction for determination of the size of the sheet, is equal to or smaller than a predetermined reference value, notifies that the sheet is separated from the guide member.
US09555983B2 Sheet transport apparatus and image recording apparatus
A sheet transport apparatus includes a first casing in which a transport path is formed; a transport unit which transports a sheet along the transport path; a second casing which is provided to be movable with respect to the first casing; a sheet support unit which is rotatably provided in the first casing at a position on a side to which the second casing is moved, the sheet support unit being changeable between a first state, a second state, and a third state and supporting the sheet at least in the third state; and an urging unit which urges the sheet support unit toward the first state within a range from the first state to the second state and which urges the sheet support unit toward the third state within a range from the second state to the third state.
US09555981B2 Apparatus and method for dispensing vehicle balancing weights
An apparatus and a method for dispensing vehicle balancing weights are disclosed. The dispenser comprises a transport unit arranged below a cartridge for storing balancing weights. The transport unit moves a balancing weight from a selected section of the cartridge on a belt conveyor for further transporting the balancing weight to a handling device. The transport unit comprises a feeder, and a plurality of stack lifters for lifting a stack of balancing weights and allowing the feeder to push a selected balancing weight under the stack of other balancing weights towards the belt conveyor.
US09555978B1 Semi-automated inventory transfer station
An inventory transfer station is provided in connection with a workspace of an inventory management system. At the inventory transfer station, items are transferred from container holders to empty containers thereby generating containers that may fulfill orders for items. The inventory transfer station may be semi-automatically configured to transfer items from the container holders to the empty containers utilizing a vertical reciprocating conveyor that feeds empty containers to the inventory transfer station via an inbound conveyor lane associated with the inventory management system. Containers that have received items from the container holder may be transferred to an outbound conveyor lane that may, via the vertical reciprocating conveyor, feed fulfilled containers to a shipping area of the workspace.
US09555976B2 Bearing stand-off devices
Various embodiments of stand-off devices and methods are disclosed. The stand-off device can space a bearing assembly apart from a support, such as a frame of a conveyor belt, thereby providing access between the bearing assembly and the frame, such as for cleaning fluid. Certain embodiments of the stand-off device include a first end and a second end, with the first end being receivable in a securing hole of the bearing assembly and the second end configured to protrude from the bearing assembly.
US09555969B2 Endless fabric belt
A fabric belt for producing a corrugated cardboard web in a corrugated cardboard machine is joined together at the two ends thereof to produce an endless belt. An outer paper side facing the corrugated cardboard web and an inner load side assigned to the drive are formed. Connecting pieces to connect the belt ends have in each case at one end transversely with respect to the belt clips lying next to one another at a spacing, and are fixed at an opposite end with a connection section at the associated belt end. In the longitudinal direction of the belt, the clips of one connecting piece interact in a force-transmitting manner with the clips of the other connecting piece. The connection section of a connecting piece is held in a receiving gap of the belt that, starting from the belt end, extends between the paper side and the load side.
US09555964B2 Material handling system
A material handling system including a receptacle; a loading opening disposed within the receptacle; a transfer opening disposed within the receptacle in adjacent angled relation to the loading opening; and a first compaction plate rotatably coupled proximate the receptacle between the loading opening and the transfer opening. As to particular embodiments, the material handling system can further include a second compaction plate movably disposed proximate the transfer opening. Upon rotation of the first compaction plate toward the second compaction plate in an immovable condition, material disposed between the first and second compaction plates is compacted to generate compacted material. As to particular embodiments, the material handling system can further include a rotatable arm and a rotatable gripper rotatably coupled to a rotatable arm first end. As to particular embodiments, the rotatable arm can be rotatably coupled to an extendable arm which can reversibly extend laterally outward.
US09555955B2 Package assembly
A package assembly (10) includes a package (14) having a body defining a receptacle for receiving a confectionery product, an outer surface for displaying a non-verbal design, and a removable overwrap (12) disposed about the body of the package, wherein the overwrap (12) is substantially opaque and includes verbal product information.
US09555950B2 Fluid product dispensing device
A fluid dispenser device comprising: a reservoir (10) containing at least two doses of fluid; a dispenser member (20), such as a piston, that is mounted to slide in said reservoir (10) so as to dispense the fluid; a dispenser head (30) that is provided with a dispenser orifice (31), said head being movable relative to said reservoir (10) so as to move said actuator member (20) in said reservoir (10) and thus dispense the fluid through said dispenser orifice (31); said dispenser head (30) including at least two viewing windows (35, 36), said device including an indicator (40) that is movable together with said reservoir (10), said indicator (40) co-operating with a respective viewing window (35, 36) after each actuation of the device.
US09555947B2 Vented steam cooking package
A vented steam cooking package includes a container formed to include an interior region and a steam-venting system. The steam-venting system is formed in the package to vent steam from the interior region to atmosphere surrounding the package during heating.
US09555946B1 Sun reflective ice chest cover
A sun reflective ice chest cover that includes an open-bottomed reflective shell having a high albedo and emissivity, said reflective shell positional enclosing an existing ice chest wherein exposed surfaces of said ice chest are encloseable interior to said reflective shell and reflection of incident sunlight and radiation of heat away from said ice chest is thereby enabled, whereby the cooler interior is maintainable at lower temperatures for periods longer than temperatures maintained interior to said cooler when used absent said reflective shell.
US09555945B2 Wedge for immobilizing objects in a box having a square or rectangular cross-section
A wedge used to wedge objects in a box the wedge being a sheet made of a rigid, resistant and foldable material, including a central portion having a polygonal shape and size substantially equivalent to those of the bottom of the box, the sheet including at least one foldable flap, attached to the central portion via folding lines or hinges, wherein the central portion is provided with multiple grooves being segments of a curve or of a straight line, along which the material is crushed and the thickness thereof is reduced, the grooves constituting folding lines inside the central portion, which facilitate the deformation of the wedge, the grooves leading to the periphery or the proximity thereof of the central portion of the wedging sheet and they are not parallel to one another or to the sides of the central portion.
US09555943B2 Cable lacing tie devices and methods of using the same
Cable lacing tie devices and methods of using the same are disclosed. The cable lacing tie devices include a head assembly and a cable lacing tape. The head assembly being configured to retain a first portion of the cable lacing tape within the head assembly and having a length of the cable lacing tape extending from the head assembly. The head assembly further adapted to retain a second portion of the cable lacing tape extending from the head assembly. The methods of using the cable lacing tie devices to hold together a plurality of objects with a cable lacing tie device include retaining a first portion of a cable lacing tape in a head assembly, looping the cable lacing tape around the plurality of objects and retaining a second portion of the cable lacing tape within the head assembly.
US09555939B2 Bottle for upright and inverted use
A liquid dispensing container is provided having a cap assembly preventing dispensing of fluid therefrom prior to both an alignment of markers and a pivoting of a nozzle which helps prevent use by children lacking dexterity and knowledge for achieving concurrent positioning of the nozzle and markers. A tamper alarm prior to purchase is provided by a pillar and tab preventing dispensing until removed, which if removed, provide a visually discernable alarm to tampering with the container. The container is capable of inverted dispensing with upward projection of fluid by the pivoting nozzle engaged with a cap assembly.
US09555935B2 Closure device
A closure device for connecting two parts is provided. The closure device includes a connector, a housing which includes a connector receptacle, into which the connector can be inserted in a closing direction for closing the closure device, a slide shiftably arranged at the housing, which for opening the closure device is shiftable along an opening direction different from the closing direction, a detent spring element which in a closed position of the closure device latchingly holds the connector at the housing and for opening the closure device can be moved out of engagement with the connector by shifting the slide in the opening direction, in order to release the connector from the housing, so that in an open position of the closure device the connector is separated from the housing, and at least one guide element which guides the connector on insertion into the connector receptacle for closing the closure device along the closing direction into the closed position and supports the connector against tilting relative to the closing direction when the slide is shifted for opening the closure device.
US09555934B2 Screwed cover embodiment having apparatus of foil-cutting and folding to the inner part in the aseptic liquid cardboard packages
A cover embodiment is provided to be used especially in aseptic cardboard liquid packages and to provide ease of use and it provides the flowing mouth to open in a maximum level by creating a homogeneous structure on the liquid flowing mouth thanks to the items located inside and enabling the aluminum foil part left inside the cardboard to be compressed between the package and the cover embodiment.
US09555930B2 Handle assembly for plastic container
A system for carrying a container comprising a plastic handle with tabs for insertion into slots on the container configured so that the tabs may be inserted when the handle is not in an upright or resting position.
US09555922B2 Lid for containers of substances and container of substances thus equipped
A- lid (20) for a container (21) comprises: a central surface (27) having a substantially circular shape, on which a line of weakening (30) is made, which defines a closing element (39) which can be opened by pulling, made in the central surface (27); and a drive tab (22), having at least a first end (25) to act as a fulcrum outside the line of weakening (30) connected to the closing element (39) with a rivet (23) and able to be driven so as to remove upward, the closing element (39) from the remaining part of the central surface (27), detaching it along the line of weakening (30). The line of weakening (30) is interrupted at one end of the closing element (39) opposite to the drive tab (22), so that the closing element (39) has a connection flap (34) solid with the remaining part of the central surface (27). In the case of aluminum, the rivet is located at 1.5-3.5 mm from the front part of the closing element (39). In the case of ferrous allogs, this distance is 4.0-6.0 mm.
US09555915B2 Dispenser display having a plurality of independent dispensing bodies
A system for displaying and dispensing has a plurality of dispensers each having a hollow body formed with at least one wall of flexible material, and a dispensing opening through a wall of the body, the body providing a default internal volume, such that deforming the hollow body reduces the internal volume, increasing pressure within the internal volume, and a support structure to which the plurality of dispensers is joined, the support structure presenting the plurality of dispensers in a specific three-dimensional pattern.
US09555914B2 Label applicator having a heat idler
The use of a heat idler moveable along a path provides speed and flexibility in the heat labeling of containers.
US09555911B2 Process for handling or processing containers for medical or pharmaceutical applications and carrier and transport or packaging container thereof
A process for the treatment or processing of containers is provided. The process includes automatically conveying the containers past a processing station for the treatment or processing by or through a conveying device and then inserting the containers into a transport or packaging container having a bottom, a circumferential side wall and an insertion opening opposite to the bottom. In some embodiments, a plurality of containers are placed on a flat supporting base so that the bottoms of the containers directly rest on the flat supporting base; the containers, while resting on the flat supporting base, are conveyed to a processing station by the conveying device to be treated or processed; and after the treatment or processing of the containers, the transport or packaging container is placed on the flat supporting base so that all the containers of the plurality of containers are accommodated in the transport or packaging container.
US09555910B2 Apparatus with opposing housings for modified atmosphere packaging of products placed in trays
When the opposing housings (1, 8) of the apparatus are closed, they form between them a small main chamber (P) delimited above by the film (H) for covering the tray and below by the tray (V) itself containing the product (M), and laterally by any suitable mechanical interface structure which surrounds the perimeter of said film and connects it to the perimeter of the upper edge (B) of the tray, this interface structure having holes (22) which are suitably distributed, are located outside the perimeter of the tray, and communicate with said main chamber (P). One or more of these holes (22) open(s) on at least one side of the tray and is/are connected to a first circuit (23, 24), while another one or more of said holes (22′) open(s) on at least one opposing side of the tray and is/are connected to a second circuit (17) which in turn is connected to the inner chambers of the two housings (1, 8). Means (18, 19, 20) are provided to operate in such a way that, in the step of vacuum formation, both said first circuit (24) and said second circuit (17) are connected to vacuum forming means (21) which are kept active for a sufficient time to eliminate some of the air from the inside of the tray and to act in such a way that said first circuit (24) is connected in the next step or at the correct time to means (25) for supplying the process gases, while said second circuit (17) is closed or remains in communication with the vacuum means (21) to ensure that the process gas entering the tray from said first circuit (22, 24) causes the residual air in the tray to flow out from and/or towards said second circuit (22′, 17), thus flushing and saturating the inner volume of the tray, which is subsequently sealed using known steps and means for welding and finally cutting the film (H).
US09555905B2 System, apparatus, and method for active debris removal
Systems, apparatuses, and methods for removal of orbital debris are provided. In one embodiment, an apparatus includes a spacecraft control unit configured to guide and navigate the apparatus to a target. The apparatus also includes a dynamic object characterization unit configured to characterize movement, and a capture feature, of the target. The apparatus further includes a capture and release unit configured to capture a target and deorbit or release the target. The collection of these apparatuses is then employed as multiple, independent and individually operated vehicles launched from a single launch vehicle for the purpose of disposing of multiple debris objects.
US09555903B2 Method for diagnosing a bleed air system fault
A method of diagnosing a bleed air system fault, where the method includes receiving a sensor signal from the at least one of the bleed air system sensor to define a sensor output, comparing the sensor output to a reference value, and diagnosing a fault in the bleed air system based on the comparison.
US09555902B1 Fleet performance optimization tool enhancement
Methods and systems are provided for managing a system that includes at least one component. The one component is removed from the system. If it is determined that the one component was removed from the system for a reason that is not failure of the one component, then it is indicated that the one component is potentially serviceable.
US09555897B2 Rotary-wing drone provided with a video camera delivering stabilized sequences of images
The drone (10) comprises a camera with a hemispherical-field lens of the fisheye type pointing to a fixed direction (Δ) with respect to the drone body. A capture area (36) of reduced size is extracted from the image formed by this lens (42), the position of this area being function of the signals delivered by an inertial unit measuring the Euler angles characterizing the attitude of the drone with respect to an absolute terrestrial reference system. The position of this area is dynamically modified in a direction (44) opposite to that of the changes of attitude (38) of the drone detected by the inertial unit. The raw pixel data are then processed to compensate for the geometric distortions introduced by the fisheye lens in the image acquired in the region of the capture area.
US09555896B2 Aircraft flight control
The invention described herein provides a flight crew with an easier and more intuitive way to control and monitor flight-control surfaces. Specifically, the invention displays all flight-control surfaces on a touch-screen display device located in an aircraft cockpit. The invention includes graphical and numerical position indicators to continuously display actual position information for flight-control surfaces. Additionally, the invention allows a flight crew to make flight-control surface adjustments through the touch-screen device. The invention further includes an engine performance indicator and a mode controller configured to display autopilot modes and to receive autopilot mode selections. A method is presented for controlling an aircraft flight-control surface via a touch screen device. The method includes receiving an indication of a flight-control surface and enabling selection of a position change. Based on the position change selection, the method includes verifying a corresponding movement and displaying an actual position of the flight-control surface.
US09555895B2 Motor pylons for a kite and airborne power generation system using same
A motor pylon system adapted for use with an airborne power generations system is disclosed. The pylons may support turbine driven generators for wind based electrical power generation which also function as electric motors in some aspects. The pylons may be designed to provide side force useful for turning a tethered flying wing flying in a circular cross wind flight path. The pylons may be designed to minimize air flow disruptions over the main wing.
US09555889B2 Crew rest area on board of a vehicle, in particular an airplane
An area on board of a vehicle, in particular of an airplane. The area has a compartment and an opening providing access to the compartment. The area includes a curtain arranged to be drawn in a closed position in which the curtain covers the opening. The curtain includes at least one magnetic curtain element provided along a lower edge of the curtain, and the area includes at least one magnetic opening element positioned along a lower edge of the opening, which at least one magnetic opening element and at least one magnetic curtain element are arranged to attract each other when the curtain is in the closed position.
US09555888B2 Pressure compensating air curtain for air cushion supported cargo loading platform
The present disclosure includes cargo loading systems and components including cargo systems utilizing one or more air cushions to elevate one or more cargo shuttles. The air cushions are formed by one or more air curtains, which include pressure compensating seals. The seals allow the air curtains to contact and seal against a floor panel, reducing leakage from the air cushion.
US09555880B2 Flexbeam rotor
A rotor hub assembly for a helicopter includes a rotor hub operably connectable to a shaft of a helicopter. One or more flex beams extend through the rotor hub, with each end of each flex beam operably connectable to a rotor blade. One or more inner bearings are located at the rotor hub to spherically support the one or more flex beams in the rotor hub. A rotor assembly for a helicopter includes a rotor hub operably connectable to a shaft of a helicopter. One or more flex beams extending through the rotor hub and one or more inner bearings are located at the rotor hub to spherically support the one or more flex beams in the rotor hub. A plurality of rotor blades are operably connected to the ends of the one or more flex beams.
US09555877B2 Landing gear
A landing gear for an aircraft having a main fitting arranged to be coupled to the aircraft and arranged to move between a stowed condition and a deployed condition and a trailing arm movably coupled to the main fitting. A torsion spring is coupled to the trailing arm such that the movement of the trailing arm causes torsion loading of the torsion spring. A stay assembly is provided which comprises the torsion spring, the stay assembly having a first condition in which it is arranged to react axial loading thereof so as to maintain the main fitting in the deployed condition and a second condition in which it is arranged to permit the main fitting to move between the stowed condition and the deployed condition.
US09555873B1 Aerial vehicle with deployable components
An unmanned aerial vehicle with deployable components (UAVDC) is disclosed. The UAVDC may comprise a fuselage, at least one wing, and at least one control surface. In some embodiments, the UAVDC may further comprise a propulsion means and/or a modular payload. The UAVDC may be configured in a plurality of arrangements. For example, in a compact arrangement, the UAVDC may comprise the at least one wing stowed against the fuselage and the at least one control surface stowed against the fuselage. In a deployed arrangement, the UAVDC may comprise the at least one wing deployed from the fuselage and the least one control surface deployed from the fuselage. In an expanded arrangement, the UAVDC may comprise the at least one wing telescoped to increase a wingspan of the deployed arrangement.
US09555869B1 Systems and methods for setting engine speed in a marine propulsion device
A method for setting an engine speed of an internal combustion engine in a marine propulsion device of a marine propulsion system to an engine speed setpoint includes determining the engine speed setpoint based on an operator demand and predicting a position of a throttle valve that is needed to achieve the engine speed setpoint. The method also includes determining a feed forward signal that will move the throttle valve to the predicted position, and after moving the throttle valve to the predicted position, adjusting the engine speed with a feedback controller so as to obtain the engine speed setpoint. An operating state of the marine propulsion system is also determined. Depending on the operating state, the method may include determining limits on an authority of the feedback controller to adjust the engine speed and/or determining whether the operator demand should be modified prior to determining the engine speed setpoint.
US09555868B2 Boat propulsion device
In a boat propulsion device, a head portion of an engine includes plug holes, first attachment portions, and a second attachment portion. The plug holes are aligned vertically and parallel or substantially parallel to a crankshaft. The first attachment portions are arranged on the periphery of the plurality of plug holes. The first attachment portions are configured to attach a plurality of ignition coils which are respectively integrated with spark plugs in a coil-on-plug configuration. A second attachment portion is provided separately from the first attachment portions. The second attachment portion is configured to attach an ignition coil connected to the spark plugs in a double ended ignition coil configuration via cables.
US09555854B2 Vehicle operable by motor and by muscular energy
A vehicle is provided which is operable to motor power and/or pedal power, in particular an electric bicycle, which includes a crankshaft drive having a bottom bracket spindle, a chain ring, which outputs a drive torque for the vehicle to a chain, an electric drive, and a cone ring transmission for the continuous variation of a gear step ratio, the cone ring transmission and the electric drive being situated at the crankshaft drive, and the cone ring transmission being connected to the crankshaft drive and set up in such a way that a torque generated by the rider is transmitted to the chain ring.
US09555848B2 Ground sliding type flexible framing system
The embodiments disclose a ground sliding type flexible framing system, comprising a vehicle body transport system, welding systems, framing fixtures, a splicing system, a fixture storage system and a fixture switching system. The fixture storage system comprises a plurality of bidirectional sliding rails arranged in parallel, storage positions for storing framing fixtures are formed on the bidirectional sliding rails, and the fixture switching system comprises a left and a right sliding table transport rail which are led to two sides of the splicing system from two ends of the bidirectional sliding rails, fixture transport rails led to the left and the right sliding table transport rail from two sides of the splicing system, respectively, sliding tables capable of running on the left and the right sliding table transport rail and a transport mechanism capable of pulling the framing fixtures positioned on the bidirectional sliding rails and the fixture transport rails.
US09555840B2 Structural reinforcement system
Disclosed are various embodiments of a structural reinforcement system. The system reinforces hollow cavities within various products to increase the structural rigidity of the product. The system generally includes a rigid carrier, a bonding material, and an insert. The rigid carrier provides the primary structural reinforcement within the cavity, and also serves as a substrate to carry the bonding material. The insert is provided to increase the structural rigidity of the reinforcement system.
US09555838B2 Mixed material tunable rocker system
A number of variations may include a rocker system using tunable parts to satisfy a number of load cases. A number of variations may include a rocker system including a vehicle rocker and at least one reinforcement attached to a first side wall or a corner of the rocker.
US09555836B2 Vehicle side structure
In a vehicle, a gusset is provided at a lower end portion of a front pillar, a body wall portion of the gusset is joined to the front pillar, and a bottom wall portion of the gusset is joined to an upper wall portion of a rocker outer reinforcement. Thus, when the front pillar is about to collapse rearward, the upper wall portion supports the bottom wall portion of the gusset from below the vehicle. Therefore, the front pillar is restrained from collapsing. Besides, the rocker outer reinforcement receives, on a surface thereof, a load input from the gusset. Therefore, the load input to the rocker outer reinforcement is dispersed, so the load can be restrained from concentrating.
US09555834B2 Motor vehicle body designed for a collision with small overlap
A motor vehicle body includes a longitudinal beam, a bumper cross member, which is fixed to one end of the longitudinal beam, wherein an end section of the bumper cross member protrudes over the longitudinal beam in the transverse direction, and a cantilever beam, which protrudes into a space between a wheel mount and the bumper cross member. The cantilever beam and the end section of the bumper cross member are disposed so as to cooperate with each other such that, during a frontal collision, in particular during a frontal collision with small overlap, the end section of the bumper cross member deformed by the frontal collision impacts an end face of the cantilever beam and can be supported at this end face so that further deformation of the end section of the bumper cross member is prevented.
US09555831B1 Tractor-trailer with convertible steering arrangement
A tractor-trailer for hauling a load is provided which is convertible from a conventional steering arrangement to a stinger steering arrangement to maneuver relatively long loads around tighter corners, roundabouts and other obstacles. The tractor-trailer includes a rear wheel assembly with a telescoping reach and a towing tractor including a chassis and a stinger to selectively attach to the telescoping reach of the rear wheel assembly. The stinger is movably coupled to the chassis to move between a stowed configuration for conventional steering and a deployed configuration for stinger steering.
US09555827B2 Motor and electric power steering apparatus including the same
The present invention relates to an electric motor and an electric power steering apparatus including the same. According to an embodiment of the present invention, problems such as a malfunction of an electric motor, damage to a component of the electric motor, and lowering of an output of the electric motor can be solved by preventing penetration of foreign substances into the electric motor, so that a steering stability of a vehicle can be improved.
US09555824B2 Method and arrangement for an electrical steering system
A method for assisting a driver of a vehicle during operation by providing the driver with a desired steering feel, involves detecting a first steering angle for an output shaft, which first steering angle indicates the position of ground engaging members; detecting a second steering angle for an input shaft, which second steering angle indicates the position of a steering device; comparing the first and second steering angles and determining a current state of a steering arrangement; and controlling a first actuator connected to the output shaft and a second actuator connected to the input shaft in response to the detected first and second steering angles, in order to achieve a desired state of the steering arrangement; and applying a torque to the steering device proportional to the angular difference between the output shaft and the input shaft using a resilient portion in an interconnection. An arrangement is also disclosed.
US09555822B2 Electric trolley
A transport device has a carriage and at least three wheels mounted at a minimum of two axles. One of the axles is a driven axle which carries only a single, centrally mounted, electrically driven wheel. A support unit is configured to accommodate an elongated load, such as a golf bag. A guide component on a control side has a handle area. When the cart is in the operational position, the drive axle at the carriage is on hand at the control side, and the support unit substantially protrudes in the direction of the control side laterally across the drive axle.
US09555814B2 Unexpected thermal event assist
A vehicle system may include a thermal sensor; and a vehicle connectivity module in communication with the thermal sensor and a plurality of vehicle systems configured to receive an indication, from the thermal sensor, indicative of detection of a thermal event external to the vehicle, and responsive to the detection, utilize at least one of the plurality vehicle systems to perform at least one assistance feature to provide notification of the thermal event. A computer-implemented method may include activating a vehicle connectivity module responsive to detection of a thermal event external to the vehicle by a vehicle thermal sensor, confirming, by the vehicle connectivity module, the detection of the thermal event by utilizing other thermal sensor inputs of the vehicle, and responsive to the confirmation, commanding a vehicle system to perform at least one assistance feature to provide notification of the thermal event to a user.
US09555810B2 Transmission control device of motorcycle
A motorcycle's transmission control device is provided in which, in a case of a clutchless shift operation, disengagement of a fit of gears of a transmission and the fit of subsequent gears thereof can be smoothly achieved. A throttle operation unit controls the degree of opening of a throttle valve to become a first throttle opening-degree when a clutchless shifting unit determines that a clutchless down-shift operation can be implemented, and controls the degree of opening of the throttle valve to become a second throttle opening-degree when the clutchless shifting unit determines that a fit between shift gears is disengaged by the clutchless down-shift operation.
US09555807B2 Automated vehicle parameter modification based on operator override
A system for automated operation of a host-vehicle includes a controller configured to operate the host-vehicle during automated operation of the host-vehicle. The controller is configured to do so in accordance with a parameter stored in the controller. The controller is also configured to determine when an operator of the host-vehicle uses a vehicle-control-input to override the controller and thereby operate the host-vehicle in a manner different from that which is in accordance with the parameter. The controller is also configured to modify the parameter in accordance with the manner of the operator.
US09555805B2 Method for freeing a vehicle by rocking when the vehicle got stuck
A method of releasing a stuck vehicle, in which a stuck situation is recognized and a rocking-free process is initiated and continued until the rocking-free process is suppressed. The rocking-free process is suppressed either after the activation of a parking brake of the vehicle, which was inactive at the beginning of and during the rocking-free process, for a predetermined time interval, or after the registration of a limit value of a deflection of a drive pedal of the vehicle and after the limit value of the deflection of the drive pedal is maintained or exceeded for a predetermined time interval, or after a vehicle speed falls to almost zero km/h, a minimum actuation of a drive pedal of the vehicle is registered, the vehicle speed is maintained for a predetermined time interval and the minimum actuation is maintained for the predetermined time interval.
US09555801B2 Active steering safety system
The present teachings provide for an active steering system for controlling a vehicle. The system can include at least one sensor and a control module. The at least one sensor can be configured to detect a leading obstacle. The control module can be configured to receive a signal from the at least one sensor, to determine a steering profile, and to execute a lane change maneuver based on the steering profile. The steering profile can include a plurality of steering angles and corresponding vehicle positions for maneuvering the vehicle from a current lane to an adjacent lane. The steering angles can be calculated to not increase the acceleration of the vehicle above an occupant comfort threshold value and to not cause the vehicle to cross an outer boundary of the adjacent lane.
US09555798B2 Drive apparatus for vehicle
A drive apparatus for a vehicle includes an engine, an MG, a first rotary shaft, a second rotary shaft, a transmission disposed between the first rotating shaft and the second rotary shaft, a driving wheel, a first clutch capable of interrupting power transmission between the engine and the first rotary shaft, a second clutch capable of interrupting power transmission between the MG and the first rotary shaft, and an ECU for controlling the engine, the MG, the transmission, the first clutch and the second clutch. The ECU releases the second clutch as a rotation speed of the first rotary shaft becomes higher than a threshold value, and sets the threshold value lower in the case where an acceleration request is issued from the driver than in the case where no acceleration request is issued to reduce the operation times for the clutch to engage or disengage the MG.
US09555794B2 Drive control system for hybrid vehicle
A drive control system is for a hybrid vehicle. The drive control system includes a power split mechanism, a brake mechanism, a first motor, an output member, a second motor and an electronic control unit. The electronic control unit is configured to obtain a temperature of the power split mechanism based on a first time that is a duration of a motor driven state, allow the motor driven state when the obtained temperature obtained by the electronic control unit is lower than a predetermined upper limit temperature, and inhibit the motor driven state when the obtained temperature is higher than or equal to the upper limit temperature.
US09555786B2 Braking system for motor vehicles and method for the operation of a braking system
A motor vehicle braking system and method operable in a brake-by-wire mode and independently of the driver, with a master brake cylinder (2) operated by a brake pedal (1) having a piston (15, 16) and a pressure chamber (17, 18), connected with a brake circuit (I, II) and wheel brakes (8,9, 10, 11). An electrically controllable pressure supplying device (5) operates the wheel brakes; and a simulation device (3) with at least one elastic element (33), provides an acceptable brake pedal feel in the brake-by-wire mode. The simulation device (3) has a simulator chamber (29) connected, or is hydraulically connected, through a first hydraulic connection (54) to the pressure chamber (17) and which has an electrically actuated isolation valve (28) with a pressure means reservoir (4) under atmospheric pressure. A media separator device (47) is arranged in the connection (46) between the simulator chamber (29) and the isolation valve (28).
US09555785B2 Brake fluid pressure control unit
A brake fluid pressure control unit for a vehicle comprises: a hydraulic block that includes a housing containing an internal channel for a first system and an internal channel for a second system, which individually allow communication with a wheel cylinder for a first wheel and a wheel cylinder for a second wheel respectively, and also containing a detected hydraulic pressure inlet hole leading to a pressure receiving part of a pressure sensor. A first hole included in the internal channel for the first system and a second hole included in the internal channel for the second system can selectively be connected to the detected hydraulic pressure inlet hole by machining such that the depth of either the first hole or the second hole is made greater than the other.
US09555784B2 Braking system and method for machine
A braking system for a machine includes a first valve assembly having a first electronically actuated proportional valve, and a second valve assembly having a second electronically actuated proportional valve. The braking system includes a first pressure sensor and a second pressure sensor disposed downstream of the first and second valve assemblies, respectively. The first and second pressure sensors are configured to determine a first pressure and a second pressure of a braking fluid from the first and second valve assembly. The braking system also includes a controller configured to receive a signal indicative of the first pressure and the second pressure of the braking fluid and compare the first pressure and the second pressure. The controller is configured to selectively actuate at least one of the first electronically actuated proportional valve and the second electronically actuated proportional valve to substantially equalize the first pressure and the second pressure.
US09555780B2 Method of controlling electronic parking brake of vehicle having dual clutch transmission
A method of controlling an electronic parking brake of a vehicle having a dual clutch transmission. The method includes: identifying a slope of an area in which the vehicle is located in order to determine whether the identified slope exceeds a predetermined slope value; determining whether both of two clutches are opened in a safe mode when the identified slope exceeds the predetermined slope value; determining whether the vehicle moves upward in a front direction when both of the two clutches are opened; and operating the electronic parking brake when the vehicle moves upward in the front direction. When the vehicle moves upward in the front direction on the inclined road, the electronic parking brake is automatically operated to prevent the vehicle from slipping in the rear direction. Therefore, the method can effectively improve the safety of the driver and vehicle even when the driver is inept in pedal operation.
US09555779B2 Electric parking brake device
Provided is an electric parking brake device in which a parking lever is driven by an electric actuator. The electric actuator includes: an electric motor which can be rotationally driven in a normal/reverse direction and of which an operation is controlled by a motor control unit in accordance with rotational loads; a converting mechanism which can convert a rotational movement into a linear movement and which can move the parking lever from a returning position to an operating position in accordance with normal rotation of the electric motor and which can move the parking lever from the operating position to the returning position in accordance with reverse rotation of the electric motor; and a load applying mechanism (a stopper, a friction material) which drives components of the converting mechanism and which applies predetermined rotational loads to the electric motor, in a state where the parking lever is moved from the operating position to the returning position in accordance with reverse rotation of the electric motor.
US09555776B2 Portable undercarriage washer for vehicles
A portable undercarriage washer for vehicles includes a spray manifold having a feed line with a proximal end and a distal end, a spray tube coupled with the distal end of the feed lines, and a plurality of spaced spray nozzles connected with spaced openings on the spray tube. A protective cover overlies the spray manifold and the spaced spray nozzles. The protective cover has a top surface, a bottom surface, a plurality of spaced openings extending between the top and bottom surfaces, and a recess formed in the bottom surface. The spacing between the spaced openings matches the spacing between the spaced spray nozzles. The protective cover has a height that is greater than or equal to the height of the spaced spray nozzles, and the protective cover has side walls that slope downwardly and outwardly between the top and bottom surfaces of the protective cover.
US09555774B2 Windscreen wiper device
A windscreen wiper device comprising a wiper blade with a spoiler at a side thereof facing away from the windscreen to be wiped, wherein the wiper device further includes a connecting device having a substantially U-shaped cross-section. Legs of the U-shaped cross-section are connected to the wiper blade on opposite sides thereof. An interior space is left open between the connecting device and the wiper blade for forming a water channel for transporting rain water therethrough.
US09555772B2 Embedded security system for environment-controlled transportation containers and method for detecting a security risk for environment-controlled transportation containers
An embedded security system for an environment-controlled trailer including a transportation refrigeration unit. The security system includes a plurality of sensors mounted to the trailer and a communication device embedded in the transportation refrigeration unit of the trailer, the communication device being configured to receive data from the plurality of sensors, and to send the received data to a controller being remote from the trailer. The controller is configured to monitor the security status of the trailer and to determine a security risk at the trailer based, at least in part, on the received data.
US09555771B2 Onboard device and vehicle anti-theft system
This onboard device measures the received power of radio waves transmitted from a base station while the engine is running and sets a near-out-of-range flag when the level of the received power has become equal to or lower than a near-out-of-range level, which indicates the possibility of going out of range. The onboard device permits a portable terminal device to obtain a new effective period for a key ID when the radio wave environment of a vehicle when the engine is stopped indicates that the vehicle is out of range, and the effective period of the key ID has expired and needs to be renewed, provided that the near-out-of-range flag has been set. Consequently, security can be enhanced during acquisition of update information for the key information with the portable terminal device.
US09555762B2 Airbag device for motor vehicle
An airbag device for motor vehicle, includes: an inflator arranged in an instrument panel in front of a front passenger seat and is capable of ejecting gas; a first airbag connected to the inflator at a base end side thereof and has a gas inflow hole through which gas can be flowed, the first airbag being for the front passenger seat; and a second airbag arranged on the first airbag at a side face portion close to a center in the vehicle width direction, the second airbag being adapted to communicate with the first airbag through first and second communication portions. The first communication portion is arranged proximal to the inflator than the second communication portion arranged proximal to the occupant side end. The first communication portion and the second airbag are communicated via a communication passageway, and the second communication portion and the second airbag are communicated directly.
US09555759B2 Knee protector structure for vehicle
A knee protector for a vehicle in which an upper bracket which generates a high reaction force to a knee input load and a lower bracket which generates a reaction force lower than the upper bracket are directly or indirectly attached, in a vertical position, to a vehicle body strength member. At least the upper bracket has a closed cross-section part on at least a part of the upper bracket. An inwardly protruding part which inwardly protrudes is formed in at least one surface of the closed cross-section part.
US09555755B2 Rear guard assembly
A rear guard assembly for mounting to a chassis of a motor vehicle. The rear guard assembly can comprise a rearward-facing guard plate and a pair of braces mounted to the rearward-facing guard plate. Each brace can comprise a collapsible shock absorber comprising a first end and a second end, wherein a longitudinal axis is aligned with the first end and the second end. Each brace can comprise a plurality of outwardly-deflecting portions between the first end and the second end, wherein a lateral axis traverses the outwardly-deflecting portions and is oriented perpendicular to the longitudinal axis, and wherein the outwardly-deflecting portions are symmetrical relative to the longitudinal axis and the lateral axis. A spacing block can be positioned intermediate the outwardly-deflecting portions and the rearward-facing guard plate. A support assembly can be connected to each brace and can include fixed arms and pivot arms.
US09555753B2 Vehicle mobile microgrid
The vehicle mobile microgrid is a vehicle on-board electrical grid dedicated to supplying all supplemental electrical needs for the vehicle utilizing recovered energy from internal combustion engine heat, vehicle motion and auxiliary electrical power generator, chemical and mechanical storage systems and electrical power from incident light energy. Unlike electrical grids that serve wide population areas, the vehicle on-board electrical grid is not meant to serve electrical demand beyond that utilized by the vehicle. This on-board electrical grid is therefore very small by comparison, and the term microgrid is meant to convey this comparative size. The microgrid utilizes a common-mode bidirectional microgrid to efficiently capture, store and distribute electrical power depending on the vehicle's demand for electrical power.
US09555751B1 Fuel-saving and energy-saving car controller
A fuel-saving and energy-saving car controller includes a power supercharge control box (51) electrically connected with a direct-current brushless motor (41) of a power supercharger (40). The power supercharge control box includes a communication module which reads data in the on-board diagnostics (8) and the car computer (7) so as to detect a rotation speed of the engine (20). Thus, the communication module transmits a signal to the single-chip control circuit (1) which drives the motor actuating circuit (42) which controls the direct-current brushless motor to regulate a rotation speed of the air inlet fan (44).
US09555746B2 Adaptable hitch system
A vehicle accessory hitch assembly for attaching an accessory to a vehicle. The vehicle may include a frame and a bed mounted to the frame. First and second base rails may be disposed on the bed and coupled to the frame of the vehicle, and the vehicle may include a vehicle trailer hitch with a receiver for accepting a shank. In one embodiment, the vehicle accessory hitch assembly may be mechanically connected to each of the first and second base rails and the vehicle trailer hitch such that the vehicle accessory hitch assembly is immovable or stationary relative to the first and second base rails and the vehicle trailer hitch. In another embodiment, the vehicle accessory hitch assembly may be adaptable to connect to differently-configured base rails and vehicle trailer hitch constructions, including different horizontal and vertical spacing between the base rails and the vehicle trailer hitch.
US09555743B2 Driver lift device
A driver lift device lifts a driver to enter an elevated cab on farm equipment or the like. The device includes an elongated post vertically mounted to a vehicle proximate an entry into a cab of the vehicle. Each of a top end and a bottom end of an elongated pole is coupled to the post such that the pole is positioned in parallel spaced relationship to the post. The pole extends through the tube wherein the tube is slidable along the pole. A foot support coupled to the tube. A winch is coupled to the top end of the pole and a cable is coupled to and extends between the winch and the tube such that operation of the winch elevates and lowers the foot support on the pole.
US09555741B2 Pivot mechanism for a vehicle external rear view mirror assembly
A pivot mechanism for a vehicle external rear view mirror assembly is disclosed. The mechanism includes: a base frame portion and a case frame portion mounted to the base frame portion for rotation about a pivot axis. A detent operable between the base frame portion and the case frame portion is provided. The detent has an engaged position and a disengaged position, the disengaged position allowing the rotation about the pivot axis. A spring mechanism clamps the case frame portion to the base frame portion and a first set of detent features to a second set of detent features. A support arm having an attachment end and a floating end is provided. An attachment end is fixed to, and is fixed against rotation with respect to the case frame portion, and the second set of detent features is fixed against rotation with respect to the base frame portion.
US09555740B1 Cross-validating sensors of an autonomous vehicle
Methods and systems are disclosed for cross-validating a second sensor with a first sensor. Cross-validating the second sensor may include obtaining sensor readings from the first sensor and comparing the sensor readings from the first sensor with sensor readings obtained from the second sensor. In particular, the comparison of the sensor readings may include comparing state information about a vehicle detected by the first sensor and the second sensor. In addition, comparing the sensor readings may include obtaining a first image from the first sensor, obtaining a second image from the second sensor, and then comparing various characteristics of the images. One characteristic that may be compared are object labels applied to the vehicle detected by the first and second sensor. The first and second sensors may be different types of sensors.
US09555737B1 Three-in-one stop/turn signal light
A stop light and turn signal lights which are incorporated into large vehicles such as a tractor trailer. A mating rear prong which is plugged into the electronics on the back of the vehicle which in turn is connected to the turn signal device usually on the steering wheel of the vehicle. The lights will first be lit on the first column of lights, then immediately the second column of lights, then immediately the third column of lights, then immediately the fourth column of lights and finally the fifth column of lights so that the device signals in a pattern from left to right that the vehicle is making a right turn or signals from right to left that the vehicle is making a left turn. When all lights are lit, it indicates a stop.
US09555736B2 Vehicle headlamp control using sensing and communication systems
A driver assistance system of a vehicle includes a forward viewing sensor disposed at the vehicle and having a field of sensing forward of the vehicle. A processor is operable to process data captured by the forward sensing sensor to determine the presence of another vehicle. A receiver is disposed at the subject vehicle and operable to receive a wireless communication of information pertaining to other vehicles or traffic participants in the vicinity of the subject vehicle. A control, responsive to determination via processing of captured data that another vehicle is present ahead of the subject vehicle, is operable to adjust a headlamp beam setting of the equipped vehicle, and the control, responsive to determination via received information that another traffic participant is present in the vicinity of the subject vehicle, is operable to adjust the headlamp beam setting of the subject vehicle.
US09555732B2 Bunk board cover system
Disclosed are hinged and non-hinged bunk board cover systems for mating over a bunk board component of a watercraft trailer. An exemplary hinged embodiment includes a main contact surface component sized to substantially cover a top surface of the bunk board component and a pair of side fastener surface components connected to the main contact surface component via a pair of hinge components. The main contact surface component, hinge components and side fastener surface components may be co-extruded into a single, “cut to length” ribbon that can be formed into a bulk roll. It is envisioned that certain embodiments may be constructed from thermoplastics, thermoplastic elastomers, or a combination thereof.
US09555731B2 Truck body with rapid load/unload cargo pods
One variation may include a truck body having one or more cargo pod lift systems around the perimeter of a truck's center aisle which may be lifted or lowered to load/unload one or more cargo pods and a method for doing the same.
US09555729B2 Car seat for protecting vertebral column
Disclosed is a car seat for protecting vertebral column, comprising: a backrest and a seat, wherein there is disposed with a troughed recess at a central portion of each of the backrest and the seat, so that when the backrest and the seat are subject to external impact, the impact damage incurred by the backrest and the seat onto a human vertebral column may be avoided, and in this way the human vertebral column can therefore be protected; in an embodiment of the present invention, there further comprises a plurality of viscous elastomers disposed inside the backrest and the seat, these viscous elastomers are set up in a corresponding arrangement on two sides of a human vertebral column, so as to assist in biasing the muscle on the two sides of the vertebral column to cause less direct impact by the external force, and to provide a cushioning effect.
US09555724B2 Vehicle seat
A favorable appearance can be achieved using a simple configuration, even when the configuration is provided with a back shell that moves up and down relative to a back frame. In a vehicle seat 10, the back of a seated person is adapted to be supported by a movable back shell 42 that is supported so as to be capable of moving in an up-down direction relative to a back frame 30. A non-movable back shell 46 that is attached so as to be incapable of displacement relative to the back frame 30 is disposed on a back face side of the movable back shell 42, and the back frame 30 is covered by the non-movable back shell 46.
US09555722B2 Seat occupancy determination apparatus
A seat occupancy determination apparatus includes a seat belt attachment detection portion, a first and a second load detection sensors, a front-rear load sum computing portion, a front-rear load difference computing portion, a memory portion, an adult possibility determination portion, and a child safety seat determination portion determining a vehicle seat determined as possibly occupied by an adult is occupied by a child safety seat in a case where a first predetermined amount increase condition satisfies by a front-rear load difference value within a time range between a time of engagement and a first time point increases by a first predetermined amount or more from the value at the first time point or earlier and a second predetermined amount decrease condition satisfies by the front-rear load difference value decreases by a second predetermined amount or more within a time range between the time of engagement and a second time point.
US09555713B2 Contactless power transmission device
A contactless power transmission device includes a power receiver, a power feeder configured to contactlessly feed power to the power receiver, the power feeder including a primary coil configured to generate magnetic flux by an input alternating current voltage, and a cover configured to cover the primary coil, and a capacitive sensor configured to supply an alternating current voltage to an electrode to measure a capacitance occurring between the electrode and foreign matter present around the cover and thereby detect the foreign matter. The frequency of the alternating current voltage of the capacitive sensor is set to be higher than the frequency of the magnetic flux generated by the primary coil.
US09555712B2 Vehicle system with batteries in series
A vehicle system is provided and includes a 12 volt alternator and a 24 volt wound rotor configured for acceptance in the 12 volt alternator.
US09555709B2 Apparatus for operating AVN monitor
An apparatus for operating an AVN (Audio, Video and Navigation) monitor for a vehicle may include a belt guider which is installed in an accommodation space of a dashboard and around which a belt, moving in a longitudinal direction of the belt guider, is wound, a guide rail fixed to the belt guider and extending in the longitudinal direction of the belt guider, a monitor hinge connected to the belt and engaged to the guide rail and an end of a connection bracket so as to move along the guide rail, wherein the connection bracket is connected to the AVN monitor, and a driving force transmission gear engaged with the belt to move the belt in the longitudinal direction.
US09555708B2 Method for controlling the display of information on a display area
In a method for controlling the display of information on a display area, the information is structured hierarchically in objects, in which an object and a path, which leads to the object in the hierarchical structure, are displayed. The path is divided into individual path elements, the path elements belonging to different hierarchy levels of the path leading to the object, and the path elements being selectable buttons, and the information display jumping to the hierarchy level of the selected path element when a path element is selected.
US09555706B1 Traction control system and process for a machine having a work implement
A traction control system configured to limit slip by a machine having a work implement including a machine motion sensor configured to determine a motion of the machine, a work implement unit configured to determine whether the work implement is in an operational state, a powertrain motion sensor configured to determine a motion of a powertrain component, and a machine powertrain controller configured to determine slip by comparing the motion of the machine to the motion of the powertrain component, wherein the machine powertrain controller is configured to command a torque reduction to the powertrain component when slip is determined.
US09555705B2 Vehicle
An ECU includes a collision determination unit, a condition determination unit, and an output suppression unit. The collision determination unit monitors an acceleration detected by a collision sensor, and determines that a vehicle collision has occurred when the acceleration is greater than a predetermined value. The condition determination unit determines whether or not a vehicular speed absolute value is smaller than a threshold vehicular speed in a determination period lasting from the determination of collision for a predetermined time. The output suppression unit suppresses an output of a vehicle driving force when the vehicular speed absolute value is smaller than the threshold vehicular speed in the determination period.
US09555703B2 Adaptive control of motor vehicle powertrain
A method and system is disclosed for blending between torque maps of a source of propulsion of a vehicle. Embodiments of the present invention are particularly applicable to automatic selection of an alternative torque map in response to a change of vehicle operating condition, for example a change of terrain. Blending according to embodiments of the present invention may substantially avoid a step change in response of the source of propulsion as accelerator position is changed.
US09555701B2 Side-by-side utility vehicle
A utility vehicle comprises a plurality of ground engaging members and a frame supported by the plurality of ground engaging members. The utility vehicle includes a front seating area and a rear seating area. A rear cargo bed is reconfigurable from a configuration where it is rearward of the rear seating area to a second configuration where it includes the rear seating area space. The vehicle includes a transmission having a final drive portion and a plurality of transmission shafts housed in a common housing, the final drive portion being forward of an end of the plurality of transmission shafts. The vehicle also includes a front suspension and a rear suspension.
US09555699B2 Power transmission apparatus for hybrid electric vehicle
A transmission for a vehicle may include first and second input shafts, first and second shifting output units, a reverse speed idle unit and an electric driving force unit. Each input shaft may include a plurality of input gears having different numbers of gear teeth. The second input shaft may be hollow and disposed at a front side of the first input shaft without any rotational interference with the first input shaft. Each shifting output unit may include an output shaft, shift rotational driving force transferred through shifting gears selectively outer-engaging with corresponding input gears by a synchronizing unit and output the shifted rotational driving force through an output gear. The reverse speed idle unit may regulate reverse speed shifting. The electric driving force unit may selectively transfer rotational driving force of a motor/generator to the first input shaft or the second shifting output unit.
US09555697B2 Adjustable canopy brackets for a vehicle
An adjustable canopy bracket for adjustably supporting a canopy to a roll bar of a vehicle, including a lower bracket plate securely positionable about a lower portion of a roll bar member of the roll bar; an upper bracket plate securely positionable about an upper portion of the roll bar member, the upper bracket plate engageable with a forward portion of the canopy; and an adjustable height mechanism engageable with a rearward portion of the canopy, the adjustable height mechanism operable with a rearward portion of the upper bracket plate, wherein adjusting the adjustable height mechanism raises and lowers the rearward portion of the canopy to provide a desired angle of the canopy relative to the roll bar member. An adjustable canopy for attaching to a roll bar of a vehicle is also disclosed and claimed.
US09555694B2 Vehicle door assembly
A vehicle door may include a door outer panel defining an exterior surface of the vehicle door; a common door inner panel located inboard of the door outer panel and configured to mount door hardware, with the common door inner panel having a periphery; and a panel extension extending around essentially all of the periphery of the common door inner panel, the panel extension being attached to the periphery of the common door inner panel and attached to the door outer panel to secure the common door inner panel to the door outer panel.
US09555692B2 Register for air conditioning
Each fin shaft of auxiliary fins passes through each of upper and lower bearing parts in a first wall part. A pair of transmission shafts provided for the upper and lower fin shafts is arranged outside of the first wall part. A cam member is rotationally arranged outside of the first wall part. A fin shaft of a main fin is rotationally supported by the first wall part. The fin shaft of the main fin has an arm and a transmission shaft. The cam member has cam holes in which the transmission shafts of the upper auxiliary fin are fitted, cam holes in which the transmission shafts of the lower auxiliary fin are fitted, and a long hole in which the transmission shaft of the fin shaft of the main fin is fitted.
US09555686B2 Temperature control systems with thermoelectric devices
Temperature control systems and methods can be designed for controlling the interior climate of a vehicle or other the climate of another desired region. The temperature control system for a vehicle can have a thermoelectric system providing heating and/or cooling, including supplemental heating and/or cooling. The thermoelectric system can transfer thermal energy between a working fluid, such as liquid coolant, and comfort air upon application of electric current of a selected polarity. The thermoelectric system can supplement or replace the heat provided from an internal combustion engine or other primary heat source. The thermoelectric system can also supplement or replace cold energy provided from a compressor-based refrigeration system or other primary cold energy source.
US09555683B2 Four-point link
A four-point link for the suspension of a rigid axle which has four bearing seats. Two bearing seats can be articulated on the axle and two can be articulated on the vehicle frame. The link has a single-piece link body which is inscribed by the trapezoid formed by the bearing seats. The link body is formed of a fiber-composite arrangement that comprises at least one longitudinal fiber arrangement. The longitudinal fiber arrangement encases the bearing seat, at least along half circumference thereof and extends along at least a portion of the link body in order to optimize loading, reduce mass and increase its application. Torsional compliance makes it possible to use relatively small and/or hard rubber bearings for articulating the four-point link or the vehicle axle.
US09555681B2 Transformation method of hybrid transportation vehicle for ground and air, and hybrid transportation vehicle itself
Transformation method of hybrid transportation vehicle for ground and air includes the following transformation and reciprocal steps: Tilting the compensation cover (7) on. Expansion of both whole wings (1) from the transportation vehicle longitudinal position around two vertical axes (2) into the flying position. Expansion of rear parts of wings (1) from the top front parts of wings (1) into the spread flying position by tilting the rear of each wing (1) around a horizontal axis (3). The take-off and landing tilting of wings (1) by an angle of attack alpha=0 to 40° of the wings onset. Front wheels track (5) is reduced by axially shifting the front wheels (5) towards the fuselage. Furthermore, a corresponding hybrid transportation vehicle for ground and air is described which contains reciprocal transformation mechanisms for transformation from a sterling double or four-track automobile into a sterling aircraft for take-off and landing on the ground or water, and vice versa.
US09555680B2 Amphibian
An amphibious motorcycle with a hull that provides desirable buoyancy for the vehicle to float while in the water and yet allows the vehicle to lean/turn during use on land is provided. The amphibious motorcycle has a front wheel with a front suspension system and a rear wheel with a rear suspension system. Also included can be at least one wheel retraction system that is operable to move the front wheel and/or the rear wheel between a deployed position for use of the amphibious motorcycle on land and a retracted position for use of the amphibious motorcycle on or in the water. The amphibious motorcycle also has a hull that can have a center portion with a center bow and two oppositely disposed and spaced apart side portions each with a side bow.
US09555674B2 Vehicle wheel information acquiring device
A vehicle wheel information acquiring device includes a vehicle wheel sensor and a vehicle-body-side device. The vehicle wheel sensor is configured to revolve around an axle with a rotation of a vehicle wheel. The vehicle-body-side device includes a reception unit, a processing unit, a rotation position acquiring unit, an on-reception rotation position storage unit, and a determination unit. The determination unit is configured to determine whether a revolution position of the vehicle wheel sensor is included in an insufficient received intensity area during a stopping operation of a vehicle.
US09555672B2 Pressure control device for a tire inflating system with a rotary feedthrough, and tire pressure changing method
A pressure control device for a vehicle tire inflating system is configured to receive compressed air via a ventilating inlet, activate at least one seal for sealing an air chamber between a stator and a rotor of a rotary feedthrough via a seal actuating outlet, and ventilate a tire at a ventilating outlet pressure via a ventilating outlet and the feedthrough. A control valve is pneumatically controllable by a control pressure, the ventilating outlet being ventilated at the outlet pressure by the control valve only when the control pressure is at least a defined minimum pressure. In response to pressure build-up at the ventilating inlet at least to the minimum pressure, the control pressure and the seal actuating pressure are built up for ventilating, but build-up of the control pressure is delayed with respect to the seal actuating pressure. Activation of a seal prior to ventilation of the ventilating outlet is possible without additional actuating channels.
US09555669B2 Pneumatic tire
A pneumatic tire includes a tread portion with an asymmetric pattern including an outboard shoulder main groove, an inboard shoulder main groove, an outboard shoulder portion between the outboard shoulder main groove and an outboard tread edge, a middle portion between the outboard shoulder main groove and the inboard shoulder main groove, and an inboard shoulder portion between the inboard shoulder main groove and an inboard tread edge, wherein the outboard shoulder portion is provided with a three dimensional sipe that has a pair of sipe surfaces extending to a depth direction of the sipe while changing its direction or opening configuration, and the inboard shoulder portion or the middle portion is provided with a two dimensional sipe that has a pair of sipe surfaces extending to a depth direction of the sipe while maintaining its direction and opening configuration.
US09555667B2 Puncture-free inner tube
A puncture-free inner tube has a hollow pipe shape, which is to be inserted in an annular space of an outer tire, which is to be mounted detachably on a tire rim having an annular shape. The tube contains a thermoplastic elastomer molded by injection molding into a transversal cross sectional shape that is similar or substantially similar to and is slightly larger than a transversal cross section of the annular space of the outer tire. The tube has a thickness that is gradually increased from a ground part toward an anti-ground part on a side of the tire rim. The tube is formed in an annular shape, and the tube is to be inserted in the annular space of the outer tire in a compressed state with a tensile stress of the outer tire.
US09555666B2 Assembly tool for wheel hub
An assembly tool for assembly and replacement of bolts on a wheel hub is revealed. The tool includes a first tool set and a second tool set. The first tool set has a base and a fastener. The base is a circular body with a receiving part. A pad is disposed on the receiving part and a bearing is arranged under the pad. The fastener includes a hexagonal head, an enlarged part, a cylindrical part and an axial hole arranged with a thread. The second tool set has a first arm and a second arm pivotally connected to each other. A wheel bolt is pressed into the wheel hub by the first tool set while the wheel hub is positioned by the first and second arms of the second tool set fastened with the wheel bolts of the wheel hub for convenient assembly of the wheel bolts.
US09555658B2 Expandable capacity pocket divider
A pocket divider including a major panel including a plurality of binding holes formed therein and a pocket panel coupled to the major panel and defining a pocket therewith. The pocket panel includes at least one binding hole formed therein. The pocket divider further includes a binding mechanism extending through the binding holes of the major panel and the at least one binding hole of the pocket panel. The at least one binding hole of the pocket panel is elongated to provide expansion capacity to the pocket.
US09555650B2 Recording device
The recording device includes an adhesive belt extending across a plurality of rotating bodies configured to support and convey a recording medium, a first sensor configured to detect that the recording medium is separated relative to the adhesive belt in a first range, a second sensor configured to detect that the recording medium P is separated relative to the adhesive belt in a second range within the first range, a take-up unit configured to take up the recording medium, and a control unit configured to control the take-up unit so as to take up the recording medium when the first sensor detects that a separation position of the recording medium is within the first range, and control the rotating body to stop movement of the adhesive belt when the second sensor detects that the separation position of the recording medium is within the second range.
US09555648B2 Method of manufacturing recorded matter, manufacturing device of recorded matter and recorded matter
Provided is a method of manufacturing a recorded matter including applying a first ink including a volatile first liquid to an intermediate transfer medium having ultraviolet transmittance; applying, using an ink jet method, second ink including a coloring agent and a polymerizable compound polymerized by irradiation of ultraviolet to locations on the intermediate transfer medium where first ink is applied; partially polymerizing the polymerizable compound by irradiating surface side of the intermediate transfer medium to which the second ink is applied with ultraviolet rays from the opposite side surface; transferring the second ink irradiated by ultraviolet in the polymerizing of the polymerizable compound to a recording medium; and curing the polymerizable compound configuring the second ink transferred to the recording medium.
US09555647B2 Printing device, control method for printing device, and control program for printing device
A printing device includes a paper medium print mode configured to execute printing on a paper medium; and a textile print mode configured to execute printing on a fabric medium, types of inks used in the textile print mode being greater in number than types of inks used in the paper medium print mode.
US09555638B2 Liquid supply flow path device and liquid ejecting apparatus using the same
A recording apparatus comprises a printer body having a case. An ink nozzle is in the interior of the printer body. An opening and closing member is movably affixed to an upper side of the printer body and is configured to open and close. An external tank is located exterior to the printer body. A tube, a portion of which is exterior to the printer body, provides a liquid from the external tank to the ink nozzle. One or both of the printer body and the opening and closing member are configured to define a tube insertion part, which has a cutout portion or a finger engage portion. The tube extends into the printer body through the cutout portion or the finger engage portion.
US09555637B2 Cartridge and liquid supplying method
A cartridge 1 is provided with an ink pack 9, an air bag 10 capable of abutting the ink pack 9, and a pressurizing chamber 11 that stores the ink pack 9 and the air bag 10. In the case where the amount of ink in the ink pack 9 decreases, pressurized air is introduced into the air bag 10, the ink pack 9 is pressed against the air bag 10, and thereby the internal pressure of the ink pack 9 is increased. After that, pressurized air is introduced into the pressurizing chamber 11 so as to increase the internal pressure of the pressurizing chamber 11 and pressurize the ink pack 9 from outside. Accordingly, the ink in the ink pack 9 is supplied from an ink supply port 12 to the inkjet printer 2.
US09555635B2 Liquid supply system
A liquid supply system adapted to be mounted in a carriage unit having a first liquid introduction portion and a second liquid introduction portion is proposed. The liquid supply system comprises two liquid supply units each having liquid supply portion adapted to liquid to the first and second liquid introduction portions, respectively. The two liquid supply units are adapted to be attached to and detached from the carriage unit. The liquid supply system further comprises a holder unit adapted to be attached to and detached from the carriage unit and adapted to fix the two liquid supply units to the carriage unit. The two liquid supply units are located between the holder unit and the carriage unit.
US09555634B2 Printing material receptacle, label, and printing apparatus
A printing material receptacle fitted on a folder of a printing apparatus that includes a writing unit. The printing material receptacle includes a housing to accommodate ink; a first recording portion formed on a face of the housing and for recording updatable first information relating to the printing material receptacle to be updatable and visible using a non-electronic method, the face being exposed from the folder when the printing material receptacle is fitted on the folder; and a second recording portion formed on the face of the housing and for recording updatable second information relating to the printing material receptacle to be updatable, invisible, and mechanically readable using a non-electronic method. The first and second recording portions are configured to be written with the first and second information respectively by the writing unit.
US09555633B2 Replay unit for waste liquid container and image forming apparatus incorporating the relay unit
An image forming apparatus includes an apparatus body, a waste liquid container accommodation part, and a waste liquid drain passage member. The waste liquid container accommodation part replaceably accommodates a first waste liquid container to contain waste liquid. The waste liquid drain passage member guides waste liquid into the waste liquid container accommodation part. The apparatus body includes a mount portion to mount a second waste liquid container having a capacity greater than the waste liquid container accommodation part. The mount portion of the apparatus body is different from the waste liquid container accommodation part. The waste liquid container accommodation part accommodates a relay unit to relay a drain passage from the waste liquid drain passage member to the second waste liquid container, replaceably with the first waste liquid container.
US09555632B2 Method of processing a silicon substrate and method of manufacturing a substrate for a liquid ejection head
Performed are a non-through hole forming step of partitioning a supply path forming region of a second surface into a first region corresponding to a forming position of a beam, a second region located adjacent to the first region on both sides thereof, and a third region that is none of the first region and the second region, and forming a plurality of non-through holes in the second region and the third region, and an etching step of subjecting a silicon substrate to anisotropic etching from the second surface, to thereby form the supply path and the beam in the supply path. In the non-through hole forming step, at least one of an interval or a depth of the non-through holes is caused to differ in the second region and the third region, to thereby control the shape and dimension of the beam to be formed in the etching step.
US09555630B2 Electrically connecting electrically isolated printhead die ground networks at flexible circuit
A printhead assembly for an inkjet-printing device includes a printhead die and a flexible circuit connected to the printhead die. The printhead die includes a substrate, a first ground network electrically connected to the substrate, a device layer, and a second ground network electrically connected to the device layer. The first ground network and the second ground network are electrically isolated from one another within the printhead die. The first ground network and the second ground network are electrically connected to one another at the flexible circuit.
US09555629B2 Liquid discharge substrate, liquid discharge head, and printing apparatus
A liquid discharge substrate according to an embodiment of the present invention includes a plurality of heating elements, a plurality of driving elements, a signal supplying unit which supplies a control signal used to control the plurality of driving elements, and a plurality of delay circuits which delay the control signal. A delay amount of a first delay circuit is different from a delay amount of a second delay circuit.
US09555627B2 Liquid ejecting apparatus
A liquid ejecting apparatus includes a modulation circuit that performs pulse modulation on an original signal to generate a modulated signal; a pair of transistors that generate an amplified modulated signal amplified from the modulated signal; a lowpass filter that smoothes the amplified modulated signal to generate a driving signal; an AD converter that performs AD conversion on a voltage based on the driving signal; a piezoelectric element that is displaced to eject a liquid when the driving signal is applied. The AD converter includes at least K (where K is an integer equal to or greater than 2) capacitors and a controller that causes the K capacitors to sample voltages based on the driving signal at temporally different timings, and subsequently equalizes the voltages and outputs a result of the AD conversion based on the equalized voltage.
US09555617B2 Dual function shoe upper printing jig
A printing jig system that includes a maintaining jig able to maintain an article for a first processing step and that is also used to maintain and align the article for a subsequent printing process step. In order to effectively be used for a first processing step and a second printing process step, a support portion supports the article in locations otherwise left unsupported by a processing aperture of the maintaining jig. The processing aperture is configured to facilitate the first processing step, such as steaming of the article. The print support portion is configured to extend through the processing aperture of the maintaining jig The maintaining jig and the print support portion are aligned and maintained relative to each other and a printing machine by a base plate adapted to removeably secure and align the maintaining jig and the print support portion.
US09555611B2 Laser stripping apparatus
Embodiments of the present invention provide a laser stripping apparatus, comprising: a frame; a laser located above the frame and a carrier stage located below the frame; a support mechanism provided on the carrier stage for carrying a flexible display substrate stripping plate; wherein the support mechanism is removably fixed to the carrier stage; the flexible display substrate stripping plate comprises a bearing substrate and a flexible display substrate provided on the bearing substrate; and when the flexible display substrate stripping plate is provided on the laser stripping apparatus, the flexible display substrate comes into contact with the support mechanism.
US09555610B2 LED light bulb with internal flexible heatsink and circuit
An LED light bulb device that includes a bulb body, a plurality of flexible circuit strips, and at least one LED. The flexible circuit strips are formed to a shape of, and adhered directly to, an interior face of the bulb body. At least one of the flexible circuit strips defines a plurality of stress-relieving notches. At least one LED is mounted to a corresponding one of the flexible circuit strips and is electrically connected to a conductive trace formed by the flexible circuit strip. The LEDs are arranged to aim inwardly relative to the bulb body. In some embodiments, a rear surface of each of the flexible circuit strips is adhesively attached to the interior face of the bulb body. In some embodiments, a plurality of LEDs are provided and arranged to provide one or both of uniform light distribution and diverse heat distribution.
US09555607B2 Tape sticking apparatus
A tape sticking apparatus includes a rubber sheet that partitions an airtight space formed above a chamber into first and second airtight spaces and, a tape frame that holds a tape above the rubber sheet, and a supply/exhaust mechanism that switches between pressurizing and depressurizing by supplying gas to or sucking gas from the first and second airtight spaces. The gas supply/exhaust mechanism includes a first flow-rate control valve that controls the flow rate of sucked gas when the first airtight space is depressurized, and a second flow-rate control valve that controls the flow rate of supplied when the first airtight space is pressurized.
US09555593B2 Apparatus for compacting fibrous plant material, especially for compacting stalk material
An apparatus for compacting stalk material, having a feeding device for feeding material to be pressed, having at least one pair of press drums which can be driven in opposite directions and which each have circumferential receiving grooves and compression rings in an alternate manner alongside one another in the axial direction, wherein the compression rings of one press drum engage in the receiving grooves of the other press drum, wherein at least one press drum is provided with a cavity and wherein this at least one press drum has a multiplicity of radially extending press channels in a manner distributed over the circumference, said press channels in each case connecting the groove bottom of the receiving grooves to the cavity, provision is made for the compression rings to have a circumferential profile having protrusions formed for example by radially external teeth having tooth tips.
US09555591B2 Tire tread with apertures and a method for the manufacture of a tire tread with apertures
A tire tread with certain features and a method for manufacturing such a tire tread are provided. More particularly, a tire tread is provided that has layers of apertures where some layers remain covered until after a certain amount of tread wear has occurred. Such apertures can comprise, for example, sipes, grooves, or other apertured features in the tread. A method of making such tire tread is also provided.
US09555587B2 Composite layup tools for aircraft fuselage barrels, methods of assembling the layup tools, and aircraft fuselage barrel sections formed utilizing the layup tools
Composite layup tools for aircraft fuselage barrels, methods of assembling the layup tools, and aircraft fuselage barrels formed utilizing the layup tools are disclosed herein. A method of assembling the layup tools includes aligning an adaptor mating surface of a splice adaptor with a mandrel mating surface of a layup mandrel and initially attaching the splice adaptor to the layup mandrel at an initial attachment point. The methods further include attaching a lower lobe of the splice adaptor to a lower lobe of the layup mandrel. A method of forming a fuselage barrel assembly includes providing two fuselage barrel sections and a splice ring, aligning the two fuselage barrel sections, locating the splice ring within the two fuselage barrel sections, and attaching both fuselage barrel sections to the splice ring. The systems include a layup tool that is formed using the methods.
US09555584B2 Stereolithography machine with cartridge containing a reservoir
A Cartridge (2; 2′; 2″) for a stereolithography machine (1), including a container (3) provided with an access opening (4), a reservoir (5) for containing a base material (6), liquid or pasty, suited to be solidified through exposure to a predefined radiation (7), said reservoir (5) being permanently associated with said container (3), feeding means (8) suited to feed said base material (6) from said reservoir (5) towards said container (3), characterized in that the bottom (9) of said container (3) is at least partially transparent to said predefined radiation (7) and is situated opposite said access opening (4).
US09555582B2 Method and assembly for additive manufacturing
An additive manufacturing method (1600) may involve additive manufacturing (1602) a walled structure (e.g., a shell or an enclosure) onto a print bed, positioning (1604) a support piece having a non-stick surface (e.g., a Teflon®) near or inside the structure, additive manufacturing (1606) a layer of material onto one or more walls and onto the support piece to create an overhang, and removing (1616) the support piece after the material making up the overhang has returned to a solid state or hardened.
US09555576B2 Method for producing resin bottles
The present invention provides a method for producing a resin bottle formed from a preform as a prototype by a blow molding process. The method comprises: a first step of measuring each of weights or wall thicknesses of a plurality of inspection parts set in a body portion of the preform; a second step of comparing each of the weights or the wall thicknesses measured by the first step with a preset set value, and thereby inspecting a difference between each of the weights or the wall thicknesses measured by the first step and the set value for each of the inspection parts; and a third step of adjusting a condition for blow molding in the blow molding process in accordance with an inspection result of each of the inspection parts.
US09555575B2 Blow mold tool with retractable base portion
Blow molding tools and a method of blow molding which provide that the tool have a retractable push up section in the base which allows for the article molded by the tool to have a recessed base internal to an otherwise hollow structure. As the push up is moveable, adjustment of the push up portion can be performed during an automated blow molding operation so as to allow release of the blow molded article.
US09555573B2 Process for making a stretch-blow moulded container having an integrally moulded handle
The present invention relates to a process for making a container having an integral handle, comprising the steps of: a) providing a preform (1) in a mould cavity (2); b) stretch-blow moulding the preform (1) to form an intermediate container (3); c) applying one or more inwardly moving plugs (5) to form one or more concave gripping region(s), whilst maintaining the pressure within the intermediate container (3) above 1 bar and whilst the temperature of the material in the gripping region of the intermediate container is at a temperature below the glass transition temperature, Tg; d) releasing excess pressure within the container, preferably prior to withdrawing the plug (5) from within the container; and e) ejecting the finished container(6) from the mould cavity (2,4).
US09555570B2 Electronic cycle counter
A monitor for maintaining a mold cycle count with an actuator sending a count signal to a processor following a mold operation. The monitor further includes a timer having an active mode and a sleep mode. The processor generates an average cycle time and an activity percentage of the mold taking into account active and sleep periods of the mold.
US09555569B2 Plastic overmolding of aluminum extrusions
A plastic overmold aluminum extrusion including at least one plastic overmold and aluminum extrusion. The aluminum extrusion is formed with sufficient cross sectional properties and features such as an internal web to help prevent undesirable collapses under injection or compression molding pressures. This improves part geometry and strength while minimizing weight. A plurality of protrusions and/or local deformations on an outer wall of the extrusion can be used to create strong mechanical interface to the plastic. Localized deformations can result from a combination of the applied plastic pressure under injection or compression molding pressures and the proximity of outer gaps of the internal web structure. A process of making the plastic overmold aluminum extrusion includes inserting at least one aluminum extrusion into a mold without mandrels and delivering plastic forming the plastic overmold.
US09555567B2 Utility glove
A utility glove formed of a glove blank of a fabric material in the shape of at least a portion of a hand having one or more areas of elastomeric material injection molded thereon to form one or more three dimensional molded portions, the three dimensional molded portions being the fabric material with the elastomeric material bonded thereto, wherein one or more three dimensional molded portions leave at least one area of fabric material of the glove blank without elastomeric material bonded to the fabric. The fabric material of the glove blank can be made from one or more fabrics, a treated fabric, a coated fabric or combinations thereof, or the fabric may have a portion with a coating on an area without elastomeric material.
US09555564B2 Method of fabricating a foamed, injection molded component with improved ductility and toughness
A method of fabricating a foamed, injection-molded component is provided. The method includes the step of plasticizing pellets including a first polymeric material and a second polymeric material within an injection barrel to form an injection material. The first polymeric material defines a first phase of the injection material and the second polymeric material defines a second phase of the injection material. The first and second phases of the injection material are immiscible. The injection material is injected into a mold to fabricate the foamed injection-molded component having microscale, microcellular voids. Upon tensile loading, submicron, secondary phase cavities are formed in the injection-molded component, resulting in improved ductility and toughness.
US09555562B2 Method for making nano-scale film
A method for making a nano-scale film includes the steps of: (a) providing a suspension including an organic solvent and a number of nano-scale particles dispersed therein; (b) dropping/releasing the suspension into a liquid having a specific gravity greater than that of the nano-scale particles; and (c) forming a uniform film of nano-scale particles on the surface of the liquid.
US09555555B2 Apparatus for cutting vitreous silica crucible
A cutting method and an apparatus are provided which enable a rim area or other part of a vitreous silica crucible to be cut off so as to leave a smooth cut surface without damaging the cut edge, etc. The apparatus for cutting the crucible comprises a disk-shaped cutting blade (10) disposed to be movable with respect to the crucible. Without rotating the crucible (20), the rotating cutting blade (10) is brought into contact with a surface of the crucible wall and pushed forward in the wall thickness direction to make a cut piercing the crucible wall. The cutting blade (10) is moved relatively to the crucible (20) in the circumferential direction of the crucible (20) while keeping the cutting blade in the state of piercing the wall. A rim area (25) of the crucible (20) is thus cut off.
US09555553B2 Slitter blade guard
A retractable safety cover for a slitting blade edge. This cover pivots about an axis that is perpendicular to the axis of rotation of the blade edge. The cover is spring loaded in the open direction and is held in the covered orientation by a spring loaded moveable block. By retracting the moveable block the blade edge is exposed for use.
US09555548B2 Robot control device for controlling robot moved according to applied force
A robot control device includes an operation axis setting unit that sets a axis rotationally moved according to an applied force as an operation axis and sets a rotational moving direction of the operation axis; a first operation force acquisition unit that obtains a first virtual force that is virtually applied to the operation axis to assume that the first virtual force is a first operation force; and an operation command unit that outputs an operation command for moving the operation axis set by the operation axis setting unit on the basis of an operation force determined from the first operation force. The operation command unit obtains a target moving direction and a target moving velocity of the operation axis on the basis of the first operation force and the rotational moving direction set by the operation axis setting unit, so as to move the operation axis.
US09555546B2 Operating machine with redundant axes and resolution of the redundancy in real time
A program for a numerical control device is disclosed that determines path points to be approached by an end effector. A control signal group is ascertained for each path point that contains its set point value for each position-controlled axis. Those values are output to the axes, moving the end effector. The degrees of freedom are fewer than the position-controlled axes. The control signal groups are ascertained so that the end effector approaches the path points at least approximately. The control signal groups are ascertained gradually during the activation of the axes. The set point values are ascertained by minimizing an objective function. The objective function that is minimized includes at least the set point values for a path point only to be approached in the future. The sequence between the currently approached point and the point approached in the future has at least one further path point.
US09555544B2 Robotic process automation
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for automating a manual process. The methods, systems, and apparatus include actions of identifying a process that (i) is manually performed by a user interacting with a computer, and (ii) is to be automated for performance by a robot that is configured to interact with another computer. Additional actions include obtaining one or more images taken of a display of the computer while the user is interacting with the computer in manually performing the process and applying a computer vision technique to identify one or more activities associated with the process. Further actions include, for each of the one or more identified activities, generating activity information associated with the activity and generating a process definition for use in causing the robot to automatically perform the process.
US09555543B2 Robot with joints of variable rigidity and method for calculating said optimized rigidity
A jointed robot capable to move on a surface is provided. It is known to limit to a predefined fixed value the torque that the motors of the joints of the robot can develop. A rigidity coefficient corresponding to the limit torque is calculated by solving a dynamic equilibrium model of the robot. The contact points of the characteristic effectors are determined by a selection from a list of potential effectors, notably as a function of a criterion of distance from a virtual ground plane. The contact forces for said effectors are calculated by optimal resolution of the equilibrium equations. Finally the torques applied in the dynamic equilibrium model of the robot and the coefficients of corresponding rigidity are calculated.
US09555539B2 Tool box with rubber peripheral fences
A tool box contains: a holder, a cover, a first peripheral fence, and a second peripheral fence. The holder includes a first abutting rib extending upwardly from a top end of a peripheral wall thereof. The cover is used for covering the holder, and between the holder and the cover is defined an accommodating space to accommodate tools. The first peripheral fence is arranged around the peripheral wall of the holder. The second peripheral fence is arranged around an outer wall of the cover and includes a contacting face extending inwardly from a bottom end of the second peripheral fence to contact with the first abutting rib of the holder.
US09555537B2 Portable tool
A casing of a hedge clipper which is a portable tool is provided with a power source housing in which an electric motor is housed and a main handle held by a worker, and blades serving as a tip tool are provided to the casing. An operation display panel is provided on the main handle, and a driving information display unit which displays a battery remaining capacity and a rotation speed of an electric motor as a plurality of pieces of driving information is provided on the operation display panel. The selection of the information to be displayed is switched by the operation of an operation switch unit provided in the operation display panel.
US09555533B2 Welding pliers multi-tool
The invention described herein generally relates to a pliers welding multi-tool including welding pliers and a plurality of welding tools that can be stowed in one or both handles of the pliers welding multi-tool. The pliers welding multi-tool handles can include rotating, sliding, or other interfaces to store or take out the pliers or other tools. Other tools integrated in the pliers portion or stored within the handles can include a welding fillet gauge, a welding thickness gauge, a welding tip remover, a welding nozzle remover, a bevel-angle tool, a root gap gauge, a plate and rod gauge, and others.
US09555531B2 Hydraulic hammer having co-axial accumulator and piston
A hydraulic hammer is disclosed having a piston and an accumulator membrane disposed external and co-axial to the piston. Additionally, a sleeve is disposed between the piston and accumulator membrane, wherein the sleeve has a plurality of radial passages formed therein that fluidly connect the accumulator membrane with the piston.
US09555526B1 Selectively lockable torque-limiting mechanism
A tool including selectively operable torque-limiting mechanism is provided. The tool includes a housing, a torque-limiting mechanism disposed within the housing and including a first gear engaged with the housing and including a number of first recesses, a second gear rotatably disposed within the housing adjacent the first gear and including a number of second recesses, a number of bearings disposed between the first gear and the second gear partially within the first recesses and partially within the second recesses, and a variable force-applying assembly engaged with the first gear opposite the second gear, a drive body engaged with the second gear and extending outwardly from the housing, and a cover disposed around the housing and selectively engaged with the drive body to control the operation of the torque-limiting mechanism.
US09555524B2 Clamping device for clamping a fastener
A clamping device for clamping a fastener, includes a clamping jaw, a first biasing member for biasing the clamping jaw, a clamping body having a central axis, a driving assembly for driving the clamping jaw to clamp the fastener, and a second member which can be driven by the first member to move axially relative to the clamping body so as to push the clamping jaw to clamp the fastener. The clamping body is formed with a notch for receiving the clamping jaw and the driving assembly is supported on the clamping body and includes a first member which can rotate and move axially relative to the clamping body. The installation structures between the clamping body, the driving assembly and the clamping jaw may be designed to be more compact so that the clamping device has a smaller size.
US09555522B2 Systems and methods for welding
A welding fixture including an electromagnet, a non-magnetic support configured to receive at least two sheets of material to be welded, and one or more clamping shoes configured to cooperate with the electromagnet to apply a clamping pressure to the at least two sheets of material and the non-magnetic support as a result of a magnetic force produced by the electromagnet is provided. A first of the at least two sheets of material is in contact with at least one of the one or more clamping shoes, and a second of the at least two sheets of material is in contact with at least the non-magnetic support. The one or more clamping shoes being shaped such that a perimeter defined by the one or more clamping shoes is located in the vicinity of a defined weld line to be welded on the at least two sheets of material, the weld line remaining substantially free from optical obstruction during production of the magnetic force.
US09555521B2 Lug nut cap remover pliers
A pliers tool for the removal of lug nut caps includes a pair of elongated handle portions, a pair of jaw portions, a pair of neck portions, a pair of V-shaped clamping plates, a pair of V-shaped channels, and a pair of V-shaped chamfered edges. The pair of handle portions are at one end of the pliers tool. The pair of jaw portions are at another end of the pliers tool. The pair of neck portions are between the handle portions and the jaw portions. A first clamping plate of the pair of V-shaped clamping plates is directly attached to a first jaw portion of the pair of jaw portions. A first channel of the pair of V-shaped channels is attached to an end of the first clamping plate. A first chamfered edge of the pair of chamfered edges is disposed on an end of the first channel.
US09555518B2 Polishing pad with multi-modal distribution of pore diameters
Polishing pads with multi-modal distributions of pore diameters are described. Methods of fabricating polishing pads with multi-modal distributions of pore diameters are also described.
US09555513B2 Method for changing the upper and lower tool of a packaging machine
A packaging machine is disclosed that includes a deep-drawing station, a filling station, a sealing station, or a combination thereof. The deep-drawing station, the sealing station, or both have an upper tool including a supporting top part. The supporting top is pivotable via a pivot mechanism, and the pivot mechanism is detachable from the supporting top part.
US09555512B2 Work holding devices
A work holding device that secures a workpiece includes a first support column, a second support column, and a plurality of part fixturing anchors. The first support column and the second support column are coupled to one another forming a longitudinal loading envelope having a width-wise dimension, a height-wise dimension, and a length-wise dimension. At least one of the support columns includes a plurality of part fixturing recesses passing through the support column in the width-wise dimension and arranged within the height-wise dimension and the length-wise dimension of the longitudinal loading envelope. The part fixturing anchors extend through the support column at the part fixturing recesses into the longitudinal loading envelope and couple the workpiece to the first and second support columns.
US09555511B2 Apparatus for the assembly and disassembly of hydraulic cylinders
The invention relates to an apparatus for the assembly and disassembly of hydraulic cylinders, composed of a pedestal-like machine frame having horizontally arranged guide means which bear, in displaceable manner, a receptacle for the cylinder barrel of the hydraulic cylinder, at least one receptacle for a support and a receptacle for a tool, and furthermore having a holder for fixing the piston rod of the hydraulic cylinder. According to the invention, the holder for fixing the piston rod has a centering carriage which is driven by a centering spindle and which comprises a piston rod receptacle, wherein the holder is designed to be rotatable about the longitudinal axis of the machine frame and the rotational movement is realized by means of a torque-controlled electromotive drive.
US09555509B2 Method for producing wellbore screen with tracer for fluid detection
A wellbore screen including: an apertured base pipe; an intermediate filtering layer including a plurality of metal fibers wrapped helically around the apertured base pipe and a fluid tracing filament wrapped helically about the apertured base pipe, the fluid tracing filament including a filament structure and a tracer carried by the filament structure, the tracer being entrainable produced fluids in a wellbore environment; and an outer apertured shell over the intermediate layer. A method for producing a wellbore screen, the method comprising: forming a filter tube by wrapping an intermediate layer, including a metal wool fiber strip and a fluid tracing filament, about an apertured base pipe in a helical arrangement under tension; positioning the filter tube within the long bore of an outer apertured sleeve; and securing the outer apertured sleeve and the filter tube together.
US09555508B2 Truss supply and rigging table systems and methods
Embodiments of the invention relate to a rigging table system that delivers the members from the cutting station to a location behind the workers at the rigging table, transports the members vertically below the surface of the floor on which the workers stand, horizontally transports the members underneath the floor on which the workers stand, and delivers the members vertically above the surface of the floor in front of the workers for assembly on the rigging table. The members are delivered through the use of systems that drop, slide, lift, and extend the members of the truss to the desired locations using automatic sensors or call buttons.
US09555507B2 Ski-chair-lift display apparatus and method
A display system is easily attached to the safety bar of a chair on a chair lift system at the beginning of a season. The display system includes brackets formed of rails holding clamp portions that may be fastened together to clamp the display system to a chair, such as to the safety bar across the lap of a rider. At the end of a season, the display system may be removed from each chair, the clamp portions removed, and the display systems stacked. In one simplified system, adjacent displays may be stacked back to back, and such adjacent pairs may be stacked with the displays in adjacent pairs positioned face-to-face. Thus, metal brackets on the backs need not scratch up the reading faces or surfaces. Meanwhile, the displays may be stored in minimal space, with great stability, while minimizing wear and damage.
US09555504B2 Method for assembling aluminum alloy parts by welding
A welded assembly of aluminum alloy part, in which (i) at least a first aluminum alloy part is procured in a solution heat treated, quenched, optionally cold worked, and naturally aged at ambient temperature or pre-aged temper, and at least a second aluminum alloy part, (ii) said parts are welded to obtain a welded assembly having a welded zone, (iii) cold working the entire welded zone between 0.3% and 5% is performed, (iv) the welded assembly thus cold worked undergoes post-weld aging to obtain a final metallurgical temper.
US09555502B2 Dual lasers for removing glass-side debris during the manufacture of thin film photovoltaic devices
Methods and systems for forming a scribe line in a thin film stack on an inner surface of a thin film photovoltaic superstrate are provided via the use of a cleaning laser beam and a scribing laser beam. The cleaning laser beam is focused directly onto the exposed surface of the superstrate such that the cleaning laser beam removes debris from the exposed surface of the superstrate, and the scribing laser beam is focused through the exposed surface of the superstrate and onto the thin film stack such that the scribing laser beam passes through the superstrate to form a scribe within the thin film stack on the inner surface of the superstrate. The method and system can further utilize a conveyor to transport the superstrate in a machine direction to move the superstrate past the cleaning laser source and the scribing laser source.
US09555500B2 Method of joining two materials by diffusion welding
A method to join a first material and a second material by diffusion welding, wherein a third material is put in between the first material and the second material during the joining process.
US09555498B2 Resistance welding machine pinch point safety sensor
There is described a continuity sensing system that operates with a resistance-welding machine. This sensing system measures continuity between the welding electrodes after the welding machine has been initiated and prevents application of high electrode force between the electrodes if the continuity measured is below a reference level. The result is a fully passive system that prevents serious high electrode force that would cause serious pinch-point injury to the operator of the welder. The present invention also includes methods of controlling pneumatic systems on resistance-welding machines to apply low force between welding electrodes until continuity between the welding electrodes has been detected.
US09555493B2 Apparatus for welding with curtain electrodes and strip electrodes
A system and method of welding is provided where a first welding power supply provides a first welding waveform to a strip electrode for welding a work piece and a second welding power supply provides a second welding waveform to at least one curtain electrode for welding the work piece. The at least one curtain electrode is positioned adjacent to a side of said strip electrode during welding.
US09555491B2 Blade elevation mechanisms and anti-backdrive mechanisms for table saws
Elevation mechanisms for table saws and anti-backdrive mechanisms for use in elevation mechanisms for table saws are disclosed. The anti-backdrive mechanisms typically include three sub-assemblies: an input assembly, an output assembly, and a fixed assembly. The anti-backdrive mechanisms prevent a torque related to the output assembly from changing the blade elevation. For example, the weight of the blade and the structure supporting the blade is prevented from backdriving the elevation mechanism and allowing the blade to drop.
US09555490B2 Miter saw with double belt drive
A miter saw includes a base, a turntable, a support assembly, and a cutting arm. The turntable is rotatably connected to the base, and the support assembly fixedly extends from the turntable. The cutting arm is pivotally connected to the support assembly. The miter saw further includes an arbor assembly, a gear assembly, a first belt member, and a second belt member.The arbor assembly is rotatably supported by the cutting arm. The gear assembly is supported by the cutting arm and positioned outside of a nominal blade space of the miter saw. The first belt member is operatively connected to the arbor assembly and the gear assembly. The second belt member is operatively connected to the gear assembly and to a motor shaft.
US09555487B2 End mill cutter
End mill cutter having a plurality of cutting edges distributed over the circumference of the mill cutter, having a flank which is adjacent to the respective cutting edge in the circumferential direction and a supporting surface which adjoins the flank on that side which faces away from the cutting edge in the circumferential direction.
US09555483B2 Tool accommodating replaceable blade
A cutting tool utilizing a replaceable blade has a body which defines a blade-accepting pocket having an interior within which the body of the blade is nestingly accepted when inserted within the pocket and for releasable securement of the blade within the blade-accepting pocket. Furthermore, the blade-accepting pocket includes an abutment surface against which a surface of the blade body bears against when the cutting edge of the blade is moved into cutting engagement with an item being cut with the tool.
US09555473B2 System and method for increasing the bulk density of metal powder
An apparatus for increasing the bulk density of metal powder may include a sealed chamber, a nozzle, and a target. The sealed chamber may include an inert environment. The nozzle may be coupled to an inert gas source and may be configured to introduce raw metal powder into a flow of the inert gas for discharge as a cold spray mixture of the raw metal powder and the inert gas into the chamber. The target may be housed within the sealed chamber and may be configured to receive an impact of the cold spray mixture. The nozzle and the target may be configured to flatten the raw metal particles into flattened metal particles in response to the cold spray mixture impacting the target.
US09555472B2 Arc melting and tilt casting apparatus
An arc melting and tilt casting apparatus having a casing provided with a vacuum chamber for housing a hearth having a melting trough and pouring means, arc-melting electrode means passing through the casing in the chamber, a mold having a melt receiving orifice, vacuum generating means, sealing means for maintaining the vacuum in the chamber and tilting means for tilting the apparatus to cause the melt to flow from the melting trough via the pouring means in the mold through the mold orifice. The hearth and mold are connected together and moveable as a single unit in the vacuum chamber and out from the chamber.
US09555471B2 Casting method and cast article
A casting method and cast article are provided. The casting method includes providing a casting furnace, the casting furnace including a withdrawal region in a lower end, positioning a mold within the casting furnace, positioning a molten material in the mold, partially withdrawing the mold a withdrawal distance through the withdrawal region in the casting furnace, the withdrawal distance providing a partially withdrawn portion, then reinserting at least a portion of the partially withdrawn portion into the casting furnace through the withdrawal region, and then completely withdrawing the mold from the casting furnace. The reinserting partially re-melts a solidified portion within the partially withdrawn portion to fill pores formed therein with the molten material. The cast article includes a microstructure and a porosity corresponding to being formed by a process comprising partially withdrawing, reinserting, and completely withdrawing of a mold from a casting furnace to form the cast article.
US09555470B1 Systems, devices, and methods involving precision component castings
Certain exemplary embodiments can provide a system, machine, device, manufacture, and/or composition of matter configured for and/or resulting from, and/or a method for, activities that can comprise and/or relate to, investment casting a product in a mold, the product comprising at least one wall, the mold comprising a core, an inner primary shell, and an outer secondary shell.
US09555467B2 Amorphous steel composites with enhanced strengths, elastic properties and ductilities
Amorphous steel composites with enhanced mechanical properties and related methods for toughening amorphous steel alloys. The composites are formed from monolithic amorphous steel and hard ceramic particulates, which must be embedded in the glass matrix through melting at a temperature above the melting point for the steel but below the melting point for the ceramic. The ceramics may be carbides, nitrides, borides, iron-refractory carbides, or iron-refractory borides. The produced composites may be one of two types, primarily distinguished by the methods for embedding the ceramic particulates in the steel. These methods may be applied to a variety of amorphous steels as well as other non-ferrous amorphous metals, and the resulting composites can be used in various applications and utilizations.
US09555463B2 Piping system
A piping system includes a flare machining mechanism and a screw machining mechanism that machines the ends of pipes by cold-pressed formation. The flare machining mechanism flares the ends of pipes outward and the screw machining mechanism machines the outside of the pipe end into a convex screw and the inside of the pipe end into a concave screw are provided on the same rotor mechanism and the same chuck. The piping system is configured to execute flare machining and screw machining of the end of the pipe by exchanging the flare machining head and the screw machining head.
US09555460B2 Method for manufacturing a split link for use in a flexible tube bending mandrel
A method for manufacturing a split link assembly having a split link (800C) that includes a first half link (801), a second half link (803) and a threaded aperture (805) formed in both the first half link (801) and second half link (803) for use in joining the first half link and second half link with a fastening device (807). The split link assembly is machined to include a head portion (811), shoulder portion (813), barrel portion (815) and base portion (817) for use in providing a highly flexible tube bending mandrel.
US09555457B2 Apparatus and method for forming a screw flight
This invention relates to an apparatus for forming a helical screw flight from a flight blank. The apparatus includes a base and an engaging means. The engaging means is movably mounted to the base and is configured to formingly engage the blank so as to form a twist in at least a portion of the flight blank corresponding to a predetermined pitch of the flight.
US09555454B2 Polymer coated sand and methods of manufacture and use
Described herein are systems for manipulating a flowable substance, comprising: a flowable substance; a heating means; a cooling means; and a composition comprising chemically inert particles coated with a stimuli-responsive material. Compositions and methods for using the compositions are also described herein.
US09555453B2 Methods and systems for abrasive cleaning and barrier coating/sealing of pipes
Methods for abrasive cleaning, existing pipes before coating interior surfaces which extends the life of piping systems such as copper, steel, lead, brass, cast iron piping and composite materials. The method can include the steps of generating pressurized gas into pipes to generate a moving air stream, intermittently injecting separate spaced apart bursts of abrasive particles into the moving air stream with different cumulative amounts of the intermittent bursts of the abrasive particles that vary based on different piping diameters, cleaning interior wall surfaces of the pipes with the intermittent bursts of the particles, reducing at least one of burrs or interior lips in the interior wall surfaces of the pipes, with the intermittent bursts of the particles and removing abrasive particles and debris caused by each one of the separate burst shots of the abrasive particles.
US09555449B2 Flux cleaning method
A flux cleaning apparatus for cleaning an object with flux by removing impurities that include flux from the object with flux includes a body, a mount, at least one steam spraying nozzle, and a steam supplying unit. The mount is coupled with the body for mounting the object with flux. The at least one steam spraying nozzle is coupled with the body for spraying steam toward the object with flux on the mount such that the object with flux is cleaned by the steam sprayed from the steam spraying nozzle. The steam supplying unit is coupled with the body and the steam supplying unit supplies steam to the at least one steam spraying nozzle.
US09555447B2 Method for inducting and singulating items to a sorter
The invention provides a method and a system for inducting items to a sorter (SRT) from a stream of items (IT1, IT2), e.g. mail or parcels, arriving at a feeding conveyor (FC). A processor (PCR) executes a control algorithm (C_A) with at least information (I_1) regarding the stream of items arriving at the feeding conveyor (FC) as input. In response, the control algorithm (C_A) generates an output (O1) indicating where to place an item picked up by a robot (R1) from the feeding conveyor (FC). The control algorithm (C_A) selects between two or more of: 1) a first induction (I1) arranged for transporting items to the sorter (SRT), 2) an empty space (E_S) on the sorter(SRT), 3) the feeding conveyor (FC), e.g. singulating bulk items on the feeding conveyor (FC), and 4) a weighing unit (W1) arranged for weighing items. By controlling the robot (R1) accordingly, it is possible to provide effective use of existing pick-and-place robots as part of a sorter induction system, where a high capacity can be obtained with a small requirement for space. E.g. it may be possible to save space for inductions, compared to what is required for manual handling with the same sorting capacity, especially this may be advantageous for items with a maximum weight of 2-3 kg.
US09555446B2 Material separator
A system and method for separating mixed materials employing an angled screen that is moved through a vertically oriented circular path by a single drive element.
US09555441B2 Dynamic synchronized masking and coating
A computer implemented system and method of coating a workpiece includes moving a coating applicator mounted to a coating dispensing robot relative to a workpiece and moving a mask mounted to a masking robot relative to the workpiece, wherein the mask is positioned between the coating applicator and the workpiece. A portion of the coating dispensed by the applicator is deposited on the workpiece, and another portion is intercepted by and deposited onto the mask. A desired pattern of coating can be deposited by moving the mask or dispenser or both in a coordinated manner.
US09555435B2 Apparatus wtih pad having a fabric structure to apply a liquid
An apparatus and a method for applying a liquid active substance to surfaces moving in a circulating manner, such as of cylinders, rolls, fabrics or other moving webs, consisting of a metering unit and an application unit. The active substance is conducted to the application unit by the metering unit, and the application unit has a pad with an open-pore mesh structure for receiving and storing the active substance and for applying the active substance as a film as a function of the degree of saturation and the contact pressure of the pad on the moving surface. Also, the use of the apparatus for keeping moving surfaces free from deposits, accumulations or contaminants.
US09555434B2 Deposition mask, producing method therefor and forming method for thin film pattern
A deposition mask for forming a thin film pattern having a predetermined shape on a substrate by deposition, includes a resin film that transmits visible light and has an opening pattern penetrating through the resin film and having the same shape and dimension as those of the thin film pattern so as to correspond to a preliminarily determined forming region of the thin film pattern on the substrate.
US09555430B2 Paint application system
A paint spraying system is proposed with a paint spraying device with a paint spray gun with a fan for dispensing paint via a spray head, which paint spraying device is connected via a paint line to a base station with a connector to a paint reservoir. In order to achieve a low and uniform paint pressure which is required in the paint spray gun, the paint spray gun is equipped with a separate pressure reducing device and the base station is equipped with a pressure monitor, which pressure reducing device and pressure monitor perform a pressure regulation of the paint pressure in the system.
US09555428B2 Device for dispensing fluids or mixtures
The present invention concerns a device (1; 51) for dispensing a fluid (L), having a supporting structure (2) provided with means (3) for coupling to a container (C) containing the fluid (L) and a collapsible chamber (6) associated with the supporting structure (2) and suited to draw and contain a measured quantity of the fluid (L). Said device comprises lever operating means (16) suited to deform the collapsible chamber (6) in order to dispense a portion of the measured quantity. The invention also implements a system for dispensing a fluid (L).
US09555425B2 Systems, devices and methods related to spray-painting fluid path for manufacture of radio-frequency modules
During fabrication of shielded radio-frequency modules where costly metallic paint is sprayed to form a conductive layer, it is desirable to reduce the amount of paint being utilized, and to reduce the likelihood of accumulation of metal particles along various paths. A closed recirculation system can be provided to yield such desirable features, and can include a reservoir for holding a volume of metallic paint, a spray apparatus for spraying metallic paint received from the reservoir, and a recirculator for recirculating the metallic paint that is not sprayed back to the reservoir. In some embodiments, the spray apparatus can be implemented so as to have reduced dimensions, and include a mechanism for switching between a spray mode and a recirculate mode. Such a spray apparatus can reduce the amount of paint being utilized, and also reduce accumulation of metal particles in the spray apparatus.
US09555423B2 Fluid injection device
A fluid injection device includes: a pulse generation section that includes a fluid chamber whose volume is changeable, and an inlet flow passage and an outlet flow passage that are connected to the fluid chamber; a first connection flow passage connected to the outlet flow passage, having an end portion; a second connection flow passage connected to the inlet flow passage; a fluid injection opening formed at the end portion of the first connection flow passage, having a diameter smaller than the diameter of the outlet flow passage; a connection flow passage tube including the first connection flow passage and having rigidity adequate to transmit pulses of fluid flowing from the fluid chamber to the fluid injection opening; and a pressure generation section that supplies fluid to the inlet flow passage.
US09555420B2 Gas stream treatment process
A process of treating a gas stream containing mercury is disclosed. The method comprises: applying a sorbent into said gas stream ahead of a particulate matter collection device, in order to adsorb at least a portion of a mercury containing compound, wherein said sorbent contains a composition comprising a compound having the following formula (SiO2)x(OH)yMzSaF: wherein M is at least one of the following metal or metalloid cations: boron, magnesium, aluminum, calcium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, zirconium, molybdenum, palladium, silver, cadmium, tin, platinum, gold, and bismuth; wherein S is a sulfur-based species selected from at least one of the following: sulfide salts, dithiocarbamates, polymer-based dithiocarbamates, and polysulfide salts; wherein F optionally exists and said F is at least one of the following: a functionalized organosilane, a sulfur-containing organosilane, an amine-containing organosilane, and an alkyl-containing organosilane at a surface area coverage of 0.01-100%; and wherein the molar ratio of y/x is equal to 0.01-0.5, the molar ratio of x/z is equal to 3-300, and the molar ratio of a/z is 1-5.
US09555418B2 Recovering valuable mined materials from aqueous wastes
Disclosed herein are systems and methods for recovering a target material from an aqueous stream. The target material can be a natively hydrophobic target material, such as a hydrocarbon material, such as coal. The target material can also have a surface modification that renders it hydrophobic. Systems for recovering the target material can comprise an extractant formulation comprising a light hydrocarbon solvent and a high molecular weight hydrophobic polymer, wherein the extractant formulation is mixable with the aqueous stream in a mixer to form an admixed solution having a hydrophobic portion and an aqueous portion, with the target material partitioning to the hydrophobic portion; a separator for isolating the hydrophobic portion from the aqueous portion; and a collector to which the hydrophobic portion is directed, wherein the target material is recovered from the hydrophobic portion.
US09555416B2 Jet mill
Disposed is a jet mill that has a cylindrical pulverization chamber (10) and a classification chamber (6) that connects to the pulverization chamber (10). A fine-powder discharge port (4a) and a classification rotor (7) are provided in the classification chamber (6). A feedstock supply port (5) and at least one gas emission nozzle (11) are provided in the pulverization chamber (10). The shape of the classification chamber (6) is a cone that starts on the inner wall of the pulverization chamber (10), and is angled towards the classification rotor (7). This configuration gives the jet mill high efficiency of pulverization and reduces the amount of powders left in the chamber when the jet mill has finished running.
US09555407B2 Laser triangulation for pipette tip position
A sample processing apparatus includes a laser triangulation system that locates the position of a lower end of a pipette tip. When the laser triangulation system identifies a discrepancy between the actual position of the lower end and the proper position of the lower end, the sample processing apparatus may undergo a compensating action to compensate for the discrepancy.
US09555406B2 Method for forming an oxide coated substrate
A method for forming an oxide coated substrate comprising heating a pre-coating mixture in the presence of a substrate to synthesize an oxide coating on the substrate. The pre-coating mixture comprises a solubilized reducing additive, a solubilized oxidizing additive, and the substrate. The heating is conducted at a temperature sufficiently high enough to exothermically react the solubilized reducing additive and solubilized oxidizing additive and low enough to control the phase and composition of the oxide.
US09555404B2 Catalyst composition and process for di-, tri- and/or tetramerization of ethylene
A catalyst composition and a process for di-, tri- and/or tetramerization of ethylene, wherein the catalyst composition comprises a chromium compound, a ligand of the general structure R1R2P—N(R3)—P(R4)—N(R5)—PR6R7, or any cyclic derivatives thereof, wherein at least one of the P or N atoms of the PNPNP-unit is member of a ring system, the ring system being formed from one or more constituent compounds of the ligand by substitution, and a co-catalyst or activator.
US09555400B2 Synergized PGM catalyst systems including platinum for TWC application
Synergized Platinum Group Metals (SPGM) catalyst system for TWC application is disclosed. Disclosed SPGM catalyst system may include a washcoat that includes stoichiometric Cu—Mn spinel structure, supported on doped ZrO2, and an overcoat that includes PGM, such as platinum (Pt) supported on carrier material oxides, such as alumina. SPGM catalyst system shows significant improvement in nitrogen oxide reduction performance under lean and also rich operating conditions. Additionally, disclosed SPGM catalyst system exhibits enhanced catalytic activity for carbon monoxide conversion. Furthermore, disclosed SPGM catalyst systems are found to have enhanced catalytic activity compared to PGM catalyst system, showing that there is a synergistic effect between PGM catalyst, such as Pt, and Cu—Mn spinel within disclosed SPGM catalyst system, which help in activity and thermal stability of disclosed SPGM catalyst.
US09555396B2 Process for oxidative desulfurization with integrated sulfone decomposition
The process provided herein is concerned with disposal of oxidized sulfur compounds formed by oxidative desulfurization. The process uses solid base catalyst in the presence of a caustic solution or solid base catalyst pretreated with a base and eliminates the need to separate the sulfones from the hydrocarbon streams and recover the hydrocarbons.
US09555393B2 Superabsorbent polymer and preparation method therefor
Disclosed herein are a superabsorbent polymer resin incorporated with a particles meeting the following properties i) to ii): i) a BET specific surface area of 300 to 1500 m2/g, ii) a porosity of 50% or more, and a method for preparing the same.
US09555392B2 Electrospun cactus mucilage nanofibers
Novel electrospun nanofibers and nanofibrous membranes, methods of manufacturing the same, and methods of using the same are provided. The nanofibers include a cactus mucilage, such as mucilage from Opuntia ficus-indica. An organic polymer can be added to the cactus mucilage before electrospinning. The nanofibrous membranes can be used in water filtration.
US09555389B2 Gas distributor nozzles
Systems and methods for injecting gas into a fluidized bed of particles are provided. The system can include a gas distribution system. The gas distribution system can include a header having a flow passage and a nozzle body coupled to the header. The nozzle body can have an inlet end in fluid communication with the flow passage and an outlet end positioned outside of the header. The nozzle body can have a longitudinal axis that is substantially perpendicular to a direction of flow through the flow passage. The nozzle body can have an orifice positioned between the inlet end and the outlet end.
US09555388B2 De novo synthesized gene libraries
De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
US09555384B2 Blender assembly
A blending appliance includes a housing with a jar receiving area defined between an upper housing and a support base. A blender jar includes a base portion and a receptacle portion, and is configured to be laterally received within the jar receiving area of the housing. A magnetic coupling system includes an upper magnetic coupler disposed in the base portion of the blender jar and a lower magnetic coupler disposed in the support base of the housing. The upper and lower magnetic couplers are magnetically coupled to one another for driving a blade assembly disposed in the receptacle portion of the blender jar. A brake mechanism is disposed on the upper magnetic coupler and is configured to stop rotation of the upper magnetic coupler when the blender jar is removed from the jar receiving area.
US09555382B2 Centrifugal microfluidic mixing apparatus with deflection element, and method of mixing
A centrifugal microfluidic device having a microfluidic mixing element with a microfluidic mixing chamber in which at least two flows emerging from channels into the chamber at separate places are redirected to land at substantially the same place on a mixing surface provides efficient mixing of two or more fluids in the chamber.
US09555379B2 Fluid path set with turbulent mixing chamber, backflow compensator
A fluid path set includes a first fluid line having a proximal end fluidly connectable to a source of a first fluid and a second fluid line having a proximal end fluidly connectable to a source of a second fluid. A flow mixing device is in fluid communication with distal ends of the first and second fluid lines. The flow mixing device includes a housing, a first fluid port provided for receiving the first fluid, and a second fluid port for receiving the second fluid. A mixing chamber is disposed within the housing and is in fluid communication with the first and second fluid ports. A third fluid port in fluid communication with the mixing chamber for discharging a mixed solution of the first and second fluids. A turbulent flow inducing member is disposed within the mixing chamber for promoting turbulent mixing of the first and second fluids.
US09555378B2 Composite polyamide membrane having preferred azo content
A thin film composite polyamide membrane comprising a porous support and a thin film polyamide layer characterized by possessing an azo (—N═N—) content of from 0.75% to 0.95%, as measured by pyrolysis gas chromatography.
US09555374B2 Method for conditioning catalysts by means of membrane filtration
The present invention relates to a method of conditioning suspended catalysts, wherein at least part of the catalyst-comprising reaction medium is taken from one or more reactors and the suspended, at least partially inactivated catalysts are separated off and purified by means of at least one membrane filtration, with at least one of the membrane filtrations being carried out as a diafiltration.
US09555373B2 Process of supplying water of controlled salinity
Desalination plant containing a plurality of membrane trains each having a plurality of RO membrane units and a plurality of NF membrane units. The ratio of RO membrane units to NF membrane units in each membrane train is in the range of 2:1 to 40:1, and each membrane train is provided with (a) a feed line for a source water that divides to provide a feed line for the RO membrane units and a feed line for the NF membrane units, (b) a permeate line for the RO membrane units and a permeate line for the NF membrane units that combine to provide an injection water line; (c) a retentate line for the RO membrane units and a retentate line for the NF membrane units; and (d) a flow controller and pressure let-down valve on the NF feed line.
US09555372B2 Fuel reformer for De-NOx trap
An emissions control system for an engine of a machine includes an exhaust conduit carrying a flow of exhaust gas from the engine, a de-NOx catalyst disposed along the exhaust conduit and configured to treat the flow of exhaust gas, a fuel reformer module configured to provide a gas stream containing hydrogen gas and carbon monoxide gas, and a junction disposed along the exhaust conduit between the engine and the de-NOx catalyst, the junction being arranged to mix at least a portion of the gas stream with the flow of exhaust gas such that the hydrogen gas and the carbon monoxide reach the de-NOx catalyst and act as reductants to regenerate the de-NOx trap.
US09555371B2 Selective catalytic reduction processes using doped cerias
Niobia- and tantala-doped ceria catalysts, their use in selective catalytic reduction (SCR) processes, and a compact after-treatment system for exhaust gases are disclosed. In some aspects, the catalyst comprises at least 91 wt. % of ceria and 0.1 to 9 wt. % of niobia or tantala doped on the ceria. While conventional SCR catalysts can deactivate at higher temperatures, the doped cerias, particularly ones having as little as 1 or 2 wt. % of Nb2O5 or Ta2O5, are activated toward NOx conversion by calcination. The doped cerias are also valuable for SCRF® catalyzed filter applications, including an after-treatment system that comprises a diesel particulate filter having inlets and outlets, and a dual-function catalyst coated on the inlets, outlets, or both. Compared with conventional SCR catalysts, the niobia or tantala-doped cerias enable a higher level of NO2 to be present.
US09555369B2 Emission control system
Methods of treating mercury contaminated gas comprising: introducing a hydrogen halide selected from HBr and HI into a mercury contaminated gas stream containing a quantity of particulate matter at an introduction rate sufficient to create a concentration of at least 0.1 ppmvd; wherein greater than 50% of all particulate matter in the mercury contaminated gas stream is a native particulate matter; contacting a quantity of active bromine with the native particulate matter; creating a doped particulate matter; coating a filtration media with the doped particulate matter; and passing a portion of the mercury contaminated gas stream through the doped particulate matter on the filtration media and other related methods are disclosed herein.
US09555368B2 Chemically-enhanced sorbent activation process and method of using same
The invention in its various embodiments is directed to methods and equipment for generating an activated sorbent from a sorbent precursor with the addition of certain chemicals that enhance the effectiveness of the activated sorbent. The invention in its various embodiments is also directed to the methods and equipment for generating some of the chemicals that are added to the raw carbonaceous material or activated sorbent to enhance its effectiveness. The invention in its various embodiments is also directed to methods and equipment for generating certain chemicals that can be added to a gas stream to convert a given gaseous pollutant to a form that is more easily removed from the gas stream.
US09555352B2 Modular pump and filter system and method
Embodiments of the invention provide a pump and filter system and method. The system includes a housing with a housing cavity and a filter cartridge, and a pump positioned in the housing cavity. The filter cartridge splits the housing cavity into a filtered region and an unfiltered region and the pump is located in the filtered region. The method includes operating the pump to pull fluid through a housing inlet into the unfiltered region, to pull fluid across the filter cartridge into the filtered region via suction pressure of the pump, and to force the fluid through the pump to a housing outlet.
US09555351B2 Filter device
A filter device having a filter element received in a filter housing, the filter housing has an inlet and an outlet. The filter element separates a crude chamber that communicates with the inlet from a pure chamber that communicates with the outlet. The filter element has an axially and eccentrically projecting plug, which in an inserted state, is plugged into a plug receptacle formed within the filter housing, and wherein at least one signal generator recognizes at least one of a presence and an absence of the plug in the plug receptacle, generating at least one signal.
US09555344B2 Process for the purification of recombinant albumin
A process is provided for the preparation of a highly pure albumin solution the process comprising subjecting albumin (preferably expressed and secreted by transformed yeast) to a series of chromatographic steps. Preferably, the process comprises the steps of positive mode cation exchange chromatography, positive mode anion exchange chromatography, positive mode affinity chromatography, negative mode affinity chromatography (preferably using immobilized aminophenylboronic acid), negative mode cation exchange chromatography, and negative or positive mode anion exchange chromatography. A process for reducing the level of nickel in an albumin solution is also disclosed, as is a recombinant albumin coding sequence comprising two or more in-frame translation stop codons. Also disclosed is a process for producing recombinant albumin, the process comprising culturing a fungal cell expressing a recombinant albumin coding sequence, wherein the cell has a reduced capacity of mannosylation of the recombinantly-expressed albumin.
US09555343B2 Process for the purification of a residue
Process for the purification of a residue containing solids and mother liquor and having a chloride ion content greater than 5000 ppm by weight relative to the weight of the residue which comprises (a) piston washing said residue with a washing fluid and (b) recovering a purified residue.
US09555342B2 Thermal processing reactor for mixtures, fabrication of the reactor, processes using the reactors and uses of the products obtained
A reactor and its internals used for the thermal processing of a mixture. The reactor comprises plates and at least part of the surface of said plates is used to perform said thermal processing. The reactor and its internals are used for the thermal processing of mixtures containing organic compounds. The processes, for thermal processing a mixture comprising organic compounds, comprising the steps of feeding the reactor and its internals and being useful for treating wastes oils and/or for destroying hazardous and/or toxic products; and/or for reusing waste products in an environmentally acceptable form and/or way, and/or for cleaning contaminated soils or beaches, and/or cleaning tar pits, and/or use in coal-oil co-processing, and/or recovering oil from oil spills, and/or PCB free transformed oils. A process for fabricating the reactor and its internals is also proposed.
US09555337B2 Method for tracking physical play objects by virtual players in online environments
Techniques are disclosed for tracking physical play objects by virtual or non-player characters in an electronic game environment. More specifically, techniques are disclosed for enabling a game system to track a physical toy object, using tracking information to update the game state, and transmitting updated game state to the toy object and update the toy state. Additionally, a player is able to control the physical toy object, and use the physical toy object to play a game. The game system may track a remote-controlled toy, a handheld toy, or the player himself or herself. The virtual feedback to changes in the physical environment results in a more immersive game experience for the player.
US09555330B2 Information processing system, storage medium having stored therein information processing program, information processing apparatus, input device, and information processing method
An example of a configuration of an information processing system of the exemplary embodiment includes a first input device on which at least a portion of a user's body is allowed to be put and an information processing apparatus for processing data obtained from the first input device. The first input device includes a first platform on which at least a portion of a user's body is put; and a distance data output unit. The distance data output unit outputs distance data determined in accordance with a distance to an object positioned in a direction away from a platform surface of the first platform. The information processing apparatus includes a data acquisition unit and a processing unit. The data acquisition unit acquires the distance data outputted by the distance data output unit. The processing unit performs a predetermined process, based on the distance data acquired by the data acquisition unit.
US09555327B1 System and method for displaying a game using a primary display and communicating alliance information among alliance members using a secondary display
The disclosure relates to systems and methods for communicating a primary display comprising information that facilitates visual presentation of a view of a game space to a primary client device and facilitating communication of alliance information among members of an alliance through a secondary client device such as a user's smartphone. The system may include a game device that allows a user to play a video game or otherwise interact with a virtual environment, and send or receive alliance information using the primary client device and send or receive alliance information using a secondary client device while playing the video game using the primary client device. The primary client device or the secondary client device may also be used to control actions taken by the alliance. Thus, alliance control may be facilitated using either or both of the primary client device and the secondary client device.
US09555325B2 Fantasy league management
One or more techniques and/or systems for managing a fantasy league are disclosed to incorporate one or more reality factors, equity lines, luxury tax, and/or revenue sharing policies into administration of the fantasy league. A reality factor may influence real life scenarios between at least one of a real player, a real team, and/or a real league, for example. Accordingly, the reality factor may be applied to at least one of a corresponding fantasy player, fantasy team, and/or fantasy league to create a fantasy rule configured to enable a fantasy environment (e.g., the fantasy player, fantasy team, fantasy league, and/or relationships thereof) to more closely emulate the real player, real team, real league, and/or corresponding relationships.
US09555324B1 Dynamic effectiveness for virtual items
An online gaming system allowing for adjustment of the effectiveness of virtual items. The system may comprise one or more processors configured to execute computer program modules. The system may include a game module configured to execute an instance of an online game and to implement the instance of the online game to facilitate participation of users in the online game. The system may include a user module configured to manage user information associated with the users in the online game. The system may include a shop module configured to present virtual items to the users in a virtual shop. The system may include a spend history module configured to obtain user spend information that characterizes past spending by the users on virtual items. The system may include an item effectiveness module configured to determine an effectiveness level of virtual items available in the online game.
US09555321B2 Method of gaming, a gaming system and a game controller
A method of gaming comprising conducting one or more paid game rounds initiated in response to the payment of a wager by a player and a series of one or more free game rounds initiated in response to a free game series trigger event, the method comprising: in each paid game round, selecting a set of paid game round symbols for display to the player, determining a paid game round outcome based on the selected symbols, and incrementing a jackpot by a paid game jackpot increment; in each free game round, selecting a set of free game round symbols for display to the player, determining a free game round outcome based on the selected symbols, and incrementing the jackpot by a free game jackpot increment; and awarding the jackpot on the occurrence of a jackpot award event.
US09555317B1 Method and system for playing a card game that includes wagers for dealt hand positions
A card game entails betting on the rank, suit, rank and suit, color, odd/even value of a card dealt to one of two positions on a table. Using a two-sided selector (button), a player selects which of the two position will count. The selection is made prior to dealing or revealing the dealt cards. Players may also bet on whether the two cards are a pair. The selector is placed in a compartment of a selector rack during the round of play.
US09555311B1 Protective overgarment
The protective overgarment is intended for use by persons who engage in potentially hazardous activities, such as motorcycling and mountaineering. The overgarment is formed of generally circumferential elements that extend around the legs, torso, and arms of the wearer. The circumferential elements are connected by a plurality of connecting elements that extend along the sides of the torso and limbs of the wearer. The elements define corresponding open ventilation passages therebetween, providing greater comfort for the wearer during warm weather. Each of the elements is formed of at least one distinct layer. One layer may be a sheet of resilient rubber or the like. Another layer may be pneumatically inflated or filled with foam plastic material. Yet another layer may also be foam-filled and covered with a stretch fabric for comfort. Additional knee, shoulder, and chest protection is provided by removable rigid plates.
US09555306B2 Ball throwing machine and method
A ball throwing machine can include a hopper for receiving one or more balls and a ball delivery device. The ball delivery device can be used to throw or pitch a ball from the hopper to a user of the machine. The ball delivery device can include wheels to impart speed to the ball and a direction system to control the projection angle of the ball. The direction system can control at least one of the up and down angle and the side to side angle of the ball as it is thrown, among possibly other throwing parameters. A controller may be provided for controlling operation of the ball throwing machine.
US09555302B1 Practice device for hitting golf balls off ground
A practice device for hitting a golf ball (1) off a cushioned golf mat (16), whereby golf ball is connected to a swing arm apparatus (1-12) attached to a structure (17) at a fixed height above ground, whereby swing arm apparatus will rotate about axis (9) after golf ball is hit. Structure (17) is attached to a mat platform (19) secured to ground when outdoors, or secured to extension of platform golfer stands on if indoors. An upper stopper (14) prevents the swing arm apparatus from going past a vertical orientation after ball is struck. A lower stopper (15) stops the ball on way back down after being hit, and supports swing arm apparatus at resting position with ball just touching cushioned golf mat. A flexible stick (20) is attached to structure visually informing golfer when club strikes the cushioned golf mat prior to striking golf ball.
US09555301B2 Modular beer pong table constructed of easily interchangeable modules
A modular beer pong table comprising a plurality of planar members. Each planar member having the ability to connect to any other planar member indiscriminately by a unique mechanism that employs an alternating pattern of protrusions which can mate with any other similar set of alternating protrusions. The mating protrusions providing for a strong joint and easy assembly. The planar members along with cap-like members combine to form a briefcase-like assembly for easy transportability and storability. The briefcase-like assembly further being able to retain two specialized stands which can be used to elevate the modular beer pong table during use. The modular beer pong table having the ability to float on water. Additional planar members of a modular nature that facilitate multiple concurrent beer pong game sessions. One embodiment employing the unique method of connecting modules for use in a toy construction set.
US09555295B2 Golf club heads and methods to manufacture golf club heads
Embodiments of golf club heads and methods to manufacture golf club heads are generally described herein. In one example, a golf club head may include a body portion and a plurality of weight portions. The plurality of weight portions may include a first set of weight portions and a second set of weight portions. Each weight portion of the first set of weight portions may be associated with a first mass, and each weight portion of the second set of weight portions may be associated with a second mass that is less than the first mass. Other examples and embodiments may be described and claimed.
US09555292B2 System and method for a motion sensing device which provides a visual or audible indication
A device includes a signaling means and a motion sensor, and logic for activating or controlling the signaling means in response to a sensed motion according to an embedded logic. The device may be used as a toy, and may be shaped like a play ball or as a handheld unit. It may be powered from a battery, either chargeable from an AC power source directly or contactless by using induction or by converting electrical energy from harvested kinetic energy. The embedded logic may activate or control the signaling means, predictably or randomly, in response to sensed acceleration magnitude or direction, such as sensing the crossing of a preset threshold or sensing the peak value. The visual means may be a numeric display for displaying a value associated with the count of the number of times the threshold has been exceeded or the peak magnitude of the acceleration sensed.
US09555291B1 Multi-layered cores for golf balls based on thermoplastic compositions containing non-acid polymers
Multi-layered golf balls containing a three-layered core assembly are provided. Preferably, at least one of the core layers is formed from a thermoplastic composition that comprises: a) thermoplastic non-acid polymer, and b) plasticizer. In one preferred embodiment, the inner core is made of a first thermoset composition, for example, polybutadiene rubber; and the intermediate core layer is made of a thermoplastic composition; and the outer core is made of a second thermoset composition. A fatty acid ester such as ethyl oleate is preferably used as the plasticizer. Suitable non-acid polymers include, for example, polyesters, polyamides, polyolefins, and polyurethanes. The core assembly has a relatively high resiliency at given compressions.
US09555284B2 Multiple sensor tracking system and method
A system and method for tracking the flight of golf balls at driving range. The system includes a plurality of hitting stations, a plurality of sensors, a computer, and a range surface. Each hitting station in the plurality of hitting stations includes a golf ball, a golf club, a monitor, and a sensor. At least one other sensor in the plurality of sensors is placed outside a hitting station. The flight path of the golf balls being calculated by the computer using parameters by the plurality of sensors. The method includes steps for determining whether a first sensor detected a first parameter and a second parameter, whether a second sensor detected a first and a second parameter, whether a third sensor detected a third parameter, and depicting the flight path of the golf balls using the first parameter, the second parameter, and the third parameter.
US09555280B2 Attachment assembly for an exercise device and an exercise device incorporating the same
An attachment assembly for an exercise device and a method of using the same. The device includes a first end and a second end; a first J-hook defining a portion of the second end; and a second J-hook defining a portion of the second end; wherein the first and second J-hooks are releasably attach the device to a separate exercise structure. The method includes providing a ring on the exercise structure, wherein the ring defines an aperture; affecting relative movement of the ring relative to an exercise assembly, defining a gap between two inverted J-hooks; positioning the ring in the gap beneath two ends of the J-hooks; affecting a relative rotation of the ring relative to the two J-hooks such that the ring is beneath a J-hook passageway defined by a downwardly facing concave surface on each J-hook; and engaging the ring with the concave surface on each J-hook.
US09555278B2 Strength training and stretching system and resistance band assembly for use therewith
A fitness station and resistance band assembly and a method of using the same. The station includes a base; a support extending upwardly from the base; a first arm extending outwardly from the support; and a plurality of attachment members provided on one or more of the base, the support or the first arm. The assembly is selectively engageable with one of the attachment members and is operable to apply a resistive force during a performance of an exercise. The assembly includes a housing that is at least partially rigid and a first resilient member for providing the resistive force located within the housing. The assembly is attached to one of the attachment members on the fitness station. A pulling motion is applied to the assembly during the performance of an exercise. A resistive force is generated within the assembly in response to the applied pulling motion.
US09555276B2 Gait rehabilitation apparatus having lateral entry mechanism and lateral entry method using the same
Disclosed herein is a gait rehabilitation apparatus including a first frame having a bottom surface which is movable at predetermined speed; a second frame extending upwards from a tip of the first frame; a load support unit which is mounted to an upper end of the second frame and is rotatable about a rotation axis thereof; a connection string, one end of which is connected to the load support unit, and the other end of which is connected to an upper body of a rehabilitant; a safety bar which is connected to the second frame and is rotatable so as to be tilted upwards; and a gait assistance link member which has a structure able to be tilted upwards, and is connected to each leg of the rehabilitant entering onto the first frame to assist rehabilitation training of the rehabilitant through mechanical movement of the gait assistance link member.
US09555275B1 Resilient hand pad and block system for relieving hand and wrist stress, and related pain, during yoga and related floor-based poses and exercises
A hand pad for stabilizing and supporting on a floor or other surface the hand of a user during stationary and dynamic exercises includes a body having a top surface defining a debossed profile of a human hand for receiving therein the hand of a user, and a bottom surface having a slip-resistant texture.
US09555268B2 Spherical ultrasonic HIFU transducer with modular cavitation sense element
An ultrasonic HIFU transducer (120) has a threaded opening into which a modular cavitation sensor (90) is removably located. The modular cavitation sensor includes a modular housing (92) containing a piezoelectric transducer for sensing acoustic signals indicative of cavitation. The modular cavitation sensor has electrodes (96,98) which engage spring contacts (112,114) in the threaded opening when the modular housing is screwed into the threaded opening. A damaged sensor can be unscrewed and replaced simply without connectors or soldering.
US09555267B2 Direct contact shockwave transducer
A system is attachable to a surface of a tissue of a patient for applying pressure pulses to the tissue. The system includes a shockwave transducer that has a shockwave generating portion and a solid transducer interface arranged to directly contact a tissue of a patient. The shockwave generating portion includes an electrical-to-shockwave energy converter operable to generate shockwaves. The transducer interface includes an electrically safe and bio-compatible material arranged to transmit the shockwaves from the shockwave generating portion to the tissue.
US09555266B2 Device for remotely cross-firing particle beams
Provided is a device for multi-portal irradiation of particle beams which makes it possible to carry out multi-portal irradiation by remote operation without an operator having to enter an irradiation room. This device for remotely multi-portal irradiation of particle beams includes an irradiation room and a control room. The irradiation room comprises an irradiation device for emitting a particle beam at an irradiation target, an irradiation control device for controlling the position and direction of the irradiation device, and a support stand for supporting the irradiation target. The control room, in turn, includes a control device and a remote operation controller. The control device controls the position and direction of the irradiation device by controlling the irradiation control device.
US09555257B2 Self resonant transmitting device
A device for powering an implant within a body of a subject from a location external to the subject, wherein the implant requires a threshold rate of power increase in order to operate in at least one mode, may include an antenna configured to wirelessly transmit energy to the implant. The device may also include a power storage unit configured to store energy from a power source incapable of delivering the threshold rate of power increase to enable the implant unit to operate in the at least one mode and a power release unit configured to release a pulse of energy from the power storage unit to the antenna after the power storage unit collects an amount of energy sufficient to enable the implant unit to operate in the at least one mode.
US09555255B2 Touch screen finger position indicator for a spinal cord stimulation programming device
A portable electronic programmer has a display screen, one or more sensors, a non-transitory memory storing instructions, and one or more electronic processors configured to execute the instructions to perform operations that include: detecting, via the one or more sensors, that the display screen of the portable electronic programmer has been engaged by an object; determining a location of the display screen of the portable electronic programmer that has been engaged; and causing an external monitor to display a visual indicator that corresponds to the location of the display screen of the portable electronic programmer, the external monitor being communicatively coupled to the portable electronic programmer.
US09555254B2 Implantable medical device with communication by way of physical connector, system and method therefore
System, implantable medical device and method for communicating between an implantable medical device and an external communication device. The implantable medical device has a physical connector, a medical module and a communication module. The medical module is configured to at least one of deliver a therapeutic output by way of the physical connector and/or sense data indicative of a physiologic condition of a patient by way of the physical connector. The external communication device is configured to communicate with the communication module by way of the physical connector. In an embodiment, electronic communication may be by way of a differential pair of connectors.
US09555251B2 Systems and methods for adjusting a pacing rate based on cardiac pressure
An implantable medical device includes a pressure input, an excitation source, a detector module, and a processor. The pressure input is configured to be joined to a pressure sensor located proximate to a cardiac chamber of the heart. The pressure input receives pressure measurements representative of a pressure in the cardiac chamber. The excitation source is configured to deliver stimulation pulses to the heart. The detector module communicates with the pressure sensor to receive and compare the pressure measurements to a pressure threshold. The processor instructs the excitation source to deliver the stimulation pulses at a pressure-based rate based on the comparison of the pressure measurements to the pressure threshold.
US09555249B2 Assessment of cardiac wall motion using impedance measurements
In accordance with the techniques for heart monitoring described in this disclosure, an implantable medical device (IMD) may assess cardiac wall motion using impedance measurements through cardiac leads. As an example, the IMD may calculate an amount or rate of change in impedance due to the motion of a wall of the heart during at least a portion of one cardiac cycle, e.g., systole, in order to assess the strength of systolic contraction.
US09555248B2 System and method for tactile C-fiber stimulation
A method is provided to deliver C tactile fiber stimulation to nervous tissue of a patient. The method comprises delivering a first tactile stimulation waveform to a first electrode combination within an array of electrodes located proximate to nervous tissue of interest. The method further provides sequentially delivering successive tactile stimulation waveforms to successive electrode combinations within the array of electrodes. The first and successive tactile stimulation waveforms include at least one series of pulses having a pulse amplitude and pulse frequency. Delaying delivery of the successive tactile stimulation waveforms by a firing delay, the pulse amplitude, pulse frequency and firing delay represent therapy parameters. The method manages at least one of the therapy parameters of the first and successive tactile stimulation waveforms to excite C tactile fibers of the nervous tissue of interest.
US09555245B2 System and method for treatment of pain related to limb joint replacement surgery
It has been discovered that pain felt in a given region of the body can be treated by stimulating a peripheral nerve at a therapeutically effective distance from the region where pain is felt to generate a comfortable sensation (i.e., paresthesia) overlapping the regions of pain. A method has been developed to reduce pain in a painful region following limb joint replacement by stimulating a peripheral nerve innervating the painful region with an electrode inserted into tissue and spaced from the peripheral nerve. This method may be used to help alleviate postoperative pain in patients following total knee arthroplasty surgery or other limb joint replacement surgeries.
US09555239B2 Electroporation appliance comprising an oblong applicator, ring electrodes and a seat for a syringe
A dynamic electroporation appliance comprises an oblong isolating applicator (1) with a rounded front part (4) and with two annular electrodes (3) arranged on its front surface at the sides of an intermediate opening (2). The intermediate opening it linked to at least one duct (9) associated with a central seat for a syringe (6) for dispensing pharmacological or aesthetic products or active ingredients. The electrodes (3) are energizable to produce a dynamic electroporation effect on the treated surface.
US09555237B2 Overvoltage protection circuitry
Overvoltage protection circuitry configured to protect internal integrated circuits within an implantable device in the presence of a high voltage event such as defibrillation or electrocautery. The circuitry allows for an internal node to rise above the voltage level of the high voltage event to insure that an overvoltage protection element is triggered, even if the voltage level of the high voltage event is below the voltage trigger level of the overvoltage protection element.
US09555232B2 Positive bolus clamp
A clamp for clamping flexible tubing is disclosed. The clamp includes a body having a first portion, a second portion, a first passage through the first portion, and a second passage through the second portion. The first passage is configured to compress a first length of the flexible tubing. The second passage is configured to compress a second length of the flexible tubing that does not overlap the first length.
US09555229B2 Method for producing silicon microneedle arrays with holes and microneedle array
A method for producing silicon microneedle arrays with drilled holes includes producing a silicon microneedle array. For each microneedle in a plurality of microneedles in the microneedle array, a laser is positioned relative to a microneedle and a drilled hole is drilled into the microneedle array by laser drilling. The drilled holes are drilled in microneedles, in flanks of the microneedles or alongside microneedles. A microneedle array includes a substrate composed of a micromechanical semiconductor material. The microneedle array has microneedles that project from the substrate and has drilled holes. The microneedles are composed of a porous micromechanical semiconductor material.
US09555228B2 Systems, devices, and methods for localized drug delivery
Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
US09555227B2 Biosynchronous transdermal drug delivery
Systems and methods for synchronizing the administration of compounds with the human body's natural circadian rhythms and addiction rhythms to counteract symptoms when they are likely to be at their worst by using an automated and pre programmable transdermal or other drug administration system.
US09555226B2 Transdermal drug delivery method and system
The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated.
US09555224B2 Reduced material tip for catheter and method of forming same
Method for fabricating a catheter including providing an inner tubular member formed from a first polymeric material, the inner tubular member having a distal section, a distal end, and a lumen defined therein by a first inner diameter; necking down at least a portion of the distal section of the inner tubular member to form a necked tip having a second inner diameter; and removing a portion of polymeric material from an inner surface along the necked tip to define a third inner diameter for the necked tip. The method can include positioning the distal section of the inner tubular member in a balloon having a working length, a distal neck, and a distal leg, with the distal end of the inner tubular member extending distally beyond a distal end of the distal leg, and coupling the distal leg of the balloon to at least a portion of the distal section of the inner tubular member.
US09555223B2 Method and apparatus for inflating and deflating balloon catheters
A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
US09555214B2 Expandable introducer sheath and related methods
The various embodiments disclosed herein relate to introducer sheaths having an expandable and retractable shaft configured to receive a positionable medical device therethrough. In some embodiments, the shaft is selectively expandable and retractable based on the position of the positionable device within the shaft.
US09555213B2 Catheter tip coating system
A catheter tip coating assembly includes a housing defining a fluid reservoir and having a fluid outlet configured to dispense fluid to an end of a piece of tubing. The catheter tip coating assembly includes a valve assembly carried by the housing and at least partly disposed in fluid communication with the fluid reservoir. The valve assembly is configured to receive the piece of tubing and configured to move between a first position to limit fluid communication between the fluid reservoir and the fluid outlet and a second position to provide fluid communication between the fluid reservoir and the fluid outlet to dispense fluid to the end of the piece of tubing. The assembly provides for careful control over the amount of liquid that is applied and the depth of the wetting.
US09555212B2 Anesthesia system with detachable anesthetic dispensing device
An anesthesia system for providing a breathing gas enriched with anesthetic has an anesthesia apparatus (2) and at least one anesthetic dispensing device (3), which is detachably coupled with the anesthesia apparatus. A fluid connection (7, 8, 9) is provided between the anesthesia apparatus and the dispensing device, which is designed to send anesthetic from the dispensing device into the anesthesia apparatus. At least one optical interface is provided between the anesthesia apparatus and the dispensing device. At least one display device is provided in the dispensing device. The optical interface has at least one light source (10), which is provided in the anesthesia apparatus, and at least one fiber optic light guide (20), which is provided in the anesthetic dispensing device (3). The light fed by the light source (10) into the fiber optic light guide is sent to the display device to directly or indirectly light the display device.
US09555202B2 Respiratory drug delivery apparatus which provides audio instructions
A respiratory drug delivery apparatus that includes a housing for holding a source of a medication, wherein the housing has a patient interface portion for delivering one or more doses of the medication to an airway of a patient, and a sound generator coupled to the housing. The sound generator is adapted to generate one or more audible instructions in response to an actuation signal. The actuation signal may generated in response to a manual actuation performed by the patient, or in response to the detection of an event relating to operation of the apparatus.
US09555200B2 Inhaler
The invention relates to an inhaler (1) comprising a capsule housing (2) for containing a medicament capsule (4). The inhaler includes an airflow path (6) through which air flows during an airflow event from at least one air inlet (8) to an outlet (10), the airflow path passing through the capsule housing. There is a first sensor (16), a processor (18) and a power source (20) for powering the processor. The capsule housing is defined by at least one wall (22) and configured such that when a capsule is located in the capsule housing and sufficient air flows along the airflow path through the capsule housing, the capsule moves within the capsule housing. The first sensor is arranged on the inhaler so that it is able to detect the movement of the capsule within the capsule housing and generate a first signal indicative of said movement. The processor receives the first signal from the first sensor and uses said first signal to determine whether the first signal is indicative of the presence, or absence, of a capsule in the capsule housing during an airflow event and generate a capsule signal indicative thereof.
US09555195B2 Drive assembly, drive component and drug delivery device
A drive assembly for a drug delivery device comprises a rotation member being configured to be rotated in a first direction during setting of a dose of a drug and to be rotated in a second direction during delivery of the dose, a drive component being configured to follow rotational movement of the rotation member in the second direction during delivery of the dose and a stop member being configured to prevent rotational movement of the drive component in the first direction. The drive component comprises a first drive part and a second drive part, coupled to each other such that relative rotational movement of the first and second drive parts is prevented and relative axial movement is permitted.
US09555191B2 Apparatus and methods for self-administration of vaccines and other medicaments
A medicament delivery device includes a housing, a medicament container disposed within the housing, an activation mechanism, a cover and an electronic circuit system. The activation mechanism includes an energy storage member configured to produce a force to deliver the dose of a medicament and/or vaccine. The cover is configured to receive at least a portion of the housing. The electronic circuit system is coupled to the housing such that a protrusion of the cover electrically isolates a battery from a portion of the electronic circuit system when the portion of the housing is received by the cover. The electronic circuit system is configured to be electrically coupled to the battery and to produce a recorded speech output when the portion of the housing is at least partially removed from the cover. The electronic circuit system configured to produce a signal when the activation mechanism is actuated.
US09555190B2 Fluid reservoir seating procedure for a fluid infusion device
A method of seating a fluid reservoir in a housing of a fluid infusion device is presented here. The method is performed prior to establishing an outgoing fluid flow path from the fluid reservoir. The method begins by detecting insertion of the fluid reservoir into the housing of the fluid infusion device. In response to detecting the insertion, the method determines whether the fluid reservoir is in need of depressurization. When the fluid reservoir is in need of depressurization, the drive motor assembly of the fluid infusion device is rewound to depressurize the fluid reservoir. After depressurizing the fluid reservoir, an equalization state for the fluid reservoir is achieved. After achieving the equilibrium state, the drive motor assembly is advanced to obtain an initial seated state for the fluid reservoir.
US09555189B2 Fluid management device having rotating carousel with container holders for vertically positioning a container during automated spiking and injection into patient
A fluid management system adapted to automatically supply fluid for injection into a patient is disclosed. The fluid management system includes a fluid management device, a fluid transfer system and a fluid injector. The fluid management device serves to store and administrate multi-dose containers. The fluid transfer system connects an outlet of these containers to the injector which withdraws a fluid from the containers via the fluid transfer system and injects the fluid to an administration device at the patient. The fluid management device includes at least one rotating carousel having a vertical axis of rotation, at least two container holders attached to the rotating carousel and adapted to position the container vertically with a septum covered end facing downwards, and a spike holder mounted below the rotating carousel and oriented so the spike holder axially aligns a spike connected to the spike holder with the axis of the container.
US09555185B2 Biomedical haemostatic powder dispenser
A biomedical haemostatic powder dispenser (1) by which individual doses of powdered medication that are stored in respective chambers of a rotatable carousel (22) are fluidized for delivery to a targeted treatment site (e.g., a wound in order to stop bleeding). In particular, a squeeze handle (7) is activated (i.e., depressed) so as to cause a blast of gas under pressure to be applied from a gas reservoir (30) to a particular one of the powder-filled chambers of the medication carousel so that a single measured dose of medication is entrained and delivered to the patient. At the same time that the squeeze handle is activated, the medication carousel is rotated so that a different powder-filled chamber is moved within a fluid path between the gas reservoir and an outlet nozzle tube (10) of the dispenser and a kit for dispensing a powder.
US09555180B2 Systems and methods for removing air from the patient's peritoneal cavity
A peritoneal dialysis (“PD”) connection apparatus includes a first connector for connecting to a PD fluid fill line; a second connector in fluid communication with the first connector, the second connector including a filter configured to allow air but not fluid to pass through the filter; and an air-tight cap manually removeable and resealable to the second connector so as to selectively expose the filter to allow air trapped in a patient's peritoneum to be vented to atmosphere.
US09555167B2 Biocompatible antimicrobial compositions
Antimicrobial compositions comprising aliphatic polyester, and an antimicrobial component effective for antimicrobial activity, and, in some embodiments, an enhancer. Example: blend of poly(lactic acid) polymer (55g) with propyleneglycol monolaurate antimicrobial component (9g), and benzoic acid enhancer (1g). Inventive resin compositions are effective against gram negative and gram positive bacteria, mold and mildew. Preferred compositions comprise materials that are GRAS (Generally Regarded As Safe).
US09555161B2 Synergistic effects of blending multiple additives in UHMWPE
Oxidation resistant crosslinked ultrahigh molecular weight polyethylene (UHMWPE) is described, wherein at least two different additives in the manufacture synergistically increase the oxidation resistance of crosslinked UHMWPE. This allows the manufacture of oxidation resistant crosslinked UHMWPE using lower levels of additives and/or lower levels of crosslinking irradiation or chemicals. The lower levels of additives and/or crosslinking produce crosslinked UHMWPE having desired physical properties not possible without the synergistic interaction of the additives. This crosslinked UHMWPE may be used in medical prostheses such as in bearing components having desired physical properties such as wear resistance and oxidation resistance not possible without the synergistic interaction of the additives.
US09555156B2 Germanium-based glass polyalkenoate cement
Disclosed herein are compositions and methods for making germanium-based glass polyalkenoate cements. Also disclosed are methods for their use as bone cements for bone augmentation procedures.
US09555150B2 Absorbent articles comprising an organic zinc salt and an anti-bacterial agent or alkali metal chloride or alkaline earth metal chloride
An absorbent article, such as a diaper, panty diaper, sanitary napkin or incontinence device includes a topsheet, a backsheet and an absorbent core enclosed between the topsheet and the backsheet. The absorbent core includes an anti-bacterial agent or an alkali metal or alkaline earth metal chloride in combination with an organic zinc salt, in particular, zinc ricinoleate. The combination of antibacterial or (earth) alkali metal chloride and organic zinc salt exerts a synergetic effect in the suppression of malodours, such as ammonia.
US09555148B2 Superabsorbing polymers with rapid absorption properties and method for producing the same
This invention relates to a method for producing a water-absorbing polymer, including the following steps: (i) mixing (α1) 0.1 to 99.999 wt % polymerizable, ethylenically unsaturated, acid-group-containing monomers; (α2) 0 to 70 wt % polymerized ethylenically unsaturated, monomers copolymerizable with (α1); (α3) 0.00 1 to 10 wt %, cross-linking agent(s); (α4) 0 to 30 wt % water-soluble polymers; and (α5) 0 to 20 wt % additive(s), wherein the total quantity by weight of (α1) to (α5) amounts to 100 wt %, (ii) radical polymerization while cross-linking, in order to form a hydrogel polymer, (iii) drying the hydrogel polymer, (iv) grinding and sifting the water-absorbing polymer, (v) surface post-cross-linking the hydrogel polymer, and (vi) drying and processing the polymer, wherein, before the admixture of the initiator and the start of radical polymerization, 0.01 to 5 wt % of a surfactant, relative to acrylic acid, 0.01 to 5 wt % foaming agent, are added.
US09555146B2 Method of sterilizing at least one object, sterilization apparatus and use of same
A method of sterilizing an object having at least first and second openings toward an inner space of the object includes connecting the first opening to a feed line for a sterilization agent, connecting the second opening to an outlet line for the sterilization agent, and conducting the sterilization agent through the feed line into the inner space, through the inner space, and out of the inner space through the outlet line.
US09555145B2 System and method for biofilm remediation
A method for removing biofilm from a lumen of a medical implant is disclosed. The method includes the steps of inserting a plasma applicator into a lumen defined in a medical implant, the lumen having a proximal end portion and a distal end portion having an opening therein, positioning the plasma applicator adjacent a biofilm formation, generating a selectively reactive plasma effluent at the plasma applicator and directing the selectively reactive plasma effluent at the biofilm formation.
US09555142B2 Method and apparatus for heat treatment of waste
The method for the heat treatment of waste includes introducing the waste by into a bag and placing the bag inside an apparatus for treating waste, the apparatus including a cylindrical barrel, a removable closure lid and a bottom moveable inside the barrel, at least in the direction of the lid. After the bag has been placed in the apparatus heat treatment of waste is carried out by raising the temperature of the lid and the bottom and by providing this lid and this bottom with a hold temperature. At least during the rise in temperature of the lid and the bottom, and before the hold temperature is reached, this lid and this bottom are moved towards each other at least once. A temperature conferred on the lid differs by at most 2° C. from the temperature of the bottom.
US09555140B2 Actinium-225 compositions of matter and methods of their use
The present invention is directed to improved methods for generating compositions comprising actinium-225.
US09555139B2 Binding ligand linked drug delivery conjugates of tubulysins
Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands. The conjugates also include a releasable bivalent linker.
US09555136B2 Coated magnetic nanoparticles
Disclosed herein are polymer-coated iron oxide magnetic nanoparticles and methods of their manufacture and use. The nanoparticles are coated with a copolymer of poly(maleic anhydride alt-H2C═CH—R1)-polyethylene glycol (PMAR-PEG), wherein R1 is a hydrophobic moiety. The molecular weights of the PMAR and PEG portions of the copolymer, as well as the core diameter of the nanoparticles are selected in order to produce optimal performance for specific applications. Representative applications of the nanoparticles include magnetic particle imaging, magnetic sentinel lymph node biopsy, and magnetic fluid hyperthermia. The disclosed nanoparticles are tools for these methods that provide previously unachieved levels of stability (e.g., via reduced agglomeration) and customizability (e.g., tuned blood circulation half-life in vivo).
US09555135B2 Cobalt-based MRI contrast agent and imaging system
Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices.
US09555128B2 Carrier-antibody compositions and methods of making and using the same
Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.
US09555127B2 Systems and methods for diminishing cell growth and inducing selective killing of target cells
The invention relates to a biological system for diminishing cell growth or inducing selective killing of target cells, in particular pathogenic bacterial or fungal cells, or cancer cells. The biological system is based on toxin-antitoxin systems, as found in prokaryotic plasmids and their host chromosomes. The biological system comprises a vehicle with a first nucleic acid sequence or amino acid sequence encoding for a prokaryotic toxin of a prokaryotic toxin-antitoxin pair, and a second nucleic acid sequence or amino acid sequence encoding for the corresponding prokaryotic antitoxin of the prokaryotic toxin-antitoxin pair. The system is characterized in that the toxin and/or the antitoxin is operably linked to a protein output modifier (POM) that comprises a nucleic acid sequence or amino acid sequence that modifies the relative rate of transcription, mRNA stability, mRNA translatability or protein stability of the toxin and/or antitoxin.
US09555126B2 Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of B-cell malignancies symptoms
An anti-CD19 maytansinoid immunoconjugate is used for treating B-cell malignancies symptom, in particular Non-Hodgkin's lymphoma.
US09555123B2 Multi-arm polyethylene glycol derivatives, conjugates and gels of pharmaceuticals and the same
A multi-arm polyethylene glycol (I) having different kinds of reactive groups and the uses thereof are disclosed, which is formed by polymerizing ethylene oxide with oligo-pentaerythritol as an initiator, wherein, PEG is same or different and is —(CH2CH2O)m-, the average value of m is an integer of 2-250; l is an integer of 1 or more. The method for producing the multi-arm polyethylene glycol having different kinds of reactive groups, the multi-arm polyethylene glycol active derivatives comprising linking groups X attached to PEG and terminal reactive groups F attached to X, the gels formed by the multi-arm polyethylene glycol active derivatives, the drug conjugates formed by the multi-arm polyethylene glycol active derivatives and drug molecules, and the uses thereof in preparing drugs are also disclosed.
US09555122B2 Conjugate with target-finding ligand and use thereof
Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
US09555121B2 Composition for forming complex, complex formed therefrom, and composition for oral administration including said complex
Provide are a composition for forming a composite, the composition including a cellulose-based compound, a polyphenol-based compound, and a solvent, wherein an amount of the polyphenol-based compound is 1 to 40 parts by weight based on 100 parts by weight of the cellulose-based compound, a composite formed from the composition, and an orally ingestible composition including the composite. The composite has characteristics of being dissolved in a solvent in a various pH ranges depending on a mixing ratio of the cellulose-based compound and the polyphenol-based compound. Therefore, when the composite is used, a composite film may be easily prepared, and the composite film may be useful in medical or foods fields where film characteristics dependent on pH is required.
US09555113B2 Compositions with a rheological modifier to reduce dissolution variability
The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.
US09555112B2 Monoclonal antibodies against HER2 epitope and methods of use thereof
This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.
US09555108B2 TCR mimic antibodies as vascular targeting tools
The present invention includes a method of delivering a therapeutic agent into and across an endothelial cell (EC) in a subject in need thereof, comprising: attaching to a T Cell receptor mimic (TCR mimic) an active agent to form a therapeutic agent; and administering to the subject the therapeutic agent in a pharmaceutically acceptable carrier, wherein the therapeutic agent effectively crosses the EC microvascular barrier. Furthermore, the present invention relates to methods of treating diseases (particularly neuronal diseases) or conditions comprising identifying a subject in need of such a treatment and administering to said subject a composition comprising a TCR mimic conjugated to an active agent.
US09555104B2 Immunotherapy composition and use thereof
The present invention relates to the field of preventing or reducing incidence or severity of an allergic immune response, and compositions for preventing or reducing incidence or severity of an allergic immune response. For example, the present invention provides compositions comprising inactivated and/or killed cells of Helicobacter pylori or a cell lysate thereof, and methods and/or uses thereof for delaying or preventing or interrupting or slowing onset of one or more allergic conditions in a subject.
US09555103B2 Beta-lactoglobulin peptides for treating cow's milk protein allergy
The present invention relates to a nutritional, preferably enteral, composition for use in the treatment of cow's milk allergy in infants allergic to cow's milk containing specific beta-lactoglobulin peptides, which are able to reduce, in particular abolish the acute symptoms of cow's milk protein allergy.
US09555099B2 Vaccines for HSV-2
Compositions of recombinant HSV-2 proteins and an agonist of the innate immune system, such as an adjuvant, are provided as a vaccine. Proteins include an envelope glycoprotein and a structural protein other than an envelope glycoprotein, e.g., a capsid or tegument protein. The vaccine is for use in either HSV-2 seropositive or seronegative subjects.
US09555097B2 Recombinant protein bodies as immunogen-specific adjuvants
An immunogen-specific is adjuvant for a vaccine or inoculum is disclosed. The adjuvant is comprised of particulate recombinant protein body-like assemblies (RPBLAs) that contain a recombinant fusion protein that contains two portions peptide-linked together. A first portion is a protein body-inducing sequence (PBIS) and a second portion is a T-cell stimulating immunogenic polypeptide whose sequence is that of a pathogenic polypeptide sequence present in or induced by a vaccine or inoculum. The adjuvant, when used as an inoculum in a host animal without a prior priming vaccination or inoculation, does not induce production of antibodies or T cell activation to the pathogenic sequence.
US09555096B2 Recombinant HVT vectors expressing antigens of avian pathogens and uses thereof
The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors, polyvalent vaccines comprising the recombinant HVT vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
US09555095B2 Computationally optimized broadly reactive antigens for H5N1 and H1N1 influenza viruses
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on H5N1 and H1N1 influenza isolates. Provided herein are optimized H5N1 and H1N1 influenza HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
US09555094B2 Isolated nucleic acid for the production of a vaccine against virus
The present invention relates to a nucleic acid for vaccine that has undergone codon optimization for expression in Bombyx mori, a vector comprising the nucleic acid, Bombyx mori comprising the vector, and a method for producing a vaccine in which they are used.
US09555093B2 Universal vaccine against H5N1 lineages
The present invention relates to a universal H5N1 vaccine. More specifically, the present invention relates to the identification of three H5N1 strains which cover the entire variants in the neutralizing epitopes of hemagglutinin among most H5N1 lineages. The present invention further relates a universal H5N1 vaccine that comprises the three H5N1 strains or that comprises hemagglutinin peptides of each of these three strains.
US09555091B2 Baculovirus-based vaccines
The present invention relates to a recombinant baculovirus comprising: (a) a nucleotide sequence encoding a foreign virus envelope protein; (b) a first promoter operatively linked to the envelope-encoding nucleotide sequence; (c) a nucleotide sequence encoding an antigen protein; and (d) a second promoter operatively linked to the antigen-encoding nucleotide sequence; and a vaccine composition using the same. The recombinant baculovirus of the present invention has an excellent efficacy on both humoral and cellular immune responses against a specific antigen (e.g., HPV L1), enabling to function as a more efficient DNA vaccine.
US09555088B2 DNA vector and transformed tumor cell vaccines
Customized whole cell cancer vaccines can be produced from autologous (ex vivo or in situ) or allogeneic human or veterinary patient cell lines. Cells are transformed with S. pyogenes DNA that expresses an Emm protein on the cell surface and cytosol. Treatment of cancer patients with an Emm vector vaccine induces an immunologic response to the cancer by enhancing immunogenicity of a tumor. Emm vaccines can be used in patients where the cancer is not identified due to lower tumor burden or used to treat a specific cancer and subsequently treat for a second type that may have arisen through metastasis.
US09555085B2 Methods for treating headache
A headache can be treated effectively by administration of a botulinum toxin to a patient at specific muscles using specific doses.
US09555084B2 Combination of growth factors, cytokines, antibacterial/antiviral factors, stem cell stimulating factors, complement proteins C3a/C4a, immunoglobulins and chemotactic factors
The present invention refers to a combination of growth factors, cytokines, antibacterial/antiviral factors, stem cell stimulating factors, complement proteins C3a/C4a, immunoglobulins and chemotactic factors. The invention also relates to a process for the preparation of said combination from serum, placenta or colostrum and to composition containing said combination for use in the treatment of conditions requiring tissue repair and regeneration and for the substitution of stem cell therapies.
US09555082B2 Formulations containing Saccharomyces boulardii and superoxide dismutase (SOD) to control obesity
Disclosed is a composition containing Saccharomyces cerevisiae var boulardii and the enzyme superoxide dismutase.
US09555079B1 Treatment of short bowel syndrome patients with colon-in-continuity
Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as teduglutide.
US09555074B2 Annexin II compositions
The present invention provides compositions and methods that involve the 36 kDa annexin II monomer, which has been identified as having immunostimulatory properties. Accordingly, in one aspect, the invention provides compositions that include at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that include administering to a subject a composition that includes at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that induce an in situ increase in the 36 kDa annexin II monomer by administering to a subject an amount of composition effective to induce localized hypoxia sufficient to cause a localized increase in annexin II.
US09555070B2 Pan-antiviral peptides for protein kinase inhibition
A method of inhibiting protein kinases by administering polypeptides derived from alpha-neurotoxin, and inhibiting protein kinases. Diseases treated thereby include cancer, influenza, Tourette's syndrome, pain, and neurological deficits.
US09555069B2 Pharmaceutical compositions comprising plant extracts and methods for reducing duration of a common cold using same
The present disclosure describes pharmaceutical compositions and methods for reducing duration, intensity, and/or bothersomeness of common colds in humans and for reducing severity or duration of common cold symptoms such as nasal congestion, runny nose, watery eyes, dry/scratchy throat and sneezing in humans exhibiting such symptoms. The compositions herein comprise extracts of at least one of Luffa Operculata (L. operculata), S. officinale (V. sabadilla), and Galphimia Glauca (G. glauca) in a pharmaceutically acceptable carrier, and in various embodiments, comprise a mixture of all three Luffa Operculata (L. operculata) 10% extract MT, S. officinale (V. sabadilla) 3× extract, and Galphimia Glauca (G. glauca) 10% extract MT in a pharmaceutically acceptable carrier.
US09555068B2 Oral compositions and route of administration for the delivery of a thylakoid extract
A new use or method of use of a thylakoid extract, for oral route of administration, and a composition comprising the thylakoid extract in adjunction with an acceptable carrier for oral administration. Also described is a method for treating or preventing a disease or disorder involving the formation of reactive oxygen species inflammation in an individual, which comprises the step of orally administering an effective dose of a thylakoid extract. Also described is an oral composition comprising purified thylakoids and a carrier for oral ingestion or oral administration, with the proviso that the carrier does not essentially consist of water, physiological saline or propylene glycol. The thylakoid extract or composition is also provided as a food or a food supplement, or as a pellet, or encapsulated granules or powder.
US09555067B2 Replication-competent vesicular stomatitis viruses
This document provides methods and materials related to vesicular stomatitis viruses. For example, replication-competent vesicular stomatitis viruses, nucleic acid molecules encoding replication-competent vesicular stomatitis viruses, methods for making replication-competent vesicular stomatitis viruses, and methods for using replication-competent vesicular stomatitis viruses to treat cancer or infectious diseases are provided.
US09555064B2 Protease-deficient Bacillus anthracis
The invention relates to a Bacillus anthracis (B. anthracis) in which more than one secreted protease is inactivated by genetic modification. Such a protease-deficient B. anthracis has an improved ability to produce recombinant secreted proteins compared to other bacteria, particularly other Bacillus. Improvements include production of intact (i.e., mature full-length) proteins, often at high yield. The disclosure provides a B. anthracis that comprises a genetic modification that inactivates a protease of the M4 family of metalloproteases and a genetic modification that inactivates a protease of the M6 family of metalloproteases. Also provided is a modified B. anthracis comprising such genetic modification transformed with a recombinant molecule encoding a product, as well as methods to prepare and use such B. anthracis.
US09555059B2 Use of dietary fibres against muscle wasting
A composition nutritional containing dietary fibers is useful for the treatment of muscle wasting, if the dietary fiber comprise at least 30 wt. % of galacto-oligosaccharides or other oligosaccharides having mainly anhydropyranose units, and having a chain length of 3-10 units. The composition may further contain other oligo- or polysaccharides, especially polysaccharides having a majority of anhydrofuranose units.
US09555056B2 Aliphatic amine polymer salts for tableting
The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.
US09555051B2 Vesicular formulations
The present invention relates to vesicular formulations for the treatment of rosacea. It also relates to a method of treating rosacea comprising administering a vesicular formulation according to the invention.
US09555045B2 Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions
A composition for use in treating corneal and conjunctival lesions, includes a prostaglandin F2alpha or analogue, in a therapeutic amount, the composition being in a form suitable for topical application on the ocular surface and is free of deleterious preservative. A method for treating surface ocular conditions in a patient in need thereof, includes administering an effective amount of the composition.
US09555043B2 High purity diaminophenothiazinium compounds including methylthioninium chloride (MTC)
This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallization (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.
US09555041B2 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
US09555029B2 Methods of colchicine administration
The invention provides improved methods for coadministration of colchicine with drugs metabolized by CYP3A4 (anciently referred to as cytochrome P450 isozyme 3A4) or the P-glycoprotein transporter, but not both. The method enables non-toxic coadministration of colchicine and the second drug at their ordinary levels safely and effectively without reducing the dose or frequency for either drug.
US09555027B2 Pharmaceutical composition
A preparation for oral administration comprising: a pregelatinized starch comprising N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-(2R,3R)-2,3-tetramethylene-butyl]-(1′R,2′S,3′R,4′S)-2,3-bicyclo[2,2,1]-heptanedicarboxyimide hydrochloride (lurasidone) represented by the formula (1) as an active ingredient; a water-soluble excipient; and a water-soluble polymeric binder, the preparation exhibiting an invariant level of elution behavior even when the content of its active ingredient is varied.
US09555025B2 Ointment with excellent formulation stability
Provided is an ointment which has excellent drug stability and excellent drug uniformity. The ointment, which comprises 1 to 5% by weight of 1-[2-[(4S)-4-hydroxy-1,2,3,4-tetrahydroquinolin-1-yl]-4-pyridyl]-2,3-bis(hydroxymethyl)-6,7-dimethoxynaphthalene·3/2 hydrate, 3 to 7% by weight of a separation inhibitor, 15 to 50% by weight of a hydrocarbon gel, a pH controller and 0.05 to 0.4% by weight of an antioxidant, has excellent drug stability and excellent drug dispersibility. In the present ointment, polyoxyethylene (196) polyoxypropylene (67) glycol is preferred as the separation inhibitor, diisopropanolamine is preferred as the pH controller, and dibutylhydroxytoluene is preferred as the antioxidant.
US09555024B2 Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
US09555019B2 Granulate containing cannabinoid, method for its manufacture and oral dosage unit comprising such granulate
The present invention relates to a granulate comprising granules made up of 40-99 wt. % of lactose particles and 1-60 wt. % of a binding component that holds together the lactose particles within the granules. Said granules have a mass weighted average diameter of 50-500 μm and said binding component is a solid dispersion or a solid solution of 10-75 wt. % of a cannabinoid in 25-80 wt. % of a lipophilic matrix. The lipophilic matrix contains at least 80 wt. % sucrose fatty acid mono-ester, the fatty acid residue being selected from C8-C18 fatty acids.The aforementioned granulate can be processed into oral dosage units in the form of tablets for oral delivery.The invention further provides a method for the manufacture of the granulate.
US09554999B2 Lyophilization of synthetic liposomal pulmonary surfactant
Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.
US09554995B2 Nanoemulsions
The invention relates to nanoemulsions useful for analytical techniques and delivery of cargoes such as pharmaceutically active agents. In particular, the invention relates to nanoemulsions comprising an oil phase dispersed in an aqueous phase and at least two peptide surfactants adsorbed at the liquid-liquid interface, one peptide surfactant comprising a short peptide sequence having α-helical propensity and at least one second polypeptide surfactant comprising at least two peptide sequences having α-helical propensity linked by a linking sequence of 3 to 11 amino acid residues. Optionally the at least one second polypeptide surfactant comprises at least one pharmacokinetic modifying agent and/or a targeting agent. Furthermore, the nanoemulsion may further comprise a cargo such as a pharmaceutically active agent.
US09554992B2 Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic
Microparticles comprising a combination of an anticholinergic, a beta2-adrenoceptor agonist, and an inhaled corticosteroid are useful for the prevention and/or treatment of respiratory diseases.
US09554990B2 Cholecystokinin secretion-promoting composition
A method is provided to promote secretion of cholecystokinin (CCK) by administering an active component. The active component includes acrylic acid and/or an unsaturated aldehyde having a main chain of 4 to 12 carbon atoms having a double bond in at least position 2 or 4, where the main chain has 4 to 9 carbon atoms when there is a double bond in only position 2, and the main chain has 9 to 12 carbon atoms when there is a double bond in only position 4. The cholecystokinin secretion-promoting composition can be used as an appetite suppressant. By adding this cholecystokinin secretion-promoting composition to food, appetite-suppressing food products can be provided.
US09554977B2 Triaromatic azomethine direct dyes, dye composition comprising at least one such dye, method of implementation and use
The present invention relates to azomethine-type direct dyes having a triaromatic unit of formula (I) below: and also the use thereof for dyeing keratin fibers, in particular human keratin fibers such as the hair. The invention also relates to a composition for dyeing keratin fibers, comprising, in a medium suitable for dyeing, such direct dyes. Another subject of the present invention is a method for dyeing keratin fibers using said dye composition. Finally, the present invention also relates to precursors of these direct dyes.
US09554975B2 Alkyl sulfate free and orthophosphate free dentifrice composition comprising fluoride source and a silica dental abrasive
A dentifrice composition is described for combating dental erosion and/or tooth wear comprising a fluoride ion source and a silica dental abrasive, the dentifrice having a Relative Dentine Abrasivity (RDA) value from 20 to 60 and a pH in the range of 6.5 to 7.5 and being free of an orthophosphate buffer or a water soluble salt of a C10-18 alkyl sulfate.
US09554973B2 Micro-encapsulation of ozonated oils
A two-part oral care system includes a plurality of micro-encapsulated vessels containing an oxidative composition inside a coating, the oxidative composition having a pH less than 7.5, and a reductant composition, the reductant composition having a pH greater than 7. The micro-encapsulated vessels isolate the oxidative and reductant compositions from reacting with one another during storage and wherein the micro-encapsulated vessels can dispense when ruptured the oxidative and reductant compositions for combining to result in a final composition for use. The oxidative composition includes an ozonated oil comprising 0.01% to 5.0% per mass of the final composition and an oxidant comprising 0.01% to 2.0% per mass of the final composition. The reductant composition may include an aloe gel, xylitol, a ferrous sulfate, a sodium bicarbonate, a calcium carbonate, a zinc gluconate, a salt, a bromelain, a papain, and at least one essential oil.
US09554971B2 Nanostructured antibacterial and remineralizing dental bonding agents and dental bonding systems
The present invention provides dental bonding agents and dental bonding systems comprising the dental bonding agents. The dental bonding agents of the invention are characterized by having antibacterial properties, and in some aspects of the invention, remineralizing properties.
US09554968B2 Trilayer coated pharmaceutical packaging
An article is described including an article surface and a coating set comprising a tie coating or layer of SiOxCy or Si(NH)xCy applied to the article surface, a barrier coating or layer of SiOx, and a pH protective layer of SiOxCy or Si(NH)xCy. The respective coatings or layers can be applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen. Examples of such an article are a prefilled thermoplastic syringe or thermoplastic pharmaceutical vial with a coated interior portion containing a pharmaceutical preparation or other fluid with a pH of 4 to 8, alternatively 5 to 9. The barrier coating or layer prevents oxygen from penetrating into the thermoplastic syringe or vial, and the tie coating or layer and pH protective coating or layer together protect the barrier layer from the contents of the syringe or vial.
US09554967B2 Adapter and drug cartridge alignment device
An alignment device for coupling a liquid drug cartridge with a longitudinal cartridge axis and a constricted neck portion with a cap and a piercable septum distal from the neck portion with an adapter is presented. The septum is perpendicular to the cartridge axis. The device comprises an adapter cannula with a longitudinal cannula axis to pierce the septum and a proximal cartridge engagement structure for axial aligned engagement with a distal end section of cartridge body. The device further comprises a distal adapter engagement structure for axial aligned engagement with the adapter. A coupling of the cartridge with the adapter is enabled via the alignment device. The adapter and the cartridge are, during the coupling, aligned by the cartridge engagement structure and the adapter engagement structure, respectively relative to each other such that the longitudinal cartridge axis and the longitudinal cannula axis form a common longitudinal axis.
US09554966B2 Upper limb training apparatus
An upper limb training apparatus includes a training apparatus main body that includes a base frame, and an operation rod to be operated by a trainee by hand. A chair is positioned in a right or in a left arm training position relative to the training apparatus main body. A monitor stand extends upward from the base frame. A monitor arm is provided in the monitor stand, and supports the monitor such that the position of the monitor can be adjusted in both right and left directions.
US09554965B2 Device for introducing shock waves into a living body and use thereof
In a device for introducing shock waves into a living body by way of at least one element (4; 12; 14) which transmits the shock waves and upon which shock pulses act, wherein at least one spring member (2) is used for generating the shock waves, a tensioning device is associated with the spring member and allows for an abrupt release of the spring member while delivering a shock pulse.
US09554963B2 System for treatment of skin conditions using at least one narrow band light source in a skin brush having an oscillating brushhead
An apparatus and corresponding method for treatment of skin conditions which includes a brushhead member which comprises a first portion which includes a plurality of rings of bristle tufts, the first portion oscillating in operation through a selected angle at a selected frequency and a second portion which also includes a plurality of rings of bristle tufts concentric with the first portion, the second portion remaining stationary in operation. At least one monochromatic light source is included, providing light directed from the brushhead in a direction substantially the same as the bristle tufts, such that the light impinges on the area of skin of the user acted on by the oscillating brushhead.
US09554962B1 Walker structure
A walker having a frame with a plurality of legs with each leg having a wheel or roller located at a respective free end for providing rolling movement of the walker. The frame is dimensioned to surround the person utilizing the walker. The user's weight can be supported by a seat member, which is releasably attached to the frame. The frame of the walker can be pivotally opened and closed to permit the entry and exit of the user with relation to interior of the walker. Depending on the height and comfort of the user, the support frame is also vertically adjustable.
US09554960B2 Wearable motion supporting device
A wearable motion supporting device includes a waist portion frame having a long base portion in a right-left direction of a wearer, a pair of right and left lower extremity frames connected to a lower portion of the waist portion frame, a back portion frame connected to an upper portion of the base portion of the waist portion frame, and a connection portion connecting the back portion frame and the base portion of the waist portion frame. The connection portion is made of a rotational mechanism of one DOF (Degree Of Freedom) on a frontal plane, for example, a four-node link mechanism.
US09554956B2 Patient turning and positioning system device
The invention comprises of a device that allows health care providers to position the body of a patient for progression of labor, for assistance in fetal resuscitation, and for other medical procedures. The device has inflatable chambers that assist the labor and delivery health care provider in turning a patient onto her right or left side while laying in bed. An inflatable positioning pad is used to further assist with the turning of a patient and/or with the shifting of a patient toward the head or the foot of the bed as needed. This device and method will allow turning to be done frequently, rapidly and safely, especially in pregnant patients with epidurals, that are overweight, or that otherwise have difficulty moving on their own.
US09554955B2 Dual-track tilt mechanism
The present invention is directed to a tilt-in-space wheelchair that limits the shift of the center of a gravity of a wheelchair occupant during tilting. The wheelchair comprises a main frame adapted to be supported on a surface by wheels, a seat frame for supporting a occupant, and an arc plate for slidably or rollably supporting the seat frame with respect to the main frame. The arc plate defines a first track and a second track that guide the tilting of the seat frame relative to the frame. The first track and second track may have non-constant curvatures. Further, the first track and second track may be arranged non-concentrically on the arc plate and may have different lengths.
US09554953B2 Mobile medical device and method for controlling a movement of the mobile medical device
The embodiments relate to a medical device and to a method for controlling a movement of the mobile medical device. The medical device includes a chassis and a control apparatus, wherein the medical device is embodied by the chassis to perform a movement in at least two spatial directions on a plane of motion and to execute a rotary movement about an axis of rotation standing perpendicularly on the plane of motion, and the control apparatus is embodied for controlling the chassis.
US09554952B2 Absorbent article
An absorbent article includes a belt placed around the waist of the wearer and an absorbent pad attached to the belt, wherein the pad includes a chassis having a topsheet, a backsheet and an absorbent core, wherein the absorbent pad is attached to a surface of the belt attaching arrangements provided on each corner of the front portion and the rear portion of the pad, wherein the waist elastic is provided at the waist portion of at least one of the front and rear portion and is movable between a contracted condition in which the topsheet and/or backsheet exhibit(s) pleats and a fully stretched condition in which the pleats of the topsheet and/or backsheet are fully stretched out, wherein the elastic force from said waist elastic is within the range of from 2 N to 7 N when the elastic is in the fully stretched condition.
US09554951B2 Absorbent articles with improved core
An absorbent article comprising a wearer-facing topsheet, a backsheet and an absorbent core disposed between the topsheet and the backsheet, characterized in that the absorbent core comprises: a first absorbent layer comprising a first substrate, a layer of first superabsorbent polymer particles deposited on the first substrate, and a fibrous layer of thermoplastic adhesive material covering the layer of first superabsorbent polymer particles; a second absorbent layer, the second absorbent layer comprising a second substrate and a mixed layer deposited on the second substrate, the mixed layer comprising a mixture of second superabsorbent particles and cellulosic fibers, the first absorbent layer and the second absorbent layer being combined together such that at least a portion of the fibrous layer of thermoplastic adhesive material of the first absorbent layer contacts at least a portion of the mixed layer of the second absorbent layer, and wherein the first absorbent layer is placed closer to the topsheet than the second layer.
US09554948B2 Absorbent products with wetness sensors
A sensor that is sensitive to the presence of aqueous-based fluids is described. The sensor has a wetness indicating material immobilized or printed on a substrate. The indicating material contains at least one electron-donating leuco dye and one electron deficient receptor, and exhibits a visual signal (e.g., vivid or strong color intensity) in a dry state, which fades or disappears when in contact with a water-containing liquid. An absorbent article incorporating such a sensor to communicate to a user that the article has been exposed to water-containing fluids is also described.
US09554940B2 System and method for delivering multiple ocular implants
Systems and methods for delivering multiple ocular implants to reduce intraocular pressure are disclosed. The ocular implants can be implanted at multiple sites within a single human eye without requiring removal of the delivery apparatus from the eye. A system for delivering multiple ocular implants can include at least two implants preloaded within a delivery device and configured to be implanted within the eye, a metering device configured to transfer energy to the implants for delivery at selected locations within the eye, wherein the metering device is configured to meter a variable amount of energy for each implant delivery event in the eye. The system can further include an injector mechanism configured to serially engage and drive each of the implants.
US09554930B2 Powered medical device deployment system
Powered medical device deployment systems and methods are described herein. An embodiment of a powered medical device deployment system has a housing, a cannula, a sheath slidably disposed over the cannula, a flush port, a trigger, a drive mechanism, and a medical device. The drive mechanism is moveable between an on state and an off state. When the drive mechanism is in the on state the sheath is axially advanced over the cannula such that the medical device can be deployed at a point of treatment.
US09554927B2 Helical stent having improved flexibility and expandability
A stent includes a central portion of helically wound undulations formed of struts, cylindrical end portions, and transition zones between the helical portion and the cylindrical portions. According to a first aspect of the invention, the torsional flexibility of the stent is maximized by having bridges connecting adjacent winding be interrupted by the maximum possible number of undulations. In one embodiment, each winding includes nineteen undulations around the circumference, bridges are provided every five undulations. According to a second aspect of the invention, uniform opening of the transition zone is achieved by altering the width, and thereby the flexibility, of a series of struts in accordance with their lengths. Specifically, the long transition zone struts are made wider.
US09554923B2 Prosthesis socket and system comprising a prosthesis socket and prosthesis device
The invention relates to a prosthesis shaft for receiving an amputation stump of an extremity, comprising connecting means for a distal prosthesis device (2), wherein the prosthesis shaft (1) comprises at least one shell (11, 12), which has an arched, open cross-section and the shell ends of which in the applied state overlap each other at least partially, at least one tensioning means (14, 15) being disposed on the shell (11, 12), said means acting in the circumferential direction and tensioning the shell ends relative to each other, and the shell (11, 12) being made of a dimensionally stable plastic having regions with varying elasticity.
US09554919B2 Intervertebral implant
An vertebral implant for fusing adjacent vertebrae or for replacing vertebral bodies is disclosed. The implant is a biocompatible metal, resorbable, or radiolucent implant conforming substantially in size and shape with an end plate of a vertebra. The implant preferably has a wedge-shaped profile to restore disc height and the natural curvature of the spine. The top and bottom surfaces of the implant have areas with a plurality of teeth to resist expulsion and provide initial stability and areas devoid of any protrusions to receive implantation instrumentation. The implant also has a stackability feature. The implant provides initial stability needed for fusion without stress shielding.
US09554913B2 Shock-absorbing implant for use in shoulder arthroplasty
A shock-absorbing implant for use in shoulder arthroplasty has a bearing surface, a mounting base affixed to or formed with the bearing surface, a convex element extending outwardly of the mounting base opposite the bearing surface, a receptacle positioned so as to slidably or pivotably receive a portion of the convex element therein, a housing receiving at least a portion of the receptacle therein, and a resilient element received in the housing and bearing against a surface of the housing and against a surface of the receptacle. The bearing surface can be concave when the implant is used as a glenoid implant. The bearing surface can be convex when the implant is used as a humeral head implant.
US09554908B2 Method and a kit of parts for implanting a penile prosthetic insert
A method for implanting a penile prosthetic insert in a corpora cavernosum of a penis and engaging a first magnetic unit with an inflatable penile prosthetic cylinder. The method includes locating a second magnetic unit outside the penis and attracting the first magnetic unit through tissue of the penis with the second magnetic unit to effect moving of the first magnetic unit and the inflatable penile prosthetic cylinder inside the corpora cavernosum. Also disclosed is a kit of parts for implanting a penile prosthetic insert in a corpora cavernosum of a penis including a first magnetic unit and a second magnetic unit for delivering an inflatable penile prosthetic cylinder into the corpora cavernosum of the penis.
US09554907B2 Synthetic chord
Synthetic chord devices and methods for using the same for connecting tissues are provided. Aspects of the synthetic chord device include a flexible cord having an attachment element at both a first and a second end, wherein each attachment element includes a piercing member coupled to a securing member that attaches the flexible cord to a first tissue. At least a portion of the flexible cord can be configured to be secured to a second tissue. Aspects of the invention also include sets of the synthetic chord device with pre-measured flexible cords. The devices and methods of the invention find use in a variety of applications, such as in is applications in which it is desired to repair a heart valve.
US09554904B2 Distal tip assembly for a heart valve delivery catheter
A catheter assembly according to the present invention includes a handle assembly, an introducer sheath, and a distal tip assembly. The distal tip assembly can include first and second retaining sleeves and a slotted tip with a non-traumatic tip guard positioned at the proximal end of the slotted tip. The handle assembly can include a fixed main handle and two or more rotating handles that allow a user to control the distal tip assembly of the catheter. Each control knob on the handle assembly controls a portion of the components on the distal by of the catheter by allowing for precise manipulation of various delivery shafts. Each delivery shaft extends from the handle assembly to respective positions towards the distal end of the catheter.
US09554898B2 Percutaneous prosthetic heart valve
A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.
US09554893B2 Haptic for accommodating intraocular lens
A haptic is provided for use in an accommodating intraocular lens. The haptic has multiple filaments, each connected to the edge of the optic at one end. Each filament has a shape that conforms to an equatorial region of the capsular bag. The haptic couples the forces exerted by the capsular bag of the eye during accommodation radially to the edge of the optic, produce a diametric expansion or compression of the optic. This diametric motion distorts the optic, producing a change in any or all of the anterior radius, the posterior radius, and the thickness. These changes affect the power of the lens and/or location of the image. The haptic may optionally have a thin membrane joining the filaments at the optic end, and may optionally have a connecting ring that joins the filaments at the end opposite that of the optic.